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Volumn 25, Issue 5, 2011, Pages 205-213

Haemoglobinopathy diagnosis: Algorithms, lessons and pitfalls

Author keywords

Algorithms; Antenatal; Haemoglobinopathy; Neonatal; Newborn; Preconceptual; Premarital; Screening; Sickle cell disease; Sickle cell trait; Thalassaemia

Indexed keywords

GLOBIN; HEMOGLOBIN;

EID: 80051664429     PISSN: 0268960X     EISSN: 15321681     Source Type: Journal    
DOI: 10.1016/j.blre.2011.04.001     Document Type: Article
Times cited : (46)

References (58)
  • 1
    • 68849132731 scopus 로고    scopus 로고
    • Strategy for identification by mass spectrometry of a new human hemoglobin variant with two mutations in Cis in the β-globin chain: Hb S-Clichy [β6(A3)Glu→Val; >8(A5)Lys→Thr]
    • Zanella-Cleon I., Prehu C., Joly P., Riou J., Becchi M., Wajcman H., et al. Strategy for identification by mass spectrometry of a new human hemoglobin variant with two mutations in Cis in the β-globin chain: Hb S-Clichy [β6(A3)Glu→Val; >8(A5)Lys→Thr]. Hemoglobin 2009, 33:177-187.
    • (2009) Hemoglobin , vol.33 , pp. 177-187
    • Zanella-Cleon, I.1    Prehu, C.2    Joly, P.3    Riou, J.4    Becchi, M.5    Wajcman, H.6
  • 2
    • 84857046256 scopus 로고    scopus 로고
    • last accessed 7th January, 2011
    • last accessed 7th January, 2011. http://www.globin.cse.psu.edu/Globin%20Gene%20Server.
  • 3
    • 78851469896 scopus 로고    scopus 로고
    • Diagnosis of beta thalassemia major from bone marrow morphology
    • Abdulsalam A.H., Sabeeh N., Bain B.J. Diagnosis of beta thalassemia major from bone marrow morphology. Am J Hematol 2011, 86:187.
    • (2011) Am J Hematol , vol.86 , pp. 187
    • Abdulsalam, A.H.1    Sabeeh, N.2    Bain, B.J.3
  • 4
    • 2942579453 scopus 로고    scopus 로고
    • Molecular diagnosis of haemoglobin disorders
    • Clark B.E., Thein S.L. Molecular diagnosis of haemoglobin disorders. Clin Lab Haematol 2004, 26:159-176.
    • (2004) Clin Lab Haematol , vol.26 , pp. 159-176
    • Clark, B.E.1    Thein, S.L.2
  • 5
    • 80051667528 scopus 로고    scopus 로고
    • Hydrops fetalis secondary to homozygous alpha thalassaemia in a low incidence area
    • Modell B. Commentary on Bowers M
    • McMullin M.F., Green B.N., Jones F. Hydrops fetalis secondary to homozygous alpha thalassaemia in a low incidence area. CME Haematology 1999, 2:54-56. Modell B. Commentary on Bowers M.
    • (1999) CME Haematology , vol.2 , pp. 54-56
    • McMullin, M.F.1    Green, B.N.2    Jones, F.3
  • 6
    • 77949357012 scopus 로고    scopus 로고
    • British Committee for Standards in Haematology, Significant haemoglobinopathies: guidelines for screening and diagnosis
    • Ryan K., Bain B.J., Worthington D., James J., Plews D., Mason A., et al. British Committee for Standards in Haematology, Significant haemoglobinopathies: guidelines for screening and diagnosis. Br J Haematol 2010, 149:35-49.
    • (2010) Br J Haematol , vol.149 , pp. 35-49
    • Ryan, K.1    Bain, B.J.2    Worthington, D.3    James, J.4    Plews, D.5    Mason, A.6
  • 9
    • 0018218882 scopus 로고
    • Stigmatization of carrier status: social implications of heterozygote genetic screening programs
    • Kenen R.H., Schmidt R.M. Stigmatization of carrier status: social implications of heterozygote genetic screening programs. Am J Public Health 1978, 68:1116-1120.
    • (1978) Am J Public Health , vol.68 , pp. 1116-1120
    • Kenen, R.H.1    Schmidt, R.M.2
  • 10
    • 77956533115 scopus 로고    scopus 로고
    • Screening student athletes for sickle cell trait - a social and clinical experiment
    • Bonham V.L., Dover G.J., Brody L.C. Screening student athletes for sickle cell trait - a social and clinical experiment. N Engl J Med 2010, 363:997-999.
