Enhanced mechanical performance and biological evaluation of a PLGA coated β-TCP composite scaffold for load-bearing applications

European Polymer Journal

Volumn 47, Issue 8, 2011, Pages 1569-1577

  Kang, Yunqing ^a   Scully, Allison ^b   Young, Daniel A ^a,c   Kim, Sungwoo ^a   Tsao, Helen ^a   Sen, Milan ^a   Yang, Yunzhi ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b Rice University   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Tricalcium phosphate; Bone tissue engineering; Functional composites; Poly(lactic co glycolic acid); Scaffold

Indexed keywords

ALKALINE PHOSPHATASE ACTIVITY; BIOLOGICAL EVALUATION; BONE REPAIR; BONE TISSUE ENGINEERING; BONE TISSUE REGENERATION; COMPOSITE SCAFFOLDS; CRACK BRIDGING; FUNCTIONAL COMPOSITES; IN-VITRO; INTERCONNECTED POROUS STRUCTURE; INTERCONNECTIVITY; LOAD-BEARING; MACROPOROUS; MECHANICAL PERFORMANCE; NEW STRATEGY; OSTEOCONDUCTIVITY; POLY(LACTIC-CO-GLYCOLIC ACID); RAT BONE MARROW; STRUCTURAL CHARACTERISTICS; THIN LAYERS; TRI-CALCIUM PHOSPHATES;

BEARINGS (MACHINE PARTS); BEARINGS (STRUCTURAL); BENDING STRENGTH; BIOCOMPATIBILITY; BIODEGRADATION; BIOMECHANICS; BONE; COMPRESSIVE STRENGTH; FRACTURE MECHANICS; MECHANICAL PROPERTIES; PHOSPHATASES; TISSUE;

SCAFFOLDS (BIOLOGY);

EID: 79961168901     PISSN: 00143057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eurpolymj.2011.05.004     Document Type: Article

References (34)

