Synthesis, release kinetics and pharmacological profile of chimeric aceclofenac prodrug

Der Pharma Chemica

Volumn 3, Issue 3, 2011, Pages 354-363

  Dhaneshwar, Suneela S ^a   Buchade, Rahul S ^a   Vetal, Sachin ^a   Gautam, Harjeet ^a   Tewari, Kunal M ^a   Karandikar, Hrushikesh M ^a  

^a BHARATI VIDYAPEETH DEEMED UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

[2 [2 [2 [2 (2,6 DICHLOROPHENYLAMINO)PHENYL]ACETOXY]ACETYLAMINO] 3 (2,3 DIHYDRO 1H INDOL 3 YL)PROPIONIC ACID METHYL ESTER]; ACECLOFENAC; AMIDE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; DICLOFENAC; HYDROCHLORIC ACID; PHOSPHATE; PRODRUG; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG DESIGN; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG RELEASE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; INTESTINE PARAMETERS; MALE; MOUSE; NONHUMAN; PAIN; PAW EDEMA; RAT; SMALL INTESTINE PH; STOMACH PH; STOMACH ULCER; STRUCTURE ANALYSIS;

EID: 79961156533     PISSN: None     EISSN: 0975413X     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. L. Laine, K. Takeuchi, A. Tarnawski, Gastroenterol., 2008, 135, 41-60.
2. J. Kelly, D. Kaufman, J. Jurgelon, J. Sheehan, R. Koff, S. Shapiro, Lancet. 1996, 348, 1413-1416.
3. M. Wolfe, Hospital Pract. 1996, 37-47.
4. G. Torri, C. Vignati, E. Agrifoglio, M. Benvenuti, B. Ceciliani, G. Letizia, U. Martorana, L. Tessar, G. Thovez, A. Siclari, Curr. Ther. Res., 1994, 55, 576-583.
5. R. Ballesteros, J. Ansoleaga, R. Tapounet, Clin. Trials J. 1990, 27, 12-19.
6. G. Giorgianni, C. Ottaviani, A. Soliano, N. Campi, Curr. Ther. Res. 1992, 51, 175-184.
7. G. Bubani, Clin. Trials J. 1988, 25, 244-253.
8. M. Grau, J. Guasch, J. Montero, A. Felipe, E. Carrasco, S. Julia, Arzneim-Forsch. 1991, 41, 1265-1276.
9. P. Musmade, G. Subramanian, K. Srinivasan, Analytica Chimica Acta. 2007, 585, 103-109.
10. R. Seymour, J. Frame, T. Negus, J. Hawkesford, J. Marsden, I. Matthew, Br. J. Oral Maxillofac. Surg. 1998, 36(5), 375-379.
11. R. Bort, X. Ponsoda, E. Carrasco, M. Gomez-Lechon, J. Castell, Drug Metab. Dispos. 1996, 24, 834-841.
12. R. Yamazaki, S. Kawai, T. Matsuzaki, N. Kaneda, Eur. J. Pharmacol. 1997, 329, 181-187.
13. C. Maurizi, Med. Hypoth. 1990, 31, 233-242.
14. G. Ronalds, W. Malcolm, A. Charles, M. Haskell, C. Stammer, J. Org. Chem. 1969, 34, 576-578.
15. R. Hitoshi, M. Masatoshi, T. Katsumi, M. Toshiki, Yoshimasa, N. Otsuk Pharmaceutical Co. Ltd. Tokyo, Japan, US patent 5607934.
16. Vogel's Textbook of Practical Organic Chemistry. 4th ed, The English Language Bookman, London, 1978.
17. H. Bundgaard, N. Nielsen, Int. J. Pharm. 1988, 43, 101-110.
18. C. Winter, E. Risley, G. Nuss, Proc. Soc. Expt. Biol. Med. 1962, 111, 544-547.
19. S. Kulkarni; Handbook of Experimental Pharmacology, Vallabh Prakashan, Delhi, 1987.
20. A. Hunjra, K. Dharmendra, N. Gairola, M. Bhojani, S. Dhaneshwar, Indian J. Pharm. Edu. Res. 2006, 40, 40-44.
21. K. Rainsford, W. Whitehouse, Inflammation Res. 1980, 10, 451-456.