Methylation of the homeobox gene, HOPX, is frequently detected in poorly differentiated colorectal cancer

Anticancer Research

Volumn 31, Issue 9, 2011, Pages 2889-2892

  Harada, Yoshikuni ^a   Kijima, Kazuhiro ^a   Shinmura, Kazuki ^a   Sakata, Makiko ^a   Sakuraba, Kazuma ^a   Yokomizo, Kazuaki ^a   Kitamura, Youhei ^a   Shirahata, Atsushi ^a   Goto, Tetsuhiro ^a   Mizukami, Hiroki ^a   Saito, Mitsuo ^a   Kigawa, Gaku ^a   Nemoto, Hiroshi ^a   Hibi, Kenji ^a  

^a SHOWA UNIVERSITY FUJIGAOKA HOSPITAL   (Japan)

Author keywords

Colorectal cancer; Gene methylation; HOPX

Indexed keywords

ADULT; ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA METHYLATION; FEMALE; GENE IDENTIFICATION; HISTOPATHOLOGY; HOMEOBOX; HOMEODOMAIN ONLY PROTEIN X GENE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

AGED; BASE SEQUENCE; CELL DIFFERENTIATION; COLORECTAL NEOPLASMS; DNA METHYLATION; DNA PRIMERS; FEMALE; GENES, HOMEOBOX; HUMANS; MALE; MIDDLE AGED;

EID: 80051620859     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Bos JL, Fearon ER, Hamilton SR, Verlaan-de Vries M, van Boom JH, van der Eb AJ and Vogelstein B: Prevalence of RAS gene mutations in human colorectal cancers. Nature 327: 293-297, 1987.
2. Baker SJ, Markowitz S, Fearon ER, Willson JK and Vogelstein B: Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 249: 912-915, 1990.
3. Nishisho I, Nakamura Y, Miyoshi Y, Miki Y, Ando H, Horii A, Koyama K, Utsunomiya J, Baba S, Hedge P, Markham A, Krush AJ, Petersen G, Hamilton SR, Nilbert MC, Levy DB, Bryan TM, Preesinger AC, Smith KJ, Su LK, Kinzler KW and Vogelstein B: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 253: 665-669, 1991. (Pubitemid 21917200)
4. Hibi K, Nakamura H, Hirai A, Fujikake Y, Kasai Y, Akiyama S, Ito K and Takagi H: Loss of H19 imprinting in esophageal cancer. Cancer Res 56: 480-482, 1996. (Pubitemid 26048601)
5. Hibi K, Taguchi M, Nakamura H, Hirai A, Fujikake Y, Matsui T, Kasai Y, Akiyama S, Ito K and Takagi H: Alternative splicing of the FHIT gene in colorectal cancers. Jpn J Cancer Res 88: 385-388, 1997.
6. Hibi K, Nakayama H, Koike M, Kasai Y, Ito K, Akiyama S and Nakao A: Colorectal cancers with both p16 and p14 methylation show invasive characteristics. Jpn J Cancer Res 93: 883-887, 2002. (Pubitemid 35012249)
7. Hibi K, Nakayama H, Kodera Y, Ito K, Akiyama S and Nakao A: CDH13 promoter region is specifically methylated in poorly differentiated colorectal cancer. Br J Cancer 90: 1030-1033, 2004. (Pubitemid 38495824)
8. Yamazaki T, Hibi K, Takase T, Tezel E, Nakayama H, Kasai Y, Ito K, Akiyama S, Nagasaka T and Nakao A: PGP9.5 as a marker for invasive colorectal cancer. Clin Cancer Res 8: 192-195, 2002.
9. Das PM and Singal R: DNA methylation and cancer. J Clin Oncol 22: 4632-4642, 2004. (Pubitemid 41185132)
10. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, White R, Smits AM and Bos JL: Genetic alterations during colorectal-tumor development. N Engl J Med 319: 525-532, 1988.
11. Chen F, Kook H, Milewski R, Gitler AD, Lu MM, Li J, Nazarian R, Schnepp R, Jen K, Biben C, Runke G, Mackay JP, Novotny J, Schwartz RJ, Harvey RP, Mullins MC and Epstein JA: Hop is an unusual homeobox gene that modulates cardiac development. Cell 110: 713-723, 2002. (Pubitemid 35283961)
12. Kook H, Yung WW, Simpson RJ, Kee HJ, Shin S, Lowry JA, Loughlin FE, Yin Z, Epstein JA and Mackay JP: Analysis of the structure and function of the transcriptional co-regulator HOP. Biochemistry 45: 10584-10590, 2006. (Pubitemid 44335688)
13. Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, Kokubo K, Kobayashi H, Kim MS, Sidransky D and Watanabe M: Potential utility of HOP homeobox gene promoter methylation as a marker of tumor aggressiveness in gastric cancer. Oncogene 29: 3263-3275, 2010.
14. Yamaguchi S, Asanoma K, Takao T, Kato K and Wake N: Homeobox gene HOPX is epigenetically silenced in human uterine endometrial cancer and suppresses estrogen-stimulated proliferation of cancer cells by inhibiting serum response factor. Int J Cancer 124: 2577-2588, 2009.
15. Chen Y, Pacyna-Gengelbach M, Deutschmann N, Niesporek S and Petersen I: Homeobox gene HOP has a potential tumor suppressive activity in human lung cancer. Int J Cancer 121: 1021-1027, 2007. (Pubitemid 47101638)
16. Yamashita K, Kim MS, Park HL, Tokumaru Y, Osada M, Inoue H, Mori M and Sidransky D: HOP/OB1/NECC1 promoter DNA is frequently hypermethylated and involved in tumorigenic ability in esophageal squamous cell carcinoma. Mol Cancer Res 6: 31-41, 2008. (Pubitemid 351378164)
17. Greenlee RT, Murray T, Bolden S and Wingo PA: Cancer statistics, 2000. CA Cancer J Clin 50: 7-33, 2000.
18. Risio M, Reato G, di Celle PF, Fizzotti M, Rossini FP and Foa R: Microsatellite instability is associated with the histological features of the tumor in nonfamilial colorectal cancer. Cancer Res 56: 5470-5474, 1996. (Pubitemid 27011382)