Increased liver steatosis in anabolic-androgenic steroid users: More evidence towards toxicant-associated fatty liver disease development

Liver International

Volumn 31, Issue 8, 2011, Pages 1240-1241

  Schwingel, Paulo A ^a,b   Zoppi, Cláudio C ^c   Cotrim, Helma P ^a  

^a FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^b FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^c UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ANABOLIC AGENT; ANDROGEN; BIOLOGICAL MARKER; REACTIVE OXYGEN METABOLITE; SEX HORMONE BINDING GLOBULIN; STEROID; TESTOSTERONE;

BLOOD SAMPLING; BODY COMPOSITION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOPING; ECHOGRAPHY; FATTY LIVER; HEPATOMEGALY; HUMAN; IMMUNOASSAY; LETTER; LIPID METABOLISM; LIPID STORAGE; MALE; NONALCOHOLIC FATTY LIVER; PROTEIN BLOOD LEVEL; SUBSTANCE ABUSE; TESTOSTERONE BLOOD LEVEL; TOXICANT ASSOCIATED FATTY LIVER DISEASE;

ANABOLIC AGENTS; ANDROGENS; FATTY LIVER; HUMANS; LIVER; MALE; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS;

EID: 79961210034     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2011.02552.x     Document Type: Letter

References (8)

1. Law K, Brunt EM. Nonalcoholic fatty liver disease. Clin Liver Dis 2010; 14: 591-604.
2. Cotrim HP, De Freitas LA, Freitas C, et al. Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions. Liver Int 2004; 24: 131-5.
3. Schwingel PA, Cotrim HP, Salles BR, et al. Anabolic-androgenic steroids: a possible new risk factor of toxicant-associated fatty liver disease. Liver Int 2011; 31: 348-53.
4. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999; 84: 3666-72.
5. Charatcharoenwitthaya P, Lindor KD. Role of radiologic modalities in the management of non-alcoholic steatohepatitis. Clin Liver Dis 2007; 11: 37-54.
6. Haider A, Gooren LJ, Padungtod P, Saad F. Improvement of the metabolic syndrome and of non-alcoholic liver steatosis upon treatment of hypogonadal elderly men with parenteral testosterone undecanoate. Exp Clin Endocrinol Diabetes 2010; 118: 167-71.
7. Roberts AG, Campbell AP, Atkins WM. The thermodynamic landscape of testosterone binding to cytochrome P450 3A4: ligand binding and spin state equilibria. Biochemistry 2005; 44: 1353-66.
8. Pikuleva IA. Cytochrome P450s and cholesterol homeostasis. Pharmacol Ther 2006; 112: 761-73.