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Volumn 41, Issue 8, 2011, Pages 594-605

Management of metastatic renal cell carcinoma in the era of targeted therapies

Author keywords

Carcinoma; Renal; Retrospective; Survival

Indexed keywords

AXITINIB; BEVACIZUMAB; EVEROLIMUS; INTERFERON; PAZOPANIB; SORAFENIB; TEMSIROLIMUS;

EID: 80051593067     PISSN: 14440903     EISSN: 14455994     Source Type: Journal    
DOI: 10.1111/j.1445-5994.2011.02540.x     Document Type: Review
Times cited : (6)

References (42)
  • 1
    • 70349302892 scopus 로고    scopus 로고
    • AIHW (Australian Institute of Health and Welfare), AACR (Australasian Association of Cancer Registries). Cancer series no. 46. Cat. no. CAN 42. Canberra: AIHW
    • AIHW (Australian Institute of Health and Welfare), AACR (Australasian Association of Cancer Registries). Cancer in Australia: An Overview, 2008. Cancer series no. 46. Cat. no. CAN 42. Canberra: AIHW; 2008.
    • (2008) Cancer in Australia: An Overview, 2008
  • 3
    • 0033978220 scopus 로고    scopus 로고
    • Systemic therapy for renal cell carcinoma
    • Motzer RJ, Russo P. Systemic therapy for renal cell carcinoma. J Urol 2000; 163: 408-17.
    • (2000) J Urol , vol.163 , pp. 408-417
    • Motzer, R.J.1    Russo, P.2
  • 5
    • 0242608613 scopus 로고    scopus 로고
    • The genetic basis of cancer of the kidney
    • Linehan WM, Walther MM, Zbar B. The genetic basis of cancer of the kidney. J Urol 2003; 170: 2163-72.
    • (2003) J Urol , vol.170 , pp. 2163-2172
    • Linehan, W.M.1    Walther, M.M.2    Zbar, B.3
  • 7
    • 56749161699 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
    • Rini BI, Halabi S, Rosenberg JE, Stadler WM, Vaena DA, Ou S-S etal. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol 2008; 26: 5422-8.
    • (2008) J Clin Oncol , vol.26 , pp. 5422-5428
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3    Stadler, W.M.4    Vaena, D.A.5    Ou, S.-S.6
  • 8
    • 77952318310 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206
    • Rini BI, Halabi S, Rosenberg JE, Stadler WM, Vaena DA, Archer L etal. Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. J Clin Oncol 2010; 28: 2137-43.
    • (2010) J Clin Oncol , vol.28 , pp. 2137-2143
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3    Stadler, W.M.4    Vaena, D.A.5    Archer, L.6
  • 9
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial
    • Escudier B, Pluzanska A, Koralewski P, Ravaud M, Bracarda S, Szczylik C etal. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 2007; 370: 2103-11.
    • (2007) Lancet , vol.370 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3    Ravaud, M.4    Bracarda, S.5    Szczylik, C.6
  • 10
    • 77952300540 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival
    • Escudier B, Bellmunt J, Negrier S, Bajetta E, Melichar B, Bracarda S etal. Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival. J Clin Oncol 2010; 28: 2144-50.
    • (2010) J Clin Oncol , vol.28 , pp. 2144-2150
    • Escudier, B.1    Bellmunt, J.2    Negrier, S.3    Bajetta, E.4    Melichar, B.5    Bracarda, S.6
  • 12
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Oudard S etal. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 2009; 27: 3584-90.
    • (2009) J Clin Oncol , vol.27 , pp. 3584-3590
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3    Michaelson, M.D.4    Bukowski, R.M.5    Oudard, S.6
  • 14
    • 70249097380 scopus 로고    scopus 로고
    • Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial
    • Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Staehler M etal. Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol 2009; 27: 3312-18.
    • (2009) J Clin Oncol , vol.27 , pp. 3312-3318
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3    Szczylik, C.4    Oudard, S.5    Staehler, M.6
  • 15
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial
    • Sternberg CN, Davis ID, Mardiak J, Szczylik C, Lee E, Wagstaff J etal. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol 2010; 28: 1061-8.
