Micro-ultrasonographic imaging of atherosclerotic progression and correlation with inflammatory markers in apolipoprotein-e knockout mice

Texas Heart Institute Journal

Volumn 38, Issue 4, 2011, Pages 364-370

  Li, Rong Juan ^a   Yang, Ya ^a   Wang, Yan Hong ^a   Xie, Jin Jie ^a   Song, Li ^a   Wang, Zheng ^a   Zhang, Yao Zhong ^a   Qind, Yan Wen ^a   Li, Zhi An ^a   Zhang, Xiao Shan ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Animal; Apolipoproteins e deficiency; Arteriosclerosis diagnosis physiopathology ultrasonography; C reactive protein physiology; Diagnostic imaging methods; Disease models; Inbred c57bl; Inflammation etiology physiopathology; Interleukins physiology; Knockout; Mice; Microscopy; Ultrasonography instrumentation methods

Indexed keywords

APOLIPOPROTEIN E; C REACTIVE PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6;

ACCURACY; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; AORTA INTIMA; AORTA MEDIA; ARTERIAL WALL THICKNESS; ARTICLE; ASCENDING AORTA; BIOMICROSCOPY; C REACTIVE PROTEIN BLOOD LEVEL; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; HISTOPATHOLOGY; IMAGE QUALITY; INTERLEUKIN 1 BLOOD LEVEL; INTERLEUKIN 6 BLOOD LEVEL; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL;

ANIMALS; AORTA; AORTIC DISEASES; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; EQUIPMENT DESIGN; FEASIBILITY STUDIES; INFLAMMATION MEDIATORS; INTERLEUKIN-1; INTERLEUKIN-6; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, ACOUSTIC; MINIATURIZATION; PREDICTIVE VALUE OF TESTS; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TUNICA INTIMA; TUNICA MEDIA;

EID: 80051725867     PISSN: 07302347     EISSN: 15266702     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Nakashima Y, Plump AS, Raines EW, Breslow JL, Ross R. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb 1994;14(1):133-40.
2. Balaban RS, Hampshire VA. Challenges in small animal noninvasive imaging. ILAR J 2001;42(3):248-62.
3. Hoit BD. New approaches to phenotypic analysis in adult mice. J Mol Cell Cardiol 2001;33(1):27-35.
4. Foster FS, Pavlin CJ, Harasiewicz KA, Christopher DA, Turnbull DH. Advances in ultrasound biomicroscopy. Ultrasound Med Biol 2000;26(1):1-27.
5. Wikstrom J, Gronros J, Bergstrom G, Gan LM. Functional and morphologic imaging of coronary atherosclerosis in living mice using high-resolution color Doppler echocardiography and ultrasound biomicroscopy. J Am Coll Cardiol 2005;46 (4):720-7.
6. Mangge H, Hubmann H, Pilz S, Schauenstein K, Renner W, Marz W. Beyond cholesterol--inflammatory cytokines, the key mediators in atherosclerosis. Clin Chem Lab Med 2004; 42(5):467-74.
7. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, Criqui M, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003;107(3):499-511.
8. Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med 2002;347(20):1557-65.
9. Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R. Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. Circulation 1986;74(6):1399-406.
10. Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE. Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 1997;96(5):1432-7.
11. Gan LM, Gronros J, Hagg U, Wikstrom J, Theodoropoulos C, Friberg P, Fritsche-Danielson R. Non-invasive real-time imaging of atherosclerosis in mice using ultrasound biomicroscopy. Atherosclerosis 2007;190(2):313-20.
12. Ross R. Atherosclerosis--an inflammatory disease. N Engl J Med 1999;340(2):115-26.
13. Ridker PM; JUPITER Study Group. Rosuvastatin in the primary prevention of cardiovascular disease among patients with low levels of low-density lipoprotein cholesterol and ele vated high-sensitivity C-reactive protein: rationale and design of the JUPITER trial. Circulation 2003;108(19):2292-7.
14. Pepys MB, Baltz ML. Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein. Adv Immunol 1983;34:141-212.
15. Black S, Kushner I, Samols D. C-reactive protein. J Biol Chem 2004;279(47):48487-90.
16. Pepys MB, Hirschfield GM. C-reactive protein: a critical update [published erratum appears in J Clin Invest 2003;112(2): 299].J Clin Invest 2003;111(12):1805-12.
17. Labarrere CA, Zaloga GP. C-reactive protein: from innocent bystander to pivotal mediator of atherosclerosis. Am J Med 2004;117(7):499-507.
18. Chi H, Messas E, Levine RA, Graves DT, Amar S. Interleukin-1 receptor signaling mediates atherosclerosis associated with bacterial exposure and/or a high-fat diet in a murine apolipoprotein E heterozygote model: pharmacotherapeutic implications. Circulation 2004;110(12):1678-85.
19. Kishimoto T. The biology of interleukin-6. Blood 1989;74(1): 1-10.
20. Ohsuzu F. The roles of cytokines, inflammation and immunity in vascular diseases. J Atheroscler Thromb 2004;11(6):313-21.
21. Dinarello CA. Interleukin-1 and interleukin-1 antagonism. Blood 1991;77(8):1627-52.
22. Dewberry R, Holden H, Crossman D, Francis S. Interleukin-1 receptor antagonist expression in human endothelial cells and atherosclerosis. Arterioscler Thromb Vasc Biol 2000; 20(11):2394-400.
23. Tilg H, Dinarello CA, Mier JW. IL-6 and APPs: anti-inflammatory and immunosuppressive mediators. Immunol Today 1997;18(9):428-32.
24. Xing Z, Gauldie J, Cox G, Baumann H, Jordana M, Lei XF, Achong MK. IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest 1998;101(2):311-20.
25. Elhage R, Clamens S, Besnard S, Mallat Z, Tedgui A, Arnal J, et al. Involvement of interleukin-6 in atherosclerosis but not in the prevention of fatty streak formation by 17beta-estradiol in apolipoprotein E-deficient mice. Atherosclerosis 2001;156 (2):315-20.
26. Schieffer B, Selle T, Hilfiker A, Hilfiker-Kleiner D, Grote K, Tietge UJ, et al. Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis. Circulation 2004;110(22):3493-500.