Unfractionated heparin for second trimester placental insufficiency: A pilot randomized trial

Journal of Thrombosis and Haemostasis

Volumn 9, Issue 8, 2011, Pages 1483-1492

  Kingdom, John C P ^a   Walker, M ^a   Proctor, L K ^a   Keating, S ^a   Shah, P S ^a   McLeod, A ^b   Keunen, J ^a   Windrim, R C ^a   Dodd, J M ^c  

^a Pediatric Oral and Maxillofacial Surgery   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Doppler ultrasound; Placental insufficiency; Placental pathology; Placental ultrasound; Randomized control trial; Unfractioned heparin

Indexed keywords

ALPHA FETOPROTEIN; CHORIONIC GONADOTROPIN; HEPARIN; PREGNANCY ASSOCIATED PLASMA PROTEIN A;

ADULT; ANXIETY; ARTICLE; CLINICAL ARTICLE; DOPPLER ECHOGRAPHY; DRUG SELF ADMINISTRATION; FALSE POSITIVE RESULT; FEMALE; HIGH RISK PATIENT; HUMAN; PILOT STUDY; PLACENTA INSUFFICIENCY; PRIORITY JOURNAL; RISK FACTOR; SCREENING TEST; SECOND TRIMESTER PREGNANCY; THROMBOPHILIA; UTERINE ARTERY;

ADULT; ANTICOAGULANTS; ANXIETY; FEASIBILITY STUDIES; FEMALE; HEPARIN; HUMANS; INJECTIONS, SUBCUTANEOUS; MIDDLE AGED; ONTARIO; PILOT PROJECTS; PLACENTAL INSUFFICIENCY; PREGNANCY; PREGNANCY OUTCOME; PREGNANCY TRIMESTER, SECOND; SELF ADMINISTRATION; TREATMENT OUTCOME; ULTRASONOGRAPHY, DOPPLER; ULTRASONOGRAPHY, PRENATAL;

EID: 80051586984     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2011.04407.x     Document Type: Article

References (53)

