Escitalopram treatment of menopausal hot flashes

Menopause

Volumn 18, Issue 8, 2011, Pages 893-896

  Freedman, Robert R ^a,b   Kruger, Michael L ^b   Tancer, Manuel E ^a  

^a Departments of Psychiatry and Behavioral Neurosciences   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Escitalopram; Hot flashes; Menopause; Thermoregulation

Indexed keywords

ESCITALOPRAM; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HOT FLUSH; HUMAN; MENOPAUSE; RANDOMIZED CONTROLLED TRIAL; RECTUM TEMPERATURE; SWEATING; TREATMENT DURATION; TREATMENT OUTCOME;

CITALOPRAM; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HOT FLASHES; HUMANS; MENOPAUSE; QUALITY OF LIFE; SEROTONIN UPTAKE INHIBITORS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; WOMEN'S HEALTH;

EID: 80051551792     PISSN: 10723714     EISSN: 15300374     Source Type: Journal    
DOI: 10.1097/gme.0b013e31820ccae9     Document Type: Article

References (20)

1. Freedman RR, Woodward S. Core body temperature during menopausal hot flushes. Fertil Steril 1996;65:1141-1144. (Pubitemid 26158629)
2. Freedman RR, Krell W. Reduced thermoregulatory null zone in postmenopausal women with hot flashes. Am J Ostet Gynecol 1999;181: 66-70. (Pubitemid 29343332)
3. Freedman RR, Woodward S. Elevated >2-adrenergic responsiveness in menopausal hot flushes: pharmacologic and biochemical studies. In: Lomax P, Schönbaum E, eds. Thermoregulation: The Pathophysiological Basis of Clinical Disorders. Basel: Karger, 1991:6-9.
4. Freedman RR. Biochemical metabolic, and vascular mechanisms in menopausal hot flashes. Fertil Steril 1998;70:1-6.
5. Freedman RR, Woodward S, Sabharwal SC. Adrenergic mechanism in menopausal hot flushes. Obstet Gynecol 1990;76:573-578. (Pubitemid 20322054)
6. Freedman RR, Dinsay R. Clonidine raises the sweating threshold in symptomatic but not in asymptomatic postmenopausal women. Fertil Steril 2000;74:20-23. (Pubitemid 30427267)
7. Brück K, Zeisberger E. Adaptive changes in thermoregulation and their neuropharmacological basis. In: Schönbaum E, Lomax P, eds. Thermoregulation: Physiology and Biochemistry. New York: Pergamon, 1990: 225-307.
8. Suvanto-Luukkonen E, Koivunen R, Sundstöm H, et al. Citalopram and fluoxetine in the treatment of postmenopausal symptoms: a prospective, randomized, 9-month, placebo-controlled, double-blind study. Menopause 2005;12:18-26. (Pubitemid 40204889)
9. Barton DL, LaVasseur BI, Sloan JA, et al. Phase III, placebo-controlled trial of three doses of citalopram for the treatment of hot flashes: NCCTG trial N05C9. J Clin Oncol 2010;28:3278-3283.
10. Sanchez C, BLgesL KP, Ebert B, Reines EH, Braetrup C. Escitalopram versus citalopram: the surprising role of the R-enantiomer. Psychopharmacology 2004;174:163-176. (Pubitemid 38916289)
11. Freedman RR, Woodward S. Behavioral treatment of menopausal hot flushes: evaluation by ambulatory monitoring. Am J Obstet Gynecol 1992;167:436-439.
12. Freedman RR, Woodward S, Brown B, Javaid J, Panday G. Biochemical and thermoregulatory effect of behavioral treatment for menopausal hot flashes. Menopause 1996;2:211-218.
13. Freedman RR, Wasson S. Miniature, hygrometric hot flash recorder. Fertil Steril 2007;88:494-496. (Pubitemid 47212151)
14. Defronzo Dobkin R, Menza M, Allen LA, et al. Escitalopram reduces hot flashes in nondepressed menopausal women: a pilot study. Ann Clin Psychiatry 2009;21:70-76.
15. Soares CN, Arsenio H, Joffe H, et al. Escitalopram versus ethinyl estradiol and norethindrone acetate for symptomatic peri-and postmenopausal women: impact on depression, vasomotor symptoms, sleep, and quality of life. Menopause 2006;13:780-786. (Pubitemid 44435032)
16. Freedman RR, Blacker CM. Estrogen raises the sweating threshold in postmenopausal women with hot flashes. Fertil Steril 2002;77:487-490. (Pubitemid 34177202)
17. Freedman RR. Treatment of menopausal hot flashes with 5-hydroxytryptophan. Maturitas 2010;65:383-385.
18. Carpenter JS, Yu M, Wu J, et al. Evaluating the role of serotonin in hot flashes after breast cancer using acute tryptophans depletion. Menopause 2009;16:644-652.
19. Stone AA, Shiffman S, Schwartz JE, Broderick JE, Hufford MR. Patient compliance with paper and electronic diaries. Control Clin Trials 2003;24: 182-199. (Pubitemid 36412017)
20. Takarangi MK, Garry M, Loftus EF. Dear diary, is plastic better than paper? I can't remember: comment on Green, Rafaeli, Bolger, Shrout, and Reis. Psychol Methods 2006;11:119-122. (Pubitemid 44084656)