Heterogenous effect of androgen receptor CAG tract length on testicular germ cell tumor risk: Shorter repeats associated with seminoma but not other histologic types

Carcinogenesis

Volumn 32, Issue 8, 2011, Pages 1238-1243

  Davis Dao, Carol A ^a   Siegmund, Kimberly D ^a   Vandenberg, David J ^a   Skinner, Eila C ^a   Coetzee, Gerhard A ^a   Thomas, Duncan C ^a   Pike, Malcolm C ^a,b   Cortessis, Victoria K ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR;

ADULT; ARTICLE; CAG REPEAT; CANCER GROWTH; CANCER RISK; CONTROLLED STUDY; HISTOPATHOLOGY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK ASSESSMENT; SEMINOMA; TRANSACTIVATION;

EID: 79961197210     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgr104     Document Type: Article

References (28)

1. Huyghe,E. et al. (2003) Increasing incidence of testicular cancer worldwide: a review. J. Urol., 170, 5-11.
2. Forman,D. et al. (1992) Familial testicular cancer: a report of the UK family register, estimation of risk and an HLA class I sib-pair analysis. Br. J. Cancer, 65, 255-262.
3. Wanderas,E.H. et al. (1997) Risk of a second germ cell cancer after treatment of a primary germ cell cancer in 2201 Norwegian male patients. Eur. J. Cancer, 33, 244-252.
4. Schnack,T.H. et al. (2009) Familial coaggregation of cryptorchidism, hypospadias, and testicular germ cell cancer: a nationwide cohort study. J. Natl Cancer Inst., 102, 187-192.
5. Henderson,B.E. et al. (1983) Epidemiology of testis cancer. In Skinner,D.G. (ed) Urological Cancer. Grune and Stratton, New York, NY, pp. 237-250.
6. Diekmann,K.P. et al. (2004) Clinical epidemiology of testicular germ cell tumors. World J. Urol., 22, 2-14.
7. Oosterhuis,J.W. et al. (2005) Testicular germ-cell tumors in a broader perspective. Nat. Rev. Cancer, 5, 210-222.
8. Rajpert-De Meyts,E. et al. (2002) Analysis of the polymorphic CAG repeat length in the androgen receptor gene in patients with testicular germ cell cancer. Int. J. Cancer, 102, 201-204.
9. Shapiro,E. et al. (2005) Immunolocalization of androgen receptor and estrogen receptors alpha and beta in human fetal testis and epididymis. J. Urol., 174, 1695-1698.
10. Merlet,J. et al. (2007) Male fetal germ cells are targets for androgens that physiologically inhibit their proliferation. Proc. Natl Acad. Sci. USA, 104, 3615-3620.
11. Rajpert-De Meyts,E. et al. (1992) Immunohistochemical identification of androgen receptors in germ cell neoplasia. J. Endocrinol., 135, R1-R4.
12. Zhou,Q. et al. (2002) Localization of androgen and estrogen receptors in adult male mouse reproductive tract. J. Androl., 23, 870-881.
13. Brinkmann,A.O. (2001) Molecular basis of androgen insensitivity. Mol. Cell. Endocrinol., 179, 105-109.
14. Chamberlain,N.L. et al. (1994) The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain effect transactivation function. Nucleic Acids Res., 22, 3181-3186.
15. Buchanan,G. et al. (2004) Structural and functional consequences of glutamine tract variation in the androgen receptor. Hum. Mol. Genet., 13, 1677-1692.
16. Crabbe,P. et al. (2007) Part of the interindividual variation in serum testosterone levels in healthy men reflects differences in androgen sensitivity and feedback set point: contribution of the androgen receptor polyglutamine tract polymorphism. J. Clin. Endocrinol. Metab., 92, 3604-3610.
17. Horvath,S. et al. (2000) The transmission/disequilibrium test and parentalgenotype reconstruction for X-chromosomal markers. Am. J. Hum. Genet., 66, 1161-1167.
18. Wang,W. et al. (2005) Androgen receptor and prostate-specific antigen gene polymorphisms and breast cancer in African-American women. Cancer. Epidemiol. Biomarkers Prev., 14, 2990-2994.
19. Giwercman,A. et al. (2004) Linkage between androgen receptor gene CAG trinucleotide repeat length and testicular germ call cancer histological type and clinical stage. Eur. J. Cancer, 40, 2152-2158.
20. Garolla,A. et al. (2005) Molecular analysis of the androgen receptor gene in testicular cancer. Endocr. Relat. Cancer, 12, 645-655.
21. Vastermark,A. et al. (2011) Polymorphic variation in the androgen receptor gene: association with risk of testicular germ cell cancer and metastatic disease. Eur. J. Cancer, 47, 413-419.
22. Turnbull,C. et al. (2010) Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer. Nat. Genet., 42, 604-607.
23. Rapley,E.A. et al. (2009) A genome-wide association study of testicular germ cell tumor. Nat. Genet., 41, 807-810.
24. Kanetsky,P.A. et al. (2009) Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. Nat. Genet., 41, 811-815.
25. Kinoshita,H. et al. (2000) Methylation of the androgen receptor minimal promoter silence transcription in human prostate cancer. Cancer Res., 60, 3623-3630.
26. Looijenga,L. et al. (1997) X inactivation in human testicular tumors: XIST expression and androgen receptor methylation status. Am. J. Pathol., 151, 581-590.
27. Heinlein,C.A. et al. (2002) The roles of androgen receptors and androgen binding proteins in nongenomic androgen actions. Mol. Endocrinol., 16, 2181-2187.
28. Shupe,J. et al. (2011) Regulation of sertoli-germ cell adhesion and sperm release by FSH and nonclassical testosterone signaling. Mol. Endocrinol., 25, 238-252.