Serum Paraoxonase-1 (PON-1) Genotype and Exposure to Organophosphorous Insectides-Is There a High-Risk Population?

Journal of Medical Toxicology

Volumn 7, Issue 3, 2011, Pages 243-247

  Matthews, Andre R ^a   Sutter, Mark E ^a,b   Rentz, Danielle E ^a  

^a NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Organophosphate; PON 1

Indexed keywords

ARYLDIALKYLPHOSPHATASE 1; CHLORPYRIFOS; CHOLESTEROL; CHOLINESTERASE; DIMPYLATE; ORGANOPHOSPHATE INSECTICIDE;

AGRICULTURAL WORKER; ANIMAL HUSBANDRY; ARTICLE; BANANA; CHOLESTEROL BLOOD LEVEL; CROP PRODUCTION; ENVIRONMENTAL HEALTH; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME INHIBITION; ENZYME METABOLISM; ENZYME PHOSPHORYLATION; ERYTHROCYTE LEVEL; GENE MUTATION; GENETIC POLYMORPHISM; GENOTYPE; HEALTH CARE ORGANIZATION; HIGH RISK POPULATION; HUMAN; INTOXICATION; NICARAGUA; NONHUMAN; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HAZARD; PHENOTYPE; TOXICOKINETICS; URINALYSIS; URINE LEVEL;

AGRICULTURAL WORKERS' DISEASES; ANIMALS; ARYLDIALKYLPHOSPHATASE; CENTERS FOR DISEASE CONTROL AND PREVENTION (U.S.); CHLORPYRIFOS; ENVIRONMENTAL EXPOSURE; HUMANS; INSECTICIDES; OCCUPATIONAL EXPOSURE; ORGANOPHOSPHORUS COMPOUNDS; RISK; UNITED STATES;

EID: 79961207265     PISSN: 15569039     EISSN: 19376995     Source Type: Journal    
DOI: 10.1007/s13181-011-0166-2     Document Type: Article

References (14)

1. Rogers HS, McCullough J, Kieszak S et al (2007) Exposure assessment of young children living in Chicago communities with historic reports of ritualistic use of mercury. Clin Tox 45: 240-247.
2. Rogers HS, Jeffrey N, Kieszak S et al (2008) Mercury exposure in young children living in New York City. J Urban Health 85(1): 39-51.
3. Backer LC, Kirkpatrick B, Fleming LE et al (2005) Occupational exposure to aerosolized brevetoxins during Florida red tide events: effects on a healthy worker population. Env Health Perspectives 113(5): 644-649.
4. Costa LG (2006) Current issues in organophosphate toxicology. Clin Chim Acta 366(1-2): 1-13.
5. United States Environmental Protection Agency. www. epa. gov/pesticides. Accessed 15 Nov 2009.
6. Clark R (2006) Insecticides: organic phosphorous compounds and carbamates. In: Flomenbaum NE, Goldfrank LR, Hoffman RS (eds) Goldfrank's toxicologic emergencies. McGraw-Hill, New York, pp 1497-1512.
7. Costa LG (1999) The role of paraoxonase (PON-1) in the detoxification of organophosphates and its human polymorphism. Chemico-Biological Interactions 119-120: 429-438.
8. Kanamori-Kataoka M (2009) Paraoxonase activity against nerve gases measured by capillary electrophoresis and characterization of human serum paraoxonase (PON-1) polymorphism in the coding region (Q192R). Anal Biochem 285: 94-100.
9. Lopez-Flores M et al (2009) Relationship between human paraoxonase-1 activity and PON-1 polymorphisms in Mexican workers exposed to organophosphate pesticides. Tox Letters 188: 84-90.
10. Sirivarasai J et al (2007) Paraoxonase (PON-1) polymorphisms and activity as the determinants of sensitivity to organophosphates in human subjects. Chem Biol Interact 20(168(3)): 184-192.
11. Byrk B (2005) Inherited and acquired interactions between ACHE and PON-1 polymorphisms modulate plasma acetylcholinesterase and paroxonase activities. J Neurochemistry 92: 1216-1227.
12. Mackness B (2003) Paraoxonase and susceptibility to organophosphorus poisoning in farmers dipping sheep. Pharmacogenetics 12(2): 81-88.
13. Lee BW et al (2003) Association between human paraoxonase gene polymorphism and chronic symptoms in pesticide-exposed workers. J Occup Environ Med 45(2): 118-122.
14. Hofman J et al (2009) Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlers. Env Health Persp 117(9): 1402-1408.