Fluoxetine treatment induces EAAT2 expression in rat brain

Journal of Neural Transmission

Volumn 118, Issue 6, 2011, Pages 849-855

  Zink, Mathias ^a   Rapp, S ^c   Donev, R ^d   Gebicke Haerter, P J ^b   Thome, J ^d  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d SWANSEA UNIVERSITY   (United Kingdom)

Author keywords

Depression; EAAT; Glia; Glutamate; Learned helplessness; Transporter

Indexed keywords

DESIPRAMINE; EXCITATORY AMINO ACID TRANSPORTER 2; FLUOXETINE; GLUTAMIC ACID; SULFUR 35; TRANYLCYPROMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; BRAIN CORTEX; CONTROLLED STUDY; DEPRESSION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MALE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA PROBE; SYNAPSE;

ANIMALS; BRAIN; BRAIN CHEMISTRY; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID TRANSPORTER 2; FLUOXETINE; GENE EXPRESSION REGULATION; GLUTAMIC ACID; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 80051665259     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-010-0536-y     Document Type: Article

References (64)

1. Almeida RF, Thomazi AP, Godinho GF, Saute JAM, Wofchuk ST, Souza DO, Ganzella M (2010a) Effects of depressive-like behavior of rats on brain glutamate uptake. Neurochem Res 35:1164-1171
2. Andin J, Stenfors C, Ross SB, Marcusson J (2004) Modulation of neuronal glutamate transporter rEAAC1 mRNA expression in rat brain by amitriptyline. Mol Brain Res 126:74-77 (Pubitemid 38781166)
3. Autry AE, Grillo CA, Piroli GG, Rothstein JD, McEwen BS, Reagan LP (2006) Glucocorticoid regulation of GLT-1 glutamate transporter isoform expression in the rat hippocampus. Neuroendocrinol 83:371-379 (Pubitemid 44729794)
4. Banasr M, Duman RS (2008) Glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors. Biol Psychiatry 64:863-870
5. Bowley MP, Drevets WC, Ongur D, Price JL (2002) Low glial numbers in the amygdala in major depressive disorder. Biol Psychiatry 52:404-412 (Pubitemid 35266731)
6. Campbell S, MacQueen G (2004) The role of the hippocampus in the pathophysiology of major depression. J Psychiatry Neurosci 29:417-426 (Pubitemid 40075713)
7. Chen HS, Lipton SA (2006) The chemical biology of clinically tolerated NMDA receptor antagonists. J Neurochem 97:1611-1626 (Pubitemid 43873656)
8. Chen W, Mahadomrongkul V, Berger UV, Bassan M, DeSilva T, Tanaka K, Irwin N, Aoki C, Rosenberg PA (2004) The glutamate transporter GLT1a is expressed in excitatory axon terminals of mature hippocampal neurons. J Neurosci 24:1136-1148 (Pubitemid 38177021)
9. Choudary PV, Molnar M, Evans SJ, Tomita H, Li JZ, Vawter MP, Myers RM, Bunney WE, Akil H, Watson SJ, Jones EG (2005) Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proc Natl Acad Sci USA 102:15653-15658 (Pubitemid 41528111)
10. Coyle JT, Duman RS (2003) Finding the intracellular signaling pathways affected by mood disorder treatments. Neuron 38:157-160 (Pubitemid 36555643)
11. Danbolt NC (2001) Glutamate uptake. Progr Neurobiol 65:1-105 (Pubitemid 32479155)
12. Figiel M, Engele J (2000) Pituitary adenylate cyclase-activating polypeptide (PACAP), a neuron-derived peptide regulating glial glutamate transport and metabolism. J Neurosci 20:3596-3605 (Pubitemid 30266222)
13. Figiel M, Maucher T, Rozyczka J, Bayatti N, Engele J (2003) Regulation of glial glutamate transporter expression by growth factors. Exp Neurol 183:124-135 (Pubitemid 37075863)
14. Furuta A, Rothstein JD, Martin LJ (1997) Glutamate transporter protein subtypes are expressed differentially during rat cns development. J Neurosci 17:8363-8375 (Pubitemid 27461059)
15. Garcia R (2002) Stress, synaptic plasticity, and psychopathology. Rev Neurosci 13:195-208 (Pubitemid 35178152)
16. Gosselin RD, Gibney S, O'Malley D, Dinan TG, Cryan JF (2009) Region specific decrease in glial gibrillary acidic protein (GFAP) immunoreactivity in the brain of a rat model of depression. Neuroscience 159:915-925
17. Henn FA (1976) Neurotransmission and glial cells: a functional relationship? J Neurosci Res 2:271-282 (Pubitemid 8030594)
18. Henn FA, Vollmayr B (2004) Neurogenesis and depression: etiology or epiphenomenon? Biol Psychiatry 56:146-150 (Pubitemid 38969146)
19. Henn FA, Vollmayr B (2005) Stress models of depression: forming genetically vulnerable strains. Neurosci Biobehav Rev 29:799-804 (Pubitemid 40755465)
