Insular hypoperfusion correlates with the severity of delusions in individuals with alzheimer's disease

Dementia and Geriatric Cognitive Disorders

Volumn 29, Issue 4, 2010, Pages 287-293

  Matsuoka, Teruyuki ^a   Narumoto, Jin ^a   Shibata, Keisuke ^a   Okamura, Aiko ^a   Nakamura, Kaeko ^a   Okuyama, Chio ^a   Nishimura, Tsunehiko ^a   Fukui, Kenji ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Alzheimer's disease; Delusion; Insula; Regional cerebral blood flow; Single photon emission computed tomography

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN BLOOD FLOW; BRAIN DYSFUNCTION; BRAIN PERFUSION; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; DELUSION; DISEASE ASSOCIATION; DISEASE EXACERBATION; DISEASE SEVERITY; FEMALE; HUMAN; INSULA; MALE; NEUROPSYCHIATRIC INVENTORY; PRIORITY JOURNAL; SCORING SYSTEM; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; DELUSIONS; FEMALE; HUMANS; ISCHEMIA; MALE; REGRESSION ANALYSIS; SEVERITY OF ILLNESS INDEX; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 77950331205     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000295115     Document Type: Article

References (30)

1. Wragg RE, Jeste DV: Overview of depression and psychosis in Alzheimer's disease. Am J Psychiatry 1989; 146: 577-587.
2. Matsumoto N, Ikeda M, Fukuhara R, Shinagawa S, Ishikawa T, Mori T, Toyota Y, Matsumoto T, Adachi H, Hirono N, Tanabe H: Caregiver burden associated with behavioral and psychological symptoms of dementia in elderly people in the local community. Dement Geriatr Cogn Disord 2007; 23: 219-224.
3. Steele C, Rovner B, Chase GA, Folstein M: Psychiatric symptoms and nursing home placement of patients with Alzheimer's disease. Am J Psychiatry 1990; 147: 1049-1051.
4. Schneider LS, Tariot PN, Dagerman KS, Davis SM, Hsiao JK, Ismail MS, Lebowitz BD, Lyketsos CG, Ryan JM, Stroup TS, Sultzer DL, Weintraub D, Lieberman JA: Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease. N Engl J Med 2006; 355: 1525-1538.
5. Kales HC, Valenstein M, Kim HM, McCarthy JF, Ganoczy D, Cunningham F, Blow FC: Mortality risk in patients with dementia treated with antipsychotics versus other psychiatric medications. Am J Psychiatry 2007; 164: 1568-1576.
6. Ballard C, Hanney ML, Theodoulou M, Douglas S, McShane R, Kossakowski K, Gill R, Juszczak E, Yu LM, Jacoby R: The dementia antipsychotic withdrawal trial (DARTAD): long-term follow-up of a randomised placebo-controlled trial. Lancet Neurol 2009; 8: 151-157.
7. Kotrla KJ, Chacko RC, Harper RG, Jhingran S, Doody R: SPECT findings on psychosis in Alzheimer's disease. Am J Psychiatry 1995; 152: 1470-1475.
8. Mega MS, Lee L, Dinov ID, Mishkin F, Toga AW, Cummings JL: Cerebral correlates of psychotic symptoms in Alzheimer's disease. J Neurol Neurosurg Psychiatry 2000; 69: 167-171.
9. Lopez OL, Smith G, Becker JT, Meltzer CC, De Kosky ST: The psychotic phenomenon in probable Alzheimer's disease: a positron emission tomography study. J Neuropsychiatry Clin Neurosci 2001; 13: 50-55.
10. Staff RT, Shanks MF, Macintosh L, Pestell SJ, Gemmell HG, Venneri A: Delusions in Alzheimer's disease: SPET evidence of right hemispheric dysfunction. Cortex 1999; 35: 549-560.
11. Nakano S, Yamashita F, Matsuda H, Kodama C, Yamada T: Relationship between delusions and regional cerebral blood flow in Alz heimer's disease. Dement Geriatr Cogn Disord 2006; 21: 16-21.
12. Bruen PD, McGeown WJ, Shanks MF, Venneri A: Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease. Brain 2008; 131: 2455-2463.
13. Sultzer DL, Brown CV, Mandelkern MA, Mahler ME, Mendez MF, Chen ST, Cummings JL: Delusional thoughts and regional frontal/temporal cortex metabolism in Alzheimer's disease. Am J Psychiatry 2003; 160: 341-349.
14. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-944.
15. Folstein MF, Folstein SE, McHugh PR: Minimental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-198.
16. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J: The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994; 44: 2308-2314.
17. Fukuhara R, Ikeda M, Nebu A, Kikuchi T, Maki N, Hokoishi K, Shigenobu K, Komori K, Tanabe H: Alteration of rCBF in Alzheimer's disease patients with delusions of theft. Neuroreport 2001; 12: 2473-2476.
18. Moran EK, Becker JA, Satlin A, Lyoo IK, Fischman AJ, Johnson KA: Psychosis of Alzheimer's disease: gender differences in regional perfusion. Neurobiol Aging 2008; 29: 1218-1225.
19. Crespo-Facorro B, Kim J, Andreasen NC, O'Leary DS, Bockholt HJ, Magnotta V: Insular cortex abnormalities in schizophrenia: a structural magnetic resonance imaging study of first-episode patients. Schizophr Res 2000; 46: 35-43.
20. Mesulam MM, Mufson EJ: Insula of the old world monkey. III. Efferent cortical output and comments on function. J Comp Neurol 1982; 212: 38-52.
21. Craig AD: How do you feel-now? The anterior insula and human awareness. Nat Rev Neurosci 2009; 10: 59-70.
22. Royall DR, Gao JH, Kellogg DL Jr: Insular Alzheimer's disease pathology as a cause of 'age-related' autonomic dysfunction and mortality in the non-demented elderly. Med Hypotheses 2006; 67: 747-758.
23. Royall D, Gao JH, Zhao X, Polk MJ, Kellogg D: Asymmetric insular function predicts positional blood pressure in nondemented elderly. J Neuropsychiatry Clin Neurosci 2009; 21: 173-180.
24. Braak H, Braak E, Bohl J, Lang W: Alzheimer's disease: amyloid plaques in the cerebellum. J Neurol Sci 1989; 93: 277-287.
25. Yamaguchi H, Hirai S, Morimatsu M, Shoji M, Nakazato Y: Diffuse type of senile plaques in the cerebellum of Alzheimer-type dementia demonstrated by beta protein immunostain. Acta Neuropathol 1989; 77: 314-319.
26. Ishii K, Sasaki M, Kitagaki H, Yamaji S, Sakamoto S, Matsuda K, Mori E: Reduction of cerebellar glucose metabolism in advanced Alzheimer's disease. J Nucl Med 1997; 38: 925-928.
27. Minoshima S, Frey KA, Foster NL, Kuhl DE: Preserved pontine glucose metabolism in Alzheimer disease: a reference region for functional brain image (PET) analysis. J Comput Assist Tomogr 1995; 19: 541-547.
28. Akiyama H, Harrop R, McGeer PL, Peppard R, McGeer EG: Crossed cerebellar and uncrossed basal ganglia and thalamic diaschisis in Alzheimer's disease. Neurology 1989; 39: 541-548.
29. Ramnani N: The primate cortico-cerebellar system: anatomy and function. Nat Rev Neurosci 2006; 7: 511-522.
30. Andreasen NC, Pierson R: The role of the cerebellum in schizophrenia. Biol Psychiatry 2008; 64: 81-88.