In vitro and in vivo studies on antitumor effects of gossypol on human stomach adenocarcinoma (AGS) cell line and MNNG induced experimental gastric cancer

Biochemical and Biophysical Research Communications

Volumn 411, Issue 4, 2011, Pages 661-666

  Gunassekaran, G R ^a   Kalpana Deepa Priya, D ^a   Gayathri, R ^a   Sakthisekaran, D ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

3 (4,5 Dimethylthiazol 2 yl) 2,5 diphenyl tetrazolium bromide (MTT); Carcino embryonic antigen (CEA); Gastric cancer; Gossypol; Human gastric adenocarcinoma cell line (AGS); Membrane damage; N Methyl N nitro N nitrosoguanidine (MNNG)

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; DNA; GLYCOPROTEIN; GOSSYPOL; PEPSIN A; RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER SURVIVAL; CELL SURVIVAL; COMPETITIVE INHIBITION; CONTROLLED STUDY; DNA CONTENT; DRUG CYTOTOXICITY; EXPERIMENTAL STUDY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MEMBRANE DAMAGE; NONHUMAN; PRIORITY JOURNAL; RAT; RNA ANALYSIS; STOMACH ADENOCARCINOMA;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; GOSSYPOL; HUMANS; MALE; NEOPLASMS, EXPERIMENTAL; PEPSIN A; RATS; RATS, WISTAR; STOMACH NEOPLASMS; TRYPAN BLUE;

ANIMALIA;

EID: 80051568636     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.06.167     Document Type: Article

References (47)

