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Volumn 13, Issue 4, 2011, Pages 302-312

Current role of pharmacogenomics in cardiovascular medicine

Author keywords

[No Author keywords available]

Indexed keywords

CLOPIDOGREL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PLACEBO; TICAGRELOR; WARFARIN;

EID: 80051673120     PISSN: 10928464     EISSN: 15343189     Source Type: Journal    
DOI: 10.1007/s11936-011-0129-6     Document Type: Article
Times cited : (2)

References (39)
  • 2
    • 47949086046 scopus 로고    scopus 로고
    • Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin
    • 18305455 10.1038/clpt.2008.10 1:CAS:528:DC%2BD1cXhtVShtr7F
    • BF Gage C Eby JA Johnson, et al. 2008 Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin Clin Pharmacol Ther 84 326 331 18305455 10.1038/clpt.2008.10 1:CAS:528:DC%2BD1cXhtVShtr7F
    • (2008) Clin Pharmacol Ther , vol.84 , pp. 326-331
    • Gage, B.F.1    Eby, C.2    Johnson, J.A.3
  • 3
    • 60849097257 scopus 로고    scopus 로고
    • Estimation of the warfarin dose with clinical and pharmacogenetic data
    • International Warfarin Pharmacogenetics Consortium. 19228618 10.1056/NEJMoa0809329
    • International Warfarin Pharmacogenetics Consortium TE Klein RB Altman, et al. 2009 Estimation of the warfarin dose with clinical and pharmacogenetic data N Engl J Med 360 753 764 19228618 10.1056/NEJMoa0809329
    • (2009) N Engl J Med , vol.360 , pp. 753-764
    • Klein, T.E.1    Altman, R.B.2
  • 4
    • 42149188553 scopus 로고    scopus 로고
    • CYP4F2 genetic variant alters required warfarin dose
    • 18250228 10.1182/blood-2007-11-122010 1:CAS:528:DC%2BD1cXkvFeis7g%3D
    • MD Caldwell T Awad JA Johnson, et al. 2008 CYP4F2 genetic variant alters required warfarin dose Blood 111 4106 4112 18250228 10.1182/blood-2007-11-122010 1:CAS:528:DC%2BD1cXkvFeis7g%3D
    • (2008) Blood , vol.111 , pp. 4106-4112
    • Caldwell, M.D.1    Awad, T.2    Johnson, J.A.3
  • 5
    • 59649117935 scopus 로고    scopus 로고
    • The largest prospective warfarin-treated cohort supports genetic forecasting
    • 18574025 10.1182/blood-2008-04-149070 1:CAS:528:DC%2BD1MXhtlGhsbc%3D
    • M Wadelius LY Chen JD Lindh, et al. 2009 The largest prospective warfarin-treated cohort supports genetic forecasting Blood 113 784 792 18574025 10.1182/blood-2008-04-149070 1:CAS:528:DC%2BD1MXhtlGhsbc%3D
    • (2009) Blood , vol.113 , pp. 784-792
    • Wadelius, M.1    Chen, L.Y.2    Lindh, J.D.3
  • 7
    • 39449086981 scopus 로고    scopus 로고
    • CYP2C9 genotype-guided warfarin prescribing enhances the efficacy and safety of anticoagulation: A prospective randomized controlled study
    • DOI 10.1038/sj.clpt.6100316, PII 6100316
    • Y Caraco S Blotnick M Muszkat 2008 CYP2C9 genotype-guided warfarin prescribing enhances the efficacy and safety of anticoagulation: a prospective randomized controlled study Clin Pharmacol Ther 83 460 470 17851566 10.1038/sj.clpt.6100316 1:CAS:528:DC%2BD1cXitlGnsbs%3D (Pubitemid 351272635)
    • (2008) Clinical Pharmacology and Therapeutics , vol.83 , Issue.3 , pp. 460-470
    • Caraco, Y.1    Blotnick, S.2    Muszkat, M.3
  • 8
    • 58749095297 scopus 로고    scopus 로고
    • Cost-effectiveness of using pharmacogenetic information in warfarin dosing for patients with nonvalvular atrial fibrillation
    • 19153410
