Voxel-based morphometry findings in Alzheimer's disease: Neuropsychiatric symptoms and disability correlations - preliminary results

Clinics

Volumn 66, Issue 6, 2011, Pages 1045-1050

  Vasconcelos, Luciano de Gois ^a   Jackowski, Andrea Parolin ^a   de Oliveira, Maira Okada ^b   Flor, Yoná Mayara Ribeiro ^a   Bueno, Orlando Francisco Amodeo ^a   Brucki, Sonia Maria Dozzi ^b  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Behavior disorder (Bpsd); Dementia; Functional impairment; MRI

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; BEHAVIOR; BRAIN; FEMALE; HUMAN; MALE; MENTAL DISEASE; NEUROPSYCHOLOGICAL TEST; NONPARAMETRIC TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PATHOPHYSIOLOGY; QUESTIONNAIRE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BEHAVIORAL SYMPTOMS; BRAIN; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MENTAL DISORDERS; NEUROPSYCHOLOGICAL TESTS; QUESTIONNAIRES; STATISTICS, NONPARAMETRIC;

EID: 79961151886     PISSN: 18075932     EISSN: None     Source Type: Journal    
DOI: 10.1590/S1807-59322011000600021     Document Type: Article

References (32)

1. Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi HM. Forecasting the global burden of Alzheimer's disease. Alzheimers Dement. 2007;3:186-191, doi: 10.1016/j.jalz.2007.04.381.
2. Sousa RM, Ferri CP, Acosta D, Albanese E, Guerra M, Huang Y, et al. Contribution of chronic diseases to disability in elderly people in countries with low and middle incomes: a 10/66 Dementia Research Group population-based survey. Lancet. 2009;374:1821-1830, doi: 10.1016/S0140-6736(09)61829-8.
3. Wimo A, Winblad B, Jönsson L. The worldwide societal costs of dementia: Estimates for 2009. Alzheimers Dement. 2010;6:98-103, doi: 10.1016/j.jalz.2010.01.010.
4. Gauthier S, Cummings J, Ballard C, Brodaty H, Grossberg G, Robert P, et al. Management of behavioral problems in Alzheimer's disease. Int Psychogeriatr. 2010;22:346-372, doi: 10.1017/S1041610209991505.
5. Apostolova LG, Cummings JL. Neuropsychiatric manifestations in mild cognitive impairment: a systematic review of the literature. Dement Geriatr Cogn Disord. 2008;25:115-126, doi: 10.1159/000112509.
6. Scarmeas N, Brandt J, Albert M, Hadjigeorgiou G, Papadimitriou A, Dubois B, et al. Delusions and hallucinations are associated with worse outcome in Alzheimer disease. Arch Neurol. 2005;62:1601-1608, doi: 10.1001/archneur.62.10.1601.
7. Garre-Olmo J, López-Pousa S, Vilalta-Franch J, de Gracia Blanco M, Vilarrasa AB. Grouping and trajectories of neuropsychiatric symptoms in patients with Alzheimer's disease. Part II: two-year patient trajectories. J Alzheimers Dis. 2010;22:1169-1180.
8. Robert PH, Verhey FR, Byrne EJ, Hurt C, De Deyn PP, Nobili F, et al. Grouping for behavioral and psychological symptoms in dementia: clinical and biological aspects. Consensus paper of the European Alzheimer disease consortium. Eur Psychiatry. 2005;20:490-496.
9. Shinno H, Inagaki T, Miyaoka T, Okazaki S, Kawamukai T, Utani E, et al. A decrease in N-acetylaspartate and an increase in myoinositol in the anterior cingulate gyrus are associated with behavioral and psychological symptoms in Alzheimer's disease. J Neurol Sci. 2007;260:132-138, doi: 10.1016/j.jns.2007.04.017.
10. Jicha GA, Carr SA. Conceptual evolution in Alzheimer's disease: implications for understanding the clinical phenotype of progressive neurodegenerative disease. J Alzheimers Dis. 2010;19:253-272.
11. Tunnard C, Whitehead D, Hurt C, Wahlund L, Mecocci P, Tsolaki M, et al. Apathy and cortical atrophy in Alzheimer's disease. Int J Geriatr Psychiatry. Epub 2010 Sep 27.
12. Bruen PD, McGeown WJ, Shanks MF, Venneri A. Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease. Brain. 2008;131 Pt 9:2455-2463, doi: 10.1093/brain/awn151.
13. Matsuoka T, Narumoto J, Shibata K, Okamura A, Nakamura K, Okuyama C, et al. Insular hypoperfusion correlates with the severity of delusions in individuals with Alzheimer's disease. Dement Geriatr Cogn Disord. 2010;29:287-293, doi: 10.1159/000295115.
