Articular cartilage injury in athletes

Cartilage

Volumn 1, Issue 3, 2010, Pages 165-179

  McAdams, Timothy R ^a   Mithoefer, Kai ^b   Scopp, Jason M ^c   Mandelbaum, Bert R ^d  

^a STANFORD UNIVERSITY   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Peninsula Regional Medical Center   (United States)

^d Santa Monica Orthopedic and Sports Medicine Foundation   (United States)

Author keywords

Cartilage repair; Microfracture; Sports injury

Indexed keywords

EID: 80051735244     PISSN: 19476035     EISSN: 19476043     Source Type: Journal    
DOI: 10.1177/1947603509360210     Document Type: Review

References (143)

1. Ahmad CS, Cohen ZA, Levine WN, Ateshian GA, Mow VC. Biomechanical and topographic considerations for autologous osteochondral grafting in the knee. Am J Sports Med. 2001;29:201-6.
2. Alford JW, Cole BJ. Cartilage restoration, part 2: techniques, outcomes, and future directions. Am J Sports Med. 2005;33:443-60.
3. Alford JW, Cole BJ. Cartilage restoration, part I: basic science, historical perspective, patient evaluation, and treatment options. Am J Sports Med. 2005;33:295-306.
4. Arendt E, Dick R. Knee injury patterns among men and women in collegiate basketball and soccer: NCAA data and review of literature. Am J Sports Med. 1995;23:694-701.
5. Aroen A, Loken S, Heir S, Alvik E, Ekland A, Granlund OG, Engebretsen L. Articular cartilage lesions in 993 consecutive knee arthroscopies. Am J Sports Med. 2004;32:211-5.
6. Arokoski J, Kiviranta I, Jurvelin J, Tammin M, Helminen HJ. Long-distance running causes site-dependent decrease of cartilage glycosaminoglycan content in the knee joint of beagle dogs. Arthritis Rheum. 1993;36:1451-9.
7. Barber FA, Chow JCY. Arthroscopic chondral osseous autograft transplantation (COR Procedure) for femoral defects. Arthroscopy. 2006;22:10-6.
8. Bartlett W, Skinner JA, Gooding CR, Carrington RW, Flanagan AM, Briggs TW, Bentley G. Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: a prospective, randomized study. J Bone Joint Surg Br. 2005;87:640-5.
9. Bartz RL, Laudicina L. Osteoarthritis after sports knee injuries. Clin Sports Med. 2005;24:39-45.
10. Bartz RL, Kamaric E, Noble PC, Lintner D, Bocell J. Topographic matching of selected donor and recipient sites for osteochondral autografting of the articular surface of the femoral condyles. Am J Sports Med. 2001;29:207-12.
11. Behrens P, Bitter T, Kurz B, Russlies M. Matrix-associated autologous chondrocyte transplantation/implantation (MACT/ MACI): 5-year follow-up. Knee. 2006;13:194-202.
12. Bentley G, Biant LC, Carrington RW, Akmal M, Goldberg A, Williams AM, et al. A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee. J Bone Joint Surg Br. 2003;85:223-30.
13. Benya PD, Schaffer JD. Dedifferentialted chondrocytes reexpress the differentialted collagen phenotype when cultured in agarose gels. Cell. 1982;30:215-24.
14. Blevins FT, Steadman JR, Rodrigo JJ, Silliman J. Treatment of articular cartilage defects in athletes: an analysis of functional outcome and lesion appearance. Orthopedics. 1998;21:761-8.
15. Borazjani BH, Chen AC, Bae WC, Patil S, Sah RL, et al. Effect of impact on chondrocyte viability during insertion of human osteochondral grafts. J Bone Joint Surg. 2006;88:1934-43.
16. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med. 1994;331:889-95.
17. Brown WE, Potter HG, Marx RG, Wickiewicz TL, Warren RF. Magnetic resonance imaging appearance of cartilage repair in the knee. Clin Orthop. 2004;422:214-23.
18. Buckwalter JA, Mankin HJ. Articular cartilage. Part II: degeneration and osteoarthrosis, repair, regeneration, and transplantation. J Bone Joint Surg Am. 1997;79:612-32.
