Prognostic relevance of disseminated tumor cells in the bone marrow of patients with primary breast cancer - Results of a standardized follow-up

Anticancer Research

Volumn 31, Issue 9, 2011, Pages 2749-2756

  Schindlbeck, Christian ^a   Pfab, G ^b   Jueckstock, J ^b   Andergassen, U ^b   Sommer, H ^b   Janni, W ^c   Friese, K ^b   Rack, B ^b  

^a Klinikum Traunstein   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Bone marrow; Breast cancer; Disseminated tumor cells; Follow up; Prognosis

Indexed keywords

ADULT; AGED; ARTICLE; BONE MARROW; BONE MARROW BIOPSY; BREAST CANCER; DISSEMINATED CANCER; DISSEMINATED TUMOR CELL; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MAJOR CLINICAL STUDY; METASTASIS; OVERALL SURVIVAL; PRIMARY TUMOR; PRIORITY JOURNAL; PROGNOSIS; TUMOR VOLUME;

BONE MARROW; BREAST NEOPLASMS; FEMALE; FOLLOW-UP STUDIES; HUMANS; PROGNOSIS;

EID: 80051605011     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Sloane JP, Ormerod MG and Neville AM: Potential pathological application of immunocytochemical methods to the detection of micrometastases. Cancer Res 40: 3079-3082, 1980.
2. Mansi JL, Berger U, Easton D, McDonnell T, Redding WH, Gazet JC, McKinna A, Powles TJ and Coombes RC: Micrometastases in bone marrow in patients with primary breast cancer: evaluation as an early predictor of bone metastases. Br Med J (Clin Res Ed) 295: 1093-1096, 1987. (Pubitemid 17151273)
3. Dearnaley DP, Sloane JP, Ormerod MG, Steele K, Coombes RC, Clink HM, Powles TJ, Ford HT, Gazet JC and Neville AM: Increased detection of mammary carcinoma cells in marrow smears using antisera to epithelial membrane antigen. Br J Cancer 44: 85-90, 1981. (Pubitemid 11078391)
4. Janni W, Gastroph S, Hepp F, Kentenich C, Rjosk D, Schindlbeck C, Dimpfl T, Sommer H and Braun S: Prognostic significance of an increased number of micrometastatic tumor cells in the bone marrow of patients with first recurrence of breast carcinoma. Cancer 88: 2252-2259, 2000. (Pubitemid 30247124)
5. Gebauer G, Fehm T, Merkle E, Beck EP, Lang N and Jager W: Epithelial cells in bone marrow of breast cancer patients at time of primary surgery: clinical outcome during long-term follow-up. J Clin Oncol 19: 3669-3674, 2001. (Pubitemid 32786279)
6. Gerber B, Krause A, Muller H, Richter D, Reimer T, Makovitzky J, Herrnring C, Jeschke U, Kundt G and Friese K: Simultaneous immunohistochemical detection of tumor cells in lymph nodes and bone marrow aspirates in breast cancer and its correlation with other prognostic factors. J Clin Oncol 19: 960-971, 2001. (Pubitemid 32176270)
7. Wiedswang G, Borgen E, Karesen R, Kvalheim G, Nesland JM, Qvist H, Schlichting E, Sauer T, Janbu J, Harbitz T and Naume B: Detection of isolated tumor cells in bone marrow is an independent prognostic factor in breast cancer. J Clin Oncol 21: 3469-3478, 2003. (Pubitemid 46594079)
8. Braun S, Pantel K, Muller P, Janni W, Hepp F, Kentenich CR, Gastroph S, Wischnik A, Dimpfl T, Kindermann G, Riethmuller G and Schlimok G: Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. N Engl J Med 342: 525-533, 2000. (Pubitemid 30117892)
9. Braun S, Vogl FD, Naume B, Janni W, Osborne MP, Coombes RC, Schlimok G, Diel IJ, Gerber B, Gebauer G, Pierga JY, Marth C, Oruzio D, Wiedswang G, Solomayer EF, Kundt G, Strobl B, Fehm T, Wong GY, Bliss J, Vincent-Salomon A and Pantel K: A pooled analysis of bone marrow micrometastasis in breast cancer. N Engl J Med 353: 793-802, 2005. (Pubitemid 41215488)
10. Janni W, Rack B, Schindlbeck C, Strobl B, Rjosk D, Braun S, Sommer H, Pantel K, Gerber B and Friese K: The persistence of isolated tumor cells in bone marrow from patients with breast carcinoma predicts an increased risk for recurrence. Cancer 103: 884-891, 2005. (Pubitemid 40270064)