    • MH Eckman J Rosand SM Greenberg BF Gage 2009 Cost-effectiveness of using pharmacogenetic information in warfarin dosing for patients with nonvalvular atrial fibrillation Ann Intern Med 150 73 83 19153410
    • (2009) Ann Intern Med , vol.150 , pp. 73-83
    • Eckman, M.H.1    Rosand, J.2    Greenberg, S.M.3    Gage, B.F.4
  • 9
    • 62349134303 scopus 로고    scopus 로고
    • Validation of VKORC1 and CYP2C9 genotypes on interindividual warfarin maintenance dose: A prospective study in Chinese patients
    • 19177029 10.1097/FPC.0b013e328326e0c7 1:CAS:528:DC%2BD1MXjsVWqsbk%3D
    • SW Huang HS Chen XQ Wang, et al. 2009 Validation of VKORC1 and CYP2C9 genotypes on interindividual warfarin maintenance dose: a prospective study in Chinese patients Pharmacogenet Genomics 19 226 234 19177029 10.1097/FPC. 0b013e328326e0c7 1:CAS:528:DC%2BD1MXjsVWqsbk%3D
    • (2009) Pharmacogenet Genomics , vol.19 , pp. 226-234
    • Huang, S.W.1    Chen, H.S.2    Wang, X.Q.3
  • 10
    • 77953304931 scopus 로고    scopus 로고
    • Warfarin genotyping reduces hospitalization rates: Results from the MM-WES (Medco-Mayo Warfarin Effectiveness Study)
    • 20381283 10.1016/j.jacc.2010.03.009 1:CAS:528:DC%2BC3cXps1ansLo%3D
    • RS Epstein TP Moyer RE Aubert, et al. 2010 Warfarin genotyping reduces hospitalization rates: results from the MM-WES (Medco-Mayo Warfarin Effectiveness Study) J Am Coll Cardiol 55 2804 2812 20381283 10.1016/j.jacc.2010.03.009 1:CAS:528:DC%2BC3cXps1ansLo%3D This community-based study demonstrated that genotyping of patients started on warfarin reduced the risk of hospitalization over the next 60 days.
    • (2010) J Am Coll Cardiol , vol.55 , pp. 2804-2812
    • Epstein, R.S.1    Moyer, T.P.2    Aubert, R.E.3
  • 11
    • 78349294600 scopus 로고    scopus 로고
    • Statistical design of personalized medicine interventions: The Clarification of Optimal Anticoagulation through Genetics (COAG) trial
    • 21083927
    • B French J Joo NL Geller, et al. 2010 Statistical design of personalized medicine interventions: the Clarification of Optimal Anticoagulation through Genetics (COAG) trial Trials 11 108 21083927
    • (2010) Trials , vol.11 , pp. 108
    • French, B.1    Joo, J.2    Geller, N.L.3
  • 12
    • 34548545280 scopus 로고    scopus 로고
    • ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    • (writing committee to revise the 2002 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction): Developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons: Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine
    • JL Anderson CD Adams EM Antman, et al. 2007 ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 2002 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction): developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons: endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine Circulation 11 e148 e304
    • (2007) Circulation , vol.11
    • Anderson, J.L.1    Adams, C.D.2    Antman, E.M.3
  • 13
    • 73449142798 scopus 로고    scopus 로고
    • 2009 focused updates: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction
    • 19923169 10.1161/CIRCULATIONAHA.109.192663 (updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention (updating the 2005 guideline and 2007 focused update): A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
    • FG Kushner M Hand SC Smith Jr, et al. 2009 2009 focused updates: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention (updating the 2005 guideline and 2007 focused update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Circulation 120 2271 2306 19923169 10.1161/CIRCULATIONAHA.109.192663