20. Holmseth S, Scott HA, Real K, Lehre KP, Leergaard TB, Bjaalie JG, Danbolt NC (2009) The concentrations and distributions of three C-terminal variants of the GLT1 (EAAT2; slc1a2) glutamate transporter protein in rat brain tissue suggest differential regulation. Neuroscience 162:1055-1071
21. Kendell SF, Krystal JH, Sanacora G, Kendell SF, Krystal JH, Sanacora G (2005) GABA and glutamate systems as therapeutic targets in depression and mood disorders. Expert Opin Ther Targets 9:153-168 (Pubitemid 40331202)
22. Knackstedt LA, Melendez RI, Kalivas PW, Knackstedt LA, Melendez RI, Kalivas PW (2010) Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking. Biol Psychiatry 67:81-84
23. Kokras N, Antoniou K, Polissidis A, Papadopoulou-Daifoti Z (2009) Antidepressants induce regionally discrete, sex-dependent changes in brain's glutamate content. Neurosci Lett 464:98-102
24. Krishnan V, Nestler EJ (2008) The molecular neurobiology of depression. Nature 455:894-902
25. Krystal JH, Sanacora G, Blumberg H, Anand A, Charney DS, Marek G, Epperson CN, Goddard A, Mason GF (2002) Glutamate and GABA systems as targets for novel antidepressant and moodstabilizing treatments. Mol Psychiatry 7(Suppl 1):S71-S80 (Pubitemid 34280651)
26. Lee Y, Gaskins D, Anand A, Shekhar A (2007) Glia mechanisms in mood regulation: a novel model of mood disorders. Psychopharmacology 191:55-65
27. Mao QX, Yang TD (2010) Amitriptyline upregulates EAAT1 and EAAT2 in neuropathic pain rats. Brain Res Bull 81:424-427
28. McCullumsmith RE, Meador-Woodruff JH (2002) Striatal excitatory amino acid transporter transcript expression in schizophrenia, bipolar disorder, and major depression. Neuropsychopharmacology 26:368-375 (Pubitemid 34159214)
29. Miller TM, Cleveland DW (2005) Medicine. Treating neurodegenerative diseases with antibiotics. Science 307:361-362 (Pubitemid 40139964)
30. Minelli A, Barbaresi P, Reimer RJ, Edwards RH, Conti F (2001) The glial glutamate transporter GLT-1 is localized both in the vicinity of and at distance from axon terminals in the rat cerebral cortex. Neuroscience 108:51-59 (Pubitemid 33152980)
31. Mineur YS, Picciotto MR, Sanacora G (2007) Antidepressant-like effects of ceftriaxone in male C57BL/6 J mice. Biol Psychiatry 61:250-252 (Pubitemid 46072785)
32. Moghaddam B (1993) Stress preferentially increases extraneuronal levels of excitatory amino acids in the prefrontal cortex: comparison to hippocampus and basal ganglia. J Neurochem 60:1650-1657 (Pubitemid 23127567)
33. Moutsimilli L, Farley S, Dumas S, Mestikawy SE, Giros B, Tzavara ET (2005) Selective cortical VGLUT1 increase as a marker for antidepressant activity. Neuropharmacology 49:890-900 (Pubitemid 41483895)
34. Ni Y, Malarkey EB, Parpura V (2007) Vesicular release of glutamate mediates bidirectional signaling between astrocytes and neurons. J Neurochem 103:1273-1284 (Pubitemid 47631817)
35. Ongur D, Drevets WC, Price JL (1998) Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci USA 95:13290-13295 (Pubitemid 28509564)
36. Paul IA, Skolnick P (2003) Glutamate and depression: clinical and preclinical studies. Ann NY Acad Sci 1003:250-272 (Pubitemid 38083061)
37. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates, 2nd edn. Academic Press, London
38. Rajkowska G (2003) Depression: what we can learn from postmortem studies. Neuroscientist 9:273-284 (Pubitemid 36899115)
39. Rapp S, Baader M, Hu M, Jennen-Steinmetz C, Henn FA, Thome J (2004) Differential regulation of synaptic vesicle proteins by antidepressant drugs. Pharmacogenomics J 4:110-113 (Pubitemid 38499994)
40. Reagan LP, Rosell DR, Wood GE, Spedding M, Munoz C, Rothstein J, McEwen BS (2004) Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: reversal by tianeptine. Proc Natl Acad Sci USA 101:2179-2184 (Pubitemid 38229035)
41. Rothstein JD, Patel S, Regan MR, Haenggeli C, Huang YH, Bergles DE, Jin L, Dykes HM, Vidensky S, Chung DS, Toan SV, Bruijn LI, Su ZZ, Gupta P, Fisher PB (2005) Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 433:73-77 (Pubitemid 40101145)
42. Sanacora G, Rothman DL, Mason G, Krystal JH (2003) Clinical studies implementing glutamate neurotransmission in mood disorders. Ann NY Acad Sci 1003:292-308 (Pubitemid 38083063)
