Neurovascular coupling: Key to gait slowing in aging?

Annals of Neurology

Volumn 70, Issue 2, 2011, Pages 189-191

  Rolita, Lydia ^a   Verghese, Joe ^b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; BLOOD OXYGENATION; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; BRAIN BLOOD VOLUME; BRAIN DYSFUNCTION; BRAIN ISCHEMIA; CEREBROVASCULAR DISEASE; COGNITION; DEATH; DISEASE SEVERITY; DOPPLER ECHOGRAPHY; EDITORIAL; ELECTROENCEPHALOGRAM; EXECUTIVE FUNCTION; FALL RISK ASSESSMENT; FALLING; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GAIT DISORDER; GLIA; HEMODYNAMICS; HUMAN; HYPERCAPNIA; HYPERTENSION; INSTITUTIONALIZATION; MIDDLE CEREBRAL ARTERY; MOTOR CONTROL; MUSCLE; NEAR INFRARED SPECTROSCOPY; NERVE; NERVE CELL; NERVE CONDUCTION; NERVE TRACT; NERVOUS SYSTEM PARAMETERS; NEUROLOGIC EXAMINATION; NEUROVASCULAR COUPLING; NUCLEAR MAGNETIC RESONANCE IMAGING; PARKINSON DISEASE; PERIPHERAL NEUROPATHY; PREFRONTAL CORTEX; PRIORITY JOURNAL; VASODILATATION; WALKING SPEED; WHITE MATTER; WORKING MEMORY;

AGING; CEREBROVASCULAR CIRCULATION; GAIT; HUMANS; REGIONAL BLOOD FLOW;

EID: 80051523315     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.22503     Document Type: Editorial

References (21)

1. Oh-Park M, Holtzer R, Xue X, Verghese J,. Conventional and robust quantitative gait norms in community-dwelling older adults. J Am Geriatr Soc 2010; 58: 1512-1518.
2. Verghese J, LeValley A, Hall CB, et al. Epidemiology of gait disorders in community-residing older adults. J Am Geriatr Soc 2006; 54: 255-261.
3. Abellan van Kan G, Rolland Y, Andrieu S, et al. Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force. J Nutr Health Aging 2009; 13: 881-889.
4. Verghese J, Ambrose AF, Lipton RB, Wang C,. Neurological gait abnormalities and risk of falls in older adults. J Neurol 2010; 257: 392-398.
5. Verghese J HR, Lipton RB, Wang C,. Quantitative gait markers and incident fall risk in older adults. J Gerontol A Biol Sci Med Sci 2009; 64: 896-901.
6. Thurman DJ, Stevens JA, Rao JK,. Practice parameter: assessing patients in a neurology practice for risk of falls (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2008; 70: 473-479.
7. Sorond FA, Galica A, Serrador JM, et al. Cerebrovascular hemodynamics, gait, and falls in an elderly population: MOBILIZE Boston Study. Neurology 2010; 74: 1627-1633.
8. Baezner H, Blahak C, Poggesi A, et al. Association of gait and balance disorders with age-related white matter changes: the LADIS study. Neurology 2008; 70: 935-942. (Pubitemid 351430742)
9. Girouard H, Iadecola C,. Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. J Appl Physiol 2006; 100: 328-335. (Pubitemid 43671125)
10. Iadecola C,. Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci 2004; 5: 347-360. (Pubitemid 38568496)
11. Sorond F, Kiely D, Galica A, et al. Neurovascular coupling is impaired in slow walkers: The MOBILIZE Boston Study. Ann Neurol 2011; 70: 213-220.
12. Matteis M, Troisi E, Monaldo BC, et al. Age and sex differences in cerebral hemodynamics: a transcranial Doppler study. Stroke 1998; 29: 963-967. (Pubitemid 28228157)
13. Galvin SD, Celi LA, Thomas KN, et al. Effects of age and coronary artery disease on cerebrovascular reactivity to carbon dioxide in humans. Anaesth Intensive Care 2010; 38: 710-71-7.
14. Niehaus L, Lehmann R, Roricht S, Meyer BU,. Age-related reduction in visually evoked cerebral blood flow responses. Neurobiol Aging 2001; 22: 35-38. (Pubitemid 32332996)
15. Holtzer R, Verghese J, Xue X, Lipton RB,. Cognitive processes related to gait velocity: results from the Einstein Aging Study. Neuropsychology 2006; 20: 215-223.
16. Verghese J, Mahoney J, Ambrose AF, et al. Effect of cognitive remediation on gait in sedentary seniors. J Gerontol A Biol Sci Med Sci 2010; 65: 1338-1343.
17. Ben-Itzhak R, Giladi N, Gruendlinger L, Hausdorff JM,. Can methylphenidate reduce fall risk in community-living older adults? A double-blind, single-dose cross-over study. J Am Geriatr Soc 2008; 56: 695-700. (Pubitemid 351473517)
18. Miyai I, Tanabe HC, Sase I, et al. Cortical mapping of gait in humans: a near-infrared spectroscopic topography study. Neuroimage 2001; 14: 1186-1192. (Pubitemid 33049860)
19. Holtzer R, Mahoney J, Izzetoglu M, et al. fNIRS study of walking and walking while talking in young and old individuals. J Gerontol A Biol Sci Med Sci (in press).
20. Takeda S, Sato N, Takeuchi D, et al. Angiotensin receptor blocker prevented beta-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling. Hypertension 2009; 54: 1345-1352.
21. Rosengarten B, Schermuly RT, Voswinckel R, et al. Sildenafil improves dynamic vascular function in the brain: studies in patients with pulmonary hypertension. Cerebrovasc Dis 2006; 21: 194-200.