    • (2009) Circulation , vol.120 , pp. 2271-2306
    • Kushner, F.G.1    Hand, M.2    Smith Jr., S.C.3
  • 14
    • 0038649988 scopus 로고    scopus 로고
    • Clopidogrel for coronary stenting: Response variability, drug resistance, and the effect of pretreatment platelet reactivity
    • DOI 10.1161/01.CIR.0000072771.11429.83
    • PA Gurbel KP Bliden BL Hiatt CM O'Connor 2003 Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity Circulation 107 2908 2913 12796140 10.1161/01.CIR. 0000072771.11429.83 (Pubitemid 36736631)
    • (2003) Circulation , vol.107 , Issue.23 , pp. 2908-2913
    • Gurbel, P.A.1    Bliden, K.P.2    Hiatt, B.L.3    O'Connor, C.M.4
  • 16
    • 33749339075 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
    • DOI 10.1182/blood-2006-04-013052
    • JS Hulot A Bura E Villard, et al. 2006 Cytochrome P450 2 C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects Blood 108 2244 2247 16772608 10.1182/blood-2006-04-013052 1:CAS:528:DC%2BD28XhtVCgur7I (Pubitemid 44497506)
    • (2006) Blood , vol.108 , Issue.7 , pp. 2244-2247
    • Hulot, J.-S.1    Bura, A.2    Villard, E.3    Azizi, M.4    Remones, V.5    Goyenvalle, C.6    Aiach, M.7    Lechat, P.8    Gaussem, P.9
  • 17
    • 58749094444 scopus 로고    scopus 로고
    • Cytochrome P-450 polymorphisms and response to clopidogrel
    • 19106084 10.1056/NEJMoa0809171 1:CAS:528:DC%2BD1MXhtVSlsbs%3D
    • JL Mega SL Close SD Wiviott, et al. 2009 Cytochrome P-450 polymorphisms and response to clopidogrel N Engl J Med 360 354 362 19106084 10.1056/NEJMoa0809171 1:CAS:528:DC%2BD1MXhtVSlsbs%3D
    • (2009) N Engl J Med , vol.360 , pp. 354-362
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 18
    • 58749090547 scopus 로고    scopus 로고
    • Genetic determinants of response to clopidogrel and cardiovascular events
    • 19106083 10.1056/NEJMoa0808227 1:CAS:528:DC%2BD1MXhtVSlsbY%3D
    • T Simon C Verstuyft M Mary-Krause, et al. 2009 Genetic determinants of response to clopidogrel and cardiovascular events N Engl J Med 360 363 375 19106083 10.1056/NEJMoa0808227 1:CAS:528:DC%2BD1MXhtVSlsbY%3D
    • (2009) N Engl J Med , vol.360 , pp. 363-375
    • Simon, T.1    Verstuyft, C.2    Mary-Krause, M.3
  • 19
    • 58249135635 scopus 로고    scopus 로고
    • Cytochrome P450 2 C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: A cohort study
    • 19108880 10.1016/S0140-6736(08)61845-0 1:CAS:528:DC%2BD1MXhtVaqtrY%3D
    • JP Collet JS Hulot A Pena, et al. 2009 Cytochrome P450 2 C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study Lancet 373 309 317 19108880 10.1016/S0140-6736(08)61845-0 1:CAS:528:DC%2BD1MXhtVaqtrY%3D
    • (2009) Lancet , vol.373 , pp. 309-317
    • Collet, J.P.1    Hulot, J.S.2    Pena, A.3
  • 20
    • 78049433100 scopus 로고    scopus 로고
    • Effects of CYP2C19 genotype on outcomes of clopidogrel treatment
    • 20979470 10.1056/NEJMoa1008410
    • G Paré SR Mehta S Yusuf, et al. 2010 Effects of CYP2C19 genotype on outcomes of clopidogrel treatment N Engl J Med 363 1704 1714 20979470 10.1056/NEJMoa1008410 This analysis of genetic data from two placebo-controlled clinical trials with lower-risk patients found no difference in relative cardiovascular risk reduction with clopidogrel between carriers and non-carriers of reduced-function CYP2C19 alleles.