19. Buckwalter JA. Evaluating methods for restoring cartilaginous articular surfaces. Clin Orthop. 1999;367S:S224-38.
20. Campbell J, Bellamy N, Gee T. Differences between systematic reviews/meta-analyses of hyaluronic acid/hyaluronan/hylan in osteoarthritis of the knee. Osteoarthritis Cartilage. 2007;15:1424-36.
21. Chow JCY, Hantes ME, Houle JB, Zalavras CG. Arthroscopic autogenous osteochondral transplantation for treating knee cartilage defects: a 2- to 5-year follow-up study. Arthroscopy. 2004;20:681-90.
22. Church S, Keating JF. Reconstruction of the anterior cruciate ligament: timing of surgery and the incidence of meniscal tears and degenerative change. J Bone Joint Surg. 2005;87: 1639-42.
23. Clark KL. Nutritional considerations in joint health. Clin Sports Med. 2007;26:101-18.
24. Curl WW, Krome J, Gordon E, Rushing J, Smith BP, Poehling GG. Cartilage injuries: a review of 31516 knee arthroscopies. Arthroscopy. 1997;13:456-60.
25. Ding C, Cicuttini F, Scott F, Cooley H, Boon C, Jones G. Natural history of knee cartilage defects and factors affecting change. Arch Int Med. 2006;166:651-8.
26. Dragoo JL, Carlson G, McCormick F, Khan-Farooqi, Zhu M, Zuk PA, et al. Healing full-thickness cartilage defects using adipose-derived stem cells. Tissue Engineering. 2007;13:1-7.
27. Dragoo JL, Samimi B, Zhu M, Hame SL, Thomas BJ, Lieberman JR, et al. Tissue-engineered cartilage and bone using stem cells from human infrapatellar fat pads. J Bone Joint Surg. 2003;85:740-7.
28. Drawer S, Fuller CW. Propensity for osteoarthritis and lower limb joint pain in retired professional soccer players. Br J Sports Med. 2001;35:402-8.
29. Drongowski RA, Coran AG, Woitys EM. Predictive value of meniscal and chondral injuries in conservatively treated anterior cruciate ligament injuries. Arthroscopy. 1994;10:97-102.
30. Engstrom B, Forssblad M, Johansson C, Tornkvist H. Does a major knee injury definitely sideline an elite soccer player? Am J Sports Med. 1990;18:101-5.
31. Erggelet C, Sittinger M, Lahm A. The arthroscopic implantation of autologous chondrocytes for the treatment of fullthickness cartilage defects of the knee joint. Arthroscopy. 2003;19:108-10.
32. Felson DT. Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med. 2000;133:635-46.
33. Ficat RP, Ficat C, Gedeon P, Toussaint JB. Spongialization: a new treatment for diseased patellae. Clin Orthop. 1979; 144:74-83.
34. Figueroa D, Calvo R, Vaisman A, Carrasco MA, Moraga C, Delgado I. Knee chondral lesions: incidence and correlation between arthroscopic and magnetic resonance findings. Arthroscopy. 2007;23:312-5.
35. Frisbie DD, Morisset S, Ho C, Rodkey WG, Steadman JR, McIlwraith CW. Effects of calcified cartilage on healing of chondral defects treated with microfracture in horses. Am J Sports Med. 2006;34:1824-31.
36. Fu FH, Zurakowski D, Browne JE, Mandelbaum B, Erggelet C, Moseley JB JR, et al. Autologous chondrocyte implantation versus debridement for treatment of full-thickness chondral defects of the knee. Am J Sports Med. 2005;33:1658-66.
37. Garretson RB III, Katolik LI, Verma N, Beck PR, Bach BR, Cole BJ. Contact pressure at osteochondral donor sites in the patellofemoral joint. Am J Sports Med. 2004;32:967-74.
38. Glaser C, Putz R. Functional anatomy of articular cartilage under compressive loading. Osteoarthritis and Cartilage. 2002;10:83-89.
39. Gobbi A, Nunag P, Malinowski K. Treatment of chondral lesions of the knee with microfracture in a group of athletes. Knee Surg Sports Traumatol Arthrosc. 2005;13:213-21.
