The administration of high-dose methylprednisolone for 24 h reduced muscle size and increased atrophy-related gene expression in spinal cord-injured rats

Spinal Cord

Volumn 49, Issue 8, 2011, Pages 867-873

  Wu, Y ^a   Hou, J ^a   Collier, L ^a   Pan, J ^a   Hou, L ^a   Qin, W ^a,b   Bauman, W A ^a,b   Cardozo, C P ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

FOXO1; methylprednisolone; muscle atrophy; muscle ubiquitin ligases; REDD1; spinal cord injury

Indexed keywords

ATROGIN 1; MEMBRANE PROTEIN; MESSENGER RNA; METHYLPREDNISOLONE; MUSCLE RING FINGER 1 PROTEIN; PROTEIN REDD1; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG MEGADOSE; GASTROCNEMIUS MUSCLE; GENE EXPRESSION; HISTOPATHOLOGY; MALE; MUSCLE ATROPHY; MUSCLE MASS; NONHUMAN; PLANTARIS MUSCLE; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; SOLEUS MUSCLE; SPINAL CORD INJURY; TRICEPS BRACHII MUSCLE;

ANALYSIS OF VARIANCE; ANIMALS; DISEASE MODELS, ANIMAL; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; MALE; METHYLPREDNISOLONE; MUSCLE PROTEINS; MUSCLE, SKELETAL; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; ORGAN SIZE; RATS; RATS, WISTAR; REPRESSOR PROTEINS; SKP CULLIN F-BOX PROTEIN LIGASES; SPINAL CORD INJURIES; TIME FACTORS; UBIQUITIN-PROTEIN LIGASES;

EID: 80051543706     PISSN: 13624393     EISSN: 14765624     Source Type: Journal    
DOI: 10.1038/sc.2011.28     Document Type: Article

References (26)

1. Frankel H. Spinal cord injury units. Paraplegia 1987; 25: 239-240.
2. Bedbrook GM. Lifetime Care of the Paraplegic Patient. Churchill Livingstone: Edinburgh, 1985.
3. Guttmann L. Spinal cord Injuries. Comprehensive Management and Research, 2nd edn. Blackwell Scientific Publications: Oxford, 1976.
4. Donovan WH, Carter RE, Bedbrook GM, Young JS, Griffiths ER. Incidence of medical complications in spinal cord injury: Patients in specialised, compared with non-specialised centres. Paraplegia 1984; 22: 282-290. (Pubitemid 16245247)
5. Hamilton BB, Rath GJ, Meyer Jr. PR, Rosen JS. A basic evaluation framework for spinal cord injury care systems. Paraplegia 1976; 14: 87-94.
6. Yarkony GM, Bass LM, Keenan V, Meyer Jr. PR. Contractures complicating spinal cord injury: Incidence and comparison between spinal cord centre and general hospital acute care. Paraplegia 1985; 23: 265-271. (Pubitemid 16240353)
7. Heinemann AW, Yarkony GM, Roth EJ, Lovell L, Hamilton B, Ginsburg K et al. Functional outcome following spinal cord injury. A comparison of specialized spinal cord injury center vs. general hospital short term care. Arch Neurol 1989; 46: 1098-1102. (Pubitemid 19246299)
8. Tator CH, Duncan EG, Edmonds VE, Lapczak LI, Andrews DF. Neurological recovery, mortality and length of stay after acute spinal cord injury associated with changes in management. Paraplegia 1995; 33: 254-262.
9. Charles ED, Fine PR, Stover SL, Wood T, Lott AF, Kronenfeld J. The costs of spinal cord injury. Paraplegia 1977-8; 15: 302-310. (Pubitemid 8274962)
10. New PW, Sundararajan V. Incidence of non-traumatic spinal cord injury in Victoria, Australia: A population-based study and literature review. Spinal Cord 2008; 46: 406-411. (Pubitemid 351793812)
11. New PW. Non-traumatic spinal cord injury: What is the ideal setting for rehabilitation? Aust Health Rev 2006; 30: 353-361.
12. Celani MG, Spizzichino L, Ricci S, Zampolini M, Franceschini M. Spinal cord injury in Italy: A multicentre retrospective study. Arch Phys Med Rehabil 2001; 82: 589-596. (Pubitemid 32423572)
13. Smith M. Efficacy of specialist versus non-specialist management of spinal cord injury within the UK. Spinal Cord 2002; 40: 11-16. (Pubitemid 34076356)
14. Simmonds F, Stevermuer T. The AROC annual report: The state of rehabilitation in Australia 2005. Aust Health Rev 2007; 31 (suppl 1): S31-S53.
15. Simmonds F, Stevermuer T. The AROC Annual Report: The state of rehabilitation in Australia 2006. Aust Health Rev 2008; 32: 85-110.
16. Guide for the Uniform Data Set for Medical Rehabilitation (Including the FIM Instrument), version 5.1. State University of New York at Buffalo: Buffalo, NY, Uniform Data System for Medical Rehabilitation, 1997.
17. New PW, Simmonds F, Stevermuer T. A population-based study comparing traumatic spinal cord injury and non-traumatic spinal cord injury using a national rehabilitation database. Spinal Cord 49: 397-403.
18. Hall KM, Cohen ME, Wright J, Call M, Werner P. Characteristics of the functional independence measure in traumatic spinal cord injury. Arch Phys Med Rehabil 1999; 80: 1471-1476. (Pubitemid 29526646)
19. Osterthum R, Post MWM, van Asbeck FW. Characteristics, lenght of stay and functional outcomes of patients with spinal cord injury in Dutch and Flemish rehabilitation centres. Spinal Cord 2009; 47: 339-344.
20. Guilcher SJT, Munce SEP, Couris CM, Fung K, Craven BC, Verrier M et al. Health care utilization in non-traumatic and traumatic spinal cord injury: A population-based study. Spinal Cord 2010; 48: 45-50.
21. O'Connor PJ. Development and utilisation of the Australian Spinal Cord Injury Register. Spinal Cord 2000; 38: 597-603.
22. Cripps RA. Spinal Cord Injury, Australia 2006-07. Injury Research and Statistics Series Number 48 (AIHW cat no. INJCAT 119). Australian Institute of Health and Welfare: Adelaide, 2008.
23. Marino RJ, Barros T, Biering-Srensen F, Burns SP, Donovan WH, Graves DE et al. International standards for neurological classification of spinal cord injury. J Spinal Cord Med 2003; (Suppl 1): S50-S56.
24. Wallace D, Duncan PW, Lai SM. Comparison of the responsiveness of the Barthel Index and the motor component of the functional independence measure in stroke: The impact of using different methods for measuring responsiveness. J Clin Epidemiol 2002; 55: 922-928. (Pubitemid 35246564)
25. Wolfe DL, Hsieh JTC, Curt A, Teasell RW. Neurological and functional outcomes spinal cord injury. TopSpinal Cord Inj Rehabil 2007; 13: 11-31. (Pubitemid 46982069)
26. National Health and Hospitals Reform Commission. A healthier future for all Australians: Final report June 2009. Available at: Http://www.health.gov.au/ internet/nhhrc/publishing.nsf/Content/ nhhrc-report (accessed 25th November 2010).