메뉴 건너뛰기




Volumn 17, Issue 16, 2011, Pages 5257-5267

Novel functional germline variants in the VEGF receptor 2 gene and their effect on gene expression and microvessel density in lung cancer

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; VASCULOTROPIN RECEPTOR 2;

EID: 80051705165     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-11-0379     Document Type: Article
Times cited : (75)

References (39)
  • 1
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • DOI 10.1038/nm0603-669
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003;9:669-676 (Pubitemid 36749215)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.-P.2    LeCouter, J.3
  • 2
    • 84970070220 scopus 로고
    • Expression of vascular endothelial Growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer
    • Takahashi Y, Kitadai Y, Bucana CD, Cleary KR, Ellis LM. Expression of vascular endothelial Growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 1995;55:3964-3968
    • (1995) Cancer Res , vol.55 , pp. 3964-3968
    • Takahashi, Y.1    Kitadai, Y.2    Bucana, C.D.3    Cleary, K.R.4    Ellis, L.M.5
  • 4
    • 18644368033 scopus 로고    scopus 로고
    • A novel peptide isolated from a phage display library inhibits tumor growth and metastasis by blocking the binding of vascular endothelial growth factor to its kinase domain receptor
    • DOI 10.1074/jbc.M203103200
    • Hetian L, Ping A, Shumei S, Xiaoying L, Luowen H, Jian W, et al. A novel peptide isolated from a phage display library inhibits tumor growth and metastasis by blocking the binding of vascular endothelial growth factor to its kinase domain receptor. J Biol Chem 2002;277:43137-43142 (Pubitemid 35285698)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.45 , pp. 43137-43142
    • Hetian, L.1    Ping, A.2    Shumei, S.3    Xiaoying, L.4    Luowen, H.5    Jian, W.6    Lin, M.7    Meisheng, L.8    Junshan, Y.9    Chengchao, S.10
  • 5
    • 50649099256 scopus 로고    scopus 로고
    • Clinical effect and future considerations for molecularly-targeted therapy in renal cell carcinoma
    • Rini BI, Flaherty K. Clinical effect and future considerations for molecularly-targeted therapy in renal cell carcinoma. Urol Oncol 2008;26:543-549
    • (2008) Urol Oncol , vol.26 , pp. 543-549
    • Rini, B.I.1    Flaherty, K.2
  • 7
    • 49449117755 scopus 로고    scopus 로고
    • Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2- pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor
    • Harris PA, Boloor A, Cheung M, Kumar R, Crosby RM, Davis-Ward RG, et al. Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl] amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J Med Chem 2008;51:4632-4640
    • (2008) J Med Chem , vol.51 , pp. 4632-4640
    • Harris, P.A.1    Boloor, A.2    Cheung, M.3    Kumar, R.4    Crosby, R.M.5    Davis-Ward, R.G.6
  • 12
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • DOI 10.1038/nrd2115, PII NRD2115
    • Folkman J. Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 2007;6:273-286 (Pubitemid 46505878)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.4 , pp. 273-286
    • Folkman, J.1
  • 13
    • 45949086825 scopus 로고    scopus 로고
    • Surrogate biomarkers in evaluating response to anti-angiogenic agents: Focus on sunitinib
    • DePrimo SE, Bello C. Surrogate biomarkers in evaluating response to anti-angiogenic agents: focus on sunitinib. Ann Oncol 2007;18Suppl 10:x11-x19
    • (2007) Ann Oncol , vol.18 , Issue.SUPPL. 10
    • DePrimo, S.E.1    Bello, C.2
  • 15
    • 0042121118 scopus 로고    scopus 로고
    • Cluster-Buster: Finding dense clusters of motifs in DNA sequences
    • DOI 10.1093/nar/gkg540