    • (2010) J Clin Oncol , vol.28 , pp. 1061-1068
    • Sternberg, C.N.1    Davis, I.D.2    Mardiak, J.3    Szczylik, C.4    Lee, E.5    Wagstaff, J.6
  • 16
    • 35448934762 scopus 로고    scopus 로고
    • Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study
    • Rixe O, Bukowski RM, Michaelson MD, Wilding G, Hudes G, Bolte O etal. Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study. Lancet Oncol 2007; 8: 975-84.
    • (2007) Lancet Oncol , vol.8 , pp. 975-984
    • Rixe, O.1    Bukowski, R.M.2    Michaelson, M.D.3    Wilding, G.4    Hudes, G.5    Bolte, O.6
  • 17
    • 70349388719 scopus 로고    scopus 로고
    • Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma
    • Rini BI, Wilding G, Hudes G, Stadler WM, Kim S, Tarazi J etal. Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma. J Clin Oncol 2009; 27: 4462-8.
    • (2009) J Clin Oncol , vol.27 , pp. 4462-4468
    • Rini, B.I.1    Wilding, G.2    Hudes, G.3    Stadler, W.M.4    Kim, S.5    Tarazi, J.6
  • 19
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial
    • Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S etal. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008; 372: 449-56.
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3    Hutson, T.E.4    Porta, C.5    Bracarda, S.6
  • 21
    • 67651201656 scopus 로고    scopus 로고
    • Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial
    • Gore ME, Szczylik C, Porta C, Bracarda S, Bjarnason GA, Oudard S etal. Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial. Lancet Oncol 2009; 10: 757-63.
    • (2009) Lancet Oncol , vol.10 , pp. 757-763
    • Gore, M.E.1    Szczylik, C.2    Porta, C.3    Bracarda, S.4    Bjarnason, G.A.5    Oudard, S.6
  • 22
    • 80051601885 scopus 로고    scopus 로고
    • Cancer Therapy Evaluation Program. Common Terminology Criteria for Adverse Events v3.0 (CTCAE). DCTD, NCI, NIH, DHHS. [Cited 2010 Apr 3]. Available from URL:
    • Cancer Therapy Evaluation Program. Common Terminology Criteria for Adverse Events v3.0 (CTCAE). DCTD, NCI, NIH, DHHS. 2006. [Cited 2010 Apr 3]. Available from URL.
    • (2006)
  • 23
    • 0036138580 scopus 로고    scopus 로고
    • Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
    • Motzer RJ, Bacik J, Murphy BA, Russo P, Mazumdar M. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 2002; 20: 289.
    • (2002) J Clin Oncol , vol.20 , pp. 289
    • Motzer, R.J.1    Bacik, J.2    Murphy, B.A.3    Russo, P.4    Mazumdar, M.5
  • 24
    • 73349084973 scopus 로고    scopus 로고
    • Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large, multicenter study
    • Heng DYC, Xie W, Regan MM, Warren MA, Golshayan AR, Sahi C etal. Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large, multicenter study. J Clin Oncol 2009; 27: 5794-9.
    • (2009) J Clin Oncol , vol.27 , pp. 5794-5799
    • Heng, D.Y.C.1    Xie, W.2    Regan, M.M.3    Warren, M.A.4    Golshayan, A.R.5    Sahi, C.6
  • 25
    • 79251574372 scopus 로고    scopus 로고
    • Prognostic factors for progression-free and overall survival with sunitinib targeted therapy and with cytokine as first-line therapy in patients with metastatic renal cell carcinoma
    • Patil S, Figlin RA, Hutson TE, Michaelson MD, Négrier S, Kim ST etal. Prognostic factors for progression-free and overall survival with sunitinib targeted therapy and with cytokine as first-line therapy in patients with metastatic renal cell carcinoma. Acta Oncol 2011; 22: 295-300.
    • (2011) Acta Oncol , vol.22 , pp. 295-300
    • Patil, S.1    Figlin, R.A.2    Hutson, T.E.3    Michaelson, M.D.4    Négrier, S.5    Kim, S.T.6
  • 26
    • 33749178081 scopus 로고    scopus 로고
    • Evaluation of nutritional and inflammatory status of advanced colorectal cancer patients and its correlation with survival
    • Read J, Choy STB, Beale P, Clarke S. Evaluation of nutritional and inflammatory status of advanced colorectal cancer patients and its correlation with survival. Nutr Cancer 2006; 55: 78-85.
