Early multifocal electroretinogram findings during intravitreal ranibizumab treatment for neovascular age-related macular degeneration

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 6, 2011, Pages 3446-3451

  Campa, Claudio ^a,b   Hagan, Richard ^b   Sahni, Jayashree N ^a,b   Brown, Malcolm C ^b   Beare, Nicholas A V ^a,b   Heimann, Heinrich ^a,b   Harding, Simon P ^a,b  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

RANIBIZUMAB; ANGIOGENESIS INHIBITOR; COLORING AGENT; DIAGNOSTIC AGENT; INDOCYANINE GREEN; MONOCLONAL ANTIBODY; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTRAST SENSITIVITY; ELECTRORETINOGRAPHY; FEMALE; FLUORESCENCE ANGIOGRAPHY; HUMAN; INDOCYANINE GREEN ANGIOGRAPHY; LONGITUDINAL STUDY; MALE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETINA FOVEA; RETINA MACULA AGE RELATED DEGENERATION; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; THICKNESS; VISUAL ACUITY; DRUG ANTAGONISM; DRUG EFFECT; INTRAVITREAL DRUG ADMINISTRATION; MIDDLE AGED; OPTICAL COHERENCE TOMOGRAPHY; PATHOPHYSIOLOGY; PHYSIOLOGY; RETINA; RETINA MACULA DEGENERATION;

AGED; AGED, 80 AND OVER; ANGIOGENESIS INHIBITORS; ANTIBODIES, MONOCLONAL; COLORING AGENTS; CONTRAST SENSITIVITY; ELECTRORETINOGRAPHY; FEMALE; FLUORESCEIN ANGIOGRAPHY; HUMANS; INDOCYANINE GREEN; INTRAVITREAL INJECTIONS; LONGITUDINAL STUDIES; MACULAR DEGENERATION; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RETINA; TOMOGRAPHY, OPTICAL COHERENCE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VISUAL ACUITY;

EID: 80051739100     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-6588     Document Type: Article

References (26)

1. Rosenfeld PJ, Brown DM, Heier JS, et al. for the MARINA Study Group. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006;355:1419-1431.
2. Brown DM, Kaiser PK, Michels M, et al. ANCHOR Study Group. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med. 2006;355:1432-1444.
3. Regillo CD, Brown DM, Abraham P, et al. Randomized, doublemasked, sham-controlled trial of ranibizumab for neovascular agerelated macular degeneration: PIER Study year 1. Am J Ophthalmol. 2008;145:239-248.
4. Fung AE, Lalwani GA, Rosenfeld PJ, et al. An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration. Am J Ophthalmol. 2007;143:566-583.
5. Kumar A, Sahni JN, Stangos AN, Campa C, Harding SP. Effectiveness of ranibizumab for neovascular age-related macular degeneration using clinician-determined retreatment strategy. Br J Ophthalmol. 2011;95:530-533.
6. Mitchell P, Korobelnik J-F, Lanzetta P, et al. Ranibizumab (Lucentis) in neovascular age-related macular degeneration: evidence from clinical trials. Br J Ophthalmol. 2010;94:2-13.
7. Sutter EE, Tran D. The field topography of ERG components in man, I: the photopic luminance response. Vision Res. 1992;32: 433-446.
8. Hood DC. Assessing retinal function with the multifocal technique. Prog Retin Eye Res. 2000;19(5):607-646.
9. Hood DC, Frishman LJ, Saszik S, Viswanathan S. Retinal origins of the primate multifocal ERG: implications for the human response. Invest Ophthalmol Vis Sci. 2002;43:1673-1685.
10. Jurklies B, Weismann M, Husing J, et al. Monitoring retinal function in neovascular maculopathy using multifocal electroretinography: early and long-term correlation with clinical findings. Graefes Arch Clin Exp Ophthalmol. 2002;240:244-264.
11. Heinemann-Vernaleken B, Palmowski A, Allgayer R, et al. Comparison of different high resolution multifocal electroretinogram recordings in patients with age-related maculopathy. Graefes Arch Clin Exp Ophthalmol. 2001;239:556-561.
12. Huang S, Wu D, Jiang F, et al. The multifocal electroretinogram in age-related maculopathies. Doc Ophthalmol. 2001;101:115-124.
13. Ruther K, Breidenbach K, Schwartz R, et al. Testing central retinal function with multifocal electroretinography before and after photodynamic therapy (in German). Ophthalmologe. 2003;100:459-464.
14. Mackay AM, Brown MC, Hagan RP, Fisher AC, Grierson I, Harding SP. Deficits in the electroretinogram in neovascular age-related macular degeneration and changes during photodynamic therapy. Doc Ophthalmol. 2007;115:69-76.
15. Moschos M, Brouzas D, Apostolopoulos M, Koutsandrea C, Loukianou E, Moschos M. Intravitreal use of bevacizumab (Avastin) for choroidal neovascularization due to ARMD: a preliminary multifocal-ERG and OCT study: multifocal-ERG after use of bevacizumab in ARMD. Doc Ophthalmol. 2007;114:37-44.
16. Karanjia R, Eng KT, Gale J, Sharma S, ten Hove MW. Electrophysiological effects of intravitreal Avastin (bevacizumab) in the treatment of exudative age-related macular degeneration. Br J Ophthalmol. 2008;92:1248-1252.
17. Pedersen KB, Møller F, Sjølie AK, Andréasson S. Electrophysiological assessment of retinal function during 6 months of bevacizumab treatment in neovascular age-related macular degeneration. Retina. 2010;30:1025-1033.
18. Manzano RP, Peyman GA, Khan P, Kivilcim M. Testing intravitreal toxicity of bevacizumab (Avastin). Retina. 2006;26:257-261.
19. Feigl B, Greaves A, Brown B. Functional outcomes after multiple treatments with ranibizumab in neovascular age-related macular degeneration beyond visual acuity. Clin Ophthalmol. 2007;1:167-175.
20. Arditi A, Cagenello R. On the statistical reliability of letter-chart visual acuity measurements. Invest Ophthalmol Vis Sci. 1993;34:120-129.
21. Ho J, Sull AC, Vuong LN, et al. Assessment of artifacts and reproducibility across spectral-and time-domain optical coherence tomography devices. Ophthalmology. 2009;116:1960-1970.
22. Harrison WW, Bearse MA Jr, Ng JS, Barez S, Schneck ME, Adams AJ. Reproducibility of the mfERG between instruments. Doc Ophthalmol. 2009;119:67-78.
23. Hood DC, Bach M, Brigell M, et al. ISCEV guidelines for clinical multifocal electroretinography (2007 edition). Doc Ophthalmol. 2008;116:1-11.
24. Hagan RP, Fisher AC, Brown MC. Examination of short binary sequences for mfERG recording. Doc Ophthalmol. 2006;113: 21-27.
25. Rosser DA, Murdoch IE, Cousens SN. The effect of optical defocus on the test-retest variability of visual acuity measurements. Invest Ophthalmol Vis Sci. 2004;45:1076-1079.
26. Elliott DB, Sanderson K, Conkey A. The reliability of the Pelli-Robson contrast sensitivity chart. Ophthalmic Physiol Opt. 1990; 10:21-24.