A duplex oligodeoxynucleotide-dendrimer bioconjugate as a novel delivery vehicle for doxorubicin in in vivo cancer therapy

Journal of Controlled Release

Volumn 155, Issue 1, 2011, Pages 88-95

  Lee, In Hyun ^a   Yu, Mi Kyung ^a   Kim, In Hwa ^a   Lee, Jae Hyuk ^b   Park, Tae Gwan ^c   Jon, Sangyong ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b Chonnam National University   (South Korea)

^c Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Cancer therapy; Dendrimers; Doxorubicin; Drug delivery system; Duplex oligonucleotides

Indexed keywords

BIOCONJUGATES; BODY WEIGHT; BREAST TUMOR; CANCER CELLS; CANCER THERAPY; CARDIOTOXICITY; DELIVERY SYSTEMS; DELIVERY VEHICLE; DOXORUBICIN; DRUG DELIVERY SYSTEM; EQUIVALENT CONCENTRATIONS; HEART TISSUES; IN-VITRO; IN-VIVO; OLIGODEOXYNUCLEOTIDES; PHARMACOKINETIC STUDIES; STABLE COMPLEXES; SUSTAINED DRUG RELEASE; TUMOR MODELS; TUMOR SIZE;

BIOMOLECULES; DENDRIMERS; DISEASES; DRUG DELIVERY; DRUG PRODUCTS; MAMMALS; OLIGONUCLEOTIDES; ONCOLOGY; PHARMACOKINETICS; TOXICITY;

TUMORS;

DENDRIMER; DOXORUBICIN; DUPLEX OLIGODEOXYNUCLEOTIDE; OLIGODEOXYNUCLEOTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BIOCONJUGATE; BREAST TUMOR; CANCER CELL; CANCER THERAPY; CARDIOTOXICITY; CLINICAL ASSESSMENT; CONJUGATION; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DOSE COMPARISON; DRUG HALF LIFE; FEMALE; IN VITRO STUDY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE; TIME TO MAXIMUM PLASMA CONCENTRATION; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BREAST NEOPLASMS; CELL LINE, TUMOR; DENDRIMERS; DOXORUBICIN; DRUG CARRIERS; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; NEOPLASMS; OLIGODEOXYRIBONUCLEOTIDES;

EID: 80051505237     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.09.008     Document Type: Article

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