Lack of genotoxicity in medical oncology nurses handling antineoplastic drugs: Effect of work environment and protective equipment

Work

Volumn 39, Issue 4, 2011, Pages 485-489

  Gulten, Tuna ^a   Evke, Elif ^a   Ercan, Ilker ^a   Evrensel, Turkkan ^a   Kurt, Ender ^a   Manavoglu, Osman ^a  

^a ULUDAG UNIVERSITY   (Turkey)

Author keywords

biological monitoring; closed system device; health care workers; Occupational exposure; sister chromatid exchange assay

Indexed keywords

ANTINEOPLASTIC AGENT;

ADULT; AIR CONDITIONING; ARTICLE; FEMALE; HEALTH CARE FACILITY; HUMAN; MIDDLE AGED; OCCUPATIONAL EXPOSURE; ONCOLOGY NURSING; PROTECTIVE CLOTHING; SISTER CHROMATID EXCHANGE;

ADULT; ANTINEOPLASTIC AGENTS; FEMALE; HEALTH FACILITY ENVIRONMENT; HUMANS; MIDDLE AGED; OCCUPATIONAL EXPOSURE; ONCOLOGIC NURSING; PROTECTIVE CLOTHING; SISTER CHROMATID EXCHANGE; VENTILATION; YOUNG ADULT;

EID: 80051508029     PISSN: 10519815     EISSN: None     Source Type: Journal    
DOI: 10.3233/WOR-2011-1198     Document Type: Article

References (27)

