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Volumn 16, Issue 15-16, 2011, Pages 722-732

Follow-on drugs: How far should chemists look?

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPEPTIN; AREDIA IV; AZITHROMYCIN; CIMETIDINE; CIPROFLOXACIN; CLARITHROMYCIN; DONEPEZIL; ETIDRONIC ACID; GREPAFLOXACIN; ISOTRETINOIN; METRONIDAZOLE; NIFEDIPINE; NORFLOXACIN; OCTREOTIDE; PAMIDRONIC ACID; PRAZOSIN; PROPRANOLOL; RASAGILINE; RETINOIC ACID; RITONAVIR; SAQUINAVIR; SELEGILINE; SPARFLOXACIN; TACRINE; TAMOXIFEN CITRATE; TERAZOSIN; TIMOLOL MALEATE; TINIDAZOLE; TOREMIFENE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERAPAMIL;

EID: 80051672475     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2011.05.011     Document Type: Review
Times cited : (28)

References (58)
  • 2
    • 78650798983 scopus 로고    scopus 로고
    • Productivity shortfalls in drug discovery: Contributions from the preclinical sciences?
    • M. Williams Productivity shortfalls in drug discovery: contributions from the preclinical sciences? J. Pharmacol. Exp. Ther. 336 2011 3 8
    • (2011) J. Pharmacol. Exp. Ther. , vol.336 , pp. 3-8
    • Williams, M.1
  • 3
    • 77649234756 scopus 로고    scopus 로고
    • How to improve R&D productivity: The pharmaceutical industry's grand challenge
    • S.M. Paul How to improve R&D productivity: the pharmaceutical industry's grand challenge Nat. Rev. Drug Discov. 9 2010 203 214
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 203-214
    • Paul, S.M.1
  • 5
    • 29144432220 scopus 로고    scopus 로고
    • Comment on "The economics of follow-on drug research and development: Trends in entry rates and the timing of development"
    • DOI 10.2165/00019053-200523120-00002
    • A. Hollis Comment on "The economics of follow-on drug research and development: trends in entry rates and the timing of development" Pharmacoeconomics 3 2005 1187 1192 (Pubitemid 41803314)
    • (2005) PharmacoEconomics , vol.23 , Issue.12 , pp. 1187-1192
    • Hollis, A.1
  • 6
    • 35448957305 scopus 로고    scopus 로고
    • Too many drugs? the clinical and economic value of incremental innovations
    • A. Werthheimer Too many drugs? The clinical and economic value of incremental innovations Res. Hum. Cap. Dev. 14 2001 77 118
    • (2001) Res. Hum. Cap. Dev. , vol.14 , pp. 77-118
    • Werthheimer, A.1
  • 7
    • 0032395322 scopus 로고    scopus 로고
    • Strategic pricing of new pharmaceuticals
    • Z.J. Lu, and W.S. Comanor Strategic pricing of new pharmaceuticals Rev. Econ. Stat. 80 2008 108 118
    • (2008) Rev. Econ. Stat. , vol.80 , pp. 108-118
    • Lu, Z.J.1    Comanor, W.S.2
  • 10
    • 0347949558 scopus 로고    scopus 로고
    • "me-too" products - Friend or foe?
    • T.H. Lee "Me-too" products - friend or foe? N. Engl. J. Med. 350 2004 211 212
    • (2004) N. Engl. J. Med. , vol.350 , pp. 211-212
    • Lee, T.H.1
  • 11
    • 23044491985 scopus 로고    scopus 로고
    • Keynote review: Is declining innovation in the pharmaceutical industry a myth?
