An ArsR-like transcriptional factor recognizes a conserved sequence motif and positively regulates the expression of phoP in mycobacteria

Biochemical and Biophysical Research Communications

Volumn 411, Issue 4, 2011, Pages 726-731

  Gao, Chun Hui ^a   Yang, Min ^a   He, Zheng Guo ^a  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

Author keywords

ArsR; Mycobacteria; PhoPR; Transcriptional regulation

Indexed keywords

BETA GALACTOSIDASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ARSR; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; BACTERIAL GENE; BACTERIAL ONE HYBRID ASSAY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE MAPPING; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC ANALYSIS; INVERTED REPEAT; MOLECULAR INTERACTION; MYCOBACTERIUM; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OPERON; PHOP GENE; POSITIVE FEEDBACK; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REPRESSOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID MOTIFS; BACTERIAL PROTEINS; BASE SEQUENCE; CONSERVED SEQUENCE; GENE EXPRESSION REGULATION, BACTERIAL; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; PHYLOGENY; PROMOTER REGIONS, GENETIC; TRANS-ACTIVATORS;

CORYNEBACTERINEAE; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS;

EID: 80051570211     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.07.014     Document Type: Article

References (28)

1. World Health Organization (WHO), Global Tuberculosis Control - Epidemiology, Strategy, Financing, Nonserial Publication, 2009.
2. Ginsberg A.M., Spigelman M. Challenges in tuberculosis drug research and development. Nat. Med. 2007, 13:290-294.
3. Walters S.B., Dubnau E., Kolesnikova I., Laval F., Daffe M., Smith I. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006, 60:312-330.
4. Frigui W., Bottai D., Majlessi L., Monot M., Josselin E., Brodin P., et al. Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP. PLoS Pathog. 2008, 4:e33.
5. Gonzalo-Asensio J., Mostowy S., Harders-Westerveen J., Huygen K., Hernández-Pando R., Thole J., et al. PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence. PLoS ONE 2008, 3:e3496.
6. Martin C., Williams A., Hernandez-Pando R., Cardona P.J., Gormley E., Bordat Y., et al. The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and guinea pigs. Vaccine 2006, 24:3408-3419.
7. Lee J.S., Krause R., Schreiber J., Mollenkopf H.-J., Kowall J., Stein R., et al. Mutation in the transcriptional regulator PhoP contributes to avirulence of Mycobacterium tuberculosis H37Ra strain. Cell Host Microbe 2008, 3:97-103.
8. Summers A.O. Damage control: regulating defenses against toxic metals and metalloids. Curr. Opin. Microbiol. 2009, 12:138-144.
9. Tottey S., Harvie D.R., Robinson N.J. Understanding how cells allocate metals using metal sensors and metallochaperones. Acc. Chem. Res. 2005, 38:775-783.
10. Lucarelli D., Russo S., Garman E., Milano A., Meyer-Klaucke W., Pohl E. Crystal structure and function of the zinc uptake regulator FurB from Mycobacterium tuberculosis. J. Biol. Chem. 2007, 282:9914-9922.
11. Campbell D.R., Chapman K.E., Waldron K.J., Tottey S., Kendall S., Cavallaro G., et al. Mycobacterial cells have dual nickel-cobalt sensors. J. Biol. Chem. 2007, 282:32298-32310.
12. Barbosa R.L., Benedetti C.E. BigR a transcriptional repressor from plant-associated bacteria regulates an operon implicated in biofilm growth. J. Bacteriol. 2007, 189:6185-6194.
13. Chauhan S., Kumar A., Singhal A., Tyagi J.S., Prasad H.K. CmtR, a cadmium-sensing ArsR-SmtB repressor cooperatively interacts with multiple operator sites to autorepress its transcription in Mycobacterium tuberculosis. FEBS J. 2009, 276:3428-3439.
14. Arunkumar A.I., Campanello G.C., Giedroc D.P. Solution structure of a paradigm ArsR family zinc sensor in the DNA-bound state. Proc. Natl. Acad. Sci. USA 2009, 106:18177-18182.
15. Cavet J.S., Graham A.I., Meng W., Robinson N.J. A cadmium-lead-sensing ArsR-SmtB repressor with novel sensory sites. Complementary metal discrimination by NmtR AND CmtR in a common cytosol. J. Biol. Chem. 2003, 278:44560-44566.
16. Guo M., Feng H., Zhang J., Wang W., Wang Y., Li Y., et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009, 19:1301-1308.
17. Li Y., Zeng J., Zhang H., He Z.-G. The characterization of conserved binding motifs and potential target genes for M. tuberculosis MtrAB reveals a link between the two-component system and the drug resistance of M. smegmatis. BMC Microbiol. 2010, 10:242.
18. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
19. Langermann S., Palaszynski S., Sadziene A., Stover C.K., Koenig S. Systemic and mucosal immunity induced by BCG vector expressing outer-surface protein A of Borrelia burgdorferi. Nature 1994, 372:552-555.
20. Jeffrey H. Miller, Experiments in Molecular Genetics, Cold Spring Harbor Laboratory, 1972.
21. Zhang L., Zhang L., Liu Y., Yang S., Gao C., Gong H., et al. Archaeal eukaryote-like Orc1/Cdc6 initiators physically interact with DNA polymerase B1 and regulate its functions. Proc. Natl. Acad. Sci. USA 2009, 106:7792-7797.
22. Blokpoel M.C.J., Murphy H.N., O'Toole R., Wiles S., Runn E.S.C., Stewart G.R., et al. Tetracycline-inducible gene regulation in mycobacteria. Nucleic Acids Res. 2005, 33:e22.
23. Crooks G.E., Hon G., Chandonia J.-M., Brenner S.E. WebLogo: a sequence logo generator. Genome Res. 2004, 14:1188-1190.
24. Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., et al. Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv. PLoS ONE 2008, 3:e2375.
25. Ryndak M., Wang S., Smith I. PhoP, a key player in Mycobacterium tuberculosis virulence. Trends Microbiol. 2008, 16:528-534.
26. Wu J., Rosen B.P. The ArsR protein is a trans-acting regulatory protein. Mol. Microbiol. 1991, 5:1331-1336.
27. Liu M., Alice A.F., Naka H., Crosa J.H. The HlyU protein is a positive regulator of rtxA1, a gene responsible for cytotoxicity and virulence in the human pathogen Vibrio vulnificus. Infect. Immun. 2007, 75:3282-3289.
28. Williams S.G., Attridge S.R., Manning P.A. The transcriptional activator HlyU of Vibrio cholerae: nucleotide sequence and role in virulence gene expression. Mol. Microbiol. 1993, 9:751-760.