A safety evaluation of DAS181, a sialidase fusion protein, in rodents

Toxicological Sciences

Volumn 122, Issue 2, 2011, Pages 567-578

  Larson, Jeffrey L ^a   Kang, Seong Kwi ^b   Choi, Bo In ^b   Hedlund, Maria ^a   Aschenbrenner, Laura M ^a   Cecil, Beth ^c   Machado, GloriaMay ^a   Nieder, Matthew ^a   Fang, Fang ^a  

^a NexBio Inc   (United States)

^b TR Laboratories Canada Inc   (Canada)

^c Alta Analytical Laboratory   (United States)

Author keywords

Alkaline phosphatase; DAS181; Desialylated erythrocytes; Desialylation; Glycoprotein; Influenza; Inhalation; Parainfluenza; Sialic acid; Sialidase; Toxicology

Indexed keywords

ALKALINE PHOSPHATASE; ANTIVIRUS AGENT; ASPARTATE AMINOTRANSFERASE; DAS 181; FLUDASE; HEMOGLOBIN; HYBRID PROTEIN; UNCLASSIFIED DRUG;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DESIALYLATION; DISEASE SEVERITY; DRUG FORMULATION; DRUG SAFETY; DRUG SCREENING; DRUG TOLERABILITY; DRY POWDER; ENZYME METABOLISM; ERYTHROCYTE COUNT; FEMALE; FOOD INTAKE; HEMATOCRIT; HEMOLYSIS; HISTOPATHOLOGY; LIVER CELL CULTURE; LIVER HISTOLOGY; LIVER TOXICITY; LUNG PARENCHYMA; LUNG TOXICITY; MALE; MEAN CORPUSCULAR VOLUME; MUSCLE CELL; NONHUMAN; ORGAN WEIGHT; OSTEOBLAST; PROTEIN MODIFICATION; RAT; RESPIRATORY TRACT PARAMETERS; RETICULOCYTE COUNT; RODENT; SKELETAL MUSCLE;

ALKALINE PHOSPHATASE; ANIMALS; CELL LINE; DRUG EVALUATION, PRECLINICAL; FEMALE; HEPATOCYTES; HUMANS; INHALATION EXPOSURE; LUNG; MALE; MICE; MICE, INBRED BALB C; NEURAMINIDASE; ORTHOMYXOVIRIDAE; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; TOXICITY TESTS;

ANIMALIA; ORTHOMYXOVIRIDAE; PARAINFLUENZA VIRUS; RATTUS; RODENTIA;

EID: 80051686737     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr109     Document Type: Article

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