    • (2010) N Engl J Med , vol.363 , pp. 997-999
    • Bonham, V.L.1    Dover, G.J.2    Brody, L.C.3
  • 11
    • 0025784180 scopus 로고
    • Thalassaemia trait and myocardial infarction: low infarction incidence in male subjects confirmed
    • Gallerani M., Scapoli C., Cicognani I., Ricci A., Martinelli L., Cappato R., et al. Thalassaemia trait and myocardial infarction: low infarction incidence in male subjects confirmed. J Intern Med 1991, 230:109-1.
    • (1991) J Intern Med , vol.230 , pp. 109-1
    • Gallerani, M.1    Scapoli, C.2    Cicognani, I.3    Ricci, A.4    Martinelli, L.5    Cappato, R.6
  • 12
    • 78049470943 scopus 로고    scopus 로고
    • Relative protection from ischaemic heart disease in beta-thalassaemia carriers
    • Bozdar M., Ahmed S., Anwar J. Relative protection from ischaemic heart disease in beta-thalassaemia carriers. J Coll Physicians Surg Pak 2010, 20:653-656.
    • (2010) J Coll Physicians Surg Pak , vol.20 , pp. 653-656
    • Bozdar, M.1    Ahmed, S.2    Anwar, J.3
  • 13
    • 40749091243 scopus 로고    scopus 로고
    • Is beta-thalassemia trait a protective factor against ischemic cerebrovascular accidents?
    • Karimi M., Borhani Haghighi A., Yazdani M., Raisi H., Giti R., et al. Is beta-thalassemia trait a protective factor against ischemic cerebrovascular accidents?. J Stroke Cerebrovasc Dis 2008, 17:79-81.
    • (2008) J Stroke Cerebrovasc Dis , vol.17 , pp. 79-81
    • Karimi, M.1    Borhani Haghighi, A.2    Yazdani, M.3    Raisi, H.4    Giti, R.5
  • 14
    • 0021930572 scopus 로고
    • Acute splenic sequestration in homozygous sickle cell disease: natural history and management
    • Emond A.M., Collis R., Darvill D., Higgs D.R., Maude G.H., Serjeant G.R. Acute splenic sequestration in homozygous sickle cell disease: natural history and management. J Pediatr 1985, 107:201-206.
    • (1985) J Pediatr , vol.107 , pp. 201-206
    • Emond, A.M.1    Collis, R.2    Darvill, D.3    Higgs, D.R.4    Maude, G.H.5    Serjeant, G.R.6
  • 15
    • 0022628893 scopus 로고
    • Prophylaxis with oral penicillin in children with sickle cell anemia. A randomized trial
    • Gaston M.H., Verter J.I., Woods G., Pegelow C., Kelleher J., Presbury G., et al. Prophylaxis with oral penicillin in children with sickle cell anemia. A randomized trial. N Engl J Med 1986, 314:1593-1599.
    • (1986) N Engl J Med , vol.314 , pp. 1593-1599
    • Gaston, M.H.1    Verter, J.I.2    Woods, G.3    Pegelow, C.4    Kelleher, J.5    Presbury, G.6
  • 16
    • 40949107353 scopus 로고    scopus 로고
    • Effectiveness of the 7-valent pneumococcal conjugate vaccine in children with sickle cell disease in the first decade of life
    • Adamkiewicz T.V., Silk B.J., Howgate J., Baughman W., Strayhorn G., Sullivan K., et al. Effectiveness of the 7-valent pneumococcal conjugate vaccine in children with sickle cell disease in the first decade of life. Pediatrics 2008, 121:562-569.
    • (2008) Pediatrics , vol.121 , pp. 562-569
    • Adamkiewicz, T.V.1    Silk, B.J.2    Howgate, J.3    Baughman, W.4    Strayhorn, G.5    Sullivan, K.6
  • 17
    • 34548753905 scopus 로고    scopus 로고
    • Clinical outcomes in children with sickle cell disease living in England: a neonatal cohort in East London
    • Telfer P., Coen P., Chakravorty S., Wilkey O., Evans J., Newell H., et al. Clinical outcomes in children with sickle cell disease living in England: a neonatal cohort in East London. Haematologica 2007, 92:905-912.