    • (2010) N Engl J Med , vol.363 , pp. 1704-1714
    • Paré, G.1    Mehta, S.R.2    Yusuf, S.3
  • 21
    • 77958100874 scopus 로고    scopus 로고
    • Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: A genetic substudy of the PLATO trial
    • 20801498 10.1016/S0140-6736(10)61274-3 1:CAS:528:DC%2BC3cXht12ks7nM
    • L Wallentin S James RF Storey, et al. 2010 Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial Lancet 376 1320 1328 20801498 10.1016/S0140-6736(10)61274-3 1:CAS:528: DC%2BC3cXht12ks7nM This study found no difference in relative cardiovascular risk reduction with ticagrelor compared to clopidogrel between carriers and non-carriers of reduced-function CYP2C19 alleles. It also suggested that any difference in cardiovascular protection by clopidogrel between carriers and non-carriers is more relevant to the acute setting rather than to chronic use of the medication.
    • (2010) Lancet , vol.376 , pp. 1320-1328
    • Wallentin, L.1    James, S.2    Storey, R.F.3
  • 22
    • 78049326068 scopus 로고    scopus 로고
    • Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: A meta-analysis
    • 20978260 10.1001/jama.2010.1543 1:CAS:528:DC%2BC3cXhtlGqurbO The meta-analysis of nine studies with higher-risk patients on clopidogrel documented a tripling of risk for stent thrombosis in carriers of reduced-function CYP2C19 alleles.
    • JL Mega T Simon JP Collet, et al. 2010 Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis JAMA 304 1821 1830 20978260 10.1001/jama.2010.1543 1:CAS:528:DC%2BC3cXhtlGqurbO The meta-analysis of nine studies with higher-risk patients on clopidogrel documented a tripling of risk for stent thrombosis in carriers of reduced-function CYP2C19 alleles.
    • (2010) JAMA , vol.304 , pp. 1821-1830
    • Mega, J.L.1    Simon, T.2    Collet, J.P.3
  • 24
    • 78650739879 scopus 로고    scopus 로고
    • ACCF/ACG/AHA 2010 Expert Consensus Document on the concomitant use of proton pump inhibitors and thienopyridines: A focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: A report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents
    • 21060077 10.1161/CIR.0b013e318202f701
    • NS Abraham MA Hlatky EM Antman, et al. 2010 ACCF/ACG/AHA 2010 Expert Consensus Document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents Circulation 122 2619 2633 21060077 10.1161/CIR.0b013e318202f701
    • (2010) Circulation , vol.122 , pp. 2619-2633
    • Abraham, N.S.1    Hlatky, M.A.2    Antman, E.M.3
  • 25
    • 49949104757 scopus 로고    scopus 로고
    • SLCO1B1 variants and statin-induced myopathy-a genomewide study
    • SEARCH Collaborative Group. 18650507 10.1056/NEJMoa0801936 1:CAS:528:DC%2BD1cXhtVShtbnF
    • SEARCH Collaborative Group E Link S Parish, et al. 2008 SLCO1B1 variants and statin-induced myopathy-a genomewide study N Engl J Med 359 789 799 18650507 10.1056/NEJMoa0801936 1:CAS:528:DC%2BD1cXhtVShtbnF
    • (2008) N Engl J Med , vol.359 , pp. 789-799
    • Link, E.1    Parish, S.2
  • 26
    • 70349739250 scopus 로고    scopus 로고
    • The SLCO1B1*5 genetic variant is associated with statin-induced side effects
    • 19833260 10.1016/j.jacc.2009.04.053 1:CAS:528:DC%2BD1MXhsVGnu77E
    • D Voora SH Shah I Spasojevic, et al. 2009 The SLCO1B1*5 genetic variant is associated with statin-induced side effects J Am Coll Cardiol 54 1609 1616 19833260 10.1016/j.jacc.2009.04.053 1:CAS:528:DC%2BD1MXhsVGnu77E
    • (2009) J Am Coll Cardiol , vol.54 , pp. 1609-1616
