Constitutively active Stat5A and Stat5B promote adipogenesis

Environmental Health and Preventive Medicine

Volumn 16, Issue 4, 2011, Pages 247-252

  Wakao, Hiroshi ^a   Wakao, Rika ^b   Oda, Atsushi ^a   Fujita, Hiroyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b PHARMACEUTICALS AND MEDICAL DEVICES AGENCY   (Japan)

Author keywords

Adipocytes; Obesity; PPARc; Signal transduction; Stat5

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; STAT5A PROTEIN; STAT5B PROTEIN; VIRUS VECTOR;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL TRANSFER; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVITY; ENZYME ANALYSIS; INTRACELLULAR SIGNALING; LIPID STORAGE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION REGULATION;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; FETAL BLOOD; HUMANS; MICE; PPAR GAMMA; STAT5 TRANSCRIPTION FACTOR; TRANSFECTION;

BOVINAE;

EID: 80051675160     PISSN: 1342078X     EISSN: 13474715     Source Type: Journal    
DOI: 10.1007/s12199-010-0193-7     Document Type: Article

References (22)

1. Haslam DW, James WP. Obesity. Lancet. 2005;366:1197-209. (Pubitemid 41393598)
2. Hossain P, Kawar B, El Nahas M. Obesity and diabetes in the developing world-a growing challenge. N Engl J Med. 2007; 356:213-5. (Pubitemid 46143224)
3. Rosen ED, Spiegelman BM. Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol. 2000;16:145-71. (Pubitemid 32037503)
4. Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature. 2006;444:847-53. (Pubitemid 46024991)
5. Tontonoz P, Spiegelman BM. Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem. 2008;77:289-312.
6. Darnell JE Jr. STATs and gene regulation. Science. 1997;277: 1630-5. (Pubitemid 27446219)
7. Teglund S, McKay C, Schuetz E, van Deursen JM, Stravopodis D, Wang D, et al. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell. 1998;93:841-50. (Pubitemid 28257589)
8. Nanbu-Wakao R, Morikawa Y, Matsumura I, Masuho Y, Muramatsu MA, Senba E, et al. Stimulation of 3T3-L1 adipogenesis by signal transducer and activator of transcription 5. Mol Endocrinol. 2002;16:1565-76. (Pubitemid 34743675)
9. Onishi M, Nosaka T, Misawa K, Mui AL, Gorman D, McMahon M, et al. Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation. Mol Cell Biol. 1998;18:3871-9. (Pubitemid 28287910)
10. Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM. mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 1994;8:1224-34.
11. Shi XM, Blair HC, Yang X, McDonald JM, Cao X. Tandem repeat of C/EBP binding sites mediates PPARgamma2 gene transcription in glucocorticoid-induced adipocyte differentiation. J Cell Biochem. 2000;76:518-27. (Pubitemid 30078460)
12. Gouilleux F, Wakao H, Mundt M, Groner B. Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO J. 1994;13: 4361-9. (Pubitemid 24295208)
13. Nanbu-Wakao R, Fujitani Y, Masuho Y, Muramatu M, Wakao H. Prolactin enhances CCAAT enhancer-binding protein-beta (C/ EBP beta) and peroxisome proliferator-activated receptor gamma (PPAR gamma) messenger RNA expression and stimulates adipogenic conversion of NIH-3T3 cells. Mol Endocrinol. 2000;14: 307-16. (Pubitemid 32295399)
14. Floyd ZE, Stephens JM. STAT5A promotes adipogenesis in nonprecursor cells and associates with the glucocorticoid receptor during adipocyte differentiation. Diabetes. 2003;52:308-14. (Pubitemid 36173183)
15. Cao Z, Umek RM, McKnight SL. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 1991;5:1538-52. (Pubitemid 21906060)
16. Wu Z, Xie Y, Bucher NL, Farmer SR. Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis. Genes Dev. 1995;9:2 350-63.
17. Yeh WC, Cao Z, Classon M, McKnight SL. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev. 1995;9: 168-81.
18. Stephens JM, Morrison RF, Pilch PF. The expression and regulation of STATs during 3T3-L1 adipocyte differentiation. J Biol Chem. 1996;271:10441-4. (Pubitemid 26149888)
19. Shang CA, Waters MJ. Constitutively active signal transducer and activator of transcription 5 can replace the requirement for growth hormone in adipogenesis of 3T3-F442A preadipocytes. Mol Endocrinol. 2003;17:2494-508. (Pubitemid 37542212)
20. Stewart WC, Baugh JE Jr, Floyd ZE, Stephens JM. STAT 5 activators can replace the requirement of FBS in the adipogenesis of 3T3-L1 cells. Biochem Biophys Res Commun. 2004;324: 355-9. (Pubitemid 39311502)
21. Kawai M, Namba N, Mushiake S, Etani Y, Nishimura R, Makishima M, et al. Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARgamma pathway. J Mol Endocrinol. 2007;38:19-34. (Pubitemid 46351590)
22. Sugii S, Olson P, Sears DD, Saberi M, Atkins AR, Barish GD, et al. PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proc Natl Acad Sci USA. 2009;106: 22504-9.