Conventional ovarian stimulation no longer exists: Welcome to the age of individualized ovarian stimulation

Reproductive BioMedicine Online

Volumn 23, Issue 2, 2011, Pages 141-148

  Nardo, Luciano G ^a,b   Fleming, Richard ^c   Howles, Colin M ^d   Bosch, Ernesto ^e   Hamamah, Samir ^f   Ubaldi, Filippo M ^g   Hugues, Jean Noel ^h   Balen, Adam H ⁱ   Nelson, Scott M ^j  

^a ST MARY S HOSPITAL   (United Kingdom)

^b GyneHealth   (United Kingdom)

^c GCRM Ltd   (United Kingdom)

^d MERCK SERONO S A   (Switzerland)

^e INSTITUTO VALENCIANO DE INFERTILIDAD   (Spain)

^f UNIV MONTPELLIER   (France)

^g GENERA Centre for Reproductive Medicine   (Italy)

^h UNIVERSITÉ PARIS 13   (France)

ⁱ Leeds Centre for Reproductive Medicine   (United Kingdom)

^j UNIVERSITY OF GLASGOW   (United Kingdom)

more..

Author keywords

anti M llerian hormone (AMH); chronological age; extremes of ovarian response; individualized ovarian stimulation; IVF

Indexed keywords

ANDROGEN; AROMATASE INHIBITOR; CHORIONIC GONADOTROPIN; CLOMIFENE CITRATE; ESTROGEN; FOLLITROPIN; GONADORELIN AGONIST; GONADORELIN ANTAGONIST; GROWTH HORMONE; HUMAN MENOPAUSAL GONADOTROPIN; INHIBIN B; LETROZOLE; LUTEINIZING HORMONE; MUELLERIAN INHIBITING FACTOR; PRASTERONE; RECOMBINANT FOLLITROPIN; RECOMBINANT LUTEINIZING HORMONE; SOMATOMEDIN C; TESTOSTERONE;

ADULT; CLINICAL PROTOCOL; DRUG DOSE INCREASE; DRUG FORMULATION; DRUG MEGADOSE; FEMALE; FERTILIZATION IN VITRO; HUMAN; INFERTILITY; INFERTILITY THERAPY; INTRACYTOPLASMIC SPERM INJECTION; MAJOR CLINICAL STUDY; META ANALYSIS (TOPIC); OUTCOMES RESEARCH; OVARY; OVARY FOLLICLE DEVELOPMENT; OVARY FUNCTION; OVARY HYPERSTIMULATION; OVARY POLYCYSTIC DISEASE; OVULATION INDUCTION; PATIENT SELECTION; PREGNANCY RATE; REVIEW; STEROIDOGENESIS; TREATMENT RESPONSE;

EID: 79961168687     PISSN: 14726483     EISSN: 14726491     Source Type: Journal    
DOI: 10.1016/j.rbmo.2011.05.008     Document Type: Note

References (67)

