The Finnish Diabetes Risk Score is associated with insulin resistance but not reduced β-cell function, by classical and model-based estimates

Diabetic Medicine

Volumn 28, Issue 9, 2011, Pages 1078-1081

  Brodovicz, K G ^a   Dekker, J M ^b,c   Rijkelijkhuizen, J M ^b   Rhodes, T ^a   Mari, A ^d   Alssema, M ^b,c   Nijpels, G ^b,c   Williams Herman, D E ^a   Girman, C J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d CNR   (Italy)

Author keywords

cell function; FINDRISC; Insulin resistance; Screening

Indexed keywords

GLUCOSE; INSULIN;

ADULT; AGED; ARTICLE; CELL FUNCTION; CLINICAL ASSESSMENT TOOL; COHORT ANALYSIS; FEMALE; FINNISH DIABETES RISK SCORE; GLUCOSE METABOLISM; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; REGISTER; SCORING SYSTEM;

ADULT; AGED; BLOOD GLUCOSE; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; FINLAND; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN-SECRETING CELLS; MALE; MIDDLE AGED; QUESTIONNAIRES; RISK FACTORS;

EID: 80051615715     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2011.03315.x     Document Type: Article

References (15)

1. Lindstrom J, Peltonen M, Eriksson JG, Aunola S, Hamalainen H, Ilanne-Parikka P et al. Determinants for the effectiveness of lifestyle intervention in the Finnish diabetes prevention study. Diabetes Care 2008; 31: 857-862.
2. Wang J, Stancakova A, Kuusisto J, Laakso M. Identification of undiagnosed Type2 diabetic individuals by the Finnish Diabetes Risk Score and biochemical and genetic markers: a population-based study of 7232 Finnish men. J Clin Endocrinol Metabol 2010; 95: 3858-3862.
3. Saaristo T, Peltonen M, Lindstrom J, Saarikoski L, Sundvall J, Eriksson JG et al. Cross-sectional evaluation of the Finnish Diabetes Risk Score: a tool to identify undetected type 2 diabetes, abnormal glucose tolerance and metabolic syndrome. Diab Vasc Dis Res 2005; 2: 67-72.
4. Schwarz PEH, Li J, Reimann M, Schutte AE, Bergmann A, Hanefeld M et al. The Finnish Diabetes Risk Score is associated with insulin resistance and progression towards Type 2 diabetes. J Clin Endocrinol Metabol 2009; 94: 920-926.
5. Bergmann A, Li J, Wang L, Schulze J, Bornstein SR, Schwarz PEH. et al. A simplified Finnish Diabetes Risk Score to predict type2 diabetes risk and disease evolution in a German population. Horm Metab Res 2007; 39: 677-682.
6. Lindstrom J, Tuomilehto J. The Diabetes Risk Score - a practical tool to predict type 2 diabetes risk. Diabetes Care 2003; 26: 725-731.
7. Mari A, Schmitz O, Gastaldelli A, Oestergaard T, Nyholm B, Ferrannini E et al. Meal and oral glucose tests for assessment of beta-cell function: modeling analysis in normal subjects. Am J Physiol Endocrinol Metab 2002; 283: E1159-E1166.
8. Ferrannini E, Gastaldelli A, Miyazaki Y, Matsuda M, Mari A, Defronzo RA. Beta-cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis. J Clin Endocrinol Metab 2005; 90: 493-500.
9. Rijkelijkhuizen JM, Girman CJ, Mari A, Alssema M, Rhodes T, Nijpels G et al. Classical and model-based estimates of beta-cell function during a mixed meal vs. an OGTT in a population-based cohort. Diabetes Res Clin Pract 2009; 83: 280-288.
10. Pascoe L, Frayling TM, Weedon MN, Mari A, Tura A, Ferrannini E et al. Beta-cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles. Diabetologia 2008; 51: 1989-1992.
11. Mari A, Tura A, Gastaldelli A, Ferrannini E. Assessing insulin secretion by modeling in multiple-meal tests - role of potentiation. Diabetes 2002; 51: S221-S226.
12. Mari A, Pacini G, Murphy E, Ludvik B, Nolan JJ. A model-based method for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care 2001; 24: 539-548.
13. Mari A, Manco M, Guidone C, Nanni G, Castagneto M, Mingrone G et al. Restoration of normal glucose tolerance in severely obese patients after bilio-pancreatic diversion: role of insulin sensitivity and beta-cell function. Diabetologia 2006; 49: 2136-2143.
14. Mari A, Pacini G, Brazzale AR, Ahren B. Comparative evaluation of simple insulin sensitivity methods based on the oral glucose tolerance test. Diabetologia 2005; 48: 748-751.
15. WHO. Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycemia - Report of a WHO/IDF Consultation. Geneva, Switzerland: World Health Organization, 2006.