    • DOI 10.1016/S1359-6446(05)03524-5, PII S1359644605035245
    • E.F. Schmid, and D.A. Smith Is declining innovation in the pharmaceutical industry a myth? Drug Discov. Today 10 2005 1031 1039 (Pubitemid 41074141)
    • (2005) Drug Discovery Today , vol.10 , Issue.15 , pp. 1031-1039
    • Schmid, E.F.1    Smith, D.A.2
  • 12
    • 34247232594 scopus 로고    scopus 로고
    • Recore: A fast and versatile method for scaffold hopping based on small molecule crystal structure conformations
    • DOI 10.1021/ci060094h
    • Maass ReCore: a fast and versatile method for scaffold hopping based on small molecule crystal structure conformations J. Chem. Inf. Model. 47 2007 390 399 (Pubitemid 46615943)
    • (2007) Journal of Chemical Information and Modeling , vol.47 , Issue.2 , pp. 390-399
    • Maass, P.1    Schulz-Gasch, T.2    Stahl, M.3    Rarey, M.4
  • 13
    • 33748099709 scopus 로고    scopus 로고
    • Drug Guru: A computer software program for drug design using medicinal chemistry rules
    • DOI 10.1016/j.bmc.2006.06.024, PII S0968089606004895
    • K.D. Stewart Drug Guru: a computer software program for drug design using medicinal chemistry rules Bioorg. Med. Chem. 14 2006 7011 7022 (Pubitemid 44307638)
    • (2006) Bioorganic and Medicinal Chemistry , vol.14 , Issue.20 , pp. 7011-7022
    • Stewart, K.D.1    Shiroda, M.2    James, C.A.3
  • 15
    • 84857042546 scopus 로고    scopus 로고
    • Fieldstere, Cresset Group, BioPark Hertfordshire, United Kingdom
    • Fieldstere, Cresset Group, BioPark Hertfordshire, United Kingdom. http://www.cresset-group.com/products/fieldstere/
  • 16
    • 84857046387 scopus 로고    scopus 로고
    • Brood, OpenEye Scientific Software, Santa Fe, New Mexico, United States
    • Brood, OpenEye Scientific Software, Santa Fe, New Mexico, United States. http://www.eyesopen.com/brood
  • 17
    • 84857046857 scopus 로고    scopus 로고
    • Core Hoping, Schrodinger, New York, New York, United States
    • Core Hoping, Schrodinger, New York, New York, United States. http://www.schrodinger.com/productsguide/
  • 18
    • 84857046385 scopus 로고    scopus 로고
    • MOE Pharmacophore Tools, Chemical Computing Group, Montreal, Quebec, Canada
    • MOE Pharmacophore Tools, Chemical Computing Group, Montreal, Quebec, Canada. http://www.chemcomp.com/journal/scaffold.htm
  • 19
  • 20
    • 33746931581 scopus 로고    scopus 로고
    • On outliers and activity cliffs - Why QSAR often disappoints
    • DOI 10.1021/ci060117s
    • G.M. Maggiora On outliers and activity cliffs - why QSAR often disappoints J. Chem. Inf. Model. 46 2006 1535 (Pubitemid 44185680)
    • (2006) Journal of Chemical Information and Modeling , vol.46 , Issue.4 , pp. 1535
    • Maggiora, G.M.1
  • 21
    • 78650811196 scopus 로고    scopus 로고
    • Competitiveness in follow-on drug R&D: A race or imitation?
    • J.A. DiMasi, and L.B. Faden Competitiveness in follow-on drug R&D: a race or imitation? Nat. Rev. Drug Discov. 10 2011 23 27
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 23-27
    • Dimasi, J.A.1    Faden, L.B.2
  • 22
    • 84857041133 scopus 로고    scopus 로고
    • OpenEye Scientic Software, Santa Fe, NM
    • OEChem - Toolkit Python Manual, OpenEye Scientic Software, Santa Fe, NM. http://www.eyesopen.com
    • OEChem - Toolkit Python Manual
  • 23
    • 33750981540 scopus 로고    scopus 로고
    • Do structurally similar ligands bind in a similar fashion?
    • DOI 10.1021/jm060167o
    • Boström Do structurally similar molecules bind in a similar fashion J. Med. Chem. 49 2006 6716 6725 (Pubitemid 44749739)
    • (2006) Journal of Medicinal Chemistry , vol.49 , Issue.23 , pp. 6716-6725
    • Bostrom, J.1    Hogner, A.2    Schmitt, S.3
  • 25
    • 67650924493 scopus 로고    scopus 로고
    • Design of compound libraries for fragment screening
    • N. Blomberg Design of compound libraries for fragment screening J. Comp. Aid. Mol. Design 23 2009 513 525
    • (2009) J. Comp. Aid. Mol. Design , vol.23 , pp. 513-525
    • Blomberg, N.1
  • 26
    • 0024716284 scopus 로고
    • Atomic physicochemical parameters for three-dimensional structure-directed quantitative structure-activity relationships. 4. Additional parameters for hydrophobic and dispersive interactions and their application for an automated superposition of certain naturally occurring nucleoside antibiotics
    • V.N. Viswanadhan Atomic physicochemical parameters for three-dimensional structure-directed quantitative structure-activity relationships. 4. Additional parameters for hydrophobic and dispersive interactions and their application for an automated superposition of certain naturally occurring nucleoside antibiotics J. Chem. Inf. Comput. Sci. 29 1989 163 172
    • (1989) J. Chem. Inf. Comput. Sci. , vol.29 , pp. 163-172
    • Viswanadhan, V.N.1
  • 27
    • 0000381930 scopus 로고    scopus 로고
    • Prediction of hydrophobic (lipophilic) properties of small organic molecules using fragmental methods: An analysis of ALOGP and CLOGP methods
    • Ghose Prediction of hydrophobic (lipophilic) properties of small organic molecules using fragmental methods: an analysis of ALOGP and CLOGP methods J. Phys. Chem. A 102 1998 3762 3772 (Pubitemid 128611348)
    • (1998) Journal of Physical Chemistry A , vol.102 , Issue.21 , pp. 3762-3772
    • Ghose, A.K.1    Viswanadhan, V.N.2    Wendoloski, J.J.3
  • 28
    • 0036740917 scopus 로고    scopus 로고
    • Why do we need so many chemical similarity search methods?