1. C. Albano, R.E. Felberbaum, J. Smitz, H. Riethmüller-Winzen, J. Engel, K. Diedrich, and P. Devroey Ovarian stimulation with HMG: results of a prospective randomized phase III European study comparing the luteinizing hormone-releasing hormone (LHRH)-antagonist cetrorelix and the LHRH-agonist buserelin. European Cetrorelix Study Group Hum. Reprod. 15 2000 526 531 (Pubitemid 30142356)
2. H.G. Al-Inany, A.M. Abou-Setta, and M. Aboulghar Gonadotrophin-releasing hormone antagonists for assisted conception Cochrane Database Syst. Rev. 19 2006 3 CD001750
3. H.G. Al-Inany, A.M. Abou-Setta, M.A. Aboulghar, R.T. Mansour, and G.I. Serour Efficacy and safety of human menopausal gonadotrophins versus recombinant FSH: a meta-analysis Reprod. Biomed. Online 16 2008 81 88 (Pubitemid 351187376)
4. J. Balasch, E. Vidal, J. Peñarrubia, R. Casamitjana, F. Carmona, M. Creus, F. Fábregues, and J.A. Vanrell Suppression of LH during ovarian stimulation: analysing threshold values and effects on ovarian response and the outcome of assisted reproduction in down-regulated women stimulated with recombinant FSH Hum. Reprod. 16 2001 1636 1643 (Pubitemid 32761742)
5. J. Balasch, F. Fábregues, J. Peñarrubia, F. Carmona, R. Casamitjana, M. Creus, D. Manau, G. Casals, and J.A. Vanrell Pretreatment with transdermal testosterone may improve ovarian response to gonadotrophins in poor-responder IVF patients with normal basal concentrations of FSH Hum. Reprod. 21 2006 1884 1893 (Pubitemid 44028265)
6. D. Barad, and N. Gleicher Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF Hum. Reprod. 21 2006 2845 2849 (Pubitemid 44566996)
7. D. Belgorosky, V.A. Sander, M.P. Yorio, A.G. Faletti, and A.B. Motta Hyperandrogenism alters intraovarian parameters during early folliculogenesis in mice Reprod. Biomed. Online 20 2010 797 807
8. P. Beretsos, G.A. Partsinevelos, E. Arabatzi, P. Drakakis, D. Mavrogianni, E. Anagnostou, K. Stefanidis, A. Antsaklis, and D. Loutradis 'hCG priming' effect in controlled ovarian stimulation through a long protocol Reprod. Biol. Endocrinol. 7 2009 91
9. C. Blockeel, M. De Vos, W. Verpoest, D. Stoop, P. Haentjens, and P. Devroey Can 200 IU of hCG replace recombinant FSH in the late follicular phase in a GnRH-antagonist cycle? A pilot study Hum. Reprod. 24 2009 2910 2916
10. Z. Blumenfeld, and T. Amit The role of growth hormone (GH), GH-receptor and GH-binding protein in reproduction and ovulation induction J. Pediatr. Endocrinol. Metab. 9 1996 145 162 (Pubitemid 26176690)
11. G. Borm, and B. Mannaerts Treatment with the gonadotrophin-releasing hormone antagonist ganirelix in women undergoing ovarian stimulation with recombinant follicle stimulating hormone is effective, safe and convenient: results of a controlled, randomized, multicentre trial. The European Orgalutran Study Group Hum. Reprod. 15 2000 1490 1498
12. E. Bosch, E. Labarta, J. Crespo, C. Simón, J. Remohí, and A. Pellicer Impact of luteinizing hormone administration on gonadotropin- releasing hormone antagonist cycles: an age-adjusted analysis Fertil. Steril. 95 2011 1031 1036
13. R.A. Cabrera, L. Stadtmauer, J.F. Mayer, W.E. Gibbons, and S. Oehninger Follicular phase serum levels of luteinizing hormone do not influence delivery rates in in vitro fertilization cycles down-regulated with a gonadotropin-releasing hormone agonist and stimulated with recombinant follicle-stimulating hormone Fertil. Steril. 83 2005 42 48 (Pubitemid 40094779)
14. S.M. Carlsen, E. Vanky, and R. Fleming Anti-Müllerian hormone concentrations in androgen-suppressed women with polycystic ovary syndrome Hum. Reprod. 24 2009 1732 1738