14. Staffen W, Bergmann J, Schönauer U, Zauner H, Kronbichler M, Golaszewski S, et al. Cerebral perfusion (HMPAO-SPECT) in patients with depression with cognitive impairment versus those with mild cognitive impairment and dementia of Alzheimer's type: a semiquantitative and automated evaluation. Eur J Nucl Med Mol Imaging. 2009;36:801-810, doi: 10.1007/s00259-008-1028-2.
15. Spalletta G, Baldinetti F, Buccione I, Fadda L, Perri R, Scalmana S, et al. Cognition and behaviour are independent and heterogeneous dimensions in Alzheimer's disease. J Neurol. 2004;251:688-695, doi: 10.1007/s00415-004-0403-6.
16. Farber NB, Rubin EH, Newcomer JW, Kinscherf DA, Miller JP, Morris JC, et al. Increased neocortical neurofibrillary tangle density in subjects with Alzheimer disease and psychosis. Arch Gen Psychiatry. 2000;57:1165-1173, doi: 10.1001/archpsyc.57.12.1165.
17. Marshall GA, Fairbanks LA, Tekin S, Vinters HV, Cummings JL. Neuropathologic correlates of activities of daily living in Alzheimer disease. Alzheimer Dis Assoc Disord. 2006;20:56-59, doi: 10.1097/01.wad.0000201852.60330.16.
18. Rabbitt P, Donlan C, Watson P, McInnes L, Bent N. Unique and interactive effects of depression, age, socioeconomic advantage, and gender on cognitive performance of normal healthy older people. Psychol Aging. 1995;10:307-313, doi: 10.1037/0882-7974.10.3.307.
19. Ashburner J, Friston KJ. Unified Segmentation. Neuroimage. 2005;26:839-851, doi: 10.1016/j.neuroimage.2005.02.018.
20. Steinberg M, Shao H, Zandi P, Lyketsos CG, Welsh-Bohmer KA, Norton MC, et al. Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study. Int J Geriatr Psychiatry. 2008;23:170-177, doi: 10.1002/gps.1858.
21. Potter GG, Plassman BL, Burke JR, Kabeto MU, Langa KM, Llewellyn DJ, et al. Cognitive performance and informant reports in the diagnosis of cognitive impairment and dementia in African Americans and whites. Alzheimers Dement. 2009;5:445-53, doi: 10.1016/j.jalz.2009.04.1234.
22. Serra L, Perri R, Cercignani M, Spanò B, Fadda L, Marra C, et al. Are the behavioral symptoms of Alzheimer's disease directly associated with neurodegeneration? J Alzheimers Dis. 2010;21:627-639.
23. Egger K, Schocke M, Weiss E, Auffinger S, Esterhammer R, Goebel G, et al. Pattern of brain atrophy in elderly patients with depression revealed by voxel-based morphometry. Psychiatry Res. 2008;164:237-244, doi: 10.1016/j.pscychresns.2007.12.018.
24. Ismail Z, Herrmann N, Rothenburg LS, Cotter A, Leibovitch FS, Rafi-Tari S, et al. A functional neuroimaging study of appetite loss in Alzheimer's disease. J Neurol Sci. 2008;271:97-103, doi: 10.1016/j.jns.2008.03.023.
25. Tekin S, Mega MS, Masterman DM, Chow T, Garakian J, Vinters HV, et al. Orbitofrontal and anterior cingulate cortex neurofibrillary tangle burden is associated with agitation in Alzheimer disease. Ann Neurol. 2001;49:355-361, doi: 10.1002/ana.72.
26. Rosen HJ, Allison SC, Schauer GF, Gorno-Tempini ML, Weiner MW, Miller BL. Neuroanatomical correlates of behavioural disorders in dementia. Brain. 2005;128 Pt 11:2612-2625, doi: 10.1093/brain/awh628.
27. Van Hoesen GW, Parvizi J, Chu CC. Orbitofrontal cortex pathology in Alzheimer's disease. Cereb Cortex. 2000;10:243-251, doi: 10.1093/cercor/10.3.243.
28. Vidoni ED, Honea RA, Burns JM. Neural correlates of impaired functional independence in early Alzheimer's disease. J Alzheimers Dis. 2010;19:517-527.
29. Salmon E, Lespagnard S, Marique P, Peeters F, Herholz K, Perani D, et al. Cerebral metabolic correlates of four dementia scales in Alzheimer's disease. J Neurol. 2005;252:283-290, doi: 10.1007/s00415-005-0551-3.
30. Caramelli P, Robitaille Y, Laroche-Cholette A, Nitrini R, Gauvreau D, Joanette Y, et al. Structural correlates of cognitive deficits in a selected group of patients with Alzheimer's disease. Neuropsych Neuropsychol Behav Neurol. 1998;11:184-190.
31. Bonthius DJ, Solodkin A, van Hoesen GW. Pathology of the insular cortex in Alzheimer disease depends on cortical architecture. J Neuropathol Exp Neurol. 2005;64:910-922, doi: 10.1097/01.jnen.0000182983.87106.d1.
32. Markesbery WR, Schmitt FA, Kryscio RJ, Davis DG, Smith CD, Wekstein DR. Neuropathologic substrate of mild cognitive impairment. Arch Neurol. 2006;63:38-46, doi: 10.1001/archneur.63.1.38.