Effect of tyrosine kinase inhibitors on tyrosine phosphorylation and motility parameters in human sperm

Archives of Andrology

Volumn 49, Issue 3, 2003, Pages 229-246

  Bajpai, M ^a,b   Asin, S ^a,c   Doncel, G F ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Cell movement; Erbstatin; Genistein; Herbimycin A; Sperm; Tyrphostin

Indexed keywords

ERBSTATIN; GENISTEIN; HERBIMYCIN A; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; STAUROSPORINE; TRITON X 100; TYRPHOSTIN; ENZYME INHIBITOR; TYROSINE;

ARTICLE; CELL ASSAY; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; INCUBATION TIME; MALE; MITOCHONDRION; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SPERMATOZOON MOTILITY; WESTERN BLOTTING; AMINO ACID SEQUENCE; DRUG ANTAGONISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; NORTHERN BLOTTING; PHOSPHORYLATION;

AMINO ACID SEQUENCE; BLOTTING, NORTHERN; BLOTTING, WESTERN; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; MALE; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; SPERM MOTILITY; TYROSINE;

EID: 79961199198     PISSN: 01485016     EISSN: None     Source Type: Journal    
DOI: 10.1080/01485010390196715     Document Type: Article

References (42)

1. Ahmad K, Bracho GE, Wolf DP, Tash JS (1995): Regulation of human sperm motility and hyperactivation components by calcium, calmodulin, and protein phosphatases. Arch Androl 35:187-208.
2. Akiyama T, Ishida J, Nakagawa S, Ogawara, H, Watanabe S, Itoh N, Shibuya M, Fukami Y (1987): Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262:5592-5595.
3. Aoki F, Ishida K, Okuno M, Kohmoto K (1994): Analysis of flagellar bending in hyperactivated hamster and mouse spermatozoa. J Reprod Fertil 101:397-403.
4. Ashizawa K, Higashio M, Tsuzuki Y (1998): Effects of tyrosine kinase inhibitor on the motility and ATP concentrations of fowl spermatozoa. Mol Reprod Dev. 49:196-202.
5. Bailey JL, Storey BT (1994): Calcium influx into mouse sperm activated by solubilized mouse zona pellucida, monitored with the calcium fluorescent indicator, Fluo-3: inhibition of the influx by three inhibitors of the zona pellucida induced acrosome reaction: Tyrphostin A48, Pertussis Toxin, and 3-Quinuclidinyl Benzilate. Mol Reprod Dev. 39:297-308.
6. Bonaccorsi LB, Luconi M, Forti G, Baldi E (1995): Tyrosine kinase inhibition reduces the plateau phase of the calcium increase in response to progesterone in human sperm. FEBS Lett. 364:83-86.
7. Bracho GE, Fritch JJ, Tash, JS (1998): Identification of flagellar proteins that initiate the activation of sperm motility in vivo. Biochem Biophys Res Commun 242:231-237.
8. Brokaw CJ (1987): Regulation of sperm flagellar motility by calcium and cAMP-dependant phosphorylation. J Cell Biochem 35:175-184.
9. Burkman LJ (1984): Characterization of hyperactivated motility by human sperm during capacitation: comparison of fertile and oligozoospermic sperm populations. Arch Androl 13:153-165.
10. Burkman LJ (1991): Discrimination between nonhyperactivated and classical hyperactivated motility patterns in human sperm using computerized analysis. Fertil Steril 2: 363-371.
11. Carrera A, Moos J, Ning XP, Gerton GL, Tesarik J, Kopf GS, Moss SB (1996): Regulation of protein tyrosine phosphorylation in human sperm by a calcium/calmodulin-dependant mechanism: identification of A kinase anchor proteins as major substrates for tyrosine phosphorylation. Dev Biol 180:284-296.
12. Chemes HE, Brugo S, Zanchetti F, Carrere C, Lavieri JC (1987): Dysplasia of the fibrous sheath: an ultrastructural defect of human spermatozoa associated with sperm immotility and primary sterility. Fertil Steril 48:664-669.
13. Chemes HE, Olmedo SB, Carrere C, Oses R, Carizza C, Leisner M, Blaquier J (1998): Ultrastructural pathology of the sperm flagellum: association between flagellar pathology and fertility prognosis in severely asthenozoospermic men. Hum Reprod 13:2521-2526.
14. Devi KU, Jha K, Patil SB, Padma P, Shivaji S (2000): Inhibition of motility of hamster sperm by protein tyrosine kinase inhibitors. Andrologia 32:95-106.
15. Dey CS, Brokaw CJ (1991): Activation of Ciona sperm motility: phosphorylation of dynein polypeptides and effects of a tyrosine kinase inhibitor. J Cell Sci 100:815-824.
16. Gazit A, Yaish P, Gilon C, Levitzki A (1989): Tyrphostins, I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 32:2344-2352.
17. Jeyendran RS, Van der Ven HH, Perez-Pelaez M, Crabo BG, Zaneveld LJ (1984): Development of an assay to assess the functional integrity of the human sperm membrane and its relationship to other semen characteristics. J Reprod Fertil 70:219-228.
