Hypercalcemia in pregnancy: A case of Milk-Alkali syndrome

Journal of General Internal Medicine

Volumn 26, Issue 8, 2011, Pages 939-942

  Kolnick, Leanne ^a   Harris, Bryan D ^a   Choma, David P ^a   Choma, Neesha N ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

hypercalcemia; milk alkali syndrome; pregnancy

Indexed keywords

ALBUMIN; AMPICILLIN; BICARBONATE; CALCIUM; CALCIUM CARBONATE; CALCIUM ION; CEFTRIAXONE; CREATININE; FUROSEMIDE; MAGNESIUM; MAGNESIUM OXIDE; NON PRESCRIPTION DRUG; PARATHYROID HORMONE; PHOSPHOROUS ACID; POTASSIUM; POTASSIUM DIHYDROGEN PHOSPHATE; PROTON PUMP INHIBITOR; VITAMIN D;

ADULT; ALBUMIN BLOOD LEVEL; ANOREXIA; ARTERIAL GAS; BICARBONATE BLOOD LEVEL; BLOOD PRESSURE; BREATHING RATE; CALCIUM BLOOD LEVEL; CALCIUM INTAKE; CASE REPORT; CREATININE BLOOD LEVEL; DIET SUPPLEMENTATION; DIZZINESS; ECHOGRAPHY; FEMALE; FLANK PAIN; GASTROESOPHAGEAL REFLUX; HEADACHE; HOSPITAL ADMISSION; HUMAN; HYPERCALCEMIA; HYPOKALEMIA; HYPOMAGNESEMIA; HYPOPHOSPHATEMIA; IRON DEFICIENCY; LETHARGY; LEUKOCYTE; MAGNESIUM BLOOD LEVEL; MILK; MILK ALKALI SYNDROME; NAUSEA; NEPHROLITHIASIS; PARATHYROID HORMONE BLOOD LEVEL; PH; PHYSICAL EXAMINATION; POTASSIUM BLOOD LEVEL; PREGNANCY; PULSE RATE; RELATIVE DENSITY; REVIEW; SINGLE DRUG DOSE; SMOKING; TEMPERATURE; URINALYSIS; VITAMIN BLOOD LEVEL; VOMITING;

ADULT; CALCIUM CARBONATE; CALCIUM, DIETARY; FEMALE; HUMANS; HYPERCALCEMIA; PREGNANCY; PREGNANCY COMPLICATIONS;

EID: 80051546372     PISSN: 08848734     EISSN: 15251497     Source Type: Journal    
DOI: 10.1007/s11606-011-1658-0     Document Type: Review

References (31)

