Genetic insights into non-anastomotic biliary strictures after orthotopic liver transplantation

Liver International

Volumn 31, Issue 8, 2011, Pages 1065-1067

  Koch, Robert O ^a   Kaser, Arthur ^a,b  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR5; GELATINASE A; GELATINASE B;

ALLELE; ARTERY THROMBOSIS; BILE DUCT OBSTRUCTION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; COHORT ANALYSIS; DONOR; EDITORIAL; FOLLOW UP; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; GRAFT RECIPIENT; HEPATIC ARTERY THROMBOSIS; HUMAN; LIVER TRANSPLANTATION; MULTIVARIATE ANALYSIS; POSTOPERATIVE PERIOD; PROMOTER REGION; REGULATORY T LYMPHOCYTE; RISK FACTOR;

CHOLANGITIS, SCLEROSING; CHOLESTASIS; FEMALE; HUMANS; IMMUNITY, INNATE; LIVER TRANSPLANTATION; MALE; MATRIX METALLOPROTEINASE 2; MUTATION; POLYMORPHISM, GENETIC; RECEPTORS, CCR5;

EID: 79961208263     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2011.02536.x     Document Type: Editorial

References (20)

1. Keeffe EB. Liver transplantation: current status and novel approaches to liver replacement. Gastroenterology 2001; 120: 749-62.
2. Buis CI, Hoekstra H, Verdonk RC, et al. Causes and consequences of ischemic-type biliary lesions after liver transplantation. J Hepatobiliary Pancreat Surg 2006; 13: 517-24.
3. Graziadei IW, Schwaighofer H, Koch R, et al. Long-term outcome of endoscopic treatment of biliary strictures after liver transplantation. Liver Transpl 2006; 12: 718-25.
4. Verdonk RC, Buis CI, Porte RJ, et al. Anastomotic biliary strictures after liver transplantation: causes and consequences. Liver Transpl 2006; 12: 726-35.
5. Heidenhain C, Pratschke J, Puhl G, et al. Incidence of and risk factors for ischemic-type biliary lesions following orthotopic liver transplantation. Transpl Int 2010; 23: 14-22.
6. Brandsaeter B, Schrumpf E, Clausen OP, et al. Recurrent sclerosing cholangitis or ischemic bile duct lesions-a diagnostic challenge? Liver Transpl 2004; 10: 1073-4.
7. Rull R, Garcia Valdecasas JC, Grande L, et al. Intrahepatic biliary lesions after orthotopic liver transplantation. Transpl Int 2001; 14: 129-34.
8. Halme L, Hockerstedt K, Lautenschlager I. Cytomegalovirus infection and development of biliary complications after liver transplantation. Transplantation 2003; 75: 1853-8.
9. Moench C, Uhrig A, Lohse AW, et al. CC chemokine receptor 5delta32 polymorphism-a risk factor for ischemic-type biliary lesions following orthotopic liver transplantation. Liver Transpl 2004; 10: 434-9.
10. Heidenhain C, Puhl G, Moench C, et al. Chemokine receptor 5Delta32 mutation reduces the risk of acute rejection in liver transplantation. Ann Transplant 2009; 14: 36-44.
11. op den Dries S, Buis CI, Adelmeijer J, et al. Combination of PSC and CCR5-Δ32 in recipients is strongly associated with development of nonanastomotic biliary strictures after liver transplantation. Liver Int 2011; 31: 1102-9.
12. ten Hove WR, de Rooij BJ, op den Dries S, et al. Matrix metalloproteinase 2 genotype is associated with non-anastomotic biliary strictures after orthotopic liver transplantation. Liver Int 2011: 31: 1110-7.
13. Ajuebor MN, Carey JA, Swain MG. CCR5 in T cell-mediated liver diseases: what's going on? J Immunol 2006; 177: 2039-45.
14. Samson M, Libert F, Doranz BJ, et al. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 1996; 382: 722-5.
15. Sternlicht MD, Werb Z. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 2001; 17: 463-516.
16. Benyon RC, Arthur MJ. Extracellular matrix degradation and the role of hepatic stellate cells. Semin Liver Dis 2001; 21: 373-84.
17. Price SJ, Greaves DR, Watkins H. Identification of novel, functional genetic variants in the human matrix metalloproteinase-2 gene: role of Sp1 in allele-specific transcriptional regulation. J Biol Chem 2001; 276: 7549-58.
18. Karlsen TH, Franke A, Melum E, et al. Genome-wide association analysis in primary sclerosing cholangitis. Gastroenterology 2010; 138: 1102-11.
19. Melum E, Franke A, Schramm C, et al. Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nat Genet 2011; 43: 17-9.
20. Guichelaar MM, Benson JT, Malinchoc M, et al. Risk factors for and clinical course of non-anastomotic biliary strictures after liver transplantation. Am J Transplant 2003; 3: 885-90.