11. Balic M, Lin H, Young L, Hawes D, Giuliano A, McNamara G, Datar RH and Cote RJ: Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype. Clin Cancer Res 12: 5615-5621, 2006.
12. Schindlbeck C, Jeschke U, Schulze S, Karsten U, Janni W, Rack, B, Sommer H and Friese K: Characterisation of disseminated tumor cells in the bone marrow of breast cancer patients by the Thomsen-Friedenreich tumor antigen. Histochem Cell Biol 123: 631-637, 2005. (Pubitemid 41126082)
13. Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Matera J, Miller MC, Reuben JM, Doyle GV, Allard WJ, Terstappen LW and Hayes DF: Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 351: 781-791, 2004. (Pubitemid 39095313)
14. Fehm T, Braun S, Muller V, Janni W, Gebauer G, Marth C, Schindlbeck C, Wallwiener D, Borgen E, Naume B, Pantel K and Solomayer E: A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementation. Cancer 107: 885-892, 2006. (Pubitemid 44291136)
15. Naume B, Borgen E, Kvalheim G, Karesen R, Qvist H, Sauer T, Kumar T and Nesland JM: Detection of isolated tumor cells in bone marrow in early-stage breast carcinoma patients: comparison with preoperative clinical parameters and primary tumor characteristics. Clin Cancer Res 7: 4122-4129, 2001. (Pubitemid 34048337)
16. Schindlbeck C, Kampik T, Janni W, Rack B, Jeschke U, Krajewski S, Sommer H and Friese K: Prognostic relevance of disseminated tumor cells in the bone marrow and biological factors of 265 primary breast carcinomas. Breast Cancer Res 7: R1174-1185, 2005.
17. Pantel K, Schlimok G, Braun S, Kutter D, Lindemann F, Schaller G, Funke I, Izbicki JR and Riethmuller G: Differential expression of proliferation- associated molecules in individual micrometastatic carcinoma cells. J Natl Cancer Inst 85: 1419-1424, 1993. (Pubitemid 23264351)
18. Schindlbeck C, Janni W, Shabani N, Kornmeier A, Rack B, Rjosk D, Gerber B, Braun S, Sommer H and Friese K: Isolated tumor cells in the bone marrow (ITC-BM) of breast cancer patients before and after anthracyclin based therapy: influenced by the HER2- and Topoisomerase IIalpha-status of the primary tumor?. J Cancer Res Clin Oncol 131: 539-546, 2005. (Pubitemid 41215309)
19. Theodoropoulos PA, Polioudaki H, Agelaki S, Kallergi G, Saridaki Z, Mavroudis D and Georgoulias V: Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer. Cancer Lett 288: 99-106, 2010.
20. Braun S, Schlimok G, Heumos I, Schaller G, Riethdorf L, Riethmuller G and Pantel K: ErbB2 overexpression on occult metastatic cells in bone marrow predicts poor clinical outcome of stage I-III breast cancer patients. Cancer Res 61: 1890-1895, 2001.
21. Fehm T, Muller V, Aktas B, Janni W, Schneeweiss A, Stickeler E, Lattrich C, Lohberg CR, Solomayer E, Rack B, Riethdorf S, Klein C, Schindlbeck C, Brocker K, Kasimir-Bauer S, Wallwiener D and Pantel K: HER2 status of circulating tumor cells in patients with metastatic breast cancer: a prospective, multicenter trial. Breast Cancer Res Treat, 2010.
22. Muller V, Stahmann N, Riethdorf S, Rau T, Zabel T, Goetz A, Janicke F and Pantel K: Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity. Clin Cancer Res 11: 3678-3685, 2005. (Pubitemid 40685584)
23. Zabaglo L, Ormerod MG, Parton M, Ring A, Smith IE and Dowsett M: Cell filtration-laser scanning cytometry for the characterisation of circulating breast cancer cells. Cytometry A 55: 102-108, 2003. (Pubitemid 37522512)
