Discovering how environmental exposures alter genes could lead to new treatments for chronic illnesses

Health Affairs

Volumn 30, Issue 5, 2011, Pages 833-841

  Olden, Kenneth ^a   Freudenberg, Nicholas ^a   Dowd, Jennifer ^a   Shields, Alexandra E ^b  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENDOCRINE DISRUPTOR; HEAVY METAL;

ADAPTATION; ARTICLE; BEHAVIOR; CHILD ABUSE; CHROMATIN; CHRONIC DISEASE; CLINICAL RESEARCH; DNA METHYLATION; EMBRYO DEVELOPMENT; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; EPIGENETICS; FAMILY VIOLENCE; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE INACTIVATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; GENOTYPE PHENOTYPE CORRELATION; HAPLOTYPE MAP; HEALTH CARE POLICY; HUMAN; HUMAN GENOME PROJECT; INTERDISCIPLINARY RESEARCH; MATERNAL CARE; METHYLATION; NERVE CELL PLASTICITY; NONHUMAN; NUCLEAR REPROGRAMMING; PHENOTYPIC PLASTICITY; RECEPTOR GENE; SOCIAL ASPECT; SOCIAL STRESS; STRESS; SURVIVAL;

CHRONIC DISEASE; ENVIRONMENTAL EXPOSURE; EPIGENESIS, GENETIC; FOOD HABITS; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HEALTH BEHAVIOR; HUMANS; RISK FACTORS; SURVIVAL ANALYSIS;

EID: 80051497823     PISSN: 02782715     EISSN: 15445208     Source Type: Journal    
DOI: 10.1377/hlthaff.2011.0078     Document Type: Article

References (48)