    • (2006) Nutr Cancer , vol.55 , pp. 78-85
    • Read, J.1    Choy, S.T.B.2    Beale, P.3    Clarke, S.4
  • 27
    • 68949110437 scopus 로고    scopus 로고
    • Influence of inflammation-based prognostic score on mortality of patients undergoing chemotherapy for far advanced or recurrent unresectable colorectal cancer
    • Ishizuka M, Nagata H, Takagi K, Kubota K. Influence of inflammation-based prognostic score on mortality of patients undergoing chemotherapy for far advanced or recurrent unresectable colorectal cancer. Ann Surg 2009; 250: 268-72.
    • (2009) Ann Surg , vol.250 , pp. 268-272
    • Ishizuka, M.1    Nagata, H.2    Takagi, K.3    Kubota, K.4
  • 28
    • 20344377869 scopus 로고    scopus 로고
    • A prospective longitudinal study of performance status, an inflammation-based score (GPS) and survival in patients with inoperable non-small-cell lung cancer
    • Forrest LM, McMillan DC, McArdle CS, Angerson WJ, Dagg K, Scott HR. A prospective longitudinal study of performance status, an inflammation-based score (GPS) and survival in patients with inoperable non-small-cell lung cancer. Br J Cancer 2005; 92: 1834-6.
    • (2005) Br J Cancer , vol.92 , pp. 1834-1836
    • Forrest, L.M.1    McMillan, D.C.2    McArdle, C.S.3    Angerson, W.J.4    Dagg, K.5    Scott, H.R.6
  • 29
    • 0036895290 scopus 로고    scopus 로고
    • Risk group assessment and clinical outcome algorithm to predict the natural history of patients with surgically resected renal cell carcinoma
    • Zisman A, Pantuck AJ, Wieder J, Chao DH, Dorey F, Said JW etal. Risk group assessment and clinical outcome algorithm to predict the natural history of patients with surgically resected renal cell carcinoma. J Clin Oncol 2002; 20: 4559-66.
    • (2002) J Clin Oncol , vol.20 , pp. 4559-4566
    • Zisman, A.1    Pantuck, A.J.2    Wieder, J.3    Chao, D.H.4    Dorey, F.5    Said, J.W.6
  • 30
    • 58249094490 scopus 로고    scopus 로고
    • Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy
    • Golshayan AR, George S, Heng DY, Elson P, Wood LS, Mekhail TM etal. Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. J Clin Oncol 2008; 27: 235-41.
    • (2008) J Clin Oncol , vol.27 , pp. 235-241
    • Golshayan, A.R.1    George, S.2    Heng, D.Y.3    Elson, P.4    Wood, L.S.5    Mekhail, T.M.6
  • 31
    • 80051579837 scopus 로고    scopus 로고
    • Histopathology in surgically treated renal cell carcinoma: is there a survival difference when stratified by stage?
    • Keegan KA, Hellenthal NJ, Chamie K, Koppie TM. Histopathology in surgically treated renal cell carcinoma: is there a survival difference when stratified by stage? J Clin Oncol 2009; 27 (Suppl): abstr 5089.
    • (2009) J Clin Oncol , vol.27
    • Keegan, K.A.1    Hellenthal, N.J.2    Chamie, K.3    Koppie, T.M.4
  • 32
    • 60549095633 scopus 로고    scopus 로고
    • Hypertension and clinical benefit of bevacizumab in the treatment of advanced renal cell carcinoma
    • Bono P, Elfving H, Utriainen T, Österlund P, Saarto T, Alanko T etal. Hypertension and clinical benefit of bevacizumab in the treatment of advanced renal cell carcinoma. Ann Oncol 2009; 20: 393.
    • (2009) Ann Oncol , vol.20 , pp. 393
    • Bono, P.1    Elfving, H.2    Utriainen, T.3    Österlund, P.4    Saarto, T.5    Alanko, T.6
  • 33
    • 79955623124 scopus 로고    scopus 로고
    • Hypertension as predictor of sunitinib treatment outcome in metastatic renal cell carcinoma
    • Bono P, Rautiola J, Utriainen T, Joensuu H. Hypertension as predictor of sunitinib treatment outcome in metastatic renal cell carcinoma. Acta Oncol 2011; 50: 569-73.
    • (2011) Acta Oncol , vol.50 , pp. 569-573
    • Bono, P.1    Rautiola, J.2    Utriainen, T.3    Joensuu, H.4
  • 34
    • 34447343347 scopus 로고    scopus 로고
    • Hypertension as a predictive factor of sunitinib activity
    • Rixe O, Billemont B, Izzedine H. Hypertension as a predictive factor of sunitinib activity. Ann Oncol 2007; 18: 1117.
    • (2007) Ann Oncol , vol.18 , pp. 1117