1. C.A. Vacanti, W. Kim, J. Upton, M.P. Vacanti, D. Mooney, and B. Schloo Tissue-engineered growth of bone and cartilage Transplant Proc 25 1993 1019 1021 (Pubitemid 23078880)
2. S.S. Kim, M. Sun Park, O. Jeon, C. Yong Choi, and B.S. Kim Poly(lactide-co-glycolide)/hydroxyapatite composite scaffolds for bone tissue engineering Biomaterials 27 8 2006 1399 1409 (Pubitemid 41739565)
3. D. Donati, C. Zolezzi, P. Tomba, and A. Vigan Bone grafting: historical and conceptual review, starting with an old manuscript by Vittorio Putti Acta Orthop 78 1 2007 19 25 (Pubitemid 46570253)
4. A.G. Mikos, S.W. Herring, P. Ochareon, J. Elisseeff, H.H. Lu, and F.J. Schoen Engineering complex tissues Tissue Eng 12 12 2006 3307 3339 (Pubitemid 46037158)
5. A.P. Gupta, and V. Kumar New emerging trends in synthetic biodegradable polymers - polylactide: a critique Eur Polym J 43 2007 4053 4074 (Pubitemid 47483695)
6. J.Y. Rho, L. Kuhn-Spearing, and P. Zioupos Mechanical properties and the hierarchical structure of bone Med Eng Phys 20 2 1998 92 102 (Pubitemid 28318322)
7. T.A. Holland, and A.G. Mikos Review: biodegradable polymeric scaffolds. Improvements in bone tissue engineering through controlled drug delivery Adv Biochem Eng Biot 102 2006 161 185 (Pubitemid 44608157)
8. R. Zhang, and P.X. Ma Poly(α-hydroxyl acids)/hydroxyapatite porous composites for bone-tissue engineering. I. Preparation and morphology J Biomed Mater Res 44 1999 446 455 (Pubitemid 29031128)
9. M. Navarro, M.P. Ginebra, J.A. Planell, S. Zeppetelli, and L. Ambrosio Development and cell response of a new biodegradable composite scaffold for guided bone regeneration J Mater Sci: Mater Med 15 2004 419 422 (Pubitemid 39012155)
10. K. Rezwan, Q.Z. Chen, J.J. Blaker, and A.R. Boccaccini Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering Biomaterials 27 18 2006 3413 3431
11. 2 nanoparticle-filled composites for tissue engineering scaffolds Compos Sci Technol 67 2007 1139 1147 (Pubitemid 46158637)
12. P. Fabbri, V. Cannillo, A. Sola, A. Dorigato, and F. Chiellini Highly porous polycaprolactone-45S5 Bioglass® scaffolds for bone tissue engineering Compos Sci Technol 70 2010 1869 1878
13. F.Z. Cui, Y. Li, and J. Ge Self-assembly of mineralized collagen composites Mater Sci Eng R R57 2007 1 27 (Pubitemid 47044908)
14. H. Hosseinkhania, M. Hosseinkhanib, F. Tianc, H. Kobayashic, and Y. Tabata Ectopic bone formation in collagen sponge self-assembled peptide-amphiphile nanofibers hybrid scaffold in a perfusion culture bioreactor Biomaterials 27 2006 5089 5098 (Pubitemid 43928128)
15. J.A. Roether, A.R. Boccaccini, L.L. Hench, V. Maquet, S. Gautier, and R. Jerome Development and in vitro characterisation of novel bioresorbable and bioactive composite materials based on polylactide foams and Bioglass® for tissue engineering applications Biomaterials 23 2002 3871 3878 (Pubitemid 34830405)
16. C.C.P.M. Verheyen, J.R. de Wijn, C.A. van Blitterswijk, K. de Groot, and P.M. Rozing Hydroxyapatite/poly(l-lactide) composites: an animal study on push-out strengths and interface histology J Biomed Mater Res 27 1993 433 444 (Pubitemid 23093987)
17. M. Peroglio, L. Gremillard, J. Chevalier, L. Chazeau, C. Gauthier, and T. Hamaide Toughening of bio-ceramics scaffolds by polymer coating J Eur Ceram Soc 27 2007 2679 2685 (Pubitemid 46196360)
18. J. Zhao, X. Lu, K. Duan, L.Y. Guo, S.B. Zhou, and J. Weng Improving mechanical and biological properties of macroporous HA scaffolds through composite coatings Colloid Surface B 74 2009 159 166
19. X.G. Miao, M.F. Tan, J. Li, Y. Xiao, and R. Crawford Mechanical and biological properties of hydroxyapatite/tricalcium phosphate scaffolds coated with poly(lactic-co-glycolic acid) Acta Biomater 4 2008 638 645 (Pubitemid 351461279)
20. H.W. Kim, J.C. Knowles, and H.E. Kim Hydroxyapatite/poly(e-caprolactone) composite coatings on hydroxyapatite porous bone scaffold for drug delivery Biomaterials 25 2004 1279 1287 (Pubitemid 37476205)
21. L.G. Gibson The mechanical behavior of cancellous bone J Biomech 18 1985 317 328
22. Y.X. Liu, J.H. Kim, D. Young, S.W. Kim, S.K. Nishimoto, and Y.Z. Yang Novel template-casting technique for fabricating b-tricalcium phosphate scaffolds with high interconnectivity and mechanical strength and in vitro cell responses J Biomed Mater Res 92A 2010 997 1006
23. S.R. Chastain, A.K. Kundu, S. Dhar, J.W. Calvert, and A.J. Putnam Adhesion of mesenchymal stem cells to polymer scaffolds occurs via distinct ECM ligands and controls their osteogenic differentiation J Biomed Mater Res 78A 1 2006 73 85 (Pubitemid 44032529)
24. J.J. Mao, X. Xin, and M. Hussain Continuing differentiation of human mesenchymal stem cells and induced chondrogenic and osteogenic lineages in electrospun PLGA nanofiber scaffold Biomaterials 28 2 2007 316 325 (Pubitemid 44537391)
25. V. Karageorgiou, and D. Kaplan Porosity of 3D biomaterial scaffolds and osteogenesis Biomaterials 26 2005 5474 5491 (Pubitemid 40592136)
26. N.L. Porter, R.M. Pilliar, and M.D. Grynpas Fabrication of porous calcium polyphosphate implants by solid freeform fabrication: a study of processing parameters and in vitro degradation characteristics J Biomed Mater Res 56 4 2001 504 515 (Pubitemid 32611214)
27. D.W. Hutmacher, J.T. Schantz, C.X.F. Lam, K.C. Tan, and T.C. Lim State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective J Tissue Eng Regen Med 1 2007 245 260
28. A.J. Wagoner Johnson, and B.A. Herschler A review of the mechanical behavior of CaP and CaP/polymer composites for applications in bone replacement and repair Acta Biomater 7 1 2011 16 30
29. K. Rezwan, Q. Chen, J. Blaker, and A. Boccaccini Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering Biomaterials 27 2006 3413 3431
30. Q.Z. Chen, and A.R. Boccaccini Poly(d, l-lactic acid) coated 45S5 bioglass-based scaffolds: processing and characterization J Biomed Mater Res A 77A 2006 445 457 (Pubitemid 47240771)
31. F.J. Martínez-Vázquez, F.H. Perera, P. Miranda, A. Pajares, and F. Guiberteau Improving the compressive strength of bioceramic robocast scaffolds by polymer infiltration Acta Biomater 6 11 2010 4361 4368
32. G. Pezzotti, and S.M.F. Asmus Fracture behavior of hydroxyapatite/polymer interpenetrating network composites prepared by in situ polymerization process Mater Sci Eng A (Struct Mater:Prop, Microstruct Process) A316 2001 231 237 (Pubitemid 32914347)
33. R.K. Nalla, J.H. Kinney, and R.O. Ritchie Mechanical fracture criteria for the failure of human cortical bone Nat Mater 2 2003 164 168
34. S.I. Roohani-Esfahani, S. Nouri-Khorasani, Z. Lu, R. Appleyard, and H. Zreiqat The influence hydroxyapatite nanoparticle shape and size on the properties of biphasic calcium phosphate scaffolds coated with hydroxyapatite-PCL composites Biomaterials 31 21 2010 5498 5509