Inherited thrombophilia in childhood arterial stroke: Data from Lebanon

Pediatric Neurology

Volumn 45, Issue 3, 2011, Pages 155-158

  Muwakkit, Samar A ^a   Majdalani, Marianne ^a   Hourani, Roula ^a   Mahfouz, Rami A ^a   Otrock, Zaher K ^a   Bilalian, Christina ^a   Chan, Anthony K ^b   Abboud, Miguel ^a   Mikati, Mohamad A ^a  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ADOLESCENT; BRAIN ISCHEMIA; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC DISORDER; GENETIC POLYMORPHISM; GENETIC SCREENING; GENETIC VARIABILITY; HEMIPARESIS; HETEROZYGOSITY; HUMAN; INFANT; LEBANON; MALE; MEDICAL RECORD REVIEW; PRESCHOOL CHILD; PRIORITY JOURNAL; RECURRENT DISEASE; REVIEW; SCHOOL CHILD; SEIZURE; THROMBOPHILIA;

EID: 80051503008     PISSN: 08878994     EISSN: 18735150     Source Type: Journal    
DOI: 10.1016/j.pediatrneurol.2011.03.002     Document Type: Article

References (46)

1. J. Broderick, G.T. Talbot, E. Prenger, A. Leach, and T. Brott Stroke in children within a major metropolitan area: the surprising importance of intracerebral hemorrhage J Child Neurol 8 1993 250 255 (Pubitemid 23215715)
2. J.K. Lynch, D.G. Hirtz, G. DeVeber, and K.B. Nelson Report of the National Institute of Neurological Disorders and Stroke workshop on perinatal and childhood stroke Pediatrics 109 2002 116 123 (Pubitemid 34049435)
3. B. Chung, and V. Wong Pediatric stroke among Hong Kong Chinese subjects Pediatrics 114 2004 e206 e212
4. C. Seidman, F. Kirkham, and S. Pavlakis Pediatric stroke: current developments Curr Opin Pediatr 19 2007 657 662 (Pubitemid 350145233)
5. G.A. deVeber, D. MacGregor, R. Curtis, and S. Mayank Neurologic outcome in survivors of childhood arterial ischemic stroke and sinovenous thrombosis J Child Neurol 15 2000 316 324 (Pubitemid 30341363)
6. V. Ganesan, M. Prengler, A. Wade, and F.J. Kirkham Clinical and radiological recurrence after childhood arterial ischemic stroke Circulation 114 2006 2170 2177 (Pubitemid 44747898)
7. R. Sträter, S. Becker, and A. von Eckardstein Prospective assessment of risk factors for recurrent stroke during childhood-a 5-year follow-up study Lancet 360 2002 1540 1545 (Pubitemid 35356368)
8. V. Ganesan, M. Prengler, M.A. McShane, A.M. Wade, and F.J. Kirkham Investigation of risk factors in children with arterial ischemic stroke Ann Neurol 53 2003 167 173 (Pubitemid 36163997)
9. S. Haywood, R. Liesner, S. Pindora, and V. Ganesan Thrombophilia and first arterial ischaemic stroke: a systematic review Arch Dis Child 90 2005 402 405 (Pubitemid 40488681)
10. G. Kenet, S. Sadetzki, and H. Murad Factor V Leiden and antiphospholipid antibodies are significant risk factors for ischemic stroke in children Stroke 31 2000 1283 1288 (Pubitemid 30351246)
11. A. Rahemtullah, and E.M. Van Cott Hypercoagulation testing in ischemic stroke Arch Pathol Lab Med 131 2007 890 901 (Pubitemid 46906380)
12. T.J. Bernard, and N.A. Goldenberg Pediatric arterial ischemic stroke Pediatr Clin North Am 55 2008 323 338 viii (Pubitemid 351442778)
13. M. Kieslich, A. Fiedler, C. Heller, W. Kreuz, and G. Jacobi Minor head injury as cause and co-factor in the aetiology of stroke in childhood: a report of eight cases J Neurol Neurosurg Psychiatry 73 2002 13 16 (Pubitemid 34713005)
14. S.G. Pavlakis, P.B. Kingsley, and M.G. Bialer Stroke in children: genetic and metabolic issues J Child Neurol 15 2000 308 315 (Pubitemid 30341362)
15. H. Tamim, R.R. Finan, and W.Y. Almawi Prevalence of two thrombophilia predisposing mutations: factor V G1691A (R506Q; Leiden) and prothrombin G20210A, among healthy Lebanese Thromb Haemost 88 2002 691 692 (Pubitemid 35174019)
16. P. Monagle, A. Chan, P. Massicotte, E. Chalmers, and A.D. Michelson Antithrombotic therapy in children: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy Chest 126 3 Suppl. 2004 645S 687S (Pubitemid 39297967)
17. P.A. Zalloua, Y. Xue, and J. Khalife Genophic Consortiumgra. Y-chromosomal diversity in Lebanon is structured by recent historical events Am J Hum Genet 82 2008 873 882
18. L.C. Jordan Stroke in childhood Neurologist 12 2006 94 102
19. J.K. Lynch Cerebrovascular disorders in children Curr Neurol Neurosci Rep 4 2004 129 138 (Pubitemid 38899064)
20. A.K.G. Chan, and G. deVeber Prothrombotic disorders and ischemic stroke in children Semin Pediatr Neurol 7 2000 301 308
21. J. Pappachan, and F.J. Kirkham Cerebrovascular disease and stroke Arch Dis Child 93 2008 890 898
22. G. deVeber, P. Monagle, and A. Chan Prothrombotic disorders in infants and children with cerebral thromboembolism Arch Neurol 55 1998 1539 1543 (Pubitemid 28566623)