    • Rixe, O.1    Billemont, B.2    Izzedine, H.3
  • 35
    • 65549119311 scopus 로고    scopus 로고
    • Arterial hypertension and clinical benefit of sunitinib, sorafenib and bevacizumab in first and second-line treatment of metastatic renal cell cancer
    • Ravaud A, Sire M. Arterial hypertension and clinical benefit of sunitinib, sorafenib and bevacizumab in first and second-line treatment of metastatic renal cell cancer. Ann Oncol 2009; 20: 966-7.
    • (2009) Ann Oncol , vol.20 , pp. 966-967
    • Ravaud, A.1    Sire, M.2
  • 36
    • 78650490672 scopus 로고    scopus 로고
    • Breaking through a plateau in renal cell carcinoma therapeutics: development and incorporation of biomarkers
    • Pal SK, Kortylewski M, Yu H, Figlin RA. Breaking through a plateau in renal cell carcinoma therapeutics: development and incorporation of biomarkers. Mol Cancer Ther 2010; 9: 3115-25.
    • (2010) Mol Cancer Ther , vol.9 , pp. 3115-3125
    • Pal, S.K.1    Kortylewski, M.2    Yu, H.3    Figlin, R.A.4
  • 37
    • 78650419842 scopus 로고    scopus 로고
    • Suppression of the nitric oxide pathway in metastatic renal cell carcinoma patients receiving vascular endothelial growth factor-signaling inhibitors
    • Robinson ES, Khankin EV, Choueiri TK, Dhawan MS, Rogers MJ, Karumanchi SA etal. Suppression of the nitric oxide pathway in metastatic renal cell carcinoma patients receiving vascular endothelial growth factor-signaling inhibitors. Hypertension 2010; 56: 1131.
    • (2010) Hypertension , vol.56 , pp. 1131
    • Robinson, E.S.1    Khankin, E.V.2    Choueiri, T.K.3    Dhawan, M.S.4    Rogers, M.J.5    Karumanchi, S.A.6
  • 38
    • 77952038495 scopus 로고    scopus 로고
    • Initial assessment, surveillance, and management of blood pressure in patients receiving vascular endothelial growth factor signaling pathway inhibitors
    • Maitland ML, Bakris GL, Black HR, Chen HX, Durand JB, Elliott WJ etal. Initial assessment, surveillance, and management of blood pressure in patients receiving vascular endothelial growth factor signaling pathway inhibitors. J Natl Cancer Inst 2010; 102: 596-604.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 596-604
    • Maitland, M.L.1    Bakris, G.L.2    Black, H.R.3    Chen, H.X.4    Durand, J.B.5    Elliott, W.J.6
  • 39
    • 74949128620 scopus 로고    scopus 로고
    • Effective strategies for management of hypertension after vascular endothelial growth factor signaling inhibition therapy: results from a phase II randomized, factorial, double-blind study of cediranib in patients with advanced solid tumors
    • Langenberg MHG, van Herpen CML, De Bono J, Schellens JHM, Unger C, Hoekman K etal. Effective strategies for management of hypertension after vascular endothelial growth factor signaling inhibition therapy: results from a phase II randomized, factorial, double-blind study of cediranib in patients with advanced solid tumors. J Clin Oncol 2009; 27: 6152-9.
    • (2009) J Clin Oncol , vol.27 , pp. 6152-6159
    • Langenberg, M.H.G.1    van Herpen, C.M.L.2    De Bono, J.3    Schellens, J.H.M.4    Unger, C.5    Hoekman, K.6
  • 40
    • 55949123335 scopus 로고    scopus 로고
    • Cardiac toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma
    • Schmidinger M, Zielinski CC, Vogl UM, Bojic A, Bojic M, Schukro C etal. Cardiac toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol 2008; 26: 5204-12.
    • (2008) J Clin Oncol , vol.26 , pp. 5204-5212
    • Schmidinger, M.1    Zielinski, C.C.2    Vogl, U.M.3    Bojic, A.4    Bojic, M.5    Schukro, C.6
  • 41
  • 42
    • 52949128348 scopus 로고    scopus 로고
    • Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib
    • Lacouture ME, Wu S, Robert C, Atkins MB, Kong HH, Guitart J etal. Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib. Oncologist 2008; 13: 1001-11.
    • (2008) Oncologist , vol.13 , pp. 1001-1011
    • Lacouture, M.E.1    Wu, S.2    Robert, C.3    Atkins, M.B.4    Kong, H.H.5    Guitart, J.6


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