Long-term administration of the fungus toxin, sterigmatocystin, induces intestinal metaplasia and increases the proliferative activity of PCNA, p53, and MDM2 in the gastric mucosa of aged Mongolian gerbils

Environmental Health and Preventive Medicine

Volumn 16, Issue 4, 2011, Pages 224-231

  Kusunoki, Masahiro ^a   Misumi, Junichi ^b   Shimada, Tatsuo ^b   Aoki, Kazuo ^c   Matsuo, Noritaka ^a   Sumiyoshi, Hideaki ^a   Yamaguchi, Takeshi ^d   Yoshioka, Hidekatsu ^a  

^a OITA UNIVERSITY   (Japan)

^b OITA UNIVERSITY   (Japan)

^c UNIVERSITY OF THE RYUKYUS SCHOOL OF MEDICINE   (Japan)

^d KANAZAWA UNIVERSITY   (Japan)

Author keywords

Intestinal metaplasia; MDM2; P53; Proliferating cell nuclear antigen (PCNA); Sterigmatocystin

Indexed keywords

CYCLINE; PROTEIN MDM2; PROTEIN P53; STERIGMATOCYSTIN;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER RISK; CARCINOGENIC ACTIVITY; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE COURSE; GERBIL; HISTOPATHOLOGY; IMMUNOPATHOLOGY; INTESTINE METAPLASIA; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; STOMACH DISEASE; STOMACH EROSION; STOMACH MUCOSA; STOMACH POLYP; TISSUE STRUCTURE;

ANIMALS; ASPERGILLUS; DISEASE MODELS, ANIMAL; GASTRIC MUCOSA; GASTRITIS; GERBILLINAE; MALE; METAPLASIA; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTO-ONCOGENE PROTEINS C-MDM2; SPECIFIC PATHOGEN-FREE ORGANISMS; STERIGMATOCYSTIN; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; FUNGI; MERIONES UNGUICULATUS;

EID: 80051689515     PISSN: 1342078X     EISSN: 13474715     Source Type: Journal    
DOI: 10.1007/s12199-010-0190-x     Document Type: Article

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