Antidepressants differentially affect expression of complexin I and II RNA in rat hippocampus

Psychopharmacology

Volumn 181, Issue 3, 2005, Pages 560-565

  Zink, Mathias ^a   Rapp, Simone ^a   Gebicke Haerter, Peter J ^a   Henn, Fritz A ^a   Thome, Johannes ^b  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^b SWANSEA UNIVERSITY   (United Kingdom)

Author keywords

Animal model; Antidepressants; Complexin; Depression; Desipramine; Fluoxetine; Synapse; Syntaxin 1A; Tranylcypromine

Indexed keywords

ANTIDEPRESSANT AGENT; COMPLEXIN; DESIPRAMINE; FLUOXETINE; PROTEIN SUBUNIT; PSYCHOTROPIC AGENT; RNA; SNARE PROTEIN; SODIUM CHLORIDE; SYNTAXIN 1A; TRANYLCYPROMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; BRAIN SLICE; CADAVER; DENDRITE; DOWN REGULATION; DRUG EFFECT; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; NERVE FIBER; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; RAT; RNA PROBE; SYNAPTIC TRANSMISSION;

ANIMALS; ANTIDEPRESSIVE AGENTS; BRAIN MAPPING; DESIPRAMINE; FLUOXETINE; GENE EXPRESSION; HIPPOCAMPUS; INJECTIONS, INTRAPERITONEAL; MALE; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SYNTAXIN 1; TRANSCRIPTION, GENETIC; TRANYLCYPROMINE;

EID: 26944457653     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-005-0017-4     Document Type: Article

References (28)

1. Alfarez DN, Joels M, Krugers HJ (2003) Chronic unpredictable stress impairs long-term potentiation in rat hippocampal CA1 area and dentate gyrus in vitro. Eur J Neurosci 17:1928-1934
2. Coyle JT, Duman RS (2003) Finding the intracellular signaling pathways affected by mood disorder treatments. Neuron 38:157-160
3. D'Sa C, Duman RS (2002) Antidepressants and neuroplasticity. Bipolar Disord 4:183-194
4. Eastwood SL, Harrison PJ (2000) Hippocampal synaptic pathology in schizophrenia, bipolar disorder and major depression: a study of complexin mRNAs. Mol Psychiatry 5:425-432
5. Eastwood SL, Harrison PJ (2001) Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins. Brain Res Bull 55:569-578
6. Eastwood SL, Burnet PW, Harrison PJ (2000) Expression of complexin I and II mRNAs and their regulation by antipsychotic drugs in the rat forebrain. Synapse 36:167-177
7. Garcia R (2002) Stress, synaptic plasticity, and psychopathology. Rev Neurosci 13:195-208
8. Glynn D, Bortnick RA, Morton J (2003) Complexin II is essential for normal neurological function in mice. Hum Mol Gen 12:2431-2448
9. Hu K, Carroll J, Rickman C, Davletov B (2002) Action of complexin on SNARE complex. J Biol Chem 277:41652-41656
10. Ishizuka T, Saisu H, Odani S, Kumanishi T, Abe T (1999) Distinct regional distribution in the brain of messenger RNAs for the two isoforms of synaphin associated with the docking/fusion complex. Neuroscience 88:295-306
11. Kinnunen AK, Koenig JI, Bilbe G (2003) Repeated variable prenatal stress alters pre- and postsynaptic gene expression in the rat frontal pole. J Neurochem 86:736-748
12. Maroun M, Richter-Levin G (2003) Exposure to acute stress blocks the induction of long-term potentiation of the amygdala-prefrontal cortex pathway in vivo. J Neurosci 23:4406-4409
13. Marz KE, Hanson PI (2002) Sealed with a twist: complexin and the synaptic SNARE complex. Trends Neurosci 25:381-383
14. McMahon HT, Missler M, Li C, Sudhof TC (1995) Complexins: cytosolic proteins that regulate SNAP receptor function. Cell 83:111-119
15. Nakahara T, Motomura K, Hashimoto K, Ueki H, Gotoh L, Hondo H, Tsutsumi T, Kuroki T, Hirano M, Uchimura H (2000) Long-term-treatment with haloperidol decreases the mRNA levels of complexin I, but not complexin II, in rat prefrontal cortex, nucleus accumbens and ventral tegmental area. Neurosci Lett 290:29-32
16. Nestler EJ, Barrot M, Dileone RJ, Eisch AJ, Gold SJ, Monteggia LM (2002) Neurobiology of depression. Neuron 34:13-28
17. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates, 2nd edn. Academic, San Diego, New York
18. Rapp S, Baader M, Hu M, Jennen-Steinmetz C, Henn FA, Thome J (2004) Differential regulation of synaptic vesicle proteins by antidepressant drugs. Pharmacogenomics J 4:110-113
19. 2+-dependent neurotransmitter release. Cell 104:71-81
20. Sawada K, Young CE, Barr AM, Longworth K, Takahashi S, Arongo V, Mann JJ, Dwork AJ, Falkai P, Phillips AG, Honer WG (2002) Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness. Mol Psychiatry 7:484-492
21. Sudhof TC (2004) The synaptic vesicle cycle. Ann Rev Neurosci 27:509-547
22. Takahashi S, Yamamoto H, Matsuda Z, Ogawa M, Yagyu K, Taniguchi T, Miyata T, Kaba H, Higuchi T, Okutani F, Fujino M (1995) Identification of two highly homologous presynaptic proteins distinctly localized at the dendritic and somatic synapses. FEBS Lett 368:455-460
23. Thome J, Sakai N, Shin K-H, Steffen C, Zhang Y-J, Impey S, Storm D, Duman RS (2000) cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment. J Neurosci 20:4030-4036
24. Thome J, Pesold B, Baader M, Hu M, Gewirtz JC, Duman RS, Henn FA (2001) Stress differentially regulates synaptophysin and synaptotagmin expression in hippocampus. Biol Psychiatry 50:809-812
25. Tokumaru H, Umayahara K, Pellegrini LL, Ishizuka T, Saisu H, Betz H, Augustine GJ, Abe T (2001) SNARE complex oligomerization by synaphin/complexin is essential for synaptic vesicle exocytosis. Cell 104:421-432
26. Yamada M, Saisu H, Ishizuka T, Takahashi H, Abe T (1999) Immunohistochemical distribution of the two isoforms of synaphin/complexin involved in neurotransmitter release: localization at the distinct central nervous system regions and synaptic types. Neuroscience 93:7-18
27. Yamada M, Takahashi K, Tsunoda M, Nishioka G, Kudo K, Ohata H, Kamijima K, Higuchi T, Momose K (2002) Differential expression of VAMP2/synaptobrevin-2 after antidepressant and electroconvulsive treatment in rat frontal cortex. Pharmacogen J 2:377-382
28. Zink M, Schmitt A, May B, Müller B, Demirakca T, Braus DF, Henn FA (2004) Differential effects of long-term treatment with clozapine of haloperidol on GABAa receptor binding and GAD67 expression. Schizophr Res 66:151-157