15. I. Cedrin-Durnerin, J.M. Bidart, P. Robert, J.P. Wolf, M. Uzan, and J.N. Hugues Consequences on gonadotrophin secretion of an early discontinuation of gonadotrophin-releasing hormone agonist administration in short-term protocol for in-vitro fertilization Hum. Reprod. 15 2000 1009 1014 (Pubitemid 30251291)
16. A. Coomarasamy, M. Afnan, D. Cheema, F. van der Veen, P.M. Bossuyt, and M. van Wely Urinary hMG versus recombinant FSH for controlled ovarian hyperstimulation following an agonist long down-regulation protocol in IVF or ICSI treatment: a systematic review and meta-analysis Hum. Reprod. 23 2008 310 315 (Pubitemid 351651234)
17. G. De Placido, C. Alviggi, A. Perino, I. Strina, F. Lisi, A. Fasolino, R. De Palo, A. Ranieri, N. Colacurci, and A. Mollo Italian Collaborative Group on Recombinant Human Luteinizing Hormone. Recombinant human LH supplementation versus recombinant human FSH (rFSH) step-up protocol during controlled ovarian stimulation in normogonadotrophic women with initial inadequate ovarian response to rFSH. A multicentre, prospective, randomized controlled trial Hum. Reprod. 20 2005 390 396 (Pubitemid 40277606)
18. L. Detti, D.B. Williams, J.C. Robins, R.A. Maxwell, and M.A. Thomas A comparison of three downregulation approaches for poor responders undergoing in vitro fertilization Fertil. Steril. 84 2005 1401 1405 (Pubitemid 41571887)
19. P. Devroey, M. Aboulghar, J. Garcia-Velasco, G. Griesinger, P. Humaidan, E. Kolibianakis, W. Ledger, C. Tomás, and B.C. Fauser Improving the patient's experience of IVF/ICSI: a proposal for an ovarian stimulation protocol with GnRH antagonist co-treatment Hum. Reprod. 24 2009 764 774
20. Duffy, J.M., Ahmad, G., Mohiyiddeen, L., Nardo, L.G., Watson, A., 2010. Growth hormone for in vitro fertilization. Cochrane Database Syst. Rev. CD000099.
21. C.I. Durnerin, K. Erb, R. Fleming, H. Hillier, S.G. Hillier, C.M. Howles, J.N. Hugues, A. Lass, H. Lyall, P. Rasmussen, J. Thong, I. Traynor, L. Westergaard, R. Yates Luveris Pretreatment Group Effects of recombinant LH treatment on folliculogenesis and responsiveness to FSH stimulation Hum. Reprod. 23 2008 421 426 (Pubitemid 351651260)
22. F. Fábregues, J. Peñarrubia, M. Creus, D. Manau, G. Casals, F. Carmona, and J. Balasch Transdermal testosterone may improve ovarian response to gonadotrophins in low-responder IVF patients: a randomized, clinical trial Hum. Reprod. 24 2009 349 359
23. R. Fanchin, D.H. Méndez Lozano, L.M. Schonäuer, J.S. Cunha-Filho, and R. Frydman Hormonal manipulations in the luteal phase to coordinate subsequent antral follicle growth during ovarian stimulation Reprod. Biomed. Online 10 2005 721 728 (Pubitemid 40796938)
24. R. Fleming, L. Harborne, D.T. MacLaughlin, D. Ling, J. Norman, N. Sattar, and D.B. Seifer Metformin reduces serum mullerian-inhibiting substance levels in women with polycystic ovary syndrome after protracted treatment Fertil. Steril. 83 2005 130 136 (Pubitemid 40094791)
25. A. Goyal, D.H. Barad, A. Weghofer, K. Oktay, and N. Gleicher Predicting improvements in ovarian reserve and pregnancy rates after supplementation of dehydroepiandrosterone (DHEA) in diminished ovarian reserve Hum. Reprod. 24 2009 O-194 i79
26. G. Griesinger, K. Diedrich, B.C. Tarlatzis, and E.M. Kolibianakis GnRH-antagonists in ovarian stimulation for IVF in patients with poor response to gonadotrophins, polycystic ovary syndrome, and risk of ovarian hyperstimulation: a meta-analysis Reprod. Biomed. Online 13 2006 628 638 (Pubitemid 44760885)
27. E.M. Heijnen, M.J. Eijkemans, C. De Klerk, S. Polinder, N.G. Beckers, E.R. Klinkert, F.J. Broekmans, J. Passchier, E.R. Te Velde, N.S. Macklon, and B.C. Fauser A mild treatment strategy for in-vitro fertilisation: a randomised non-inferiority trial Lancet 369 2007 743 749