    • Frith MC, Li MC, Weng Z. Cluster-Buster: finding dense clusters of motifs in DNA sequences. Nucleic Acids Res 2003;31:3666-3668 (Pubitemid 37442218)
    • (2003) Nucleic Acids Research , vol.31 , Issue.13 , pp. 3666-3668
    • Frith, M.C.1    Li, M.C.2    Weng, Z.3
  • 16
    • 0346373654 scopus 로고    scopus 로고
    • Selecting a Maximally Informative Set of Single-Nucleotide Polymorphisms for Association Analyses Using Linkage Disequilibrium
    • DOI 10.1086/381000
    • Carlson CS, Eberle MA, Rieder MJ, Yi Q, Kruglyak L, Nickerson DA. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet 2004;74:106-120 (Pubitemid 38085242)
    • (2004) American Journal of Human Genetics , vol.74 , Issue.1 , pp. 106-120
    • Carlson, C.S.1    Eberle, M.A.2    Rieder, M.J.3    Yi, Q.4    Kruglyak, L.5    Nickerson, D.A.6
  • 17
    • 0016319012 scopus 로고
    • Estimation of linkage disequilibrium in randomly mating populations
    • Hill WG. Estimation of linkage disequilibrium in randomly mating populations. Heredity 1974;33:229-239
    • (1974) Heredity , vol.33 , pp. 229-239
    • Hill, W.G.1
  • 18
    • 33747832183 scopus 로고    scopus 로고
    • FASTSNP: An always up-to-date and extendable service for SNP function analysis and prioritization
    • Yuan HY, Chiou JJ, Tseng WH, Liu CH, Liu CK, Lin YJ, et al. FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization. Nucleic Acids Res 2006;34:W635-W641
    • (2006) Nucleic Acids Res , vol.34
    • Yuan, H.Y.1    Chiou, J.J.2    Tseng, W.H.3    Liu, C.H.4    Liu, C.K.5    Lin, Y.J.6
  • 19
    • 0042622245 scopus 로고    scopus 로고
    • Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN
    • DOI 10.1093/nar/gkg605
    • Farre D, Roset R, Huerta M, Adsuara JE, Rosello L, Alba MM, et al. Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN. Nucleic Acids Res 2003;31:3651-3653 (Pubitemid 37442215)
    • (2003) Nucleic Acids Research , vol.31 , Issue.13 , pp. 3651-3653
    • Farre, D.1    Roset, R.2    Huerta, M.3    Adsuara, J.E.4    Rosello, L.5    Alba, M.M.6    Messeguer, X.7
  • 20
    • 0029147486 scopus 로고
    • Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor
    • Patterson C, Perrella MA, Hsieh CM, Yoshizumi M, Lee ME, Haber E. Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor. J Biol Chem 1995;270:23111-23118
    • (1995) J Biol Chem , vol.270 , pp. 23111-23118
    • Patterson, C.1    Perrella, M.A.2    Hsieh, C.M.3    Yoshizumi, M.4    Lee, M.E.5    Haber, E.6
  • 21
    • 77952309862 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor 1 (IGF1R) gene copy number is associated with survival in operable non-smallcell lung cancer: A comparison between IGF1R fluorescent in situ hybridization, protein expression, and mRNA expression
    • Dziadziuszko R, Merrick DT, Witta SE, Mendoza AD, Szostakiewicz B, Szymanowska A, et al. Insulin-like growth factor receptor 1 (IGF1R) gene copy number is associated with survival in operable non-smallcell lung cancer: a comparison between IGF1R fluorescent in situ hybridization, protein expression, and mRNA expression. J Clin Oncol 2010;28:2174-2180
    • (2010) J Clin Oncol , vol.28 , pp. 2174-2180
    • Dziadziuszko, R.1    Merrick, D.T.2    Witta, S.E.3    Mendoza, A.D.4    Szostakiewicz, B.5    Szymanowska, A.6
  • 23
    • 58149307905 scopus 로고    scopus 로고
    • Identification of importin 8 (IPO8) as the most accurate reference gene for the clinicopathological analysis of lung specimens
    • Nguewa PA, Agorreta J, Blanco D, Lozano MD, Gomez-Roman J, Sanchez BA, et al. Identification of importin 8 (IPO8) as the most accurate reference gene for the clinicopathological analysis of lung specimens. BMC Mol Biol 2008;9:103.
