Anti-diabetic effect of standardized herbal formula PM021 consisting of Mori Folium and Aurantii Fructus on type II diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats

Diabetes Research and Clinical Practice

Volumn 93, Issue 2, 2011, Pages 198-204

  Kim, Jong Hoon ^a   Chung, Hwan Suck ^b   Kang, Moonkyu ^c   Kim, Yong ^b   Kim, Byung Su ^d   Kim, Youn Sub ^d   Bae, Hyunsu ^b  

^a Chonbuk National University   (South Korea)

^b Kyung Hee University   (South Korea)

^c Central Research Institute   (South Korea)

^d Gachon University College of Medicine   (South Korea)

Author keywords

Diabetes; LETO; OLETF

Indexed keywords

GLUCOSE; HERBACEOUS AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; AURANTII FRUCTUS; BLOOD GLUCOSE MONITORING; CONTROLLED STUDY; DIABETIC OBESITY; DRUG EFFECT; DRUG MECHANISM; FEMALE; FOOD INTAKE; GENETIC REGULATION; GLUCOSE BLOOD LEVEL; HERB; HERBAL MEDICINE; MALE; MORI FOLIUM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; OTSUKA LONG EVANS TOKUSHIMA FATTY RAT; RAT; TOXICITY TESTING; TREATMENT DURATION; URINE VOLUME; WEIGHT CHANGE;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; DRUG TOXICITY; EATING; HYPOGLYCEMIC AGENTS; MALE; PLANT PREPARATIONS; RATS; RATS, INBRED OLETF; URINE;

EID: 80051571596     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2011.03.037     Document Type: Article

References (25)

1. Lago R.M., Singh P.P., Nesto R.W. Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials. Lancet 2007, 370:1129-1136.
2. Nissen S.E., Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007, 356:2457-2471.
3. Modak M., Dixit P., Londhe J., Ghaskadbi S., Paul A.D.T. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr 2007, 40:163-173.
4. Nojima H., Kimura I., Chen F.J., Sugihara Y., Haruno M., Kato A., et al. Antihyperglycemic effects of N-containing sugars from Xanthocercis zambesiaca, Morus bombycis, Aglaonema treubii, and Castanospermum australe in streptozotocin-diabetic mice. J Nat Prod 1998, 61:397-400.
5. Andallu B., Varadacharyulu N. Antioxidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin-diabetic rats. Clin Chim Acta 2003, 338:3-10.
6. Kim H., Jang M.H., Shin M.C., Chang H.K., Lee T.H., Lim B.V., et al. Folium mori increases cell proliferation and neuropeptide Y expression in dentate gyrus of streptozotocin-induced diabetic rats. Biol Pharm Bull 2003, 26:434-437.
7. Huang Y.T., Wang G.F., Chen C.F., Chen C.C., Hong C.Y., Yang M.C. Fructus aurantii reduced portal pressure in portal hypertensive rats. Life Sci 1995, 57:2011-2020.
8. Liu J.C., Chan P., Hsu F.L., Chen Y.J., Hsieh M.H., Lo M.Y., et al. The in vitro inhibitory effects of crude extracts of traditional Chinese herbs on 3-hydroxy-3-methylglutaryl-coenzyme A reductase on Vero cells. Am J Chin Med 2002, 30:629-636.
9. Kurowska E.M., Manthey J.A. Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia. J Agric Food Chem 2004, 52:2879-2886.
10. Kim H.M., Kim H.J., Park S.T. Inhibition of immunoglobulin E production by Poncirus trifoliata fruit extract. J Ethnopharmacol 1999, 66:283-288.
11. Singh D., Chopra K. The effect of naringin, a bioflavonoid on ischemia-reperfusion induced renal injury in rats. Pharmacol Res 2004, 50:187-193.
12. Huang Y.T., Lin H.C., Chang Y.Y., Yang Y.Y., Lee S.D., Hong C.Y. Hemodynamic effects of synephrine treatment in portal hypertensive rats. Jpn J Pharmacol 2001, 85:183-188.
13. Jung U.J., Lee M.K., Jeong K.S., Choi M.S. The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice. J Nutr 2004, 134:2499-2503.
14. Jung U.J., Lee M.K., Park Y.B., Kang M.A., Choi M.S. Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. Int J Biochem Cell Biol 2006, 38:1134-1145.
15. Chen Y.T., Zheng R.L., Jia Z.J., Ju Y. Flavonoids as superoxide scavengers and antioxidants. Free Radic Biol Med 1990, 9:19-21.
16. Calderone V., Chericoni S., Martinelli C., Testai L., Nardi A., Morelli I., et al. Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels. Naunyn Schmiedebergs Arch Pharmacol 2004, 370:290-298.
17. McGarry J.D. Disordered metabolism in diabetes: have we underemphasized the fat component?. J Cell Biochem 1994, 55(Suppl.):29-38.
18. Kawano K., Hirashima T., Mori S., Saitoh Y., Kurosumi M., Natori T. Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 1992, 41:1422-1428.
19. Antin J., Gibbs J., Holt J., Young R.C., Smith G.P. Cholecystokinin elicits the complete behavioral sequence of satiety in rats. J Comp Physiol Psychol 1975, 89:784-790.
20. Moran T.H., Bi S. Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors. Philos Trans R Soc Lond B Biol Sci 2006, 361:1211-1218.
21. Shima K., Zhu M., Mizuno A. Pathoetiology and prevention of NIDDM lessons from the OLETF rat. J Med Invest 1999, 46:121-129.
22. Kawano K., Hirashima T., Mori S., Natori T. OLETF (Otsuka Long-Evans Tokushima Fatty) rat: a new NIDDM rat strain. Diabetes Res Clin Pract 1994, 24(Suppl.):S317-S320.
23. Suzuki Y.A., Tomoda M., Murata Y., Inui H., Sugiura M., Nakano Y. Antidiabetic effect of long-term supplementation with Siraitia grosvenori on the spontaneously diabetic Goto-Kakizaki rat. Br J Nutr 2007, 97:770-775.
24. Little R.R., Sacks D.B. HbA1c: how do we measure it and what does it mean?. Curr Opin Endocrinol Diabetes Obes 2009, 16:113-118.
25. Reaven G.M., Brand R.J., Chen Y.D., Mathur A.K., Goldfine I. Insulin resistance and insulin secretion are determinants of oral glucose tolerance in normal individuals. Diabetes 1993, 42:1324-1332.