28. T.E. Hickey, D.L. Marrocco, F. Amato, L.J. Ritter, R.J. Norman, R.B. Gilchrist, and D.T. Armstrong Androgens augment the mitogenic effects of oocyte-secreted factors and growth differentiation factor 9 on porcine granulosa cells Biol. Reprod. 73 2005 825 832 (Pubitemid 41356143)
29. S.G. Hillier Gonadotropic control of ovarian follicular growth and development Mol. Cell. Endocrinol. 179 2001 39 46 (Pubitemid 32564951)
30. P.G. Hompes, F.J. Broekmans, D.A. Hoozemans, R. Schats FIRM group Effectiveness of highly purified human menopausal gonadotropin vs. recombinant follicle-stimulating hormone in first-cycle in vitro fertilization- intracytoplasmic sperm injection patients Fertil. Steril. 89 2008 1685 1693 (Pubitemid 351756496)
31. C.M. Howles, H. Saunders, V. Alam, P. Engrand FSH Treatment Guidelines Clinical Panel Predictive factors, a corresponding treatment algorithm for controlled ovarian stimulation in patients treated with recombinant human follicle stimulating hormone (follitropin alfa) during assisted reproduction technology (ART) procedures. An analysis of patients Curr. Med. Res. Opin. 22 2006 907 918 (Pubitemid 43875558)
32. J.N. Hugues, M. Attalah, F. Hervé, B. Martin-Pont, M.L. Kottler, and J. Santarelli Effects of short-term GnRH agonist - human menopausal gonadotrophin stimulation in patients pre-treated with progestogen Hum. Reprod. 7 1992 1079 1084
33. J.A. Huirne, R. Homburg, and C.B. Lambalk Are GnRH antagonists comparable to agonists for use in IVF? Hum. Reprod. 22 2007 2805 2813 (Pubitemid 351696806)
34. P. Humaidan, M. Bungum, L. Bungum, and C. Yding Andersen Effects of recombinant LH supplementation in women undergoing assisted reproduction with GnRH agonist down-regulation and stimulation with recombinant FSH: an opening study Reprod. Biomed. Online 8 2004 635 643 (Pubitemid 38744939)
35. E.R. Klinkert, F.J. Broekmans, C.W. Looman, J.D. Habbema, and E.R. te Velde Expected poor responders on the basis of an antral follicle count do not benefit from a higher starting dose of gonadotrophins in IVF treatment: a randomized controlled trial Hum. Reprod. 20 2005 611 615 (Pubitemid 40425484)
36. E.R. Klinkert, F.J. Broekmans, C.W. Looman, J.D. Habbema, and E.R. te Velde The antral follicle count is a better marker than basal follicle-stimulating hormone for the selection of older patients with acceptable pregnancy prospects after in vitro fertilization Fertil. Steril. 83 2005 811 814 (Pubitemid 40348610)
37. E.M. Kolibianakis, C. Albano, J. Kahn, M. Camus, H. Tournaye, A.C. Van Steirteghem, and P. Devroey Exposure to high levels of luteinizing hormone and estradiol in the early follicular phase of gonadotropin-releasing hormone antagonist cycles is associated with a reduced chance of pregnancy Fertil. Steril. 79 2003 873 880 (Pubitemid 36385006)
38. E.M. Kolibianakis, K. Zikopoulos, J. Schiettecatte, J. Smitz, H. Tournaye, M. Camus, A.C. Van Steirteghem, and P. Devroey Profound LH suppression after GnRH antagonist administration is associated with a significantly higher ongoing pregnancy rate in IVF Hum. Reprod. 19 2004 2490 2496 (Pubitemid 39481272)
39. E.M. Kolibianakis, J. Collins, B.C. Tarlatzis, P. Devroey, K. Diedrich, and G. Griesinger Among patients treated for IVF with gonadotrophins and GnRH analogues, is the probability of live birth dependent on the type of analogue used? A systematic review and meta-analysis Hum. Reprod. Update 12 2006 651 671 (Pubitemid 44605507)
