Quercetin inhibits α-MSH-stimulated melanogenesis in B16F10 melanoma cells

Phytotherapy Research

Volumn 25, Issue 8, 2011, Pages 1166-1173

  Yang, Yeon Mi ^a   Son, Young Ok ^b   Lee, Seung Ah ^a,c   Jeon, Young Mi ^a   Lee, Jeong Chae ^a  

^a Chonbuk National University   (South Korea)

^b UNIVERSITY OF KENTUCKY   (United States)

^c Chonnam Techno College   (South Korea)

Author keywords

B16F10 melanoma cells; cAMP; melanogenesis; quercetin; tyrosinase

Indexed keywords

ALPHA INTERMEDIN; ARBUTIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIHYDROXYPHENYLALAMINECHROME TAUTOMERASE; DIPHENOLASE; KOJIC ACID; MELANIN; MONOPHENOL MONOOXYGENASE; PHOSPHO PROTEIN KINASE A; QUERCETIN; TYROSINASE RELATED PROTEIN 1; TYROSINASE RELATED PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL FREE SYSTEM; CONTROLLED STUDY; CYTOTOXICITY; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME SYNTHESIS; MELANOCYTE; MELANOGENESIS; MELANOMA; MELANOMA CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; TREATMENT RESPONSE;

ALPHA-MSH; ANIMALS; CELL DIFFERENTIATION; CELL GROWTH PROCESSES; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; MELANINS; MELANOCYTES; MELANOMA, EXPERIMENTAL; MICE; MONOPHENOL MONOOXYGENASE; OXIDOREDUCTASES; PHOSPHORYLATION; PIGMENTATION; QUERCETIN; TUMOR CELLS, CULTURED;

EID: 80051681350     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3417     Document Type: Article

References (33)