    • Voora, D.1    Shah, S.H.2    Spasojevic, I.3
  • 28
    • 37549058754 scopus 로고    scopus 로고
    • Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study
    • 17975119 10.1161/ATVBAHA.107.153981 1:CAS:528:DC%2BD2sXhsVeiu7fN
    • D Shiffman ES O'Meara LA Bare, et al. 2008 Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study Arterioscler Thromb Vasc Biol 28 173 179 17975119 10.1161/ATVBAHA.107.153981 1:CAS:528:DC%2BD2sXhsVeiu7fN
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 173-179
    • Shiffman, D.1    O'Meara, E.S.2    Bare, L.A.3
  • 29
    • 38349118892 scopus 로고    scopus 로고
    • Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: The CARE and WOSCOPS trials
    • 18222353 10.1016/j.jacc.2007.05.057 1:CAS:528:DC%2BD1cXhtV2nt7c%3D
    • OA Iakoubova CH Tong CM Rowland, et al. 2008 Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials J Am Coll Cardiol 51 435 443 18222353 10.1016/j.jacc.2007.05.057 1:CAS:528: DC%2BD1cXhtV2nt7c%3D
    • (2008) J Am Coll Cardiol , vol.51 , pp. 435-443
    • Iakoubova, O.A.1    Tong, C.H.2    Rowland, C.M.3
  • 30
    • 38349130543 scopus 로고    scopus 로고
    • A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study
    • 18222354 10.1016/j.jacc.2007.09.044 1:CAS:528:DC%2BD1cXhtV2ntL4%3D
    • D Shiffman DI Chasman RY Zee, et al. 2008 A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study J Am Coll Cardiol 51 444 448 18222354 10.1016/j.jacc.2007.09.044 1:CAS:528:DC%2BD1cXhtV2ntL4%3D
    • (2008) J Am Coll Cardiol , vol.51 , pp. 444-448
    • Shiffman, D.1    Chasman, D.I.2    Zee, R.Y.3
  • 31
    • 38349171836 scopus 로고    scopus 로고
    • Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: Results from the PROVE IT-TIMI 22 study
    • 18222355 10.1016/j.jacc.2007.10.017 1:CAS:528:DC%2BD1cXhtV2ntL8%3D
    • OA Iakoubova MS Sabatine CM Rowland, et al. 2008 Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study J Am Coll Cardiol 51 449 455 18222355 10.1016/j.jacc.2007.10.017 1:CAS:528:DC%2BD1cXhtV2ntL8%3D
    • (2008) J Am Coll Cardiol , vol.51 , pp. 449-455
    • Iakoubova, O.A.1    Sabatine, M.S.2    Rowland, C.M.3
  • 32
    • 64049119620 scopus 로고    scopus 로고
    • Kinesin family member 6 variant Trp719Arg does not associate with angiographically defined coronary artery disease in the Ottawa Heart Genomics Study
    • 19371834 10.1016/j.jacc.2008.12.051 1:CAS:528:DC%2BD1MXkslGqtb0%3D
    • AF Stewart S Dandona L Chen, et al. 2009 Kinesin family member 6 variant Trp719Arg does not associate with angiographically defined coronary artery disease in the Ottawa Heart Genomics Study J Am Coll Cardiol 53 1471 1472 19371834 10.1016/j.jacc.2008.12.051 1:CAS:528:DC%2BD1MXkslGqtb0%3D
    • (2009) J Am Coll Cardiol , vol.53 , pp. 1471-1472
    • Stewart, A.F.1    Dandona, S.2    Chen, L.3
  • 33
    • 77956947971 scopus 로고    scopus 로고
    • KIF6 polymorphism as a predictor of risk of coronary events and of clinical event reduction by statin therapy
    • 20854963 10.1016/j.amjcard.2010.05.033 1:CAS:528:DC%2BC3cXhtFOntbjF
    • Y Li OA Iakoubova D Shiffman, et al. 2010 KIF6 polymorphism as a predictor of risk of coronary events and of clinical event reduction by statin therapy Am J Cardiol 106 994 998 20854963 10.1016/j.amjcard.2010.05.033 1:CAS:528:DC%2BC3cXhtFOntbjF A meta-analysis of the data available at the time, from seven cohort studies, suggested an association between the KIF6 W719R variant and disease.