40. Gooding CR, Bartlett W, Bentley G, Skinner JA, Carrington R, Flanagan A. A prospective, randomized study comparing two techniques of autologous chondrocyte implantation for osteochondral defects in the knee: periosteum covered versus type I/III covered. Knee. 2006;13:203-10.
41. Gorsline RT, Kaeding CC. The use of NSAIDs and nutritional supplements in athletes with osteoarthritis: prevalence, benefits, and consequences. Clin Sports Med. 2005;24:71-82.
42. Grande DA, Pitman MI, Peterson L, Menche D, Klein M. The repair of experimentally produced defects in rabbit articular cartilage by autologous chondrocyte implantation. J Orthop Res. 1989;7:208-18.
43. Gross A. Fresh osteochondral allograft for posttraumatic knee defects: surgical technique. Op Tech Orthop. 1997;7: 334-9.
44. Gudas R, Kelesinskas RJ, Kimtys V, Stankevicius E, Toliusis V, Benotavicius G, Smailys A. A prospective randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint in young athletes. Arthroscopy. 2005;21:1066-75.
45. Guettler JH, Demetropoulos CK, Yang KH, Jurist KA. Osteochondral defects in the human knee: influence of defect size on cartilage rim stress and load redistribution to surrounding cartilage. Am J Sports Med. 2004;32:1451-8.
46. Hambly K, Bobic V, Wondrasch B, Van Assche D, Marlovitis S. Autologous chondrocyte implantation postoperative care and rehabilitation: science and practice. Am J Sports Med. 2006;34:1020-38.
47. Hangody L, Fule P. Autologois osteochondral mosaicplasty for the treatment of full thickness defects of weight bearing joints: ten years of experimental and clinical experience. J Bone Joint Surg Am. 2003;85 Suppl 2:25-32.
48. Hangody L, Rathonyi GK, Duska Z, Vasarhelyi G, Fules P, Modis L. Autologous osteochondral mosaicplasty: surgical technique. J Bone Joint Surg Am. 2004;86 Suppl 1:65-72.
49. Hefti F, Beguiristain J, Krauspe R, Moller-Madsen B, Riccio V, Tschauner C, et al. Osteochondritis dissecans: a multicenter study of the European Pediatric Orthopedic Society. J Pediatr Orthop B. 1999;8:231-45.
50. Henderson I, Gui J, Lavigne P. Autologous chondrocyte implantation: natural history of postimplantation periosteal hypertrophy and effects of repair-site debridement on outcome. Arthroscopy. 2006;22:1318-24.
51. Hoemann CD, Hurtig M, Rossomacha E, Sun J, Chevrier A, Shive MS. Chitosan-glycerol phosphate/blood implants improve hyaline cartilage repair in ovine microfracture defects. J Bone Joint Surg. 2005;87:2671-86.
52. Homminga GN, Bulstra SK, Bouwmeester PSM, VanderLinden AJ. Perichondral grafting for cartilage lesions of the knee. J Bone Joint Surg. 1990;72:1003-7.
53. Horas U, Pelinkovic D, Aigner T. Autologous chondrocyte implantation and osteochondral cylinder transplantation in cartilage repair of the knee joint: a prospective comparative trial. J Bone Joint Surg Am. 2003;85:185-92.
54. Hui JH, Chen F, Thambyah A, Lee EH. Treatment of chondral lesions in advanced osteochondritis dissecans: a comparative study of the efficacy of chondrocytes, mesenchymal stem cells, periosteal graft, and mosaicplasty (osteochondral autograft) in animal models. J Pediatri Orthop. 2004;24: 427-33.
55. Insall J. The Pridie debridement operation for osteoarthritis of the knee. Clin Orthop. 1974;101:61-7.
56. International Cartilage Repair Society (ICRS) Web site. http://www.cartilage.org.
57. Jackson DW, Lalor PA, Aberman HM, Simon TM. Spontaneous repair of full-thickness defects of articular cartilage in a goat model. J Bone Joint Surg Am. 2001;83:53-64.
58. Jones G, Bennell K, Cicuttini FM. Effect of physical activity on cartilage development in healthy kids. Br J Sports Med. 2003;37:382-3.
59. Jones SJ, Lyons RA, Sibert J, Evans R, Palmer SR. Changes in sports injuries to children between 1983 and 1998: comparison of case series. J Public Health Med. 2001;23:268-71.