18. Katz DF, Yanagimachi R (1981): Movement characteristics of hamster and guinea pig sperm upon attachment to the zona pellucida. Biol Reprod 24:785-791.
19. Leclerc P, de Lamirande E, Gagnon C (1996): Cyclic adenosine 3′,5′ monophsophate-dependent regulation of protein tyrosine phosphorylation in relation to human sperm capacitation and motility. Biol Reprod 55:684-692.
20. Levitz SM, Diamond RD (1985): A rapid colorimetric assay of fungal viability with tetrazolium salt MTT. J Infect Dis 152:938-945.
21. Levitzki A, Gazit A (1995): Tyrosine kinase inhibition: an approach to drug development. Science 267:1782-1787.
22. Leyton L, LeGuen P, Bunch D, Saling PM (1992): Regulation of mouse gamete interaction by a sperm tyrosine kinase. Proc Natl. Acad Sci USA 89:11692-11695.
23. Lindemann CB, Orlando A, Kanous KS (1992): The flagellar beat of rat sperm is organized by the interaction of two functionally distinct populations of dynein bridges with a stable central axonemal partition. J Cell Science 102:249-260.
24. Mahony MC, Gwathmey TY (1999): Protein tyrosine phosphorylation during hyperactivated motility of Cynomolgus monkey (Macaca fascicularis) spermatozoa. Biol Reprod 60:1239-1243.
25. Majumder GC, Dey CS, Haldar S, Barua M (1990): Biochemical parameters of initiation and regulation of sperm motility. Arch Androl 24:287-303.
26. Morisawa M, Hayashi H (1985): Phosphorylation of 15k axonemal protein is the trigger initiating trout sperm motility. Biomed Res 6:181-184.
27. Si Y, Okuno M (1993): The sliding of the fibrous sheath through the axoneme proximally together with microtubule extrusion. Exp Cell Res 208:170-174.
28. Si Y, Okuno M (1999): Role of tyrosine phosphorylation of flagellar proteins in hamster sperm hyperactivation. Biol Reprod 61:240-246.
29. Stanwell C, Burke TR, Yuspa SH (1995): The erbstatin analogue methyl 2,5-dihydroxycinnamate cross-links proteins and is cytotoxic to normal and neoplastic epithelial cells by a mechanism independent of tyrosine kinase inhibition. Cancer Res 55:4950-4956.
30. Tash JS (1989): Protein phosphorylation: the second messenger signal transducer of flagellar motility. Cell Motil Cytoskeleton 4:332-339.
31. Tash JS, Bracho GE (1994): Regulation of sperm motility: Emerging evidence for a major role for protein phosphatases. J Androl 15:505-509.
32. Tash JS, Bracho GE (1998): Identification of phosphoproteins coupled to initiation of motility in live epididymal mouse sperm. Biochem Biophys Res Commun 251:557-563.
33. Tesarik J, Moos J, Mendoza C (1993): Stimulation of protein tyrosine phosphorylation by a progesterone receptor on the cell surface of human sperm. Endocrinology 133:328-335.
34. Turner RM, Johnson LR, Haig-Ladewig L, Gerton GL, Moss SB (1998): An X-linked gene encodes a major human sperm fibrous sheath protein, hAKAP82: genomic organization, protein kinase A-RII binding, and distribution of the precursor in the sperm tail. J Biol Chem 273:32135-41.
35. Turner RM, Eriksson RLM, Gerton G, Moss SB (1999): Relationship between sperm motility and the processing and tyrosine phosphorylation of two human sperm fibrous sheath proteins, pro-hAKAP82 and hAKAP82. Mol Hum Reprod 5:816-824.
36. Umezawa K, Hori T, Tajima H, Imoto M, Isshiki K, Takeuchi T (1990): Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors. FEBS Letters 2:198-200.
37. Vijayaraghavan S, Trautman KD, Goueli SA, Carr DW (1997a): A tyrosine-phosphrylated 55-kilodalton motility-associated bovine sperm protein is regulated by cyclic adenosine 3′5′-monophosphates and calcium. Biol Reprod 56:1450-1457.
38. Vijayaraghavan S, Olson GE, NagDas S, Winfrey VP, Carr DW (1997b): Subcellular localization of the regulatory subunits of cyclic adenosine 3′,5′-monophosphate-dependent protein kinase in bovine spermatozoa. Biol Reprod. 57:1517-1523.
39. Vijayaraghavan S, Mohan J, Gray H, Khatra B, Carr DW (2000): A role of phosphorylation of glycogen synthase kinase-3α in bovine sperm motility regulation. Biol Reprod 62:1647-1654.
40. Visconti PE, Kopf GS (1998): Regulation of protein phosphorylation during sperm capacitation. Biol Reprod 59:1-6.
41. White DR, Aitken RJ (1989): Relationship between calcium, cyclic AMP, ATP, and intracellular pH and the capacity of hamster spermatozoa to express hyperactivated motility. Gamete Res 22:163-177.
42. Yunes R, Doncel GF, Acosta AA (1994): Phosphotyrosine-containing proteins and hyperactivated motility in human sperm. Fertil Steril November, ASRM Annual Meeting Supplement: S3.