1. An SM, Kim HJ, Kim JE, Boo YC,. 2008. Flavonoids, taxifolin and luteolin attenuate cellular melanogenesis despite increasing tyrosinase protein levels. Phytother Res 22: 1200-1207.
2. Boissy RE, Visscher M, DeLong MA,. 2005. DeoxyArbutin: a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency. Exp Dermatol 14: 601-608. (Pubitemid 41030927)
3. Bradford MM,. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-250.
4. Buscà R, Ballotti R,. 2000. Cyclic AMP a key messenger in the regulation of skin pigmentation. Pig Cell Res 13: 60-69. (Pubitemid 30324886)
5. Chang TS,. 2009. An updated review of tyrosinase inhibitors. Int J Mol Sci 10: 2440-2475.
6. Chen QX, Kubo I,. 2002. Kinetics of mushroom tyrosinase inhibition by quercetin. J Agric Food Chem 50: 4108-4012.
7. Erden IM, Kahraman A, Koken T,. 2001. Beneficial effect of quercetin on oxidative stress induced by ultraviolet A. Clin Exp Dermatol 26: 536-539. (Pubitemid 32955469)
8. Ferreira JF, Luthria DL, Sasaki T, Heyerick A,. 2010. Flavonoids from Artemisia annua L. as antioxidants and their potential synergism with artemisinin against malaria and cancer. Molecules 15: 3135-3170.
9. Fujii T, Saito M,. 2009. Inhibitory effect of quercetin isolated from rose hip (Rosa canina L.) against melanogenesis by mouse melanoma cells. Biosci Biotechnol Biochem 73: 1989-1993.
10. Gamet-Payrastre L, Manenti S, Gratacap MP, Tulliez J, Chap H, Payrastre B,. 1999. Flavonoids and the inhibition of PKC and PI3-kinase. Gen Pharmacol 32: 279-286.
11. Itoh K, Hirata N, Masuda M, et al,. 2009. Inhibitory effects of Citrus hassaku extract and its flavanone glycosides on melanogenesis. Biol Pharm Bull 32: 410-415.
12. Jiménez-Cervantes C, Martínez-Esparza M, Pérez C, Daum N, Solano F, García-Borrón JC,. 2001. Inhibition of melanogenesis in response to oxidative stress: transient downregulation of melanocyte differentiation markers and possible involvement of microphthalmia transcription factor. J Cell Sci 114: 2335-2344. (Pubitemid 32633704)
13. Katsarou A, Davoy E, Xenos K, Armenaka M, Theoharides TC,. 2000. Effect of an antioxidant (quercetin) on sodium-lauryl-sulfate-induced skin irritation. Contact Dermatitis 42: 85-89. (Pubitemid 30077113)
14. Kim DS, Park SH, Kwon SB, Li K, Youn SW, Park KC,. 2004. (-)-Epigallocatechin-3-gallate and hinokitiol reduce melanin synthesis via decreased MITF production. Arch Pharm Res 27: 334-339. (Pubitemid 43073757)
15. Kim S, Lee J, Jung E, et al,. 2009. 6-Benzylaminopurine stimulates melanogenesis via cAMP-independent activation of protein kinase A. Arch Dermatol Res 301: 253-258.
16. Kootstra A,. 1994. Protection from UV-B-induced DNA damage by flavonoids. Plant Mol Biol 26: 771-774. (Pubitemid 2158300)
17. Laughton MJ, Halliwell B, Evans PJ, Hoult JR,. 1989. Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin. Effects on lipid peroxidation, hydroxyl radical generation and bleomycin-dependent damage to DNA. Biochem Pharmacol 38: 2859-2865. (Pubitemid 19219848)
18. Lee JC, Kim J, Park JK, Chung GH, Jang YS,. 2003. The anti-oxidant, rather than pro-oxidant, activities of quercetin on normal cells: Quercetin protects mouse thymocytes from glucose oxidase-mediated apoptosis. Exp Cell Res 291: 386-397. (Pubitemid 37485726)
19. Lee JC, Lim KT, Jang YS,. 2002. Identification of Rhus verniciflua Stokes compounds that exhibit free radical scavenging and anti-apoptotic properties. Biochim Biophys Acta 1570: 181-191.
20. Maresca V, Flori E, Briganti S, et al,. 2008. Correlation between melanogenic and catalase activity in in vitro human melanocytes: a synergic strategy against oxidative stress. Pigment Cell Melanoma Res 21: 200-205. (Pubitemid 351551218)
21. Metodiewa D, Jaiswal AK, Cenas N, Dickancaite E, Segura-Aguilar J,. 1999. Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product. Free Radic Biol Med 26: 107-116. (Pubitemid 29001498)
22. Motoyashiki T, Morita T, Ueki H,. 1996. Involvement of the rapid increase in cAMP content in the vanadate-stimulated release of lipoprotein lipase activity from rat fat pads. Biol Pharm Bull 19: 1412-1416. (Pubitemid 26403243)
23. Mukherjee AK, Basu S, Sarkar N, Ghosh AC,. 2001. Advances in cancer therapy with plant-based natural products. Curr Med Chem 8: 1467-1486. (Pubitemid 32894010)
24. Naeyaert JM, Eller M, Gordon PR, Park HY, Gilchrest BA,. 1991. Pigment content of cultured human melanocytes does not correlate with tyrosinase message level. Br J Dermatol 125: 297-303.
25. Nagata H, Takekoshi S, Takeyama R, Homma T, Yoshiyuki Osamura R,. 2004. Quercetin enhances melanogenesis by increasing the activity and synthesis of tyrosinase in human melanoma cells and in normal human melanocytes. Pigment Cell Res 17: 66-73. (Pubitemid 38166441)
26. Ochiai M, Nagao M, Wakabayashi K, Sugimura T,. 1984. Superoxide dismutase acts as an enhancing factor for quercetin mutagenesis in rat-liver cytosol by preventing its decomposition. Mutat Res 129: 19-24. (Pubitemid 14023359)
27. Ohguchi K, Akao Y, Nozawa Y,. 2006. Stimulation of melanogenesis by the citrus flavonoid naringenin in mouse B16 melanoma cells. Biosci Biotechnol Biochem 70: 1499-1501. (Pubitemid 43961833)
28. Postaire E, Jungmann H, Bejot M, Heinrich U, Tronnier H,. 1997. Evidence for antioxidant nutrients-induced pigmentation in skin: results of a clinical trial. Biochem Mol Biol Int 42: 1023-1033. (Pubitemid 28297595)
29. Sahu SC, Washington MC,. 1991. Quercetin-induced lipid peroxidation and DNA damage in isolated rat-liver nuclei. Cancer Lett 58: 75-79.
30. Shibahara S, Takeda K, Yasumoto K, et al,. 2001. Microphthalmia- associated transcription factor (MITF): multiplicity in structure, function, and regulation. J Invest Dermatol Sym Proc 6: 99-104. (Pubitemid 33758613)
31. Shoji T, Masumoto S, Moriichi N, et al,. 2005. Procyanidin trimers to pentamers fractionated from apple inhibit melanogenesis in B16 mouse melanoma cells. J Agric Food Chem 53: 6105-6111. (Pubitemid 41126654)
32. Sin BY, Kim HP,. 2005. Inhibition of collagenase by naturally occurring flavonoids. Arch Pharm Res 28: 1152-1155.
33. Yang EB, Zhang K, Cheng LY, Mack P,. 1998. Butein, a specific protein tyrosine kinase inhibitor. Biochem Biophys Res Commun 245: 435-438. (Pubitemid 28418520)