Synthesized glucocorticoid, dexamethasone regulates the expressions of β2-adrenoceptor and glucocorticoid receptor mRNAs but not proteins in slow-twitch soleus muscle of rats

Journal of Toxicological Sciences

Volumn 36, Issue 4, 2011, Pages 479-486

  Sato, Shogo ^a,b   Shirato, Ken ^a   Tachiyashiki, Kaoru ^c   Imaizumi, Kazuhiko ^a  

^a WASEDA UNIVERSITY   (Japan)

^b JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^c JOETSU UNIVERSITY OF EDUCATION   (Japan)

Author keywords

Atrophy; Dexamethasone; Glucocorticoid receptor; Skeletal muscle; 2 adrenoceptor

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D; HUR PROTEIN; MESSENGER RNA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EXTENSOR DIGITORUM LONGUS MUSCLE; MALE; MUSCLE CELL; MUSCLE TWITCH; NONHUMAN; PROTEIN EXPRESSION; RAT; SKELETAL MUSCLE; SOLEUS MUSCLE; TRANSCRIPTION REGULATION;

RATTUS;

EID: 79961160230     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.36.479     Document Type: Article

References (26)

1. Blaxall, B.C., Pellett, A.C., Wu, S.C., Pende, A. and Port, J.D. (2000): Purification and characterization of β-adrenergic receptor mRNA-binding protein. J. Biol. Chem., 275, 4290-4297
2. Bodine, S.C., Latres, E., Baumhueter, S., Lai, V.K.Nunez,L.,Clarke, B.A., Poueymirou, W.T., Panaro, F.J., Na, E., Dharmarajan, K., Pan, Z.Q., Valenzuela, D.M., DeChiara, T.M., Stitt, T.N., Yancopoulos, G.D. and Glass, D.J. (2001): Identification of ubiquitin ligases required for skeletal muscle atrophy. Science, 294, 1704-1708.
3. Collins, S., Altschmied, J., Herbsman, O., Caron, M.G., Mellon, P.L. and Lefkowitz, R.J. (1990): A cAMP response element in the β2-adrenergic receptor gene confers transcriptional autoregulation by cAMP. J. Biol. Chem., 265, 19330-19335.
4. Cornett, L.E., Hiller, F.C., Jacobi, S.E., Cao, W. and McGraw, D.W.(1998): Identification of a glucocorticoid response element in the rat β2-adrenergic receptor gene. Mol. Pharmacol., 54, 1016-1023.
5. Dohm, G.L., Elton, C.W., Friedman, J.E., Pilch, P.F., Pories, W.J., Atkinson, S.M.Jr. and Caro, J.F. (1991): Decreased expression of glucose transporter in muscle from insulin-resistant patients. Am. J. Physiol., 260, E459-E463.
6. Elenkov, I.J. and Chrousos, G.P. (2006): Stress system-organization, physiology and immunoregulation. Neuroimmunomodulation,13, 257-267.
7. Fan, X.C. and Steitz, J.A. (1998): Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs. EMBO J., 17, 3448-3460.
8. Hasselgren, P.O. (1999): Glucocorticoids and muscle catabolism.Curr. Opin. Clin. Nutr. Metab. Care, 2, 201-205.
9. Hinkle, R.T., Hodge, K.M., Cody, D.B., Sheldon, R.J., Kobilka, B.K. and Isfort, R.J. (2002): Skeletal muscle hypertrophy and anti-atrophy effects of clenbuterol are mediated by the β2-adrenergic receptor. Muscle Nerve, 25, 729-734.
10. Huang, H., Gazzola, C., Pegg, G.G. and Sillence, M.N. (1998):Effect of corticosterone on β-adrenoceptor density in rat skeletal muscle. J. Anim. Sci., 76, 999-1003.
11. Huang, H., Gazzola, C., Pegg, G.G. and Sillence, M.N. (2000): Differential effects of dexamethasone and clenbuterol on rat growth and on β2-adrenoceptors in lung and skeletal muscle. J. Anim. Sci., 78, 604-608.
12. Kawano, F., Tanihata, J., Sato, S., Nomura, S., Shiraishi, A., Tachiyashiki, K. and Imaizumi, K. (2009): Effects of dexamet-hasone on the expression of β1-, β2- and β3-adrenoceptor mRNAs in skeletal and left ventricle muscles in rats. J. Physiol. Sci., 59, 383-390.
13. Kern, M., Wells, J.A., Stephens, J.M., Elton, C.W., Friedman, J.E., Tapscott, E.B., Pekala, P.H. and Dohm, G.L. (1990): Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level. Biochem. J., 270, 397-400.
14. Livingstone, I., Johnson, M.A. and Mastaglia, F.L. (1981): Effects of dexamethasone on fibre inftypes in rat muscle. Neuropathol. Appl. Neurobiol., 7, 381-398.
15. Löfberg, E., Gutierrez, A., Wernerman, J., Anderstam, B., Mitch, W.E., Price, S.R., Bergström, J. and Alvestrand, A. (2002):Effects of high doses of glucocorticoids on free amino acids, ribosomes and protein turnover in human muscle. Eur. J. Clin. Invest., 32, 345-353.
16. Loflin, P.T., Chen, C.Y., Xu, N. and Shyu, A.B. (1999): Transcriptional pulsing approaches for analysis of mRNA turnover in mammalian cells. Methods, 17, 11-20.
17. Lynch, G.S. and Ryall, J.G. (2008): Role of β-adrenoceptor signaling in skeletal muscle: implications for muscle wasting and disease. Physiol. Rev., 88, 729-767.
18. Peng, S.S., Chen, C.Y., Xu, N. and Shyu, A.B. (1998): RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein. EMBO J., 17, 3461-3470.
19. Ricketson, D., Hostick, U., Fang, L., Yamamoto, K.R. and Darimont, B.D. (2007): A conformational switch in the ligand-binding domain regulates the dependence of the glucocorticoid receptor on Hsp90. J. Mol. Biol., 368, 729-741.
20. Ryall, J.G. and Lynch, G.S. (2008): The potential and the pitfalls of β-adrenoceptor agonists for the management of skeletal muscle wasting. Pharmacol. Ther., 120, 219-232.
21. Sato, S., Nomura, S., Kawano, F., Tanihata, J., Tachiyashiki, K. and Imaizumi, K. (2008): Effects of the β2-agonist clenbuterol on β1-and β2-adrenoceptor mRNA expressions of rat skeletal and left ventricle muscles. J. Pharmacol. Sci., 107, 393-400.
22. Sato, S., Nomura, S., Kawano, F., Tanihata, J., Tachiyashiki, K. and Imaizumi, K. (2010): Adaptive effects of the β2-agonist clenbuterol on expression of β2-adrenoceptor mRNA in rat fast-twitch fiber-rich muscles. J. Physiol. Sci., 60, 119-127.
23. Schakman, O., Gilson, H. and Thissen, J.P. (2008): Mechanisms of glucocorticoid-induced myopathy. J. Endocrinol., 197, 1-10.
24. The Physiological Society of Japan (2004): Guiding principles for the care and use of animals in the field of physiological sciences. Jpn. J. Physiol., 54, 98.
25. Thomason, D.B. and Booth, F.W. (1990): Atrophy of the soleus muscle by hindlimb unweighting. J. Appl. Physiol., 68, 1-12.
26. Wang, W., Furneaux, H., Cheng, H., Caldwell, M.C., Hutter, D.Liu, Y., Holbrook, N. and Gorospe, M. (2000): HuR regulates p21 mRNA stabilization by UV light. Mol. Cell. Biol., 20, 760- 769.