60. Kim LS, Axelrod IJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage. 2006;14:286-94.
61. Kish G, Modis L, Hangody L. Osteochondral mosaicplasty for the treatment of focal chondral and osteochondral lesions of the knee and talus in the athlete: rationale, indications, technique, and results. Clin Sports Med. 1999;18:45-66.
62. Kiviranta I, Tammi M, Jurvelin J, Arokoski J, Saamanen AM, Helminen HJ. Articular cartilage thickness and glycosaminoglycan distribution in the canine knee joint after strenuous running exercise. Clin Orthop. 1992;283:302-8.
63. Koh J, Wirsing K, Lautenschlager E, Zhang LO. The effect of graft height mismatch on contact pressures following osteochondral grafting. Am J Sports Med. 2004;32:317-20.
64. Koh JL, Kowalski A, Lautenschlager E. The effect of angled osteochondral grafting on contact pressure: a biomechanical study. Am J Sports Med. 2006;34:116-9.
65. Kohn D. Arthroscopy in acute injuries of anterior cruciatedeficient knees: fresh and old intraarticular lesions. Arthroscopy. 1986;2:98-102.
66. Krishnan SP, Skinner JA, Carrington RWJ, Flanagan AM, Briggs TW, Bentley G. Collagen-covered autologous chondrocyte implantation for osteochondritis dissicans of the knee: two- to seven-year results. J Bone Joint Surg. 2006;88:203-5.
67. Kruez PC, Erggelet C, Steinwachs M, Krause SJ, Lahm A, Niemeyer P, et al. Is microfracture of chondral defects in the knee associated with different results in patients aged 40 years or younger? Arthroscopy. 2006;22:1180-6.
68. Kruez PC, Steinwachs M, Erggelet C, Lahm A, Krause S, Ossendorf C, et al. Importance of sports in cartilage regeneration after autologous chondrocyte implantation: a prospective study with a 3-year follow-up. Am J Sports Med. 2007;35:1261-8.
69. Kujala UM, Kettunen J, Paananen H, Aalto T, Battie MC, Impivaara O, et al. Knee osteoarthritis in former runners, soccer players, weight lifters, and shooters. Arth Rheum. 1995;38:539-46.
70. Lane JG, Massie JB, Ball ST, Amiel ME, Chen AC, Bae WC, et al. Follow-up of osteochondral plug transfers in a goat model: a 6-month study. Am J Sports Med. 2004;32:1440-50.
71. Lee EH, Hui JHP. The potential of stem cells in orthopaedic surgery. J Bone Joint Surg. 2006;88:841-51.
72. Lee JH, Prakash KVB, Pengatteeri YH, Park SE, Koh HS, Han CW. Chondrocyte apoptosis in the regenerated articular cartilage after allogenic chondrocyte transplantation in the rabbit knee. J Bone Joint Surg. 2007;89:977-83.
73. Levy AS, Lohnes J, Sculley S, LeCrow M, Garrett W. Chondral delamination of the knee in soccer players. Am J Sports Med. 1996;24:634-39.
74. Lexar E. Substitution of whole or half joints from freshly amputated extremities by free plastic operation. Surg Gynecol Obstet. 1908;6:601-7.
75. Liu G, Kawaguchi H, Ogasawara T, Asawa Y, Kishimoto J, Takahashi T, et al. Optimal combination of soluble factors for tissue engineering of permanent cartilage from cultured human chondrocytes. J Biol Chem. 2007;282:20407-15.
76. Liu Y, Shu XZ, Prestwich GD. Osteochondral defect repair with autologous bone marrow-derived mesenchymal stem cells in an injectable, in situ, cross-linked synthetic extracellular matrix. Tissue Eng. 2006;12:3405-16.
77. Lohmander LS, Roos H, Dahlberg L, Hoerrner LA, Lark MW. Temporal patterns of stromelysin, tissue inhibitor and proteoglycan fragments in synovial fluid after injury to the knee criciate ligament or meniscus. J Orthop Res. 1994;12:21-8.