    • R.P. Sheridan, and S.K. Kearsley Why do we need so many chemical similarity search methods? Drug Discov. Today 7 2002 903 911
    • (2002) Drug Discov. Today , vol.7 , pp. 903-911
    • Sheridan, R.P.1    Kearsley, S.K.2
  • 30
    • 0033103478 scopus 로고    scopus 로고
    • Structure of acetylcholinesterase complexed with E2020 (Ariceptα): Implications for the design of new anti-Alzheimer drugs
    • DOI 10.1016/S0969-2126(99)80040-9
    • G. Kryger Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs Structure 7 1999 297 307 (Pubitemid 29159689)
    • (1999) Structure , vol.7 , Issue.3 , pp. 297-307
    • Kryger, G.1    Silman, I.2    Sussman, J.L.3
  • 31
    • 0036349129 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors
    • M.W. Jann Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors Clin. Pharmacokinet. 41 2002 719 739 (Pubitemid 34948194)
    • (2002) Clinical Pharmacokinetics , vol.41 , Issue.10 , pp. 719-739
    • Jann, M.W.1    Shirley, K.L.2    Small, G.W.3
  • 32
    • 0031054507 scopus 로고    scopus 로고
    • Saquinavir pharmacokinetics alone and in combination with ritonavir in HIV-infected patients
    • C. Merry Saquinavir pharmacokinetics alone and in combination with ritonavir in HIV-infected patients AIDS 11 1997 29 33
    • (1997) AIDS , vol.11 , pp. 29-33
    • Merry, C.1
  • 33
    • 0034667858 scopus 로고    scopus 로고
    • Safety and efficacy results of a randomized trial comparing adjuvant toremifene and tamoxifen in postmenopausal patients with node-positive breast cancer. Finnish Breast Cancer Group
    • K. Holli Safety and efficacy results of a randomized trial comparing adjuvant toremifene and tamoxifen in postmenopausal patients with node-positive breast cancer. Finnish Breast Cancer Group J. Clin. Oncol. 18 2000 3487 3494
    • (2000) J. Clin. Oncol. , vol.18 , pp. 3487-3494
    • Holli, K.1
  • 35
    • 0142029588 scopus 로고    scopus 로고
    • Ocular side-effects in breast cancer patients treated with tamoxifen and toremifene: A randomized follow-up study
    • DOI 10.1034/j.1600-0420.2003.00116.x
    • M. Parkkari Ocular side-effects in breast cancer patients treated with tamoxifen and toremifene: a randomized follow-up study Acta Ophtalmol. Scand. 81 2003 495 499 (Pubitemid 37265670)
    • (2003) Acta Ophthalmologica Scandinavica , vol.81 , Issue.5 , pp. 495-499
    • Parkkari, M.1    Paakkala, A.-M.2    Salminen, L.3    Holli, K.4
  • 36
    • 8744295366 scopus 로고    scopus 로고
    • Stroke incidence with toremifene is lower than with tamoxifen in breast cancer patients
    • H.A. Harvey, and A. Hajba Stroke incidence with toremifene is lower than with tamoxifen in breast cancer patients Proc. Am. Soc. Clin. Oncol. 22 2003 741
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 741
    • Harvey, H.A.1    Hajba, A.2
  • 38
    • 0026593561 scopus 로고
    • Comparative study of pamidronate disodium and etidronate disodium in the treatment of cancer-related hypercalcemia
    • R. Gucalp Comparative study of pamidronate disodium and etidronate disodium in the treatment of cancer-related hypercalcemia J. Clin. Oncol. 10 1992 134 142
    • (1992) J. Clin. Oncol. , vol.10 , pp. 134-142
    • Gucalp, R.1
  • 39
    • 0020582752 scopus 로고
    • Comparative pharmacokinetics of metronidazole and tinidazole as influenced by administration route
    • J. Mattila Comparative pharmacokinetics of metronidazole and tinidazole is influenced by administration route Antimicrob. Agents Chemother. 23 1983 721 725 (Pubitemid 13087010)
