Regulation of hepatic stem/progenitor phenotype by microenvironment stiffness in hydrogel models of the human liver stem cell niche

Biomaterials

Volumn 32, Issue 30, 2011, Pages 7389-7402

  Lozoya, Oswaldo A ^a,b   Wauthier, Eliane ^a,b   Turner, Rachael A ^a,b   Barbier, Claire ^a,b   Prestwich, Glenn D ^c   Guilak, Farshid ^d   Superfine, Richard ^e   Lubkin, Sharon R ^a   Reid, Lola M ^a,b  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF UTAH   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e University of North Carolina at Chapel Hill   (United States)

Author keywords

Differentiation; Human hepatic stem cells; Human hepatoblasts; Hyaluronans; Maturational lineages; Microenvironment mechanical properties

Indexed keywords

HEPATIC STEM CELL; HUMAN HEPATOBLASTS; HYALURONANS; MATURATIONAL LINEAGES; MICROENVIRONMENTS;

BIOMECHANICS; BODY FLUIDS; CELL PROLIFERATION; ELASTICITY; GENE EXPRESSION; HYDROGELS; STEM CELLS; STIFFNESS;

CELL CULTURE;

HYALURONIC ACID;

ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL EXPANSION; CELL PROLIFERATION; CELL SIZE; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; FLOW MEASUREMENT; GENE EXPRESSION; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYDROGEL; IMMUNOHISTOCHEMISTRY; LIVER STEM CELL; MICROENVIRONMENT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; RIGIDITY; STEM CELL; STEM CELL NICHE; THREE DIMENSIONAL IMAGING;

CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; DIFFUSION; ELASTICITY; GENE EXPRESSION; HUMANS; HYALURONIC ACID; HYDROGELS; LIVER; PHENOTYPE; STEM CELL NICHE; STEM CELLS;

EID: 80051545803     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.06.042     Document Type: Article

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