Stepwise aromatic nucleophilic substitution in continuous flow. Synthesis of an unsymmetrically substituted 3,5-diamino-benzonitrile library

Molecular Diversity

Volumn 15, Issue 3, 2011, Pages 631-638

  Lengyel, László ^a   Gyóllai, Viktor ^a   Nagy, Tamás ^a,c   Dormán, György ^a   Terleczky, Péter ^b   Háda, Viktor ^b   Nógrádi, Katalin ^b   Sebők, Ferenc ^b   Ürge, László ^a   Darvas, Ferenc ^a  

^a Thalesnano Inc   (Hungary)

^b GEDEON RICHTER LTD   (Hungary)

^c EGIS PHARMACEUTICALS LTD   (Hungary)

Author keywords

Continuous flow chemistry; Enhanced parameter space; Fluorine amine exchange; Nucleophilic substitution

Indexed keywords

3,5 DIAMINO BENZONITRILE DERIVATIVE; BENZENE DERIVATIVE; BENZONITRILE; FLUORINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; NUCLEOPHILICITY; PRIORITY JOURNAL; SYNTHESIS; TEMPERATURE;

EID: 80051582709     PISSN: 13811991     EISSN: 1573501X     Source Type: Journal    
DOI: 10.1007/s11030-010-9300-3     Document Type: Article

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