1. Buyse FG, Wormgoor BH, Bernard JT, Koudstaal J. Anticoagulant therapy of patients with repeated placental infarction. Obstet Gynecol 1974; 43: 844-8.
2. Gris JC, Mercier E, Quere I, Lavigne-Lissalde G, Cochery-Nouvellon E, Hoffet M, Ripart-Neveu S, Tailland ML, Dauzat M, Mares P. Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder. Blood 2004; 103: 3695-9.
3. Dodd JM, McLeod A, Windrim RC, Kingdom J. Antithrombotic therapy for improving maternal or infant health outcomes in women considered at risk of placental dysfunction. Cochrane Database Syst Rev 2010; 6: CD006780.
4. Mello G, Parretti E, Fatini C, Riviello C, Gensini F, Marchionni M, Scarselli GF, Gensini GF, Abbate R. Low-molecular-weight heparin lowers the recurrence rate of preeclampsia and restores the physiological vascular changes in angiotensin-converting enzyme DD women. Hypertension 2005; 45: 86-91.
5. Rey E, Garneau P, David M, Gauthier R, Leduc L, Michon N, Morin F, Demers C, Kahn SR, Magee LA, Rodger M. Dalteparin for the prevention of recurrence of placental-mediated complications of pregnancy in women without thrombophilia: a pilot randomized controlled trial. J Thromb Haemost 2009; 7: 58-64.
6. Kincaid-Smith P, North RA, Fairley KF, Kloss M, Ihle BU. Prevention of pre-eclampsia in high risk women with renal disease: a prospective randomized trial of heparin and dipyridamole. Nephrology 1995; 1: 297-300.
7. Yu YH, Shen LY, Zhong M, Zhang Y, Su GD, Gao YF, Quan S, Zeng L. [Effect of heparin on fetal growth restriction]. Zhonghua Fu Chan Ke Za Zhi 2004; 39: 793-6.
8. Franco C, Walker M, Robertson J, Fitzgerald B, Keating S, McLeod A, Kingdom JC. Placental infarction and thrombophilia. Obstet Gynecol 2011; 117: 929-34.
9. Sarig G, Vidergor G, Brenner B. Assessment and management of high-risk pregnancies in women with thrombophilia. Blood Rev 2009; 23: 143-7.
10. Urman B, Ata B, Yakin K, Alatas C, Aksoy S, Mercan R, Balaban B. Luteal phase empirical low molecular weight heparin administration in patients with failed ICSI embryo transfer cycles: a randomized open-labeled pilot trial. Hum Reprod 2009; 24: 1640-7.
11. Drewlo S, Walker M, McLeod A, Dodd J, Kingdom JC. Heparin in human placental development and the prevention of placental complications of pregnancy. Fetal Matern Med Rev 2010; 21: 1-19.
12. Toal M, Chan C, Fallah S, Alkazaleh F, Chaddha V, Windrim RC, Kingdom JC. Usefulness of a placental profile in high-risk pregnancies. Am J Obstet Gynecol 2007; 196: 363 e1-7.
13. Dugoff L. First- and second-trimester maternal serum markers for aneuploidy and adverse obstetric outcomes. Obstet Gynecol 2010; 115: 1052-61.
14. Cnossen JS, Morris RK, ter Riet G, Mol BW, van der Post JA, Coomarasamy A, Zwinderman AH, Robson SC, Bindels PJ, Kleijnen J, Khan KS. Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis. CMAJ 2008; 178: 701-11.
15. Proctor LK, Toal M, Keating S, Chitayat D, Okun N, Windrim RC, Smith GC, Kingdom JC. Placental size and the prediction of severe early-onset intrauterine growth restriction in women with low pregnancy-associated plasma protein-A. Ultrasound Obstet Gynecol 2009; 34: 274-82.
16. Toal M, Keating S, Machin G, Dodd J, Adamson SL, Windrim RC, Kingdom JC. Determinants of adverse perinatal outcome in high-risk women with abnormal uterine artery Doppler images. Am J Obstet Gynecol 2008; 198: 330 e1-7.
17. Proctor LK, Whittle WL, Keating S, Viero S, Kingdom JC. Pathologic basis of echogenic cystic lesions in the human placenta: role of ultrasound-guided wire localization. Placenta 2010; 31: 1111-5.
18. Jauniaux E, Moscoso G, Campbell S, Gibb D, Driver M, Nicolaides KH. Correlation of ultrasound and pathologic findings of placental anomalies in pregnancies with elevated maternal serum alpha-fetoprotein. Eur J Obstet Gynecol Reprod Biol 1990; 37: 219-30.
19. Bower S, Bewley S, Campbell S. Improved prediction of preeclampsia by two-stage screening of uterine arteries using the early diastolic notch and color Doppler imaging. Obstet Gynecol 1993; 82: 78-83.
20. Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 1992; 30: 473-83.
21. Marteau TM, Bekker H. The development of a six-item short-form of the state scale of the Spielberger State-Trait Anxiety Inventory (STAI). Br J Clin Psychol 1992; 31 (Pt 3): 301-6.
22. Cox JL, Holden JM, Sagovsky R. Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. Br J Psychiatry 1987; 150: 782-6.
23. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. Obstet Gynecol 2002; 99: 159-67.
24. Kramer MS, Platt RW, Wen SW, Joseph KS, Allen A, Abrahamowicz M, Blondel B, Breart G. A new and improved population-based Canadian reference for birth weight for gestational age. Pediatrics 2001; 108: E35.
25. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1, 500 gm. J Pediatr 1978; 92: 529-34.
26. Bell MJ, Ternberg JL, Feigin RD, Keating JP, Marshall R, Barton L, Brotherton T. Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Ann Surg 1978; 187: 1-7.
27. Kraus FT, Redline RW, Gersell DJ, Nelson DM, Dicke JM. AFIP Atlas of Nontumour Pathology: Placental Pathology. Washington, DC: American Registry of Pathology, 2004.
28. Rosenberg KB, Monk C, Glickstein JS, Levasseur SM, Simpson LL, Kleinman CS, Williams IA. Referral for fetal echocardiography is associated with increased maternal anxiety. J Psychosom Obstet Gynaecol 2010; 31: 60-9.