43. Shumake J, Gonzalez-Lima F (2003) Brain systems underlying susceptibility to helplessness and depression. Behav Cogn Neurosci Rev 2:198-221
44. Shumake J, Poremba A, Edwards E, Gonzalez-Lima F (2000) Congenital helpless rats as a genetic model for cortex metabolism in depression. Neuroreport 11:3793-3798
45. Shumake J, Conejo-Jimenez N, Gonzalez-Pardo H, Gonzalez-Lima F (2004) Brain differences in newborn rats predisposed to helpless and depressive behavior. Brain Res 1030:267-276 (Pubitemid 39574958)
46. Sutherland ML, Delaney TA, Noebels JL (1996) Glutamate transporter mRNA expression in proliferative zones of the developing and adult murine CNS. J Neurosci 16:2191-2207 (Pubitemid 26154331)
47. Thome J, Sakai N, Shin K-H, Steffen C, Zhang Y-J, Impey S, Storm D, Duman RS (2000) cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment. J Neurosci 20:4030-4036 (Pubitemid 30365673)
48. Tordera RM, Pei Q, Sharp T (2005) Evidence for increased expression of the vesicular glutamate transporter, VGLUT1, by a course of antidepressant treatment. J Neurochem 94:875-883 (Pubitemid 41170576)
49. Torp R, Danbolt NC, Babaie E, Bjoras M, Seeberg E, Storm-Mathisen J, Ottersen OP (1994) Differential expression of two glial glutamate transporters in the rat brain: an in situ hybridization study. Eur J Neurosci 6:936-942 (Pubitemid 24185316)
50. van Groen T, Kadish I, Wyss JM (2004) Retrosplenial cortex lesions of area Rgb (but not of area Rga) impair spatial learning and memory in the rat. Behav Brain Res 154:483-491 (Pubitemid 39093999)
51. Vollmayr B, Henn FA (2001) Learned helplessness in the rat: improvements in validity and reliability. Brain Res Protoc 8:1-7 (Pubitemid 32777872)
52. Wang B, Gonzalo-Ruiz A, Sanz JM, Campbell G, Lieberman AR (2001) Glutamatergic components of the retrosplenial granular cortex in the rat. J Neurocytol 30:427-441
53. Wiedemann C (2009) Neuron-glia interactions: an intimate relationship. Nat Rev Neurosci 10:318
54. Willner P, Mitchell PJ (2002) The validity of animal models of predisposition to depression. Behav Pharmacol 13:169-188 (Pubitemid 34816463)
55. Yamada M, Takahashi K, Tsunoda M, Nishioka G, Kudo K, Ohata H, Kamijima K, Higuchi T, Momose K (2002) Differential expression of VAMP2/synaptobrevin-2 after antidepressant and electroconvulsive treatment in rat frontal cortex. Pharmacogenomics J 2:377-382 (Pubitemid 36175800)
56. Yang CH, Huang CC, Hsu KS (2005) Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake. J Neurosci 25:4288-4293
57. Yang Y, Gozen O, Watkins A, Lorenzini I, Lepore A, Gao Y, Vidensky S, Brennan J, Poulsen D, Won PJ, Li JN, Robinson MB, Rothstein JD, Rothstein JD (2009) Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1. Neuron 61:880-894
58. Yang Y, Gozen O, Vidensky S, Robinson MB, Rothstein JD (2010) Epigenetic regulation of neuron-dependent induction of astroglial synaptic protein GLT1. Glia 58:277-286
59. Zarate CA Jr, Du J, Quiroz J, Gray NA, Denicoff KD, Singh J, Charney DS, Manji HK (2003) Regulation of cellular plasticity cascades in the pathophysiology and treatment of mood disorders: role of the glutamatergic system. Ann NY Acad Sci 1003:273-291 (Pubitemid 38083062)
60. Zarate CA Jr, Singh JB, Carlson PJ, Brutsche NE, Ameli R, Luckenbaugh DA, Charney DS, Manji HK (2006a) A randomized trial of an N-methyl-D-aspartate antagonist in treatmentresistant major depression. Arch Gen Psychiatry 63:856-864 (Pubitemid 44188478)
61. Zarate CA Jr, Singh JB, Quiroz JA, De JG, Denicoff KK, Luckenbaugh DA, Manji HK, Charney DS (2006b) A doubleblind, placebo-controlled study of memantine in the treatment of major depression. Am J Psychiatry 163:153-155 (Pubitemid 43050119)
62. Zink M, Rapp S, Gebicke-Härter P, Henn FA, Thome J (2005) Antidepressants differentially affect expression of complexin I and II RNA in rat hippocampus. Psychopharmacology 181:560-565 (Pubitemid 41480905)
63. Zink M, Vollmayr B, Gebicke-Härter P, Henn FA (2009) Reduced expression of GABA transporter GAT3 in helpless rats, an animal model of depression. Neurochem Res 34:1584-1593
64. Zink M, Vollmayr B, Gebicke-Härter P, Henn FA (2010) Reduced expression of glutamate transporters vGluT1, EAAT2 and EAAT4 in learned helpless rats, an animal model of depression. Neuropharmacology 58:465-563