Method development and validation for optimised separation of salicylic, acetyl salicylic and ascorbic acid in pharmaceutical formulations by hydrophilic interaction chromatography and response surface methodology

Journal of Chromatography A

Volumn 1218, Issue 35, 2011, Pages 5995-6003

  Hatambeygi, Nader ^a   Abedi, Ghazaleh ^b   Talebi, Mohammad ^a  

^a Kimiafaam Pharmaceutical Co   (Iran)

^b IRAN POLYMER AND PETROCHEMICAL INSTITUTE   (Iran)

Author keywords

Box Behnken; Derringer's desirability function; Hydrophilic interaction chromatography (HILIC); ICH guidelines; Optimisation; Response surface methodology (RSM)

Indexed keywords

BOX-BEHNKEN; DERRINGER'S DESIRABILITY FUNCTION; HYDROPHILIC INTERACTION CHROMATOGRAPHY (HILIC); ICH GUIDELINES; OPTIMISATIONS; RESPONSE SURFACE METHODOLOGY;

ACETONITRILE; AMMONIUM COMPOUNDS; DESIGN; DESIGN OF EXPERIMENTS; KETONES; LIQUID CHROMATOGRAPHY; MATHEMATICAL MODELS; OPTIMIZATION; ORGANIC ACIDS; STATISTICS; SURFACE PROPERTIES;

HYDROPHILICITY;

ACETONITRILE; ACETYLSALICYLIC ACID; AMMONIUM ACETATE; ASCORBIC ACID; BUFFER; SALICYLIC ACID;

ACCURACY; ANALYTIC METHOD; ARTICLE; BOX BEHNKEN METHOD; CHEMICAL INTERACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DERRINGER DESIRABILITY FUNCTION; DRUG DETERMINATION; DRUG FORMULATION; FEASIBILITY STUDY; HYDROPHILIC INTERACTION CHROMATOGRAPHY; IONIC STRENGTH; MATHEMATICAL MODEL; PH; PHASE SEPARATION; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; RESPONSE SURFACE METHOD; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; TEMPERATURE; VALIDATION PROCESS;

ACETATES; ACETONITRILES; ANALYSIS OF VARIANCE; ASCORBIC ACID; ASPIRIN; CHROMATOGRAPHY, LIQUID; DRUG CONTAMINATION; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LEAST-SQUARES ANALYSIS; MODELS, CHEMICAL; REPRODUCIBILITY OF RESULTS; SALICYLIC ACID; SENSITIVITY AND SPECIFICITY; TABLETS; TEMPERATURE;

EID: 79961170901     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.06.009     Document Type: Article

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