Topical emulsions containing ceramides: Effects on the skin barrier function and anti-inflammatory properties

European Journal of Lipid Science and Technology

Volumn 113, Issue 8, 2011, Pages 961-966

  Carneiro, Rita ^b   Salgado, Ana ^a   Raposo, Sara ^a   Marto, Joana ^a   Simões, Sandra ^a   Urbano, Manuela ^b   Ribeiro, Helena M ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b Produtos Farmacêuticos   (Portugal)

Author keywords

Anti inflammatory activity; Ceramides; Hydrocortisone; Permeation studies; Stability; TEWL

Indexed keywords

EID: 80051702336     PISSN: 14387697     EISSN: 14389312     Source Type: Journal    
DOI: 10.1002/ejlt.201000495     Document Type: Article

References (27)

1. Halvarsson, K., Loden, M., Increasing quality of life by improving the quality of skin in patients with atopic dermatitis. Int. J. Cosmet. Sci. 2007, 29, 69-83.
2. Cork, M. J., Danby, S. G., Vasilopoulos, Y. J., Lane, M. E., et al., Epidermal barrier dysfunction in atopic dermatitis. J. Invest. Dermatol. 2009, 129, 1892-1908.
3. Addor, F. A. S., Aoki, V., Skin barrier in atopic dermatitis. An. Bras. Dermatol. 2010, 85, 184-194.
4. Jung, T., Stingl, G., Atopic dermatitis: Therapeutic concepts evolving from new pathophysiologic insights. J. Allergy Clin. Immunol. 2008, 122, 1074-1081.
5. Machado, M., Bronze, M. R., Ribeiro, H. M., New cosmetic emulsions for dry skin. J. Cosmet. Dermatol. 2007, 6, 239-242.
6. Coderch, L., De Pera, M., Fonollosa, J., De La Maza, A., Parra, J., Efficacy of stratum corneum lipid supplementation on human skin. Contact Dermatitis 2002, 47, 139-146.
7. Park, K. Y., Kim, D. H., Jeong, M. S., Li, K., Seo, S. J., Changes of antimicrobial peptides and transepidermal water loss after topical application of tacrolimus and ceramide-dominant emollient in patients with atopic dermatitis. J. Korean Med. Sci. 2010, 25, 766-771.
8. Chamlin, S. L., Kao, J., Frieden, I. J., Sheu, M. Y., et al., Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: Changes in barrier function provide a sensitive indicator of disease activity. J. Am. Acad. Dermatol. 2002, 47, 198-208.
9. Na, J. I., Hwang, J. S., Park, H. J., Kim, D. H., et al., A new moisturizer containing physiologic lipid granules alleviates atopic dermatitis. J. Dermatol. Treat. 2010, 21, 23-27.
10. GUIDELINE ICH. Q2 (R1), Validation of analytical procedures, Text and methodology. EU: Adopted by CPMP, November 94, issued as CPMP/ICH/381/95, 2005, 2-15.
11. GUIDELINE EMEA. Stability testing of existing active substances and related finished products. Issued as CPMP/QWP/122/02, 2003, 5-13.
12. European Pharmacopeia 6.0 - microbiological examination of non-sterile products, 2008, 1, 2.6.12.
13. Young, J. M., De Young, L. M., in: Spector, J., Back, N. Liss, A. R. (Eds.), Pharmacological Methods in the Control of Inflammation, Alan R. Liss, Inc., New York (USA) 1989, pp. 215-231.
14. OECD, Guidance Document for the Conduct of Skin Absorption Studies, Organization for Economic Cooperation and Development, Paris 2004.
15. Ribeiro, H. M., Morais, J. A., Eccleston, G. M., Structure and rheology of semisolid o/w creams containing cetyl alcohol/non-ionic surfactant mixed emulsifier and different polymers. Int. J. Cosmet. Sci. 2004, 26, 47-59.
16. Man, M. Q., Feingold, K. R., Thornfeldt, C. R., Elias, P. M., Optimization of physiological lipid mixtures for barrier repair. J. Invest. Dermatol. 1996, 106, 1096-1101.
17. Man, M. Q., Feingold, K. R., Elias, P. M., Exogenous lipids influence permeability barrier recovery in acetone-treated murine skin. Arch. Dermatol. 1993, 129, 728-738.
18. Novotný, J., Pospechová, K., Hrabálek, A., Cáp, R., Vávrová, K., Synthesis of fluorescent C24-ceramide: Evidence for acyl chain length dependent differences in penetration of exogenous NBD-ceramides into human skin. Bioorg. Med. Chem. Lett. 2009, 19, 6975-6977.
19. Magnusson, B. M., Cross, S. E., Winckle, G., Roberts, M. S., Determination of in vitro permeability and tissue reservoir characteristics in human skin layers. Skin Pharmacol. Physiol. 2006, 19, 336-342.
20. Pellanda, C. L., Ph. D. Thesis, Topical Bioavailability of Glucocorteroids - Dermatopharmacokinetic and dermatopharmacodynamic of topically applied triamcinolone acetonide in humans, University of Basel, Basel, Switzerland 2006.
21. Vickers, C. F., Stratum corneum reservoir for drugs. Adv. Biol. Skin 1972, 12, 177-189.
22. Dias, M., Hadgraft, J., Lane, M. E., Influence of membrane-solvent-solute interactions on solute permeation in model membranes. Int. J. Pharm. 2007, 336, 108-114.
23. Dias, M., Hadgraft, J., Lane, M. E., Influence of membrane-solvent-solute interactions on solute permeation in skin. Int. J. Pharm. 2007, 340, 65-70.
24. Salgado, A., Silva, A. N., Machado, M., Duarte, M. A., Ribeiro, H. M., Development, stability and in vitro permeation studies of gels containing mometasone furoate for the treatment of dermatitis of the scalp. Br. J. Pharm. Sci. 2010, 46, 109-114.
25. Lee, C. H., Choi, H. K., Effect of gramicidin on percutaneous permeation of a model drug. AAPS PharmSciTech 2000, 1, 55-62.
26. Savic, S., Savic, M., Tamburic, S., Vuleta, G., et al., An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation. Eur. J. Pharm. Sci. 2007, 30, 441-450.
27. Cho, Y. A., Gwak, H. S., Transdermal delivery of ketorolac tromethamine: Effects of vehicles and penetration enhancers. Drug Dev. Ind. Pharm. 2004, 30, 557-564.