24. Weihrauch MR, Skibowski E, Draube A, Geller A, Tesch H, Diehl V and Bohlen H: Immunomagnetic enrichment and detection of isolated tumor cells in bone marrow of patients with epithelial malignancies. Clin Exp Metastasis 19: 617-621, 2002. (Pubitemid 35454572)
25. Schindlbeck C, Stellwagen J, Jeschke U, Karsten U, Rack B, Janni W, Juckstock J, Tulusan A, Sommer H and Friese K: Immunomagnetic enrichment of disseminated tumor cells in bone marrow and blood of breast cancer patients by the Thomsen-Friedenreich-Antigen. Clin Exp Metastasis 25: 233-240, 2008.
26. Kruger W, Datta C, Badbaran A, Togel F, Gutensohn K, Carrero I, Kroger N, Janicke F and Zander AR: Immunomagnetic tumor cell selection - implications for the detection of disseminated cancer cells. Transfusion 40: 1489-1493, 2000. (Pubitemid 32048535)
27. Wiedswang G, Borgen E, Karesen R and Naume B: Detection of isolated tumor cells in BM from breast-cancer patients: significance of anterior and posterior iliac crest aspirations and the number of mononuclear cells analyzed. Cytotherapy 5: 40-45, 2003. (Pubitemid 36382934)
28. Gervasoni A, Monasterio Munoz RM, Wengler GS, Rizzi A, Zaniboni A and Parolini O: Molecular signature detection of circulating tumor cells using a panel of selected genes. Cancer Lett 263: 267-279, 2008.
29. Becker S, Becker-Pergola G, Banys M, Krawczyk N, Wallwiener D, Solomayer E, Schuetz C and Fehm T: Evaluation of a RT-PCR based routine screening tool for the detection of disseminated epithelial cells in the bone marrow of breast cancer patients. Breast Cancer Res Treat 117: 227-233, 2009.
30. Benoy IH, Elst H, Philips M, Wuyts H, Van Dam P, Scharpe S, Van Marck E, Vermeulen PB and Dirix LY: Prognostic significance of disseminated tumor cells as detected by quantitative real-time reverse-transcriptase polymerase chain reaction in patients with breast cancer. Clin Breast Cancer 7: 146-152, 2006. (Pubitemid 44044011)
31. Rack B, Juckstock J, Genss EM, Schoberth A, Schindlbeck C, Strobl B, Heinrigs M, Rammel G, Zwingers T, Sommer H, Friese K and Janni W: Effect of zoledronate on persisting isolated tumour cells in patients with early breast cancer. Anticancer Res 30: 1807-1813, 2010.
32. Riethdorf S, Fritsche H, Muller V, Rau T, Schindlbeck C, Rack B, Janni W, Coith C, Beck K, Janicke F, Jackson S, Gornet T, Cristofanilli M and Pantel K: Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system. Clin Cancer Res 13: 920-928, 2007. (Pubitemid 46340368)
33. Pachmann K, Clement JH, Schneider CP, Willen B, Camara O, Pachmann U and Hoffken K: Standardized quantification of circulating peripheral tumor cells from lung and breast cancer. Clin Chem Lab Med 43: 617-627, 2005. (Pubitemid 41460612)
34. Pachmann K, Camara O, Kavallaris A, Krauspe S, Malarski N, Gajda M, Kroll T, Jorke C, Hammer U, Altendorf-Hofmann A, Rabenstein C, Pachmann U, Runnebaum I and Hoffken K: Monitoring the response of circulating epithelial tumor cells to adjuvant chemotherapy in breast cancer allows detection of patients at risk of early relapse. J Clin Oncol 26: 1208-1215, 2008.
35. Stathopoulou A, Vlachonikolis I, Mavroudis D, Perraki M, Kouroussis C, Apostolaki S, Malamos N, Kakolyris S, Kotsakis A, Xenidis N, Reppa D and Georgoulias V: Molecular detection of cytokeratin-19-positive cells in the peripheral blood of patients with operable breast cancer: evaluation of their prognostic significance. J Clin Oncol 20: 3404-3412, 2002.
36. Daskalaki A, Agelaki S, Perraki M, Apostolaki S, Xenidis N, Stathopoulos E, Kontopodis E, Hatzidaki D, Mavroudis D and Georgoulias V: Detection of cytokeratin-19 mRNA-positive cells in the peripheral blood and bone marrow of patients with operable breast cancer. Br J Cancer 101: 589-597, 2009.