1. Mathers CD, Loncar D. Updated projections of global mortality and burden of disease, 2002-2030: data sources, methods and results. Geneva: World Health Organization; 2006.
2. National Human Genome Research Institute. International HapMap Project [Internet]. Bethesda (MD): NHGRI; [cited 2011 Mar 16]. Available from: http://www.genome.gov/10001688
3. Manolio TA. Genomewide association studies and assessment of the risk of disease. N Engl J Med. 2010;363(2):166-76.
4. Bjornsson HT, Fallin MD, Feinburg AP. An integrated epigenetic and genetic approach to common health diseases. Trends Genet. 2004;20(8): 350-8.
5. Poirier LA, Ulasoua TI. The prospective role of abnormal methyl metabolism in cadmium toxicity. Environ Health Perspect. 2002; 110(Suppl 5):793-5.
6. Sutherland JE, Costa M. Epigenetics and the environment. Ann N Y Acad Sci. 2003;983:151-60.
7. Weaver IC, Meaney MJ, Szyf M. Maternal care effects on the hippocampal transcriptome and anxietymedication behavior. Nat Neurosci. 2009; 12:1559-66.
8. McGowan PO, Szyf M. The epi genetics of social adversity in early life: implications for mental health. Neurobiol Dis. 2010;37:13-25.
9. Bennett-Boker PE, Wilkowski J, Burke DT. Age associated activation of epigenetically repressed genes in the mouse. Genetics. 2003;165: 2055-62.
10. Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballester M, et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci. 2005;102(30): 10604-9.
11. Tanner CM, Ohtman R, Goldman SM, Langston W. Parkinson disease in twins: an etiologic study. JAMA. 1999;281:341-6.
12. Baranzini SE, Mudge J, Van Velkinburg JC, Khankhanian P, Khrebtukova I, Miller NA, et al. Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature 2010;464:1351-6.
13. Lichtenstein P, Niels VH, Verkasala PK. Environmental and heritable factors in the causation of cancer: analysis of cohorts of twins from Sweden. New Engl J Med. 2000; 343:78-85.
14. Poulsen P, Kyvik KO, Vaag A. Heritability of type II (non-insulindependent) diabetes mellitus and abnormal glucose tolerance-a population-based twin study. Diabetologia. 1999;42:139-45.
15. Sarafino EP, Goldfedder J. Genetic factors in the presence, severity, and triggers of asthma. Arch Dis Child. 1984;75:112-6.
16. Feinberg AP. Phenotypic plasticity and the epigenetics of human disease. Nature. 2007;447:433-40.
17. Lewontin R. The adaptations of populations to varying environments. Cold Spring Harb Symp Quant Biol. 1957;22:395-408.
18. Vercelli D. Genetics, epigenetics, and the environment: switching, buffering, releasing. J Allergy Clin Immunol. 2004;113:381-6.
19. Waterland RA, Jirtle RL. Transposable elements for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. 2003;23: 5293-300.
20. vy/a mice. FASEB J. 1998;12:949-57.
21. Szyf M. Epigenomics and its implications for medicine. Genomics Personal Med. 2009;1:60-73.
22. Wren JD, Garner HR. Data mining analysis suggests an epigenetic pathogenesis for type II diabetes. J Biomed Biotech. 2005;2:104-15.
23. Waterland RA, Michels KB. Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr. 2007;27:363-88.
24. Talmud PJ, Humphries SE. Geneenvironmental interaction in lipid metabolism and effect on coronaryheart disease risk. Curr Opin Lipidol. 2002;12:149-54.
25. Devaskar SU, Thamotharan M. Metabolic programming in the pathogenesis of insulin resistance. Rev Endocr Metab Disord. 2007;8: 105-13.
26. Lund G, Anderson L, Lauria M, Lindholm M, Fraga MF, Villar-Garea A, et al. DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E. J Biol Chem. 2004;279:29147-54.
27. Wren JD, Garner HR. Data-mining analysis suggests an epigenetic pathogenesis for type 2 diabetes. J Biomed Biotech. 2005;2:104-12.
28. Mackay DJ, Boonen SE, Clayton-Smith J, Goodship J, Hahnemann JM, Kant SG, et al. A maternal hypomethylation syndrome presenting as transient neonatal diabetes mellitus. Hum Genet. 2006;120: 262-9.
29. Helden AJ, Hassal M. Phenotypic plasticity in growth and development rates of Armadillidium vulgare. Israel J Zool. 1998;44:379-94.
30. Workman P. Breaking the silence: the rise of epigenetic therapy. J Natl Cancer Inst. 2002; 94:874-5.
31. Kopelovich L, Crowell JA, Fay JR. The epigenome as a target for cancer chemoprevention. J Natl Cancer Inst. 2003;95:1747-57.
32. Kaiser J. Environmental institute lays plans for gene hunt. Science. 1997;278:569-70.
33. Brown PO, Hartwell L. Genomics and human disease-variations on variations. Nat Genet. 1998;18:91-3.
34. Olden K, Wilson S. Environmental health and genomics: visions and implications. Nat Rev Genet. 2000;1:149-53.
35. Olden K, Guthrie J. Genomics: implications for toxicology. Mutat Res. 2001;443:3-10.
36. Waters MD, Tennant RW, Olden K. Toxicogenomic approach for assessing toxicant related diseases. Mutat Res. 2003;544:415-24.
37. Livingston RJ, von Niederhausern A, Jegga AG, Crawford DC, Carlson CS, Rieder MJ, et al. Pattern of sequence variation across 213 environmental response genes. Genome Res. 2004; 14(10A):1821-31.
38. National Institute of Environmental Health Sciences. Chemical effects in biological systems (CEBS) [Internet]. Research Triangle Park (NC): NIEHS; 2010 [cited 2011 Mar 30]. Available from: http://www.niehs.nih.gov/research/resources/databases/cebs/index.cfm
39. Waters MD, Fostel JM. Toxicogenomics and systems toxicology: aims and prospects. Nat Rev Genetics. 2004;5:936-48.
40. Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, et al. The sequence of the human genome. Science. 2001;29:1304-51.
41. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, et al. Initial sequencing and analysis of the human genome. Nature. 2001;409:860-921.
42. International HapMap Consortium. A haplotype map of the human genome. Nature. 2005;437: 1299-1320.
43. McCarthy M, Hirschhorn JN. Genome-wide association studies: potential next steps on a genetic journey. Hum Mol Genet. 2008; 17(R2):R156-65.
44. Wade N. A decade later, gene map yields few new cures. New York Times. 2010 Jun 13:1;27.
45. Freudenberg N, Olden K. Finding synergy: reducing disparities in health by modifying multiple determinants. Am J Public Health. 2010;100:S25-S30.
46. National Institutes of Health. Genes, environment and health initiative (GEI) [home page on the Internet]. Bethesda (MD): NIH; 2010 [cited 2011 Mar 30]. Available from: http://gei.nih.gov/index.asp
47. Rideout WM, Eggan K, Jaemisch R. Nuclear cloning and epigenetic reprogramming of the genome. Science. 2001;293:1093-8.
48. McKeown T. The complexity of the medical task. Bull N Y Acad Med. 1968; 44(2):83-101.