1. R.W. Anderson, W.H. Puckett, Jr., W.J. Dana, T.V. Nguyen, J.C. Theiss and T.S. Matney, Risk of handling injectable anti-neoplastic agents, AmJHosp Pharm 39 (1982), 1881-1887. (Pubitemid 12002311)
2. U. Baykal, S. Seren and S. Somken, A description of oncology nurses' working conditions in Turkey, Eur J Oncol Nurs Article in press (2009), doi:10. 1016/j.ejon.2009.04.004.
3. V. Brumen and D. Horvat, Work environment influence on cytostatics induced genotoxicity in oncologic nurses, AmJInd Med 30 (1996), 67-71. (Pubitemid 26279459)
4. D. Cavallo, L.C. Ursini, B. Pernicono, A.D. Francesco, M. Giglio, F.M. Rubino, A. Marinaccio and S. Iavicoli, Evaluation of genotoxic effects induced by exposure to antineoplastic drugs in lymphocytes and exfoliated buccal cells of oncology nurses and pharmacy employees. Mutat Res 587 (2005), 45-51. (Pubitemid 41509159)
5. D. Cavallo, L.C. Ursini, E. Omodeo-Sale and S. Iavicoli, Micronucleus induction and FISH analysis in buccal cells and lymphocytes of nurses administering antineoplastic drugs, Mutat Res 628 (2007), 11-18. (Pubitemid 46283528)
6. S. Eisenberg, Safe handling and administration of antineoplastic chemotherapy, J Infus Nurs 32 (2009), 23-32.
7. J. Fuchs, J.G. Hengstler, D. Jung, G. Hiltl, J. Konietzko and F Oesch, DNA damage in nurses handling antineoplastic agents, Mutat Res 342 (1995), 17-23.
8. J. Gambrell and S. Moore, Assessing workplace compliance with handling of antineoplastic agents, Clin J Oncol Nurs 10(4) (2006), 473-477.
9. M.G. Jakab, J. Major and A. Tompa, Follow-up genotoxico-logical monitoring of nurses handling antineoplastic drugs, J Toxicol Environ Health A 62 (2001), 307-318. (Pubitemid 32184299)
10. V. Kasuba, R. Rozgaj and V. Vrhovac-Garaj, Analysis of sister chromatid exchanges and micronuclei in peripheral blood lymphocytes of nurses handling cytostatic drugs, J Appl Toxicol 19 (1999), 401-404.
11. S. Kevekordes, T.W. Gebel, M. Hellwing, W. Dames and H. Dunkelberg, Human effect monitoring in cases of occupational exposure to antineoplastic drugs: a method comparison, J Occup Environ Med Medicine 55 (1998), 145-149. (Pubitemid 28212192)
12. N. Kopjar, V. Garj-Vrhovac, V. Kasuba, R. Rozgaj, S. Ramic, V. Pavlica and D. Zeljezic, Assessment of genotoxic risks in Crotian health care workers occupationally exposed to cyto-toxic drugs: A multi-biomarker approach, Int J Hyg Environ Health 212 (2009), 414-431.
13. N. Kopjar, V. Kasuba, R. Rozgaj, D. Zeljezic, M. Milic, S. Ramic, V. Pavlica and S. Milkovic-Kraus, The genotoxic risk in health care workers occupationally exposed to cytotoxic drugs: A comprehensive evaluation by the SCE assay, J Environ Sci Health A 44 (2009), 462-479.
14. S. Kumar, S.W. Lobo, A.K. Dubey and S.K. Pandey, Teratogenic effects of 5-fluorouracil on rat brain, Nepal Med Coll J 8 (2006), 7-8.
15. A. Lanza, FS. Robustelli della Cuna, C. Zibera, P. Pedrazzoli and G. Robustelli della Cuna, Somatic mutations at the T-cell antigen receptor, in antineoplastic drug-exposed populations: comparison with sister chromatid exchange frequency, Int Arch Occup Environ Health 72 (1999), 315-322. (Pubitemid 29421578)
16. R.M. Mader, A. Kokalj, E. Kratochvil, A. Pilger and H. W. Rüdiger, Longitudinal biomonitoring of nurses handling antineoplastic drugs, J Clin Nurs 18 (2008), 263-269.
17. U. Oestriecher, G. Stephan and M. Glatzel, Chromosome and SCE analysis in peripheral lymphocytes of persons occupationally exposed to cytostatic drugs handled with and without use of safety covers, Mutat Res 242 (1990), 271-277. (Pubitemid 20372931)
18. D. Park, S. Kim, H. Kang, J. Oh, J.Y. Jang, S. Shin, T.K. Kim, Y.J. Choi, S.H. Lee, K.Y. Kim, S.S. Joo and Y.B. Kim, Preventive effect of piperonyl butoxide on cyclophosphamide-induced teratogenesis in rats, Birth Defects Res B Dev Reprod Toxicol 86 (2009), 402-408.
19. A. Pilger, I. Köhler, H. Stether, R.M. Mader, B. Rizovski, R. Terkola, E. Diem, E. Franz-Hainzl, C. Konnaris, E. Valic and H. W. Rüdiger, Long-term monitoring of sister chromatid exchanges and micronucleus frequencies in pharmacy personel occupationally exposed to cytostatic drugs, Int Arch Occup Environ Health 73 (2000), 442-448.
20. PV. Rekhadevi, N. Sailaja, M. Chandrasekhar, M. Mahboob, M.F Rahman and P. Grover, Genotoxicity assessment in oncology nurses handling anti-neoplastic drugs, Mutagenesis 22 (2007), 395-401. (Pubitemid 350098495)
21. A. Sahin, A. Tatar, S. Oztas, B. Seven, E. Varoglu, A. Yesilyurt and A.K. Ayan, Evaluation of the genotoxic effects of chronic low-dose ionizing radiation exposure on nuclear medicine workers, Nucl. Med. Biol. 36 (2009) 575-578.
22. M. Sasaki, M. Dakeishi, S. Hoshi, N. Ishm, K. Murata, Assessment of DNA damage in Japanese nurses handling antineoplastic drugs by the comet assay, J. Occup. Health. 50 (2008), 7-12. (Pubitemid 351680002)
23. B. Singh, R. S. Gupta, Mutagenic responses of thirteen an-ticancer drugs on mutation induction at multiple genetic loci and or sister chromatid exchanges in Chinese hamster ovary cells, Cancer Research. 43 (1983), 577-84. (Pubitemid 13193851)
24. M. Sorsa, M. Hamelia, E. Jarviluoma., Handling anti-cancer drugs from hazard identification to risk management, Ann.N.Y.Acad. Sci 1076 (2006), 628-634. (Pubitemid 44955294)
25. A. Testa, M. Giachelia, S. Palma, M. Appolloni, L. Padua, G. Tranfo et al., Occupational exposure to antineoplastic agents induces high level of chromosome damage. Lack of an effect of GST polymorphism, Toxicol Appl Pharmacol 223(1) (2007), 46-55. (Pubitemid 47224967)
26. J. Yoshida, G. Tei, C. Mochizuki, Y. Masu, S. Koda and S. Kumagai, Use of a closed system device to reduce occupational contamination and exposure to antineoplastic drugs in the hospital work environment, Ann Occup Hyg 53 (2009), 153-160.
27. J. Yoshida, H Kosaka, K. Tomioka and S. Kumagai, Genotoxic risks to nurses from contamination of the work environment with antineoplastic drugs in Japan, J Occup Health 48 (2006), 517-522. (Pubitemid 46057884)