    • (2010) Am J Cardiol , vol.106 , pp. 994-998
    • Li, Y.1    Iakoubova, O.A.2    Shiffman, D.3
  • 34
    • 78049327781 scopus 로고    scopus 로고
    • Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies
    • 20933357 10.1016/j.jacc.2010.06.022 1:CAS:528:DC%2BC3cXhsF2htL3N
    • TL Assimes H Hólm S Kathiresan, et al. 2010 Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies J Am Coll Cardiol 56 1552 1563 20933357 10.1016/j.jacc.2010.06.022 1:CAS:528:DC%2BC3cXhsF2htL3N This case-control study with 17,000 cases of coronary disease and almost 40,000 controls found no evidence for an association between the KIF6 W719R variant and disease.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 1552-1563
    • Assimes, T.L.1    Hólm, H.2    Kathiresan, S.3
  • 35
    • 70749096913 scopus 로고    scopus 로고
    • Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
    • Myocardial Infarction Genetics Consortium. 10.1038/ng.327
    • Myocardial Infarction Genetics Consortium 2009 Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants Nat Genet 41 334 341 10.1038/ng.327
    • (2009) Nat Genet , vol.41 , pp. 334-341
  • 36
    • 61349137526 scopus 로고    scopus 로고
    • Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease
    • 19198611 10.1038/ng.314
    • DA Trégouët IR König J Erdmann, et al. 2009 Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease Nat Genet 41 283 285 19198611 10.1038/ng.314
    • (2009) Nat Genet , vol.41 , pp. 283-285
    • Trégouët, D.A.1    König, I.R.2    Erdmann, J.3
  • 37
    • 77955467684 scopus 로고    scopus 로고
    • KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: Results from the PROSPER study
    • 20215968 10.1097/HJR.0b013e328336a0dd
    • OA Iakoubova M Robertson CH Tong, et al. 2010 KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER study Eur J Cardiovasc Prev Rehabil 17 455 461 20215968 10.1097/HJR. 0b013e328336a0dd
    • (2010) Eur J Cardiovasc Prev Rehabil , vol.17 , pp. 455-461
    • Iakoubova, O.A.1    Robertson, M.2    Tong, C.H.3
  • 38
    • 79955875125 scopus 로고    scopus 로고
    • No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the Heart Protection Study
    • 10.1016/j.jacc.2011.02.015 21458191
    • JC Hopewell S Parish R Clarke, et al. 2011 No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the Heart Protection Study J Am Coll Cardiol 10.1016/j.jacc.2011.02.015 21458191 The analysis of genetic data from more than 18,000 participants in the Heart Protection Study found no significant difference in the benefit conferred by statin use in carriers of the KIF6 W719R variant compared to non-carriers.
    • (2011) J Am Coll Cardiol
    • Hopewell, J.C.1    Parish, S.2    Clarke, R.3
  • 39
    • 78049333867 scopus 로고    scopus 로고
    • The KIF6 collapse
    • 20888161 10.1016/j.jacc.2010.06.023
    • EJ Topol SB Damani 2010 The KIF6 collapse J Am Coll Cardiol 56 1564 1566 20888161 10.1016/j.jacc.2010.06.023
    • (2010) J Am Coll Cardiol , vol.56 , pp. 1564-1566
    • Topol, E.J.1    Damani, S.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.