    • (2008) BMC Mol Biol , vol.9 , pp. 103
    • Nguewa, P.A.1    Agorreta, J.2    Blanco, D.3    Lozano, M.D.4    Gomez-Roman, J.5    Sanchez, B.A.6
  • 24
    • 33746197428 scopus 로고    scopus 로고
    • Adaptive linear step-up procedures that control the false discovery rate
    • DOI 10.1093/biomet/93.3.491
    • Benjamini Y, Krieger A, M, Yekutieli D. Adaptive linear step-up procedures that control the false discovery rate. Biometrika 2006;93:491-507. (Pubitemid 44599846)
    • (2006) Biometrika , vol.93 , Issue.3 , pp. 491-507
    • Benjamini, Y.1    Krieger, A.M.2    Yekutieli, D.3
  • 25
    • 79960987794 scopus 로고    scopus 로고
    • Using false discovery rates for multiple comparisons in ecology and evolution
    • Pike N. Using false discovery rates for multiple comparisons in ecology and evolution. Methods Ecol Evol 2011;2:278-282
    • (2011) Methods Ecol Evol , vol.2 , pp. 278-282
    • Pike, N.1
  • 28
    • 9244222682 scopus 로고    scopus 로고
    • Association of vascular endothelial growth factor (VEGF) and VEGF receptor gene polymorphisms with coronary artery lesions of Kawasaki disease
    • DOI 10.1203/01.PDR.0000145280.26284.B9
    • Kariyazono H, Ohno T, Khajoee V, Ihara K, Kusuhara K, Kinukawa N, et al. Association of vascular endothelial growth factor (VEGF) and VEGF receptor gene polymorphisms with coronary artery lesions of Kawasaki disease. Pediatr Res 2004;56:953-959 (Pubitemid 39552779)
    • (2004) Pediatric Research , vol.56 , Issue.6 , pp. 953-959
    • Kariyazono, H.1    Ohno, T.2    Khajoee, V.3    Ihara, K.4    Kusuhara, K.5    Kinukawa, N.6    Mizuno, Y.7    Hara, T.8
  • 29
    • 66149118241 scopus 로고    scopus 로고
    • Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans
    • Calvo SE, Pagliarini DJ, Mootha VK. Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans. Proc Natl Acad Sci U S A 2009;106:7507-7512
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 7507-7512
    • Calvo, S.E.1    Pagliarini, D.J.2    Mootha, V.K.3
  • 30
    • 66749149929 scopus 로고    scopus 로고
    • The -271 G>A polymorphism of kinase insert domain-containing receptor gene regulates its transcription level in patients with non-small cell lung cancer
    • An SJ, Chen ZH, Lin QX, Su J, Chen HJ, Lin JY, et al. The -271 G>A polymorphism of kinase insert domain-containing receptor gene regulates its transcription level in patients with non-small cell lung cancer. BMC Cancer 2009;9:144.