    • (2007) Haematologica , vol.92 , pp. 905-912
    • Telfer, P.1    Coen, P.2    Chakravorty, S.3    Wilkey, O.4    Evans, J.5    Newell, H.6
  • 18
    • 58349102500 scopus 로고    scopus 로고
    • Implementation of universal newborn bloodspot screening for sickle cell disease and other clinically significant haemoglobinopathies in England: screening results for 2005-7
    • Streetly A., Latinovic R., Hall K., Henthorn J. Implementation of universal newborn bloodspot screening for sickle cell disease and other clinically significant haemoglobinopathies in England: screening results for 2005-7. J Clin Pathol 2009, 62:26-30.
    • (2009) J Clin Pathol , vol.62 , pp. 26-30
    • Streetly, A.1    Latinovic, R.2    Hall, K.3    Henthorn, J.4
  • 19
    • 77955738527 scopus 로고    scopus 로고
    • Positive screening and carrier results for the England-wide universal newborn screening programme by ethnicity and area for 2005-07
    • Streetly A., Latinovic R., Henthorn J. Positive screening and carrier results for the England-wide universal newborn screening programme by ethnicity and area for 2005-07. J Clin Pathol 2010, 63:626-629.
    • (2010) J Clin Pathol , vol.63 , pp. 626-629
    • Streetly, A.1    Latinovic, R.2    Henthorn, J.3
  • 20
    • 77957334334 scopus 로고    scopus 로고
    • One-third of the new paediatric patients with sickle cell disease in The Netherlands are immigrants and do not benefit from neonatal screening
    • Peters M., Fijnvandraat K., van den Tweel X.W., Garre F.G., Giordano P.C., van Wouwe J.P., et al. One-third of the new paediatric patients with sickle cell disease in The Netherlands are immigrants and do not benefit from neonatal screening. Arch Dis Child 2010, 95:822-825.
    • (2010) Arch Dis Child , vol.95 , pp. 822-825
    • Peters, M.1    Fijnvandraat, K.2    van den Tweel, X.W.3    Garre, F.G.4    Giordano, P.C.5    van Wouwe, J.P.6
  • 21
    • 57149121739 scopus 로고    scopus 로고
    • Newborn screening for sickle cell disease using tandem mass spectrometry
    • Boemer F., Ketelslegers O., Minon J.M., Bours V., Schoos R. Newborn screening for sickle cell disease using tandem mass spectrometry. Clin Chem 2008, 54:2036-2041.
    • (2008) Clin Chem , vol.54 , pp. 2036-2041
    • Boemer, F.1    Ketelslegers, O.2    Minon, J.M.3    Bours, V.4    Schoos, R.5
  • 22
    • 24944506479 scopus 로고    scopus 로고
    • Rapid and specific detection of clinically significant haemoglobinopathies using electrospray mass spectrometry-mass spectrometry
    • Daniel Y.A., Turner C., Haynes R.M., Hunt B.J., Dalton R.N. Rapid and specific detection of clinically significant haemoglobinopathies using electrospray mass spectrometry-mass spectrometry. Br J Haematol 2005, 130:635-643.
    • (2005) Br J Haematol , vol.130 , pp. 635-643
    • Daniel, Y.A.1    Turner, C.2    Haynes, R.M.3    Hunt, B.J.4    Dalton, R.N.5
  • 27
    • 77957133346 scopus 로고    scopus 로고
    • Carrier screening for Beta-thalassaemia: a review of international practice
    • Cousens N.E., Gaff C.L., Metcalfe S.A., Delatycki M.B. Carrier screening for Beta-thalassaemia: a review of international practice. Eur J Hum Genet 2010, 18:1077-1083.
    • (2010) Eur J Hum Genet , vol.18 , pp. 1077-1083
    • Cousens, N.E.1    Gaff, C.L.2    Metcalfe, S.A.3    Delatycki, M.B.4
  • 28
    • 40749096818 scopus 로고    scopus 로고
    • SHIFT Research Team. Delay between pregnancy confirmation and sickle cell and thalassaemia screening: a population-based cohort study
    • Dormandy E., Gulliford M.C., Reid E.P., Brown K., Marteau T.M. SHIFT Research Team. Delay between pregnancy confirmation and sickle cell and thalassaemia screening: a population-based cohort study. Br J Gen Pract 2008, 58:154-159.