1. Crew K.D., Neugut A.I. Epidemiology of gastric cancer. World J. Gastroenterol. 2006, 12:354-362.
2. Arivazhagan S., Kavitha K., Nagini S. Erythrocyte lipid peroxidation and antioxidants in gastric cancer patients. Cell Biochem. Funct. 1997, 15:15-18.
3. Lewin K.J., Appelman H.D. Atlas of Tumor Pathology 1995, Armed Forces Institute of Pathology, Washington DC.
4. Laurén P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta. Pathol. Microbiol. Scand. 1965, 64:31-49.
5. Endo H., Takahaski K., Kinoshita N., Utsunoniya T., Baba T. An approach to the detection of possible etiologic factors in human gastric cancer. Gann. Monogr. Cancer Res. 1975, 17:17-29.
6. Arivazhagan S., Balasenthil S., Nagini S. Modulatory effects of garlic and neem leaf extracts on N-methyl-N′-nitro-N-Nitrosoguanidine (MNNG) induced oxidative stress in Wistar rats. Cell Biochem. Funct. 2000, 18:17-21.
7. Mirrish S.S. Fromation of N-nitroso compounds chemistry kinetics and in vivo occurrence. Toxicol. Appl. Pharmacol. 1975, 31:325-351.
8. Tuszynski G.P., Cossu G. Differential cytotoxicity of gossypol on human melonoma, colon carcinoma, and other tissue culture cell lines. Cancer Research 1984, 44:768-771.
9. Jaroszewski J.W., Kaplan O., Cohen J.J. Action of gossypol and rhodamine 123 on wild type and multi-drug resistant MCF-7 human breast cancer cells: 31pnuclear magnetic resonance and toxicity studies. Cancer Res. 1990, 50:6936-6943.
10. Wang Y.C., Rao P.N. Effect of gossypol on DNA synthesis and cell cycle progression of mammalian cells in vitro. Cancer Res. 1984, 44:35-38.
11. Gilbert N.E., O'Reilly J.E., Chang C.J., Lin Y.C., Brueggemeier R.W. Antiproliferative activity of gossypol and gossypolone on human breast cancer cells. Life Sci. 1995, 57:61-67.
12. Tso W.W. Gossypol inhibits Ehrlich ascites tumour cell proliferation. Cancer Lett. 1984, 24:257-261.
13. Rao P.N., Wang Y., Lotzova E., Khan A.A., Rao S.P., Stephens L.C. Antitumour effects of gossypol on murine tumours. Cancer Chemotherapy Pharmacology 1985, 15:20-25.
14. Flack M.R., Pyle R.G., Mullen N.M., Lorenzo B., Wu Y.W., Knazek R.A., Nisula B.C., Reidenberg M.M. Oral gossypol in the treatment of metastatic adrenal cancer. J. Clin. Endocrinol. Metab. 1993, 76:1019-1024.
15. Mohammad R.M., Wang S., Banerjee S., Wu X., Chen J., Sarkar F.H. Nonpeptidic small-molecule inhibitor of Bcl2 and Bcl-XL (-)-gossypol, enhances biological effect of genistein against BXPC-3 human pancreatic cancer cell line. Pancreas 2005, 31:317-324.
16. Mohammad R.M., Wang S., Aboukameel A., Chen B., Wu X., Chen J., Alkatib A. Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L)(-)-gossypol) against diffuse large cell lymphoma. Molecular Cancer Therapy 2005, 4:13-21.
17. Gunassekaran G.R., Gayathri R., Kalpana Deepa Priya D., Murugan S., Sakthisekaran D. Protective role of gossypol against N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) induced gastric carcinogenesis in experimental rats. Int. J. Med. Med. Sci. 2010, 2:121-127.
18. Bergmeyer H.U. Methods in Enzymatic Analysis 1984, vol. 5. VCH Publishers., pp. 232-233. 3rd ed.
19. Zhitkovich A., Costa M. A simple, sensitive assay to detect DNA-protein crosslinks in intact cells and in vivo. Carcinogenesis 1992, 13:1485-1489.
20. Levine R.L. Carbonyl modified proteins in cellular regulation, aging, and disease. Free Radic. Biol. Med. 2002, 32:790-796.
21. Burton K. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem. J. 1956, 62:315-323.
22. Rawal U.M., Patel U.S., Rao G.N., Desai R.R. Clinical and biochemical studies on cataractous human lens III. Quantitative study of protein, RNA and DNA. Arogya J. Health Sci. 1977, 3:69-72.
23. Lowry O.H., Rosenbrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin's phenol reagent. J. Biol. Chem. 1951, 193:265-276.
24. Niebes P. Determination of enzyme and degradation products of GAG metabolism in the serum of healthy and varicose subjects. Clin. Chim. Acta 1972, 42:399-408.
25. Wagner W.D. More sensitive assay discriminating galactosamine and glucosamine in mixtures. Anal. Biochem. 1974, 94:394-397.
26. Warren L. The thiobarbituric acid assay of sialic acid. J. Biol. Chem. 1959, 234:1971-1975.
27. Graham D.Y. Helicobacter pylori infection is the primary cause of gastric cancer. J. Gastroenterol. 2000, 35(Suppl. 12):90-97.
28. Palli D. Epidemiology of gastric cancer: an evaluation of available evidence. J. Gastroenterol. 2000, 35(Suppl. 12):84-89.
29. Nagabhushan M., Bhide S.V. Curcumin as an inhibitor of cancer. J. Am. Coll. Nutr. 1992, 11:1992-1998.
30. Plummer S.M., Holloway K.A., Manson M.M., Munks R.J., Kaptein A., Farrow S., Howells L. Inhibition of cyclooxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signaling complex. Oncogene 1999, 18:6013-6020.
31. Sen C.H., Packer L. Antioxidant and redox regulation of gene transcription. FASEB J. 1996, 10:709-720.
32. Balci A., Sahin F.I., Ekmekci A. Gossypol induced apoptosis in the human promyelocytic leukemia cell line HL 60. Tohoku J. Exp. Med. 1999, 189:51-57.
33. Benz C.C., Keniry M.A., Ford J.M., Townsend A.J., Cox F.W., Palayoor S., Matlin S.A., Hait W.N., Cowan K.H. Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantiomers. Mol. Pharmacol. 1990, 37:840-847.
34. Huang Y.W., Wang L.S., Chang H.L., Ye W., Dowd M.K., Wan P.J., Lin Y.C. Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells. Anticancer Res. 2006, 26:1925-1933.
35. Zhang M., Liu H., Guo R., Ling Y., Wu X., Li B., Roller P.P., Wang S., Yang D. Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. Biochem. Pharmacol. 2003, 66:93-103.
36. Wu Y.W., Chik C.L., Knazek R.A. An in vitro and in vivo study of antitumor effects of Gossypol on human SW-13Adrenocortical carcinoma. Cancer Res. 1989, 49:3754-3758.
37. Tso W.W. Gossypol inhibits Ehrlich ascites tumor cell proliferation. Cancer Lett. 1984, 24:257-261.
38. Miller J.A. Carcinogenesis by chemicals: an overview. Cancer Res. 1970, 30:559-576.
39. Beard S.E., Capaldi S.R., Gee P. Stress responses to DNA damaging agents in the human colon carcinoma cell line. RKO. Mutat. Res. 1996, 371:1-13.
40. Jessup J.M., Ishii S., Mitzol T., Edmiston K.H., Shoji Y. CEA facilitates experimental metastasis a mechanism that does not involve adhesion to liver cells. Clin. Exp. Metastasis 1999, 17:481-488.
41. Krop-Watorek A., Laskowska A., Salwa J., Klopocki A.G., Grunert F., Ugorski M. CEA related proteins on human urothelial cell lines of different transfection grades. Cancer Lett. 1999, 139:15-22.
42. Yoshioka T., Masuko T., Kotanagi H., Aizawa O., Saito Y., Nakazato H., Koyama K., Hashimoto Y. Homotypic adhesion through carcinoembryonic antigen plays a role in hepatic metastasis development. Jpn. J. Cancer Res. 1998, 89:177-185.
43. Crook M. The determination of plasma or serum sialic acid. Clin. Biochem. 1993, 26:31-38.
44. Dich J., Zahm S.H., Hanberg A., Adami H.O. Pesticides and cancer. Cancer Causes Control 1997, 8:420-443.
45. Erbil K., Jones J.D., Klee G.G. Use and limitations of serum total and Lipid-bound sialic acid concentrations as markers for colorectal cancer. Cancer 1985, 55:404-409.
46. Kokoglu E., Sonmez H., Uslu E., Uslu I. Sialic acid levels in various types of cancer. Cancer Biochem. Biophys. 1992, 13:57-64.
47. Palani V., Senthilkumaran R.K., Govindasamy S. Biochemical evaluation of antitumour effect of Muthu Marunthu (a herbal formulation) on experimental fibrosarcoma in rats. J. Ethnopharmacol. 1999, 65:257-265.