    • (2009) BMC Cancer , vol.9 , pp. 144
    • An, S.J.1    Chen, Z.H.2    Lin, Q.X.3    Su, J.4    Chen, H.J.5    Lin, J.Y.6
  • 31
    • 70349937895 scopus 로고    scopus 로고
    • Glucose is a key regulator of VEGFR2/KDR in human epithelial ovarian carcinoma cells
    • Adham SA, Coomber BL. Glucose is a key regulator of VEGFR2/KDR in human epithelial ovarian carcinoma cells. Biochem Biophys Res Commun 2009;390:130-135
    • (2009) Biochem Biophys Res Commun , vol.390 , pp. 130-135
    • Adham, S.A.1    Coomber, B.L.2
  • 32
    • 4344643796 scopus 로고    scopus 로고
    • Relevance of tumor microenvironment for progression, therapy and drug development
    • DOI 10.1097/00001813-200401000-00002
    • Henning T, Kraus M, Brischwein M, Otto AM, Wolf B. Relevance of tumor microenvironment for progression, therapy and drug development. Anticancer Drugs 2004;15:7-14. (Pubitemid 39140166)
    • (2004) Anti-Cancer Drugs , vol.15 , Issue.1 , pp. 7-14
    • Henning, T.1    Kraus, M.2    Brischwein, M.3    Otto, A.M.4    Wolf, B.5
  • 33
    • 70349554296 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression and neovascularization in non - Small cell lung carcinoma
    • Ozbudak IH, Ozbilim G, Kucukosmanoglu I, Dertsiz L, Demircan A. Vascular endothelial growth factor expression and neovascularization in non - small cell lung carcinoma. Int J Surg Pathol 2009;17:390-395
    • (2009) Int J Surg Pathol , vol.17 , pp. 390-395
    • Ozbudak, I.H.1    Ozbilim, G.2    Kucukosmanoglu, I.3    Dertsiz, L.4    Demircan, A.5
  • 34
    • 77954722597 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers
    • Smith NR, Baker D, James NH, Ratcliffe K, Jenkins M, Ashton SE, et al. Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers. Clin Cancer Res 2010;16:3548-3561
    • (2010) Clin Cancer Res , vol.16 , pp. 3548-3561
    • Smith, N.R.1    Baker, D.2    James, N.H.3    Ratcliffe, K.4    Jenkins, M.5    Ashton, S.E.6
  • 35
    • 39749144726 scopus 로고    scopus 로고
    • Biomarkers of response to epidermal growth factor receptor inhibitors in non-small-cell lung cancer working group: Standardization for use in the clinical trial setting
    • DOI 10.1200/JCO.2007.12.9858
    • Eberhard DA, Giaccone G, Johnson BE. Biomarkers of response to epidermal growth factor receptor inhibitors in Non-Small-Cell Lung Cancer Working Group: standardization for use in the clinical trial setting. J Clin Oncol 2008;26:983-994 (Pubitemid 351398092)
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.6 , pp. 983-994
    • Eberhard, D.A.1    Giaccone, G.2    Johnson, B.E.3
  • 36
    • 64249126008 scopus 로고    scopus 로고
    • PI-3 kinase-PTEN signaling node: An intercept point for the control of angiogenesis
    • Castellino RC, Muh CR, Durden DL. PI-3 kinase-PTEN signaling node: an intercept point for the control of angiogenesis. Curr Pharm Des 2009;15:380-388
    • (2009) Curr Pharm des , vol.15 , pp. 380-388
    • Castellino, R.C.1    Muh, C.R.2    Durden, D.L.3
  • 38
    • 34547453935 scopus 로고    scopus 로고
    • Characterization of the amplicon on chromosomal segment 4q12 in glioblastoma multiforme
    • DOI 10.1215/15228517-2007-009
    • Holtkamp N, Ziegenhagen N, Malzer E, Hartmann C, Giese A, von Deimling A. Characterization of the amplicon on chromosomal segment 4q12 in glioblastoma multiforme. Neuro Oncol 2007;9:291-297 (Pubitemid 47169661)
    • (2007) Neuro-Oncology , vol.9 , Issue.3 , pp. 291-297
    • Holtkamp, N.1    Ziegenhagen, N.2    Malzer, E.3    Hartmann, C.4    Giese, A.5    Von Deimling, A.6
  • 39
    • 38049005528 scopus 로고    scopus 로고
    • Cutaneous T-cell lymphoma-associated lung cancers show chromosomal aberrations differing from primary lung cancer
    • Hahtola S, Burghart E, Puputti M, Karenko L, Abdel-Rahman WM, Vakeva L, et al. Cutaneous T-cell lymphoma-associated lung cancers show chromosomal aberrations differing from primary lung cancer. Genes Chromosomes Cancer 2008;47:107-117
    • (2008) Genes Chromosomes Cancer , vol.47 , pp. 107-117
    • Hahtola, S.1    Burghart, E.2    Puputti, M.3    Karenko, L.4    Abdel-Rahman, W.M.5    Vakeva, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.