40. E.M. Kolibianakis, C.A. Venetis, K. Diedrich, B.C. Tarlatzis, and G. Griesinger Addition of growth hormone to gonadotrophins in ovarian stimulation of poor responders treated by in-vitro fertilization: a systematic review and meta-analysis Hum. Reprod. Update 15 2009 613 622
41. I.P. Kosmas, K. Zikopoulos, I. Georgiou, E. Paraskevaidis, C. Blockeel, H. Tournaye, J. Van Der Elst, and P. Devroey Low-dose HCG may improve pregnancy rates and lower OHSS in antagonist cycles: a meta-analysis Reprod. Biomed. Online 19 2009 619 630
42. A. La Marca, G. Sighinolfi, D. Radi, C. Argento, E. Baraldi, A.C. Artenisio, G. Stabile, and A. Volpe Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART) Hum. Reprod. Update 16 2010 113 130
43. P. Lehert, and D. Ezcurra Comparison between r-hFSH and hMG in ART: a systematic review and meta-analysis including 4040 women and 16 studies Hum. Reprod. 25 2010 i100 i101 O-256
44. K. Lossl, C.Y. Andersen, A. Loft, N.L. Freiesleben, S. Bangsbøll, and A.N. Andersen Short-term androgen priming by use of aromatase inhibitor and hCG before controlled ovarian stimulation for IVF. A randomized controlled trial Hum. Reprod. 23 2008 1820 1829 (Pubitemid 352020003)
45. N.S. Macklon, R.L. Stouffer, L.C. Giudice, and B.C. Fauser The science behind 25 years of ovarian stimulation for in vitro fertilization Endocr. Rev. 27 2006 170 207
46. K. Majumder, T.A. Gelbaya, I. Laing, and L.G. Nardo The use of anti-Müllerian hormone and antral follicle count to predict the potential of oocytes and embryos Eur. J. Obstet. Gynecol. Reprod. Biol. 150 2010 166 170
47. R. Marrs, D. Meldrum, S. Muasher, W. Schoolcraft, L. Werlin, and E. Kelly Randomized trial to compare the effect of recombinant human FSH (follitropin alfa) with or without recombinant human LH in women undergoing assisted reproduction treatment Reprod. Biomed. Online 8 2004 175 182 (Pubitemid 38208463)
48. N. Massin, I. Cedrin-Durnerin, C. Coussieu, J. Galey-Fontaine, J.P. Wolf, and J.N. Hugues Effects of transdermal testosterone application on the ovarian response to FSH in poor responders undergoing assisted reproduction technique - a prospective, randomized, double-blind study Hum. Reprod. 21 2006 1204 1211
49. R. Matorras, B. Prieto, A. Exposito, R. Mendoza, L. Crisol, P. Herranz, and S. Burgués Mid-follicular LH supplementation in women aged 35-39 years undergoing ICSI cycles: a randomized controlled study Reprod. Biomed. Online 19 2009 879 887
50. M.H. Mochtar, F. Van der Veen, M. Ziech, and M. van Wely Recombinant Luteinizing Hormone (rLH) for controlled ovarian hyperstimulation in assisted reproductive cycles Cochrane Database Syst. Rev. 2 2007 CD005070
51. L.G. Nardo, A.P. Yates, S.A. Roberts, P. Pemberton, and I. Laing The relationships between AMH, androgens, insulin resistance and basal ovarian follicular status in non-obese subfertile women with and without polycystic ovary syndrome Hum. Reprod. 24 2009 2917 2923
52. L.G. Nardo, T.A. Gelbaya, H. Wilkinson, S.A. Roberts, A. Yates, P. Pemberton, and I. Laing Circulating basal anti-Müllerian hormone levels as predictor of ovarian response in women undergoing ovarian stimulation for in vitro fertilization Fertil. Steril. 92 2009 1586 1593
53. S.M. Nelson, R.W. Yates, and R. Fleming Serum anti-Müllerian hormone and FSH: prediction of live birth and extremes of response in stimulated cycles - implications for individualization of therapy Hum. Reprod. 22 2007 2414 2421 (Pubitemid 47289055)
54. S.M. Nelson, R.W. Yates, H. Lyall, M. Jamieson, I. Traynor, M. Gaudoin, P. Mitchell, P. Ambrose, and R. Fleming Anti-Müllerian hormone-based approach to controlled ovarian stimulation for assisted conception Hum. Reprod. 24 2009 867 875