    • (1983) Antimicrobial Agents and Chemotherapy , vol.23 , Issue.5 , pp. 721-725
    • Mattila, J.1    Mannisto, P.T.2    Mantyla, R.3
  • 40
    • 34248171312 scopus 로고    scopus 로고
    • Tinidazole for the treatment of vaginal infections
    • M.D. Nailor, and J.D. Sobel Tinidazole for the treatment of vaginal infections Exp. Opin. Investig. Drugs 16 2007 743 751
    • (2007) Exp. Opin. Investig. Drugs , vol.16 , pp. 743-751
    • Nailor, M.D.1    Sobel, J.D.2
  • 42
    • 0016720002 scopus 로고
    • Comparison of cardiac effect of timolol and propranolol
    • M.R. Achong Comparison of cardiac effect of timolol and propranolol Clin. Pharmacol. Ther. 18 1975 278 286
    • (1975) Clin. Pharmacol. Ther. , vol.18 , pp. 278-286
    • Achong, M.R.1
  • 43
    • 0022550696 scopus 로고
    • Pharmacology of terazosin
    • DOI 10.1016/0002-9343(86)90846-6
    • J.J. Kyncl Pharmacology of terazosin Am. J. Med. 80 1986 12 19 (Pubitemid 16047544)
    • (1986) American Journal of Medicine , vol.80 , Issue.5 B , pp. 12-19
    • Kyncl, J.J.1
  • 44
    • 0029797383 scopus 로고    scopus 로고
    • Erythromycin, clarithromycin and azithromycin: Are the differences real?
    • G.W. Amsden Erythromycin, clarithromycin and azithromycin: are the differences real? Clin. Ther. 18 1996 56 72
    • (1996) Clin. Ther. , vol.18 , pp. 56-72
    • Amsden, G.W.1
  • 45
    • 4143124486 scopus 로고    scopus 로고
    • Macrolides and ketolides: Azithromycin, clarithromycin, telithromycin
    • DOI 10.1016/j.idc.2004.04.010, PII S0891552004000716
    • J.M. Zuckerman Macrolides and ketolides: azithromycin, clarithromycin, telithromycin Infect. Dis. Clin. N. Am. 18 2004 621 649 (Pubitemid 39089098)
    • (2004) Infectious Disease Clinics of North America , vol.18 , Issue.3 , pp. 621-649
    • Zuckerman, J.M.1
  • 46
    • 0028316927 scopus 로고
    • Structure-activity and structure-side-effect relationships for the quinolone antibacterials
    • J.M. Domagala Structure-activity and structure-side-effect relationships for the quinolone antibacterials J. Antimicrob. Chemother. 33 1994 685 706 (Pubitemid 24149805)
    • (1994) Journal of Antimicrobial Chemotherapy , vol.33 , Issue.4 , pp. 685-706
    • Domagala, J.M.1
  • 47
    • 0018819081 scopus 로고
    • Cimetidine and ranitidine: Comparison of effects on hepatic drug metabolism
    • D.A. Henry Cimetidine and ranitidine: comparison of effects on hepatic drug metabolism Br. Med. J. 281 1980 775 777 (Pubitemid 10048547)
    • (1980) British Medical Journal , vol.281 , Issue.6243 , pp. 775-777
    • Henry, D.A.1    MacDonald, I.A.2    Kitchingman, G.3
  • 48
    • 0035979401 scopus 로고    scopus 로고
    • Randomized comparison of ticlopidine and clopidogrel after intracoronary stent implantation in a broad patient population
    • M. Taniuchi Randomized comparison of ticlopidine and clopidogrel after intracoronary stent implantation in a broad patient population Circulation 104 2001 539 543 (Pubitemid 32738122)
    • (2001) Circulation , vol.104 , Issue.5 , pp. 539-543
    • Taniuchi, M.1    Kurz, H.I.2    Lasala, J.M.3
  • 49
    • 0008462418 scopus 로고
    • J.W. Corcoran, F.E. Hahn, Springer-Verlag
    • A. DiMarco J.W. Corcoran, F.E. Hahn, Antibiotics 1974 Springer-Verlag 101 128
    • (1974) Antibiotics , pp. 101-128
    • Dimarco, A.1
  • 50
    • 0000356472 scopus 로고
    • Doxorubicin, anticancer antibiotics
    • S.T. Crooke, S.D. Reich, Academic Press
    • F. Arcamone Doxorubicin, anticancer antibiotics S.T. Crooke, S.D. Reich, Medicinal Chemistry Vol. 17 1981 Academic Press
    • (1981) Medicinal Chemistry , vol.17 VOL.