29. Larsson AK, Svalenius EC, Marsal K, Dykes AK. Parental level of anxiety, sense of coherence and state of mind when choroid plexus cysts have been identified at a routine ultrasound examination in the second trimester of pregnancy: a case control study. J Psychosom Obstet Gynaecol 2009; 30: 95-100.
30. Aite L, Zaccara A, Trucchi A, Brizzi C, Nahom A, Iacobelli B, Capolupo I, Bagolan P. When uncertainty generates more anxiety than severity: the prenatal experience with cystic adenomatoid malformation of the lung. J Perinat Med 2009; 37: 539-42.
31. Kaandorp SP, Goddijn M, van der Post JA, Hutten BA, Verhoeve HR, Hamulyak K, Mol BW, Folkeringa N, Nahuis M, Papatsonis DN, Buller HR, van der Veen F, Middeldorp S. Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. N Engl J Med 2010; 362: 1586-96.
32. Gris JC, Chauleur C, Faillie JL, Baer G, Mares P, Fabbro-Peray P, Quere I, Lefrant JY, Haddad B, Dauzat M. Enoxaparin for the secondary prevention of placental vascular complications in women with abruptio placentae. The pilot randomised controlled NOH-AP trial. Thromb Haemost 2010; 104: 771-9.
33. Laskin CA, Spitzer KA, Clark CA, Crowther MR, Ginsberg JS, Hawker GA, Kingdom JC, Barrett J, Gent M. Low molecular weight heparin and aspirin for recurrent pregnancy loss: results from the randomized, controlled HepASA Trial. J Rheumatol 2009; 36: 279-87.
34. Hart R, McMahon CA. Mood state and psychological adjustment to pregnancy. Arch Womens Ment Health 2006; 9: 329-37.
35. Barnett B, Schaafsma MF, Guzman AM, Parker GB. Maternal anxiety: a 5-year review of an intervention study. J Child Psychol Psychiatry 1991; 32: 423-38.
36. Austin MP, Tully L, Parker G. Examining the relationship between antenatal anxiety and postnatal depression. J Affect Disord 2007; 101: 169-74.
37. Grant KA, McMahon C, Austin MP. Maternal anxiety during the transition to parenthood: a prospective study. J Affect Disord 2008; 108: 101-11.
38. Fertl KI, Bergner A, Beyer R, Klapp BF, Rauchfuss M. Levels and effects of different forms of anxiety during pregnancy after a prior miscarriage. Eur J Obstet Gynecol Reprod Biol 2009; 142: 23-9.
39. Lee MJ, Roman AS, Lusskin S, Chen D, Dulay A, Funai EF, Monteagudo A. Maternal anxiety and ultrasound markers for aneuploidy in a multiethnic population. Prenat Diagn 2007; 27: 40-5.
40. Cheng PJ, Wu TL, Shaw SW, Chueh HY, Lin CT, Hsu JJ, Hsieh TT, Soong YK. Anxiety levels in women undergoing prenatal maternal serum screening for Down syndrome: the effect of a fast reporting system by mobile phone short-message service. Prenat Diagn 2008; 28: 417-21.
41. Hewison J, Nixon J, Fountain J, Hawkins K, Jones CR, Mason G, Morley S, Thornton JG. A randomised trial of two methods of issuing prenatal test results: the ARIA (Amniocentesis Results: Investigation of Anxiety) trial. BJOG 2007; 114: 462-8.
42. Crowther CA, Hiller JE, Moss JR, McPhee AJ, Jeffries WS, Robinson JS. Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med 2005; 352: 2477-86.
43. Akolekar R, Syngelaki A, Sarquis R, Zvanca M, Nicolaides KH. Prediction of early, intermediate and late pre-eclampsia from maternal factors, biophysical and biochemical markers at 11-13weeks. Prenat Diagn 2011; 31: 66-74.
44. Thilaganathan B, Wormald B, Zanardini C, Sheldon J, Ralph E, Papageorghiou AT. Early-pregnancy multiple serum markers and second-trimester uterine artery Doppler in predicting preeclampsia. Obstet Gynecol 2010; 115: 1233-8.
45. Krebs C, Macara LM, Leiser R, Bowman AW, Greer IA, Kingdom JC. Intrauterine growth restriction with absent end-diastolic flow velocity in the umbilical artery is associated with maldevelopment of the placental terminal villous tree. Am J Obstet Gynecol 1996; 175: 1534-42.
46. Nordenvall M, Ullberg U, Laurin J, Lingman G, Sandstedt B, Ulmsten U. Placental morphology in relation to umbilical artery blood velocity waveforms. Eur J Obstet Gynecol Reprod Biol 1991; 40: 179-90.
47. Green D, Hull RD, Brant R, Pineo GF. Lower mortality in cancer patients treated with low-molecular-weight versus standard heparin. Lancet 1992; 339: 1476.
48. Sobel ML, Kingdom J, Drewlo S. Angiogenic response of placental villi to heparin. Obstet Gynecol 2011; 117: 1375-83.
49. Sela S, Natanson-Yaron S, Zcharia E, Vlodavsky I, Yagel S, Keshet E. Local retention versus systemic release of soluble VEGF receptor-1 are mediated by heparin-binding and regulated by heparanase. Circ Res 2011; 108: 1063-70.
50. Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, Sibai BM, Epstein FH, Romero R, Thadhani R, Karumanchi SA. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 2006; 355: 992-1005.
51. Fitzgerald B, Levytska K, Kingdom J, Walker M, Baczyk D, Keating S. Villous trophoblast abnormalities in extremely preterm deliveries with elevated second trimester maternal serum hCG or inhibin-A. Placenta 2011; 32: 339-45.
52. Bujold E, Morency AM, Roberge S, Lacasse Y, Forest JC, Giguere Y. Acetylsalicylic acid for the prevention of preeclampsia and intra-uterine growth restriction in women with abnormal uterine artery Doppler: a systematic review and meta-analysis. J Obstet Gynaecol Can 2009; 31: 818-26.
53. Yu CK, Papageorghiou AT, Parra M, Palma Dias R, Nicolaides KH. Randomized controlled trial using low-dose aspirin in the prevention of pre-eclampsia in women with abnormal uterine artery Doppler at 23weeks' gestation. Ultrasound Obstet Gynecol 2003; 22: 233-9.