78. Magnusson PB. Technique of debridemnt of the knee joint for arthritis. Surg Clin North Am. 1946;26:226-49.
79. Maletius W, Messner K. The long-term prognosis for severe damage to the weightbearing cartilage in the knee: a 14-year clinical and radiographic follow-up in 28 young athletes. Acta Orthop Scand. 1996;67:165-8.
80. Malinin T, Temple HT, Buck BE. Transplantation of osteochondral allografts after cold storage. J Bone Joint Surg. 2006; 88:762-70.
81. Mandelbaum B, Browne JE, Fu F, Micheli LJ, Moseley JB, Erggelet C, et al. Treatment outcomes of autologous chondrocyte implantation for full-thickness articular cartilage defects of the trochlea. Am J Sports Med. 2007;35:915-21.
82. Mandelbaum BR, Waddell D. Etiology and pathophysiology of osteoarthritis. Orthopedics. 2005;28:1-8.
83. Mandelbaum BT, Browne JE, Fu F, Micheli J, Mosley JB, Erggelet C, et al. Articular cartilage lesions of the knee. Am J Sports Med. 2000;26:853-61.
84. Marcacci M, Berruto M, Brocchetta D, Delcogliano A, Ghinelli D, Gobbi A, et al. Articular cartilage engineering with Hyalograft C. Clin Orthop. 2005;435:96-105.
85. Marcacci M, Kon E, Delcogliano M, Filardo G, Busacca M, Zaffagnini S. Arthroscopic autologous osteochondral grafting for cartilage defects of the knee: prospective study results at a minimum 7-year follow-up. Am J Sports Med. 2007;35: 2014-21.
86. Marcacci M, Kon E, Zaffagnini S, Iacono F, Neri MP, Vascellari A, et al. Multiple osteochondral arthroscopic grafting (mosaicplasty) for cartilage defects of the knee: prospective study results at 2-year follow-up. Arthroscopy. 2005;21:462-70.
87. Marder RA, Hopkins G, Timmerman L. Arthroscopic microfracture of chondral defects of the knee: a comparison of two postoperative treatments. Arthroscopy. 2005;21:152-8.
88. McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA. 2000;283:1469-75.
89. McCulloch PC, Kang RW, Sobhy MH, Hayden JK, Cole BJ. Prospective evaluation of prolonged fresh osteochondral allograft transplantation of the femoral condyle: minimum 2-year follow-up. Am J Sports Med. 2007;35:411-20.
90. Minas T. The role of cartilage repair techniques, including chondrocyte transplantation, in focal chondral knee damage. Instr Course Lect. 1999;48:629-43.
91. Mithoefer K, Williams RJ III, Warren RF, Wichiewicz TL, Marx RF. High-impact athletics after knee articular cartilage repair. Am J Sports Med. 2006;34:1413-8.
92. Mithoefer K, Williams RJ, Warren RF, Potter HG, Spock CR, Jones BC, et al. Chondral resurfacing of articular cartilage defects in the knee with the microfracture technique. J Bone Joint Surg. 2006;88:294-305.
93. Mithoefer K, Steadman JR. The microfracture technique. Tech Knee Surg. 2006;5:140-8.
94. Mithoefer K, Williams RJ, Warren RF, Potter HG, Spock CR, Jones EC, et al. The microfracture technique for treatment of articular cartilage lesions in the knee: a prospective cohort evaluation. J Bone Joint Surg. 2005;87:1911-20.
95. Mithöfer K, Peterson L, Mandelbaum BR, et al. Articular cartilage repair in soccer players with autologous chondrocyte transplantation: functional outcome and return to competition. Am J Sports Med. 2005;33:1639-46.
96. Mithöfer K, Minas T, Peterson L, et al. Functional outcome of articular cartilage repair in adolescent athletes. Am J Sports Med. 2005;3:1147-53.
97. Mizuno S, Alleman F, Glowacki J. Effects of medium perfusion on matrix production by bovine chondrocytes in three-dimensional collagen sponges. J Biomed Mater Res. 2001;56:368-75.
98. Moti AW, Micheli LJ. Meniscal and articular cartilage injury in the skeletally immature knee. Instr Course Lect. 2003;52:683-90.
99. Najm WI, Reinsch S, Hoehler F, Tobis JS, Harvey PW. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind crossover trial. BMC Muscul Disord. 2004;5:6.
