Reversed-phase TLC study of the lipophilicity of fourteen 1,3-benzoxazol-2(3H)-one derivatives and comparison with isomeric 1,2-benzisoxazol-3(2H)-one analogs

Journal of Planar Chromatography - Modern TLC

Volumn 24, Issue 4, 2011, Pages 348-351

  Skibiński, Robert ^a   Sławik, Tomasz ^a   Kaczkowska, Martyna ^a  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

1,2 Benzisoxazol 3(2H) one; 1,3 Benzoxazol 2(3H) one; Calculated partition coefficients; Lipophilicity; RP TLC

Indexed keywords

1,2-BENZISOXAZOL-3(2H)-ONE; 1,3-BENZOXAZOL-2(3H) -ONE; CALCULATED PARTITION COEFFICIENTS; LIPOPHILICITY; RP-TLC;

BENZENE; HYDROPHOBIC CHROMATOGRAPHY; HYDROPHOBICITY; METHANOL; SURFACE CHEMISTRY; THIN LAYER CHROMATOGRAPHY;

PRINCIPAL COMPONENT ANALYSIS;

1,2 BENZISOXAZOL 3 (2H)ONE; 1,3 BENZOXAZOL 2 (3H)ONE; 5 BROMO 1,3 BENZOXAZOL 2 (3H)ONE; 5 CHLORO 1,3 BENZOXAZOL 2 (3H)ONE; 5 FLUORO 1,3 BENZOXAZOL 2 (3H)ONE; 5,7 DIBROMO 1,3 BENZOXAZOL 2 (3H)ONE; 6 AMINO 1,3 BENZOXAZOL 2(3H)ONE; 6 BROMO 1,3 BENZOXAZOL 2 (3H)ONE; 6 CHLORO 1,3 BENZOXAZOL 2 (3H)ONE; 6 FLUORO 1,3 BENZOXAZOL 2 (3H)ONE; 6 NITRO 1,3 BENZOXAZOL 2 (3H)ONE; 7 AMINO 1,3 BENZOXAZOL 2 (3H)ONE; 7 BROMO 1,3 BENZOXAZOL 2 (3H)ONE; 7 CHLORO 1,3 BENZOXAZOL 2 (3H)ONE; 7 FLUORO 1,3 BENZOXAZOL 2 (3H)ONE; BENZOXAZOLE DERIVATIVE; GLYCINE; METHANOL; UNCLASSIFIED DRUG; WATER;

ARTICLE; HYDROPHOBICITY; LIPOPHILICITY; PH; REVERSE PHASE THIN LAYER CHROMATOGRAPHY; THIN LAYER CHROMATOGRAPHY;

EID: 80051721180     PISSN: 09334173     EISSN: 17890993     Source Type: Journal    
DOI: 10.1556/JPC.24.2011.4.14     Document Type: Article

References (15)

1. B. Morak-Młodawska, K. Pluta, J. Liq. Chromatogr. Relat. Technol. 31 (2008) 611-618.
2. M. Waksumndzka-Hajnos, D. Matosiuk, A. Petruczynik, U. Kijkowska-Murak, Acta Chromatogr. 20 (2008) 563-573.
3. T. Inglot, A. Gumieniczek, Ł. Komsta, A. Kasińska, Chromatographia 68 (2008) 977-985.
4. E. Pȩkala, H. Marona, Biomed. Chromatogr. 23 (2009) 543-550.
5. K. Kulig, B. Malawska, J. Planar Chromatogr. 22 (2009) 141-144.
6. A. Pyka, J. Liq. Chromatogr. Relat. Technol. 31 (2008) 611-618.
7. M. Negwer, H. G. Scharnow, Viley-VCH, Weinheim, 2001.
8. J. Sam, J. L. Valentine, J. Pharm. Sci. 58 (1969) 1043-1054.
9. T. Sławik, R. Skibiński, B. Paw, G. Działo, Acta Chromatogr. 21 (2009) 251-258.
10. T. Sławik, C. Kowalski, J. Chromatogr. A 21 (2002) 295-299.
11. T. Braumann, J. Chromatogr. 323 (1986) 191-225.
12. K. Dross, Ch. Sonntag, R. Mannhold, J. Chromatogr. A 639 (1993) 287-294.
13. K. Dross, Ch. Sonntag, R. Mannhold, J. Chromatogr. A 673 (1994) 113-124.
14. I. V. Tetko, V. J. Tanchuk, VCC - Lab, 2002, http://146.107.217. 178/servlets/vcc.lab?action-alogps.
15. M. Daszykowski, B. Walczak, D. L. Massart, Chemom. Intell. Lab. Syst. 65 (2003) 97-112.