Asymmetric synthesis of diverse α,α-diarylmethylamines via aryl Grignard additions to chiral N-2,4,6-triisopropylbenzenesulfinylimines

Tetrahedron

Volumn 67, Issue 37, 2011, Pages 7035-7041

  Han, Zhengxu ^a   Busch, Robert ^a   Fandrick, Keith R ^a   Meyer, Angelica ^a   Xu, Yibo ^a   Krishnamurthy, Dhileep K ^a   Senanayake, Chris H ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Asymmetric synthesis; Chiral diarylmethylamines; Chiral sulfinamide; Sulfinylimine

Indexed keywords

ALPHA, ALPHA DIARYLMETHYLAMINE; ELECTROPHILE; GRIGNARD REAGENT; METHYLAMINE; N (4 FLUOROBENZYLIDENE) 2,4,6 TRIISOPROPYLBENZENESULFINAMIDE; N (4 METHOXYBENZYLIDENE) 2,4,6 TRIISOPROPYLBENZENE; N (4 TRIFLUOROMETHYLBENZYLIDENE) 2,4,6 TRIISOPROPYLBENZ; N 4 (4 CHLOROBENZYLIDENE) 2,4,6 TRIISOPROPYLBENZENESULFINAMIDE; NUCLEOPHILE; SULFINAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CHIRALITY; ELECTRON TOMOGRAPHY; ELECTROPHILICITY; ENANTIOSELECTIVITY; ENVIRONMENTAL TEMPERATURE; GRIGNARD REACTION; NONHUMAN; NUCLEOPHILICITY; PRIORITY JOURNAL; STEREOCHEMISTRY;

EID: 80051682395     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2011.07.019     Document Type: Article

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