    • (2008) Br J Gen Pract , vol.58 , pp. 154-159
    • Dormandy, E.1    Gulliford, M.C.2    Reid, E.P.3    Brown, K.4    Marteau, T.M.5
  • 29
    • 77952400779 scopus 로고    scopus 로고
    • Antenatal screening for haemoglobinopathies in primary care: a cohort study and cluster randomised trial to inform a simulation model. The Screening for Haemoglobinopathies in First Trimester (SHIFT) trial
    • last accessed 7th January, 2011
    • Dormandy E., Bryan S., Gulliford M.C., Roberts T.E., Ades A.E., Calnan M., et al. Antenatal screening for haemoglobinopathies in primary care: a cohort study and cluster randomised trial to inform a simulation model. The Screening for Haemoglobinopathies in First Trimester (SHIFT) trial. Health Technol Assess 2010, 14(20). last accessed 7th January, 2011. http://www.hta.ac.uk/project/1401.asp.
    • (2010) Health Technol Assess , vol.14 , Issue.20
    • Dormandy, E.1    Bryan, S.2    Gulliford, M.C.3    Roberts, T.E.4    Ades, A.E.5    Calnan, M.6
  • 30
    • 0026484251 scopus 로고
    • Factors affecting the uptake of prenatal diagnosis for sickle cell disease
    • Petrou M., Brugiatelli M., Ward R.H., Modell B. Factors affecting the uptake of prenatal diagnosis for sickle cell disease. J Med Genet 1992, 29:820-823.
    • (1992) J Med Genet , vol.29 , pp. 820-823
    • Petrou, M.1    Brugiatelli, M.2    Ward, R.H.3    Modell, B.4
  • 31
    • 36248946234 scopus 로고    scopus 로고
    • Prenatal control of Hb Bart's disease in Southern China
    • Liao C., Li Q., Wei J., Feng Q., Li J., Huang Y., et al. Prenatal control of Hb Bart's disease in Southern China. Hemoglobin 2007, 31:471-475.
    • (2007) Hemoglobin , vol.31 , pp. 471-475
    • Liao, C.1    Li, Q.2    Wei, J.3    Feng, Q.4    Li, J.5    Huang, Y.6
  • 32
    • 34447116924 scopus 로고    scopus 로고
    • Molecular basis of haemoglobinopathies in the UAE: implications for prenatal diagnosis and prevention programmes
    • Baysal E., Yousef I., Abdullah H., Essa M., Taleb M., Redha A. Molecular basis of haemoglobinopathies in the UAE: implications for prenatal diagnosis and prevention programmes. Emirates Med J 2007, 25:7-21.
    • (2007) Emirates Med J , vol.25 , pp. 7-21
    • Baysal, E.1    Yousef, I.2    Abdullah, H.3    Essa, M.4    Taleb, M.5    Redha, A.6
  • 33
    • 41949086953 scopus 로고    scopus 로고
    • Sociocultural challenges of thalassaemia birth in Islamic and developing countries
    • Karimi M., Nima J. Sociocultural challenges of thalassaemia birth in Islamic and developing countries. J Pediatr Hematol Oncol 2008, 30:335.
    • (2008) J Pediatr Hematol Oncol , vol.30 , pp. 335
    • Karimi, M.1    Nima, J.2
  • 34
    • 76449108988 scopus 로고    scopus 로고
    • Attitude toward prenatal diagnosis for β-thalassemia major and medical abortion in Southern Iran
    • Karimi M., Johari S., Cohan N. Attitude toward prenatal diagnosis for β-thalassemia major and medical abortion in Southern Iran. Hemoglobin 2010, 34:49-54.
    • (2010) Hemoglobin , vol.34 , pp. 49-54
    • Karimi, M.1    Johari, S.2    Cohan, N.3
  • 35
    • 0034064855 scopus 로고    scopus 로고
    • Prenatal diagnosis of beta-thalassaemia in Pakistan: experience in a Muslim country
    • Ahmed S., Saleem M., Sultana N., Raashid Y., Waqar A., Anwar M., et al. Prenatal diagnosis of beta-thalassaemia in Pakistan: experience in a Muslim country. Prenat Diagn 2000, 20:378-383.
    • (2000) Prenat Diagn , vol.20 , pp. 378-383
    • Ahmed, S.1    Saleem, M.2    Sultana, N.3    Raashid, Y.4    Waqar, A.5    Anwar, M.6
  • 36
    • 8744272457 scopus 로고    scopus 로고
    • Iranian national thalassaemia screening programme
    • Samavat A., Modell M. Iranian national thalassaemia screening programme. BMJ 2004, 329:1134-1137.