1. CL Cope 1936 Base changes in alkalosis produced by the treatment of gastric ulcers with alkalies Clin Sci 2 297 300
2. WS Haubrich 2005 Sippy of the Sippy diet regimen Gastroenterology 128 4 832 15825066 10.1053/j.gastro.2005.02.042
3. BW Sippy 1915 Gastric and duodenal ulcer: medical cure by an efficient removal of gastric juice corrosion JAMA 64 1625 1630
4. LL Hardt AB Rivers 1923 Toxic manifestations following the alkaline treatment of peptic ulcer Arch Intern Med 31 171 186
5. MJ Jamieson 1985 Hypercalcemia Br Med J 290 378 382 10.1136/bmj.290.6465. 378 1:STN:280:DyaL2M%2FpvVKhtQ%3D%3D
6. DP Beall HB Henslee HR Webb RH Scofield 2006 Milk-alkali syndrome: a historical review and description of the modern version of the syndrome Am J Med Sci 331 5 233 242 16702792 10.1097/00000441-200605000-00001 (Pubitemid 43804600)
7. Patel AM, Goldfarb S. Got Calcium? Welcome to milk-alkali syndrome. J Am Soc Nephrol. 2010; e1-4.
8. CS Kovacs HM Kronenberg 1997 Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation Endocr Rev 18 832 872 9408745 10.1210/er.18.6.832 1:CAS:528:DyaK1cXkvFCl (Pubitemid 28009569)
9. Gagel RF. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. 2nd ed. New York: Raven Press; 1993:411-512.
10. TR Kelly 1991 Primary hyperparathyroidism during pregnancy Surgery 110 1028 1033 1745971 1:STN:280:DyaK38%2FotV2rug%3D%3D
11. JE Richter 2003 Gastroesophageal reflux disease during pregnancy Gastroenterol Clin North Am 32 235 261 12635418 10.1016/S0889-8553(02)00065-1 (Pubitemid 36292708)
12. S Fill Malfertheiner MV Malfertheiner K Monkemuller FW Rohl P Malfertheiner SD Costa 2009 Gastroesophageal reflux disease and management in advanced pregnancy: a prospective survey Digestion 79 2 115 120 19321944 10.1159/000209381
13. MSM Ardawi HAN Nasrat HS Ba'Aqueel 1997 Calcium-regulating hormones and parathyroid hormone-related peptide in normal human pregnancy and postpartum: a longitudinal study Eur J Endocrinol 137 402 409 9368509 10.1530/eje.0.1370402 1:CAS:528:DyaK2sXnt1agu7s%3D (Pubitemid 27452175)
14. MK Picolos CR Sims JM Mastrobattista MA Carroll VR Lavis 2004 Milk-alkali syndrome in pregnancy Obstet Gynecol 104 5 Pt 2 1201 1204 15516453 10.1097/01.AOG.0000128109.44291.e2
15. R St-Arnaud A Arabian VW Yu O Akhouayri JC Knutson SA Strugnell 2008 1 alpha, 24(S)(OH)2D2 normalizes bone morphology and serum parathyroid hormone without hypercalcemia in 25-hydroxyvitamin D-1-hydroxylase (CYP27B1)-deficient mice, an animal model of vitamin D deficiency with secondary hyperparathyroidism J Endocrinol Investig 1 8 711 717
16. Goodman, WG, Quarles, LD. Brenner and Rector's The Kidney, 8th edition. Philadelphia: Saunders Elsevier. 2007. 1904-1930.
17. ZS Agus 1999 Hypomagnesemia J Am Soc Nephrol 10 7 1616 1622 10405219 1:STN:280:DyaK1Mzjt1Wgsg%3D%3D (Pubitemid 29297539)
18. DP Beall RH Scofield 1995 Milk-alkali syndrome associated with calcium carbonate consumption Med Baltimore 74 89 96 10.1097/00005792-199503000-00004 1:STN:280:DyaK2M7pvVGgsQ%3D%3D
19. MJ Amaya Garcia M Acosta Feria A Soto Moreno, et al. 2004 Primary hyperparathyroidism in pregnancy Gynecol Endocrinol 18 114 114 10.1080/09513590310001653008 (Pubitemid 38264900)
20. MV Gordon LP McMahon PS Hamblin 2005 Life-threatening milk-alkali syndrome resulting from antacid ingestion during pregnancy Med J Aust 182 7 350 351 15804228 (Pubitemid 40514934)
21. ME Ullian SL Linas 1988 The milk-alkali syndrome in pregnancy Miner Electrolyte Metabol 14 4 208 210 1:STN:280:DyaL1M%2Fps1Ohtg%3D%3D
22. CS Bailey JJ Weiner OM Gibby MD Penney 2008 Excessive calcium ingestion leading to milk-alkali syndrome Ann Clin Biochem 45 5 527 529 18753431 10.1258/acb.2008.008006 1:CAS:528:DC%2BD1cXht12itbbM
23. JS Bradley RT Wassel L Lee S Nambiar 2009 Intravenous ceftriaxone and calcium in the neonate: assessing the risk for cardiopulmonary adverse events Pediatrics 123 4 e609 e613 19289450 10.1542/peds.2008-3080
24. RA Wise AJ Polito V Krishnan 2006 Respiratory physiologic changes in pregnancy Immunol Allergy Clin N Am 26 1 12 10.1016/j.iac.2005.10.004 (Pubitemid 43144608)
25. SK Gill L O'Brien TR Einarson G Koren 2009 The safety of proton pump inhibitors (PPIs) in pregnancy: a meta-analysis Am J Gastroenterol 104 6 1541 1545 19491869 10.1038/ajg.2009.122 1:CAS:528:DC%2BD1MXms12jt7w%3D
26. SK Gill L O'Brien G Koren 2009 The safety of histamine 2 (H2) blockers in pregnancy: a meta-analysis Dig Dis Sci 54 9 1835 1838 19051023 10.1007/s10620-008-0587-1 1:CAS:528:DC%2BD1MXptVGnsbg%3D
27. B Pasternak A Hviid 2010 Use of proton-pump inhibitors in early pregnancy and the risk of birth defects N Engl J Med 363 2114 2123 21105793 10.1056/NEJMoa1002689 1:CAS:528:DC%2BC3cXhsV2gs7zL
28. CS Ennen EF Magann 2006 Milk-alkali syndome presenting as acute renal insufficiency during pregnancy Obstet Gynecol 108 3 Pt 2 785 786 17018502 10.1097/01.AOG.0000204867.25582.e5 (Pubitemid 44306426)
29. GE Kleinman H Rodriquez MC Good MR Caudle 1991 Hypercalcemic crisis in pregnancy associated with excessive ingestion of calcium carbonate antacid (milk-alkali syndrome): Successful treatment with hemodialysis Obstet Gynecol 78 3 Pt 2 496 499 1870805 1:STN:280:DyaK3Mzjtl2jsw%3D%3D
30. A Morton 2002 Milk-alkali syndrome in pregnancy, associated with elevated levels of parathyroid hormone-related protein Intern Med J 32 492 496 12380706 10.1046/j.1445-5994.2002.00277.x 1:STN:280:DC%2BD38nit1GntQ%3D%3D
31. S Addington N Larson RH Scofield 2006 Milk-alkali syndrome in pre-eclamptic pregnancy: report of a patient and evaluation of albumin-corrected calcium in pre-eclamptic pregnancies J Okla State Med Assoc 99 9 480 484 17087071