An integrative genomics approach identifies activation of thioredoxin/thioredoxin reductase-1-mediated oxidative stress defense pathway and inhibition of angiogenesis in obese nondiabetic human subjects

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 8, 2011, Pages

  Das, Swapan K ^a   Sharma, Neeraj K ^a   Hasstedt, Sandra J ^b   Mondal, Ashis K ^a   Ma, Lijun ^a   Langberg, Kurt A ^a   Elbein, Steven C ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; PALMITIC ACID; THIOREDOXIN; THIOREDOXIN REDUCTASE 1; TRANSCRIPTION FACTOR NRF2;

ADAPTATION; ADULT; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; CORRELATION ANALYSIS; CPEB4 GENE; DNA POLYMORPHISM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; FAT CONTENT; FEMALE; GENE; GENE CONTROL; GENE EXPRESSION; GENOMICS; GENOTYPE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; METABOLIC REGULATION; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; SUBCUTANEOUS FAT;

ADIPOSE TISSUE; ADULT; DOWN-REGULATION; GENOME-WIDE ASSOCIATION STUDY; GENOMICS; HUMANS; MIDDLE AGED; NEOVASCULARIZATION, PHYSIOLOGIC; OBESITY; OXIDATIVE STRESS; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; SUBCUTANEOUS FAT; THIOREDOXIN REDUCTASE 1; UP-REGULATION; YOUNG ADULT;

EID: 79961232942     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-0101     Document Type: Article

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