    • (2004) BMJ , vol.329 , pp. 1134-1137
    • Samavat, A.1    Modell, M.2
  • 38
    • 67049116457 scopus 로고    scopus 로고
    • Premarital screening programmes for haemoglobinopathies, HIV and hepatitis viruses: review and factors affecting their success
    • Alswaidi F.M., O'Brien S.J. Premarital screening programmes for haemoglobinopathies, HIV and hepatitis viruses: review and factors affecting their success. J Med Screen 2009, 16:22-28.
    • (2009) J Med Screen , vol.16 , pp. 22-28
    • Alswaidi, F.M.1    O'Brien, S.J.2
  • 39
    • 68949212294 scopus 로고    scopus 로고
    • Population programs for the detection of couples at risk for severe monogenic genetic diseases
    • Zlotogora J. Population programs for the detection of couples at risk for severe monogenic genetic diseases. Hum Genet 2009, 126:247-253.
    • (2009) Hum Genet , vol.126 , pp. 247-253
    • Zlotogora, J.1
  • 40
    • 34249705137 scopus 로고    scopus 로고
    • Obligatory premarital tests for β-thalassaemia in the Gaza Strip: evaluation and recommendations
    • Tarazi I., Al Najjar E., Lulu N., Sirdah M. Obligatory premarital tests for β-thalassaemia in the Gaza Strip: evaluation and recommendations. Int J Lab Hematol 2007, 29:111-118.
    • (2007) Int J Lab Hematol , vol.29 , pp. 111-118
    • Tarazi, I.1    Al Najjar, E.2    Lulu, N.3    Sirdah, M.4
  • 41
    • 33750303409 scopus 로고    scopus 로고
    • Genetic disease in the Arab world
    • Bayoumi R.A., Yardumian A. Genetic disease in the Arab world. BMJ 2006, 333:819.
    • (2006) BMJ , vol.333 , pp. 819
    • Bayoumi, R.A.1    Yardumian, A.2
  • 42
    • 33750375590 scopus 로고    scopus 로고
    • Genetic disorders in the Arab world
    • Al-Gazali L., Hamamy H., Al-Arrayad S. Genetic disorders in the Arab world. BMJ 2006, 333:831-834.
    • (2006) BMJ , vol.333 , pp. 831-834
    • Al-Gazali, L.1    Hamamy, H.2    Al-Arrayad, S.3
  • 44
    • 0032547518 scopus 로고    scopus 로고
    • Thalassaemia in Britain: a tale of two communities. Births are rising among British Asians but falling in Cypriots
    • Gill P.S., Modell B. Thalassaemia in Britain: a tale of two communities. Births are rising among British Asians but falling in Cypriots. BMJ 1998, 317:761-762.
    • (1998) BMJ , vol.317 , pp. 761-762
    • Gill, P.S.1    Modell, B.2
  • 45
    • 59449095626 scopus 로고    scopus 로고
    • Prevention of homozygous beta thalassemia by premarital screening and prenatal diagnosis in India
    • Tamhankar P.M., Agarwal S., Arya V., Kumar R., Gupta U.R., Agarwal S. Prevention of homozygous beta thalassemia by premarital screening and prenatal diagnosis in India. Prenat Diagn 2009, 29:83-88.
    • (2009) Prenat Diagn , vol.29 , pp. 83-88
    • Tamhankar, P.M.1    Agarwal, S.2    Arya, V.3    Kumar, R.4    Gupta, U.R.5    Agarwal, S.6
  • 46
    • 0029798775 scopus 로고    scopus 로고
    • Twenty-year outcome analysis of genetic screening programs for Tay-Sachs and β-Thalassemia disease carriers in high schools
    • Mitchell J.J., Capua A., Clow C., Scriver C.R. Twenty-year outcome analysis of genetic screening programs for Tay-Sachs and β-Thalassemia disease carriers in high schools. Am J Med Genet 1996, 59:793-798.
    • (1996) Am J Med Genet , vol.59 , pp. 793-798
    • Mitchell, J.J.1    Capua, A.2    Clow, C.3    Scriver, C.R.4
  • 48
    • 0023238370 scopus 로고
    • Sickle cell trait as a risk factor for sudden death in physical training
    • Kark J.A., Posey D.M., Schumacher H.R., Ruehle C.J. Sickle cell trait as a risk factor for sudden death in physical training. N Engl J Med 1987, 317:781-787.