23. R.F. Franco, and P.H. Reitsma Gene polymorphisms of the haemostatic system and the risk of arterial thrombotic disease Br J Haematol 115 2001 491 506 (Pubitemid 34015638)
24. D. Feinbloom, and K.A. Bauer Assessment of hemostatic risk factors in predicting arterial thrombotic events Arterioscler Thromb Vasc Biol 25 2005 2043 2053 (Pubitemid 41416299)
25. N.L. Smith, J.C. Bis, and S. Biagiotti Variation in 24 hemostatic genes and associations with non-fatal myocardial infarction and ischemic stroke J Thromb Haemost 6 2008 45 53
26. V. Ganesan, H. Kelsey, J. Cookson, A. Osborn, and F.J. Kirkham Activated protein C resistance in childhood stroke Lancet 347 1996 260
27. A. de Paula Sabino, D.D. Ribeiro, M.G. Carvalho, J. Cardoso, L.M. Dusse, and A.P. Fernandes Factor V Leiden and increased risk for arterial thrombotic disease in young Brazilian patients Blood Coagul Fibrinolysis 17 2006 271 275
28. A. Komitopoulou, H. Platokouki, Z. Kapsimali, H. Pergantou, E. Adamtziki, and S. Aronis Mutations and polymorphisms in genes affecting hemostasis proteins and homocysteine metabolism in children with arterial ischemic stroke Cerebrovasc Dis 22 2006 13 20 (Pubitemid 43875155)
29. M. Bonduel, G. Sciuccati, and M. Hepner Factor V Leiden and prothrombin gene G20210A mutation in children with cerebral thromboembolism Am J Hematol 73 2003 81 86 (Pubitemid 36578428)
30. R.C. Rey, G. de Larrañaga, and S. Lepera Activated protein C resistance in patients with arterial ischemic stroke J Stroke Cerebrovasc Dis 10 2001 128 131 (Pubitemid 32701601)
31. A. Gürgey, and L. Mesci The prevalence of factor V Leiden (1691 G>A) mutation in Turkey Turk J Pediatr 39 1997 313 315 (Pubitemid 127562936)
32. K. Brown, R. Luddington, D. Williamson, P. Baker, and T. Baglin Risk of venous thromboembolism associated with a G to A transition at position 20210 in the 3′-untranslated region of the prothrombin gene Br J Haematol 98 1997 907 909 (Pubitemid 27421633)
33. I.J. Perry, H. Refsum, R.W. Morris, S.B. Ebrahim, P.M. Ueland, and A.G. Shaper Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men Lancet 346 1995 1395 1398
34. P. Frosst, H.J. Blom, and R. Milos A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase Nat Genet 10 1995 111 113
35. R.V. Alluri, V. Mohan, S. Komandur, K. Chawda, J.R. Chaudhuri, and Q. Hasan MTHFR C677T gene mutation as a risk factor for arterial stroke: a hospital based study Eur J Neurol 12 2005 40 44
36. H.S. Markus, N. Ali, R. Swaminathan, A. Sankaralingam, J. Molloy, and J. Powell A common polymorphism in the methylenetetrahydrofolate reductase gene, homocysteine, and ischemic cerebrovascular disease Stroke 28 1997 1739 1743 (Pubitemid 27391442)
37. I. Zak, B. Sarecka-Hujar, and I. Kopyta The T allele of the 677C>T polymorphism of methylenetetrahydrofolate reductase gene is associated with an increased risk of ischemic stroke in Polish children J Child Neurol 24 2009 1262 1267
38. W.Y. Almawi, R.R. Finan, H. Tamim, J.L. Daccache, and N. Irani-Hakime Differences in the frequency of the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene among the Lebanese population Am J Hematol 76 2004 85 87 (Pubitemid 38579547)
39. M. Barbagallo, P. Pavone, and G. Incorpora Two siblings with a homozygous MTHFR C677T (G80A-RFC1) mutation and stroke Childs Nerv Syst 25 2009 361 365
40. S. Barreirinho, A. Ferro, and M. Santos Inherited and acquired risk factors and their combined effects in pediatric stroke Pediatr Neurol 28 2003 134 138 (Pubitemid 36434160)
41. M.D. McColl, E.A. Chalmers, and A. Thomas Factor V Leiden, prothrombin 20210G>A and the MTHFR C677T mutations in childhood stroke Thromb Haemost 81 1999 690 694 (Pubitemid 29216551)
42. R. Duran, B. Biner, M. Demir, C. Celtik, S. Karasaliholu, and V. Factor Leiden mutation and other thrombophilia markers in childhood ischemic stroke Clin Appl Thromb Hemost 11 2005 83 88 (Pubitemid 40194202)
43. N. Akar, E. Akar, G. Deda, T. Sipahi, and A. Orsal Factor V1691 G-A, prothrombin 20210 G-A, and methylenetetrahydrofolate reductase 677 C-T variants in Turkish children with cerebral infarct J Child Neurol 14 1999 749 751
44. W. Zenz, Z. Bodó, and J. Plotho Factor V Leiden and prothrombin gene G 20210 A variant in children with ischemic stroke Thromb Haemost 80 1998 763 766 (Pubitemid 28521719)
45. J.K. Lynch, C.J. Han, L.E. Nee, and K.B. Nelson Prothrombotic factors in children with stroke or porencephaly Pediatrics 116 2005 447 453 (Pubitemid 44161473)
46. S. Gökben, A. Tosun, and N. Bayram Arterial ischemic stroke in childhood: risk factors and outcome in old versus new era J Child Neurol 22 2007 1204 1208