Ginsenoside Rb3 ameliorates myocardial ischemia-reperfusion injury in rats

Pharmaceutical Biology

Volumn 49, Issue 9, 2011, Pages 900-906

  Shi, Yaohui ^a   Han, Bing ^b   Yu, Xiaofeng ^a   Qu, Shaochun ^a   Sui, Dayuan ^a  

^a JILIN UNIVERSITY   (China)

^b YANTAI UNIVERSITY   (China)

Author keywords

antioxidant; Ginsenoside Rb3; microcirculation; myocardial ischemia reperfusion

Indexed keywords

ANGIOTENSIN II; CREATINE KINASE MB; ENDOTHELIN; GINSENOSIDE RB3; LACTATE DEHYDROGENASE; MALONALDEHYDE; PROTECTIVE AGENT; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; HEART INFARCTION SIZE; HEART LEFT VENTRICLE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HISTOPATHOLOGY; MICROCIRCULATION; NONHUMAN; OXIDATIVE STRESS; RAT; REPERFUSION INJURY;

ANGIOTENSIN II; ANIMALS; ANTIOXIDANTS; CARDIOTONIC AGENTS; CHINA; CREATINE KINASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ENDOTHELINS; GINSENOSIDES; HEART VENTRICLES; L-LACTATE DEHYDROGENASE; MALONDIALDEHYDE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; PANAX; PHYTOTHERAPY; PLANT EXTRACTS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SINGLE-BLIND METHOD; SUPEROXIDE DISMUTASE;

ARALIACEAE; PANAX GINSENG; RATTUS;

EID: 80051499883     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2011.554845     Document Type: Article

References (16)

1. Attele AS, Wu JA, Yuan CS. (1999). Ginseng pharmacology: Multiple constituents and multiple actions. Biochem Pharmacol, 58, 1685-1693. (Pubitemid 29505408)
2. Braunwald E, Kloner RA. (1985). Myocardial reperfusion: A doubleedged sword? J Clin Invest, 76, 1713-1719.
3. de Gusmão FM, Becker C, Carvalho MH, Barros LF. (2005). Angiotensin II inhibition during myocardial ischemia-reperfusion in dogs: Effects on leukocyte infiltration, nitric oxide synthase isoenzymes activity and left ventricular ejection fraction. Int J Cardiol, 100, 363-370.
4. Haiyun L, Yijia L, Honggang L, Honghai W. (2004). Protective effect of total flavones from Elsholtzia blanda (TFEB) on myocardial ischemia induced by coronary occlusion in canines. J Ethnopharmacol, 94, 101-107. (Pubitemid 38942840)
5. Ji LL, Stratman FW, Lardy HA. (1988). Antioxidant enzyme systems in rat liver and skeletal muscle. Influences of selenium deficiency, chronic training, and acute exercise. Arch Biochem Biophys, 263, 150-160.
6. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem, 193, 265-275.
7. McCord JM, Fridovich I. (1969). Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem, 244, 6049-6055.
8. Moens AL, Claeys MJ, Timmermans JP, Vrints CJ. (2005). Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological process. Int J Cardiol, 100, 179-190.
9. Neves LA, Almeida AP, Khosla MC, Campagnole-Santos MJ, Santos RA. (1997). Effect of angiotensin-(1-7) on reperfusion arrhythmias in isolated rat hearts. Braz J Med Biol Res, 30, 801-809. (Pubitemid 127519600)
10. Niccoli G, Burzotta F, Galiuto L, Crea F. (2009). Myocardial no-reflow in humans. J Am Coll Cardiol, 54, 281-292.
11. Ohkawa H, Ohishi N, Yagi K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem, 95, 351-358. (Pubitemid 9194347)
12. Ozdemir R, Parlakpinar H, Polat A, Colak C, Ermis N, Acet A. (2006). Selective endothelin a (ETA) receptor antagonist (BQ-123) reduces both myocardial infarct size and oxidant injury. Toxicology, 219, 142-149. (Pubitemid 43120714)
13. Wang T, Yu XF, Qu SC, Xu HL, Sui DY. (2010). Ginsenoside Rb3 inhibits angiotensin II-induced vascular smooth muscle cells proliferation. Basic Clin Pharmacol Toxicol, 107, 685-689.
14. Wang Z, Li M, Wu WK, Tan HM, Geng DF. (2008). Ginsenoside Rb1 preconditioning protects against myocardial infarction after regional ischemia and reperfusion by activation of phosphatidylinositol-3-kinase signal transduction. Cardiovasc Drugs Ther, 22, 443-452.
15. Xie JT, Shao ZH, Vanden Hoek TL, Chang WT, Li J, Mehendale S, Wang CZ, Hsu CW, Becker LB, Yin JJ, Yuan CS. (2006). Antioxidant effects of ginsenoside Re in cardiomyocytes. Eur J Pharmacol, 532, 201-207.
16. Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen CJ. (2004). Molecular mechanisms and clinical applications of ginseng root for cardiovascular disease. Med Sci Monit, 10, RA187-RA192. (Pubitemid 39166444)