55. A. Nyboe Andersen, P. Humaidan, G. Fried, J. Hausken, L. Antila, S. Bangsbøll, P.E. Rasmussen, S. Lindenberg, H.E. Bredkjaer, H. Meinertz Nordic LH study group Recombinant LH supplementation to recombinant FSH during the final days of controlled ovarian stimulation for in vitro fertilization. A multicentre, prospective, randomized, controlled trial Hum. Reprod. 23 2008 427 434 (Pubitemid 351651237)
56. A. Nyboe Andersen, V. Goossens, S. Bhattacharya, A.P. Ferraretti, M.S. Kupka, J. de Mouzon, and K.G. Nygren European IVF-monitoring (EIM) Consortium, for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology and intrauterine inseminations in Europe, 2005: results generated from European registers by ESHRE: ESHRE. The European IVF Monitoring Programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE) Hum. Reprod. 24 2009 1267 1287
57. F. Olivennes, C.M. Howles, A. Borini, M. Germond, G. Trew, M. Wikland, F. Zegers-Hochschild, H. Saunders, V. Alam CONSORT study group Individualizing FSH dose for assisted reproduction using a novel algorithm: the CONSORT study Reprod. Biomed. Online 18 2009 195 204
58. T. Piltonen, L. Morin-Papunen, R. Koivunen, A. Perheentupa, A. Ruokonen, and J.S. Tapanainen Serum anti-Müllerian hormone levels remain high until late reproductive age and decrease during metformin therapy in women with polycystic ovary syndrome Hum. Reprod. 20 2005 1820 1826 (Pubitemid 40932362)
59. B. Popovic-Todorovic, A. Loft, H.E. Bredkjaeer, S. Bangsbøll, I.K. Nielsen, and A.N. Andersen A prospective randomized clinical trial comparing an individual dose of recombinant FSH based on predictive factors versus a 'standard' dose of 150 IU/day in 'standard' patients undergoing IVF/ICSI treatment Hum. Reprod. 18 2003 2275 2282 (Pubitemid 37427803)
60. C. Rubio, A. Mercader, P. Alamá, C. Lizán, L. Rodrigo, E. Labarta, M. Melo, A. Pellicer, and J. Remohí Prospective cohort study in high responder oocyte donors using two hormonal stimulation protocols: impact on embryo aneuploidy and development Hum. Reprod. 25 2010 2290 2297
61. S. Shanbhag, L. Aucott, S. Bhattacharya, M.A. Hamilton, and A.R. McTavish Interventions for 'poor responders' to controlled ovarian hyperstimulation (COH) in in-vitro fertilisation (IVF) Cochrane Database Syst. Rev. 1 2007 CD004379
62. C.S. Sipe, M.R. Thomas, B.J. Stegmann, and B.J. Van Voorhis Effects of exogenous testosterone supplementation in gonadotrophin stimulated cycles Hum. Reprod. 25 2010 690 696
63. F. Ubaldi, L. Rienzi, E. Baroni, S. Ferrero, M. Iacobelli, M.G. Minasi, F. Sapienza, S. Romano, A. Colasante, K. Litwicka, and E. Greco Hopes and facts about mild ovarian stimulation Reprod. Biomed. Online 14 2007 675 681 (Pubitemid 46951699)
64. J. van Disseldorp, C.B. Lambalk, J. Kwee, C.W. Looman, M.J. Eijkemans, B.C. Fauser, and F.J. Broekmans Comparison of inter- and intra-cycle variability of anti-Mullerian hormone and antral follicle counts Hum. Reprod. 25 2010 221 227
65. Weissman, A., Howles, C.M., 2009. Textbook of Assisted Reproductive Technologies: Laboratory and Clinical Perspectives, third ed., vol. 2, Clinical techniques. London (United Kingdom): Informa UK Ltd. Treatment strategies in assisted reproduction for the low responder patient, pp. 577-615 (Chapter 44).
66. A. Wiser, O. Gonen, Y. Ghetler, T. Shavit, A. Berkovitz, and A. Shulman Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study Hum. Reprod. 25 2010 2496 2500
67. Y. Yoshimura, M. Ando, S. Nagamatsu, M. Iwashita, T. Adachi, and K. Sueoka Effects of insulin-like growth factor-I on follicle growth, oocyte maturation, and ovarian steroidogenesis and plasminogen activator activity in the rabbit Biol. Reprod. 55 1996 152 160 (Pubitemid 26293152)