Analysis of the urinary glucose-[ 15N, 15N-ureide content in the study of the lactose-[ 15N, 15N-ureide metabolism in healthy humans

European Journal of Clinical Nutrition

Volumn 65, Issue 8, 2011, Pages 959-964

  De Preter, V ^a   Houben, E ^a   Windey, K ^a   Luypaerts, A ^a   Verbeke, K ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

ammonia metabolism; GC MS; lactose 15N, 15N ureide; stable isotopes

Indexed keywords

GLUCOSE; LACTOSE; LACTULOSE; NITROGEN 15; UREA;

ADULT; ARTICLE; CARBOHYDRATE METABOLISM; FECES ANALYSIS; FEMALE; FOOD INTAKE; GAS CHROMATOGRAPHY; HUMAN; MALE; MASS SPECTROMETRY; NORMAL HUMAN; QUANTITATIVE ANALYSIS; RETROSPECTIVE STUDY; TEST MEAL; URINALYSIS; URINARY EXCRETION; VOLUNTEER;

ADULT; DIET; FECES; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUCOSE; HUMANS; LACTOSE; LACTULOSE; MALE; PREBIOTICS; RETROSPECTIVE STUDIES; UREA; URINALYSIS; YOUNG ADULT;

EID: 80051472029     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2011.63     Document Type: Article

References (15)

1. De Preter V, Geboes K, Verbrugghe K, De Vuyst L, Vanhoutte T, Huys G et al. (2004). The in vivo use of the stable isotope-labelled biomarkers lactose-[N-15]ureide and [H-2(4)]tyrosine to assess the effects of pro- and prebiotics on the intestinal flora of healthy human volunteers. Br J Nutr 92, 439-446. (Pubitemid 40282546)
2. De Preter V, Vanhoutte T, Huys G, Swings J, Rutgeerts P, Verbeke K (2006). Effect of lactulose and Saccharomyces boulardii administration on the colonic urea-nitrogen metabolism and the bifidobacteria concentration in healthy human subjects. Aliment Pharmacol Ther 23, 963-974.
3. Diggory RT, Cuschieri A (1985). The effect of dose and osmolality of lactulose on the oral-caecal transit time determined by the hydrogen breath test and the reproducibility of the test in normal subjects. Ann Clin Res 17, 331-333. (Pubitemid 16168579)
4. Geboes KP, De Preter V, Luypaerts A, Bammens B, Evenepoel P, Ghoos Y et al. (2005). Validation of lactose[N-15,N-15]ureide as a tool to study colonic nitrogen metabolism. Am J Physiol Gastrointest Liver Physiol 288, G994-G999. (Pubitemid 40563142)
5. Heine WE, Berthold HK, Klein PD (1995). A novel stable isotope breath test: 13C-labeled glycosyl ureides used as noninvasive markers of intestinal transit time. Am J Gastroenterol 90, 93-98.
6. Hofmann E (1931). Ueber den Abbau von glucoseureid durch Bakterien. Biochem Zeitschr 243, 416-422.
7. Holgate AM, Read NW (1983). Relationship between small bowel transit-Time and absorption of a solid meal-influence of metoclopramide, magnesium-sulfate, and lactulose. Dig Dis Sci 28, 812-819. (Pubitemid 13051915)
8. Jackson AA, Bundy R, Hounslow A, Murphy JL, Wootton SA (1999). Metabolism of lactose-[13C]ureide and lactose-[15N, 15N]ureide in normal adults consuming a diet marginally adequate in protein. Clin Sci (Lond) 97, 547-555. (Pubitemid 29527833)
9. Jackson AA, Gibson NR, Bundy R, Hounslow A, Millward DJ, Wootton SA (2004). Transfer of (15)N from oral lactose-ureide to lysine in normal adults. Int J Food Sci Nutr 55, 455-462. (Pubitemid 40073913)
10. Morrison DJ, Dodson B, Preston T, Weaver LT (2001). Rapid quality control analysis of (13)C-enriched substrate synthesis by isotope ratio mass spectrometry. Rapid Commun Mass Spectrom 15, 1279-1282. (Pubitemid 32720536)
11. Morrison DJ, Dodson B, Preston T, Weaver LT (2003). Gastrointestinal handling of glycosyl [13C]ureides. Eur J Clin Nutr 57, 1017-1024.
12. Ruemmele FM, Heine WE, Keller KM, Lentze MJ (1997). Metabolism of glycosyl ureides by human intestinal brush border enzymes. Biochim Biophys Acta 1336, 275-280. (Pubitemid 27364183)
13. Schoorl MN (1903). Les ureides (carbamides) des sucres. Rev Trav Chim 22, 1.
14. Verbeke K, De Preter V, Geboes K, Daems T, van den Mooter G, Evenepoel P et al. (2005). In vivo evaluation of a colonic delivery system using isotope techniques. Aliment Pharmacol Ther 21, 187-194. (Pubitemid 40222972)
15. Wutzke KD, Heine WE, Plath C, Leitzmann P, Radke M, Mohr C et al. (1997). Evaluation of oro-coecal transit time: A comparison of the lactose-[13C, 15N]ureide 1. Eur J Clin Nutr 51, 11-19.