100. Nam EK, Makhsous M, Koh J, Bowen M, Nuber G, Zhang LQ. Biomechanical and histological evaluation of osteochondral transplantation in a rabbit model. Am J Sports Med. 2004;32:308-16.
101. Nebelung W, Wuschech H. Thirty-five years of follow-up of anterior cruciate ligament-deficient knees in high-level athletes. Arthroscopy. 2005;21:696-702.
102. Nehrer S, Domayer S, Dorotka R, Schatz K, Bindreiter U, Kotz R. Three-year clinical outcome after chondrocyte transplantation using a hyaluronan matrix for cartilage repair. Eur J Rad. 2006;57:3-8.
103. Ogilvie-Harris DJ, Jackson RW. The arthroscopic treatment of chondromalacia patella. J Bone Joint Surg. 1984;66:660-5.
104. Ossendorf C, Kaps C, Kreuz PC, Burmester GR, Sittinger M, Erggelet C. Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results. Arthrit Res Ther. 2007;9:1-11.
105. Outerbridge RE. The etiology of chondromalacea patellae. J Bone Joint Surg. 1961;43:752-67.
106. Pearce SG, Hurtig MB, Clarnette R, Kalra M, Cowan B, Miniaci A. An investigation of 2 techniques for optimizing joint surface congruency using multiple cylindrical osteochondral autografts. Arthroscopy. 2001;17:50-5.
107. Pearle AD, Warren RF, Rodeo SA. Basic science of articular cartilage and osteoarthritis. Clin Sports Med. 2005;24: 1-12.
108. Peterson L, Brittberg M, Kiviranta I, Akerlund EL, Lindahl A. Autologous chondrocyte transplantation: biomechanics and long-term durability. Am J Sports Med. 2002;30:2-12.
109. Petersen W, Zelle S, Zantop T. Arthroscopic implantation of a three dimensional scaffold for autologous chondrocyte transplantation. Arch Orthop Trauma Surg. 2008;128:505-8.
110. Piasecki DD, Spindler KP, Warren TA, Andrish JT, Parker RD. Intraarticular injuries associated with anterior cruciate ligament tear: findings at ligament reconstruction in high school and recreational athletes. Am J Sports Med. 2003;31: 601-5.
111. Potter HG, Foo LF. Magnetic resonance imaging of articular cartilage. Am J Sports Med. 2006;34:661-7.
112. Potter HG, Linklater JM, Allen AA, Hannafin JA, Haas SB. Magnetic resonance imaging of articular cartilage in the knee. J Bone Joint Surg Am. 1998;80:1276-84.
113. Pridie KH. A method of resurfacing osteoarthritic knee joints. J Bone Joint Surg. 1959;41:618-9.
114. Rae PJ, Noble J. Arthroscopic drilling of osteochondral lesions of the knee. J Bone Joint Surg. 1989;71:534-41.
115. Reddy S, Pedowitz DI, Parekh SG, Sennett BJ, Okereke E. The morbidity associated with osteochondral harvest from asymptomatic knees for the treatment of osteochondral lesions of the talus. Am J Sports Med. 2007;35:80-5.
116. Rodrigo JJ, Steadman RJ, Silliman JF. Improvement of fullthickness chondral defect healing in the human knee after debridement and microfracture using continuous passive motion. Am J Knee Surg. 1994;7:109-16.
117. Roos EM, Dahlberg L. Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage. Arthrit Rheum. 2005;52:3507-14.
118. Roos H, Lindberg H, Ornell M. Soccer as a cause of hip and knee osteoarthritis. Ann Rheum Dis. 1996;55:690-8.
119. Roos H. Are there long-term sequelae from soccer? Clin Sports Med. 1998;17:819-83.
120. Schonholtz GJ, Ling B. Arthroscopic chondroplasty of the patella. Arthroscopy. 1985;1:92-6.
121. Sharma A, Wood LD, Richardson JB, Roberts S, Kuiper NJ. Glycosaminoglycan profiles of repair tissue formed following autologous chondrocyte implantation differ from control cartilage. Arthrit Res Ther. 2007;9:R79.