    • (1987) N Engl J Med , vol.317 , pp. 781-787
    • Kark, J.A.1    Posey, D.M.2    Schumacher, H.R.3    Ruehle, C.J.4
  • 49
    • 34447617616 scopus 로고    scopus 로고
    • Last accessed 7th January, 2011
    • Kark J. Sickle cell trait Last accessed 7th January, 2011. http://www.sickle.bwh.harvard.edu/sickle_trait.html.
    • Sickle cell trait
    • Kark, J.1
  • 50
    • 81355153079 scopus 로고    scopus 로고
    • Prevention of exercise-related death unexplained by pre-existing disease (EDU) associated with sickle cell trait (SCT) without hemoglobin (Hb) screening or Hb specific management
    • Kark J.A., Labotka R.J., Gradner J.W., Ward F.T. Prevention of exercise-related death unexplained by pre-existing disease (EDU) associated with sickle cell trait (SCT) without hemoglobin (Hb) screening or Hb specific management. Blood 2010, 116:416-417.
    • (2010) Blood , vol.116 , pp. 416-417
    • Kark, J.A.1    Labotka, R.J.2    Gradner, J.W.3    Ward, F.T.4
  • 51
    • 0018095385 scopus 로고
    • 32P and acute leukemia: development of leukemia in a patient with hemoglobin Yakima
    • Bagby G.C., Richert-Boe K., Koler R.D. 32P and acute leukemia: development of leukemia in a patient with hemoglobin Yakima. Blood 1978, 52:350-354.
    • (1978) Blood , vol.52 , pp. 350-354
    • Bagby, G.C.1    Richert-Boe, K.2    Koler, R.D.3
  • 52
    • 37349096565 scopus 로고    scopus 로고
    • Prenatal diagnosis of beta-thalassemia: 12 years' experience at a single laboratory in Pakistan
    • Ahmed S. Prenatal diagnosis of beta-thalassemia: 12 years' experience at a single laboratory in Pakistan. Prenat Diagn 2007, 27:1224-1227.
    • (2007) Prenat Diagn , vol.27 , pp. 1224-1227
    • Ahmed, S.1
  • 53
    • 0030608774 scopus 로고    scopus 로고
    • Levels of Hb A2 in heterozygotes and homozygotes for β-thalassemia mutations: influence of mutations in the CACCC and ATAAA motifs of the β-globin gene promoter
    • Huisman T.H. Levels of Hb A2 in heterozygotes and homozygotes for β-thalassemia mutations: influence of mutations in the CACCC and ATAAA motifs of the β-globin gene promoter. Acta Haematol 1997, 98:187-194.
    • (1997) Acta Haematol , vol.98 , pp. 187-194
    • Huisman, T.H.1
  • 56
    • 77956897748 scopus 로고    scopus 로고
    • New and known β-thalassemia determinants masked by known and new δ gene defects [Hb A(2)-Ramallah or δ6(A3)Glu→Gln, GAG>>CAG]
    • Phylipsen M., Harteveld C.L., de Metz M., Gallivan M.V., Arkesteijn S.G., Luo H.Y., et al. New and known β-thalassemia determinants masked by known and new δ gene defects [Hb A(2)-Ramallah or δ6(A3)Glu→Gln, GAG>>CAG]. Hemoglobin 2010, 34:445-450.
    • (2010) Hemoglobin , vol.34 , pp. 445-450
    • Phylipsen, M.1    Harteveld, C.L.2    de Metz, M.3    Gallivan, M.V.4    Arkesteijn, S.G.5    Luo, H.Y.6
  • 57
    • 80051670926 scopus 로고    scopus 로고
    • Increased haemoglobin A2 percentage in HIV infection: disease or treatment?
    • Wilkinson M.J., Bain B.J., Phelan L., Benzie A. Increased haemoglobin A2 percentage in HIV infection: disease or treatment?. AIDS 2007, 14:37-42.
    • (2007) AIDS , vol.14 , pp. 37-42
    • Wilkinson, M.J.1    Bain, B.J.2    Phelan, L.3    Benzie, A.4
  • 58
    • 77954856578 scopus 로고    scopus 로고
    • Hydrops fetalis associated with homozygosity for Hb Adana [alpha59(E8)Gly->Asp (alpha2)]
    • Nainggolan I.M., Harahap A., Setianingsih I. Hydrops fetalis associated with homozygosity for Hb Adana [alpha59(E8)Gly->Asp (alpha2)]. Hemoglobin 2010, 34:394-401.
    • (2010) Hemoglobin , vol.34 , pp. 394-401
    • Nainggolan, I.M.1    Harahap, A.2    Setianingsih, I.3


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