    • Arcamone, F.1
  • 51
    • 0022404158 scopus 로고
    • CNS-related side-effects with metoprolol and atenolol
    • DOI 10.1007/BF00543713
    • J.R. Cove-Smith, and C.A. Kirk CNS-related side-effects with metoprolol and atenolol Eur. J. Pharmacol. 28 1985 69 72 (Pubitemid 16218645)
    • (1985) European Journal of Clinical Pharmacology , vol.28 , Issue.SUPPL. 1 , pp. 69-72
    • Cove-Smith, J.R.1    Kirk, C.A.2
  • 52
    • 0029065431 scopus 로고
    • Randomised comparison of ganciclovir and high-dose acyclovir for long-term cytomegalovirus prophylaxis in liver-transplant recipients
    • J.D. Winston Randomised comparison of ganciclovir and high-dose acyclovir for long-term cytomegalovirus prophylaxis in liver-transplant recipients Lancet 346 1995 69 74
    • (1995) Lancet , vol.346 , pp. 69-74
    • Winston, J.D.1
  • 53
    • 0001228598 scopus 로고
    • Oral delivery of 5-HT1D receptor agonists: Towards the discovery of 311C90, a novel antimigraine agent
    • A.P. Hill Oral delivery of 5-HT1D receptor agonists: towards the discovery of 311C90, a novel antimigraine agent Headache 34 1995 308
    • (1995) Headache , vol.34 , pp. 308
    • Hill, A.P.1
  • 54
    • 0035752584 scopus 로고    scopus 로고
    • Zolmitriptan: Differences from sumatriptan
    • P.J. Goadsby, and C.J. Boes Zolmitriptan: differences from sumatriptan Curr. Med. Res. Opin. 17 2001 46 50
    • (2001) Curr. Med. Res. Opin. , vol.17 , pp. 46-50
    • Goadsby, P.J.1    Boes, C.J.2
  • 55
    • 0034057335 scopus 로고    scopus 로고
    • Preclinical overview of brinzolamide
    • L. DeSantis Preclinical overview of brinzolamide Survey Ophtalnol. 44 2000 S119 S129
    • (2000) Survey Ophtalnol. , vol.44
    • Desantis, L.1
  • 56
    • 0034907128 scopus 로고    scopus 로고
    • Comparison of topical brinzolamide 1% and dorzolamide 2% eye drops given twice daily in addition to timolol 0.5% in patients with primary open-angle glaucoma or ocular hypertension
    • J.E. Michaud Comparison of topical brinzolamide 1% and dorzolamide 2% eye drops given twice daily in addition to timolol 0.5% in patients with primary open-angle glaucoma or ocular hypertension Am. J. Ophtalmol. 132 2001 235 243
    • (2001) Am. J. Ophtalmol. , vol.132 , pp. 235-243
    • Michaud, J.E.1
  • 57
    • 77953857048 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: A randomized, double-blind, placebo-controlled trial
    • C.J. Bailey Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomized, double-blind, placebo-controlled trial Lancet 375 2010 2223 2233
    • (2010) Lancet , vol.375 , pp. 2223-2233
    • Bailey, C.J.1
  • 58
    • 79955387833 scopus 로고    scopus 로고
    • Discovery of a clinical candidate from the structurally unique diox-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors
    • 10.1021/jm200049r
    • V. Mascitti Discovery of a clinical candidate from the structurally unique diox-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors J. Med. Chem. 2011 10.1021/jm200049r
    • (2011) J. Med. Chem.
    • Mascitti, V.1


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