122. Shelbourne KD, Jari S, Gray T. Outcome of untreated traumatic articular cartilage defects of the knee: a natural history study. J Bone Joint Surg Am. 2003;85 Suppl 2:8-16.
123. Shintani N, Kurth T, Hunziker EB. Expression of cartilage- related genes in bovine synovial tissue. J Orthop Res. 2007;25:813-9.
124. Skoog T, Johansson SH. The formation of articular cartilage from free perichondrial grafts. Plast Reconst Surg. 1976;57:1-6.
125. Smith AD, Tao SS. Knee injuries in young athletes. Clin Sports Med. 1995;14:629-50.
126. Smith-Peterson MN. Evolution of mould arthroplasty of the hip joint. J Bone Joint Surg. 1948;30:59-75.
127. Sprague NF 3rd. Arthroscopic debridement for degenerative knee joint disease. Clin Orthop Relat Res. 1981;160:118-23.
128. Steadman JR, Rodkey WG, Singleton SB. Microfracture technique for full thickness chondral defects: technique and clinical results. Oper Tech Orthopedics. 1997;7:300-4.
129. Steadman JR, Briggs KK, Rodrigo JJ, Kocher MS, Gill TJ, Rodkey WG. Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year follow-up. Arthroscopy. 2003;19:477-84.
130. Steadman JR, Miller BS, Karas SG, Schlegel TF, Briggs KK, Hawkins RJ. The microfracture technique in the treatment of full-thickness chondral lesions of the knee in National Football League players. J Knee Surg. 2003;16:83-6.
131. Steinwachs M, Kreuz PC. Autologous chondrocyte implantation in chondral defects of the knee with a type I/III collagen membrane: a prospective study with a 3-year follow-up. Arthroscopy. 2007;23:381-7.
132. Stone KR, Walgenbach AW, Freyer A, Turek TJ, Speer DP. Articular cartilage paste grafting to full-thickness articular cartilage knee joint lesions: a 2- to 12-year follow-up. Arthroscopy. 2006; 22:291-9.
133. Theosakis J, Adderly B, Fox B. The arthritis cure: the medical miracle that can halt, reverse, and may even cure osteoarthritis. Vol. XVI. 1st ed. New York: St. Martin's Press; 1997.
134. Towheed TE. Current status of glucosamine therapy in osteoarthritis. Arthr Rheum. 2003;49:601-4.
135. Trattnig S, Pinker K, Drestan C, Plank C, Millinton S, Marlavits S. Matrix-based autologous chondrocyte implantation for cartilage repair with Hyalograft C: two-year follow-up by magnetic resonance imaging. Eur J Rad. 2006;57:9-15.
136. Victor von Engelhardt L, Kraft CN, Pennekamp PH, Schild HH, Schmitz A, von Falkenhausen M. The evaluation of articular cartilage lesions of the knee with a 3-tesla magnet. Arthroscopy. 2007;23:496-502.
137. Vrahas MS, Mithoefer K, Joseph D. Long-term effects of articular impaction. Clin Orthop. 2004;423:40-3.
138. Wang DA, Varghese S, Sharma B, Strehin I, Fermanian S, Gorham J. Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration. Nat Mater. 2007;6:385-92.
139. Wang CT, Lin J, Chang CJ, Lin YT, Hou SM. Therapeutic effects of hyaluronic acid on osteoarthritis of the knee: a meta-analysis of randomized controlled trials. J Bone Joint Surg. 2004;86:538-55.
140. Williams RJ, Ranawat AS, Potter HG, Carter T, Warren RF. Fresh stored allografts for the treatment of osteochondral defects of the knee. J Bone Joint Surg. 2007;89:718-26.
141. Williams SK, Amiel D, Ball ST, Allen RT, Wong VW, Chen AC, et al. Prolonged storage effects on the articular cartilage of fresh human osteochondral allografts. J Bone Joint Surg. 2003;85:2111-20.
142. Wood JJ, Malek MA, Frassica FJ, Polder JA, Mohan AK, Bloom ET, et al. Autologous cultured chondrocytes: adverse events reported to the United States Food and Drug Administration. J Bone Joint Surg. 2006;88:503-7.
143. Yan H, Yu C. Repair of full-thickness cartilage defects with cells of different origin in a rabbit model. Arthroscopy. 2007;23:178-87.