Dietary administration of Curcumin modifies transcriptional profile of genes involved in inflammatory cascade in horse leukocytes

Italian Journal of Animal Science

Volumn 8, Issue SUPPL. 2, 2009, Pages 84-86

  Farinacci, Maura ^a   Gaspardo, Brigitta ^a   Colitti, Monica ^a   Stefanon, Bruno ^a  

^a UNIVERSITY OF UDINE   (Italy)

Author keywords

Curcumin; Cytokines; Horses; Osteoarthritis

Indexed keywords

ANIMALIA; EQUIDAE;

EID: 80051566772     PISSN: 15944077     EISSN: None     Source Type: Journal    
DOI: 10.4081/ijas.2009.s2.84     Document Type: Article

References (12)

1. Banerjee, M., Tripathi, L.M., Srivastava, V.M., Puri, A., Shukla, R., 2003. Modulation of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat. Immunopharmacol. Immunotoxicol. 25:213-224.
2. Bustin, S.A., 2000. Absolute quantification of mRNA using realtime reverse transcription polymerase chain reaction assays. J. Mol. Endocrinol. 25:169-193.
3. Feghali, C.A., Wright, T.M., 1997. Cytokines in acute and chronic inflammation. Front. Biosci. 2:12-26.
4. Gangl, M., Serteyn, D., Lejeune, J.P., Schneider, N., Grulke, S., Peters, F., Vila, T., Deby-Dupont, G., Deberg, M., Henrotin, Y., 2007. A type II-collagen derived peptide and its nitrated form as new markers of inflammation and cartilage degradation in equine osteochondral lesions. Res. Vet. Sci. 82:68-75.
5. Goldring, M.B., 2000. The role of the chondrocyte in osteoarthritis. Arthritis Rheum. 4:1916-1926.
6. Islam, S., Kermode, T., Sultana, D., Moskowitz, R.W., Mukhtar, H., Malemud, C.J., Goldberg, V.M., Haqqi, T.M., 2001. Expression profile of protein tyrosine kinase genes in human osteoarthritis chondrocytes. Osteoarthr. Cartil. 9:684-693.
7. Jeffcott, L.B., Henson, F.M.D., 1998. Studies on growth cartilage in the horse and their application to aetiopathogenesis of dyschondroplasia (Osteochondrosis). Vet. J. 156:177-192.
8. Mengshol, J.A., Mix, K.S., Brinckerhoff, C.E., 2002. Matrix metalloproteinases as therapeutic targets in arthritic diseases: bull's-eye or missing the mark. Arthritis Rheum. 46:13-20.
9. Rozen, S., Skaletsky, H.J., 2000. Primer3 on the WWW for general users and for biologist programmers. In: S. Misener, S.A. Krawetz, N.J. Totowa (eds) Bioinformatics methods and protocols: methods in molecular biology. Humana Press, Totowa, NJ USA, pp. 365-386.
10. Shakibaei, M., John, T., Schulze-Tanzil, G., Lehmann, I., Mobasheri, A., 2007. Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis. Biochem. Pharmacol. 73:1434-1445.
11. SPSS, 1997. Statistical Package for Social Science SPSS Advanced Statistics 7.5. SPSS Inc, Chicago, IL, USA.
12. Todhunter, R.J., Lust, G., 1990. Pathophysiology of synovitis: clinical signs and examination in horses. Compend. Contin. Educ. Pract. Vet. 12:980-992.